SRPX2 is overexpressed in gastric cancer and promotes cellular migration and adhesion

International Journal of Cancer

Volumn 124, Issue 5, 2009, Pages 1072-1080

  Tamaka, Kaoru ^a   Aran, Tokuzo ^a   Maegawa, Mari ^a   Matsumoto, Kazuko ^a   Kaneda, Hiroyasu ^a   Kudo, Kanae ^a   Fujita, Yoshihike ^a   Yokote, Hideyuki ^a   Yanagihara, Kazuyoshi ^b   Yamada, Yasuhide ^c   Okamoto, Isamu ^a   Nakagawa, Kazuhiko ^a   Nishio, Kazuto ^a  

^a KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^c NATIONAL CANCER CENTER HOSPITAL   (Japan)

Author keywords

Cellular adhesion; Cellular migration; Gastric cancer; SRPX2

Indexed keywords

FOCAL ADHESION KINASE; MESSENGER RNA; NERVE PROTEIN; PROTEIN SRPX2; UNCLASSIFIED DRUG; FOCAL ADHESION KINASE 1; PTK2 PROTEIN, HUMAN; SRPX2 PROTEIN, HUMAN;

ADULT; AGED; ARTICLE; CELL ADHESION; CELL GROWTH; CELL MIGRATION; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; STOMACH CANCER; TISSUE DISTRIBUTION; CELL MOTION; CYTOPLASM; GENETICS; METABOLISM; MIDDLE AGED; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; STOMACH TUMOR; TUMOR CELL LINE;

ADULT; AGED; CELL ADHESION; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CYTOPLASM; FEMALE; FOCAL ADHESION KINASE 1; HUMANS; MALE; MIDDLE AGED; NERVE TISSUE PROTEINS; PHOSPHORYLATION; RNA, MESSENGER; STOMACH NEOPLASMS;

EID: 58749111083     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.24065     Document Type: Article

References (24)

1. Kurosawa H, Goi K, Inukai T, Inaba T, Chang KS, Sliinjyo T, Rakes-traw KM, Kaeve CW, Look AT. Two candidate downstream target genes for E2A-HLF. Blood 1999;93:321-32.
2. Roll P, Rudolf G, Pereira S, Royer B, Scheffer IE, Massacrier A, Vai-enti MP, Roeckel-Trevisiol N, Jamali S, Beclin C, Seegmuller C, Metz-Lutz MN, et al. SRPX2 mutations in disorders of language cortex and cognition. Hum Mol Genet 2006; 15:1195-207.
3. Royer B, Soares DC, Barlow PN, Bontrop RE, Roll P, Robaglia-Schlupp A, Blancher A, Levasseur A, Cau P, Pontarotti P, Szepetowski P. Molecular evolution of the human SRPX2 gene that causes brain disorders of the Rolandic and Sylvian speech areas. BMC Genet 2007:8:72.
4. O'Leary IM, Bromek K, Black GM, Uhrinova S, Schmitz C, Wang X, Krych M, Atkinson JP, Uhrin D, Barlow PN. Backbone dynamics of complement control protein (CCP) modules reveals mobility in binding surfaces. Protein Sci 2004:13:1238-50.
5. Soares DC, Gerloff DL, Syme NR, Coulson AF, Parkinson J, Barlow PN. Large-scale modelling as a route to multiple surface comparisons of the CCP module family. Protein Eng Des Sel 2005:18:379-88.
6. Meindl A, Carvalho MR, Herrmann K. Lorenz B, Achatz If. Apfel-stedt-Sylla E, Wittwer B, Ross M, Meitinger T. A gene (SRPX) encoding a sushi-repeat-containing protein is deleted in patients with X-linked retinitis pigmentosa. Hum Mol Genet 1995;4:2339-46.
7. Dry KL, Aldred MA, Edgar AJ, Brown J, Manson FD, Ho MF, Prosser J, Hardwick LI, Lennon AA, Thomson K, Keuren MV, Kurnit DM, et al. Identification of a novel gene, ETX1 from Xpll.l, a candidate gene for X-linked retintis pigmentosa (RP3). Hum Mol Genet 1995;4:2347-53.
8. Callebaut 1, Gilges D, Vigon I, Mornon JP. HYR, an extracellular module involved in cellular adhesion and related to the immunoglobulin- like fold. Protein Sci 2000;9:1382-90.
9. Yamada Y, Arao T, Gotoda T, Taniguchi H, Oda I, Shirao K, Shi-mada Y, Hamaguchi T, Kato K, Hamano T, Koizumi F, Tamura T, et al. Identification of prognostic biomarkers in gastric cancer using endoscopic biopsy samples. Cancer Sci 2008:99:2193-99.
10. Yamanaka R, Arao T, Yajima N, Tsuchiya N, Horama J, Tanaka R, Sano M, Oide A, Sekijima M, Nishio K. Identification of expressed genes characterizing long-term survival in malignant glioma patients. Oncogene 2006:25:5994-6002.
11. Parsons JT. Focal adhesion kinase: the first ten years. J Cell Sci 2003; 116:1409-16.
12. Pala D, Kapoor M, Woods A, Kennedy L, Liu S, Chen S, Bursell L, Lyons KM, Carter DE, Beier F, Leask A. Focal adhesion kinase/Src suppresses early chondrogenesis: central role of CCN2. J Biol Chem 2008:283:9239-47.
13. Lan CC, Wu CS, Chiou MH, Hsieh PC, Yu HS. Low-energy helium-neon laser induces locomotion of the immature melanoblasts and promotes melanogenesis of the more differentiated melanoblasts: recapitulation of vitiligo repigraentation in vitro. I Invest Dermatol 2006; 126:2119-26.
14. Mousa SA. Cell adhesion molecules: potential therapeutic & diagnostic implications. Mol Bioteehnol 2008:38:33-40.
15. Vestweber D, Blanks IE. Mechanisms that regulate the function of the selectins and their ligands. Physiol Rev 1999;79:181-213.
16. Mineur P, Guignandon A, Lambert ChA, Amblard M, Lapiere ChM, Nusgens BV. RODS and DGEA-induced [Ca2+]i signalling in human dermal fibroblasts. Biochim Biophys Acta 2005:1746:28-37.
17. Sehaller MD. FAK and paxillin; regulators of N-cadherin adhesion and inhibitors of cell migration? J Cell Biol 2004;166:157-9.
18. Mitra SK, Schlaepfer DD. Tntegrin-regulated FAK-Src signaling in normal and cancer cells. Curr Opin Cell Biol 2006; 18:516-23.
19. Royer-Zemmour B, Ponsole-Lenfant M, Gara H, Roll P, Leveque C, Massacrier A, Ferracci G, Cillario I, Robaglia-Schlupp A, Vincentelli R, Cau P, Szepetowski P. Epileptic and developmental disorders of the speech cortex: ligand/reeeptor interaction of wild-type and mutant SRPX2 with the plasminogen activator receptor uPAR. Hum Mol Genet 2008;17:3617-30.
20. Witz IP. The selectin-selectin ligand axis in tumor progression. Cancer Metastasis Rev 2008;27:19-30.
21. Barthel SR. Gavino JD, Descheny L, Dimitroff CI. Targeting selectins and selectin ligands in inflammation and cancer. Expert Opin Ther Targets 2007;11:1473-91.
22. Oh IY, Yoon CH, Hur J, Kim JH, Kim TY, Lee CS, Park KW, Chae IH, Oh BH, Park YB, Kim HS. Involvement of E-selectin in recruitment of endothelial progenitor cells and angiogenesis in ischemic muscle. Blood 2007:110:3891-9.
23. Egami K, Murohara T, Aoki M, Matsuishi T. Ischemia-induced angiogenesis: role of inflammatory response mediated by P-selectin. J Leu-koc Biol 2006:79:971-6.
24. Hunger SP. Chromosomal translocations involving the E2A gene in acute lymphoblastic leukemia: clinical features and molecular pathogenesis. Blood 1996;87:1211-24.