PTEN inhibitor bisperoxovanadium protects oligodendrocytes and myelin and prevents neuronal atrophy in adult rats following cervical hemicontusive spinal cord injury

Neuroscience Letters

Volumn 573, Issue , 2014, Pages 64-68

  Walker, Chandler L ^a   Xu, Xiao Ming ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

BpV; Neuron atrophy; Oligodendrocyte survival; PTEN; Spinal cord injury

Indexed keywords

BISPEROXOVANADIUM; FAST BLUE; MYELIN; NEUROPROTECTIVE AGENT; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE INHIBITOR; UNCLASSIFIED DRUG; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; VANADIUM DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CELL DEATH; CERVICAL SPINAL CORD INJURY; CONTROLLED STUDY; FEMALE; IMMUNOFLUORESCENCE; MOTONEURON; MYELINATION; NONHUMAN; NOTE; OLIGODENDROGLIA; PRIORITY JOURNAL; RAT; REMYELINIZATION; TISSUE INJURY; WHITE MATTER; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL SURVIVAL; CERVICAL SPINAL CORD; DRUG EFFECTS; METABOLISM; MYELIN SHEATH; PATHOLOGY; SPINAL CORD INJURIES; SPRAGUE DAWLEY RAT;

ANIMALS; CELL SURVIVAL; CERVICAL CORD; FEMALE; MOTOR NEURONS; MYELIN SHEATH; NEUROPROTECTIVE AGENTS; OLIGODENDROGLIA; PTEN PHOSPHOHYDROLASE; RATS, SPRAGUE-DAWLEY; SPINAL CORD INJURIES; VANADIUM COMPOUNDS; WHITE MATTER;

EID: 84902084784     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2014.02.039     Document Type: Note

References (34)

1. Ek C.J., Habgood M.D., Callaway J.K., Dennis R., Dziegielewska K.M., Johansson P.A., Potter A., Wheaton B., Saunders N.R. Spatio-temporal progression of grey and white matter damage following contusion injury in rat spinal cord. PLoS ONE 2010, 5:e12021.
2. Norenberg M.D., Smith J., Marcillo A. The pathology of human spinal cord injury: defining the problems. J. Neurotrauma 2004, 21:429-440.
3. Warden P., Bamber N.I., Li H., Esposito A., Ahmad K.A., Hsu C.Y., Xu X.M. Delayed glial cell death following Wallerian degeneration in white matter tracts after spinal cord dorsal column cordotomy in adult rats. Exp. Neurol. 2001, 168:213-224.
4. Totoiu M.O., Keirstead H.S. Spinal cord injury is accompanied by chronic progressive demyelination. J. Comp. Neurol. 2005, 486:373-383.
5. Crowe M.J., Bresnahan J.C., Shuman S.L., Masters J.N., Beattie M.S. Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys. Nat. Med. 1997, 3:73-76.
6. Liu X.Z., Xu X.M., Hu R., Du C., McDonald J.W., Dong H.X., Wu Y.J., Fan G.S., Jacquin M.F., Hsu C.Y., Choi D.W. Neuronal and glial apoptosis after traumatic spinal cord injury. J. Neurosci. 1997, 17:5395-5406.
7. Whitaker C.M., Beaumont E., Wells M.J., Magnuson D.S., Hetman M., Onifer S.M. Rolipram attenuates acute oligodendrocyte death in the adult rat ventrolateral funiculus following contusive cervical spinal cord injury. Neurosci. Lett. 2008, 438:200-204.
8. Chuenkova M.V., Furnari F.B., Cavenee W.K., Pereira M.A. Trypanosoma cruzi trans-sialidase: a potent and specific survival factor for human Schwann cells by means of phosphatidylinositol 3-kinase/Akt signaling. Proc. Natl. Acad. Sci. U. S. A. 2001, 98:9936-9941.
9. Harrington E.P., Zhao C., Fancy S.P., Kaing S., Franklin R.J., Rowitch D.H. Oligodendrocyte PTEN is required for myelin and axonal integrity, not remyelination. Ann. Neurol. 2010, 68:703-716.
10. Liu S., Stewart T.J., Howard M.J., Chakrabortty S., Holekamp T.F., McDonald J.W. Embryonic stem cells differentiate into oligodendrocytes and myelinate in culture and after spinal cord transplantation. Proc. Natl. Acad. Sci. U. S. A. 2001, 97:6126-6131.
11. Tyler W.A., Gangoli N., Gokina P., Kim H.A., Covey M., Levison S.W., Wood T.L. Activation of the mammalian target of rapamycin (mTOR) is essential for oligodendrocyte differentiation. J. Neurosci. 2009, 29:6367-6378.
12. Ogata T., Iijima S., Hoshikawa S., Miura T., Yamamoto S., Oda H., Nakamura K., Tanaka S. Opposing extracellular signal-regulated kinase and Akt pathways control schwann cell myelination. J.Neurosci. 2004, 24:6724-6732.
13. Walker C.L., Walker M.J., Liu N.K., Risberg E.C., Gao X., Chen J., Xu X.M. Systemic bisperoxovanadium activates Akt/mTOR, reduces autophagy, and enhances recovery following cervical spinal cord injury. PLOS ONE 2012, 7:e30012.
14. Flores A.I., Narayanan S.P., Morse E.N., Shick H.E., Yin X., Kidd G., Avila R.L., Kirschner D.A., Macklin W.B. Constitutively active Akt induces enhanced myelination in the CNS. J. Neurosci. 2008, 28:7174-7183.
15. Narayanan S.P., Flores A.I., Wang F., Macklin W.B. Akt signals through the mammalian target of rapamycin pathway to regulate CNS myelination. J. Neurosci. 2009, 29:6860-6870.
16. Slaets H., Dumont D., Vanderlocht J., Noben J.P., Leprince P., Robben J., Hendriks J., Stinissen P., Hellings N. Leukemia inhibitory factor induces an antiapoptotic response in oligodendrocytes through Akt-phosphorylation and up-regulation of 14-3-3. Proteomics 2008, 8:1237-1247.
17. Wang X.Q., Yao R.Q., Liu X., Huang J.J., Qi D.S., Yang L.H. Quercetin protects oligodendrocyte precursor cells from oxygen/glucose deprivation injury in vitro via the activation of the PI3K/Akt signaling pathway. Brain Res. Bull. 2011, 86:277-284.
18. Xu C., Lv L., Zheng G., Li B., Gao L., Sun Y. Neuregulin1beta1 protects oligodendrocyte progenitor cells from oxygen glucose deprivation injury induced apoptosis via ErbB4-dependent activation of PI3-kinase/Akt. Brain Res. 2012, 1467:104-112.
19. Beaumont E., Whitaker C.M., Burke D.A., Hetman M., Onifer S.M. Effects of rolipram on adult rat oligodendrocytes and functional recovery after contusive cervical spinal cord injury. Neurosci. 2009, 163:985-990.
20. Loy D.N., Magnuson D.S., Zhang Y.P., Onifer S.M., Mills M.D., Cao Q.L., Darnall J.B., Fajardo L.C., Burke D.A., Whittemore S.R. Functional redundancy of ventral spinal locomotor pathways. J. Neurosci. 2002, 22:315-323.
21. Loy D.N., Talbott J.F., Onifer S.M., Mills M.D., Burke D.A., Dennison J.B., Fajardo L.C., Magnuson D.S., Whittemore S.R. Both dorsal and ventral spinal cord pathways contribute to overground locomotion in the adult rat. Exp. Neurol. 2002, 177:575-580.
22. Gensel J.C., Tovar C.A., Hamers F.P., Deibert R.J., Beattie M.S., Bresnahan J.C. Behavioral and histological characterization of unilateral cervical spinal cord contusion injury in rats. J. Neurotrauma 2006, 23:36-54.
23. Gruner J.A. A monitored contusion model of spinal cord injury in the rat. J. Neurotrauma 1992, 9:123-128.
24. Zhang Q.G., Wu D.N., Han D., Zhang G.Y. Critical role of PTEN in the coupling between PI3K/Akt and JNK1/2 signaling in ischemic brain injury. FEBS Lett. 2007, 581:495-505.
25. Liu N.K., Zhang Y.P., Titsworth W.L., Jiang X., Han S., Lu P.H., Shields C.B., Xu X.M. A novel role of phospholipase A(2) in mediating spinal cord secondary injury. Ann. Neurol. 2006, 59:606-619.
26. Giovanelli Barilari M., Kuypers H.G. Propriospinal fibers interconnecting the spinal enlargements in the cat. Brain Res. 1969, 14:321-330.
27. Sterling P., Kuypers H.G. Anatomical organization of the brachial spinal cord of the cat. 3. The propriospinal connections. Brain Res. 1968, 7:419-443.
28. Cote M.P., Detloff M.R., Wade R.E., Lemay M.A., Houle J.D. Plasticity in ascending long propriospinal and descending supraspinal pathways in chronic cervical spinal cord injured rats. Front. Physiol. 2012, 3:330.
29. De Paula M.L., Cui Q.L., Hossain S., Antel J., Almazan G. The PTEN inhibitor bisperoxovanadium enhances myelination by amplifying IGF-1 signaling in rat and human oligodendrocyte progenitors. Glia 2014, 62:64-77.
30. Kobayashi N.R., Fan D.P., Giehl K.M., Bedard A.M., Wiegand S.J., Tetzlaff W. BDNF and NT-4/5 prevent atrophy of rat rubrospinal neurons after cervical axotomy, stimulate GAP-43 and Talpha1-tubulin mRNA expression, and promote axonal regeneration. J. Neurosci. 1997, 17:9583-9595.
31. Ma J., Novikov L.N., Wiberg M., Kellerth J.O. Delayed loss of spinal motoneurons after peripheral nerve injury in adult rats: a quantitative morphological study. Exp. Brain Res. 2001, 139:216-223.
32. Eng C. PTEN: one gene, many syndromes. Hum. Mutat. 2003, 22:183-198.
33. Fraser M.M., Zhu X., Kwon C.H., Uhlmann E.J., Gutmann D.H., Baker S.J. Pten loss causes hypertrophy and increased proliferation of astrocytes in vivo. Cancer Res. 2004, 64:7773-7779.
34. Chalhoub N., Kozma S.C., Baker S.J. S6k1 is not required for Pten-deficient neuronal hypertrophy. Brain Res. 2006, 1100:32-41.