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Volumn 13, Issue 1, 2014, Pages

Overexpression of CIP2A is an independent prognostic indicator in nasopharyngeal carcinoma and its depletion suppresses cell proliferation and tumor growth

Author keywords

Cell growth; CIP2A; Nasopharyngeal carcinoma; Proliferation; Survival

Indexed keywords

CANCEROUS INHIBITOR OF PROTEIN PHOSPHATASE 2A; MESSENGER RNA; MYC PROTEIN; ONCOPROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; AUTOANTIGEN; KIAA1524 PROTEIN, HUMAN; MEMBRANE PROTEIN; MYC PROTEIN, HUMAN; TUMOR MARKER;

EID: 84902084685     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-13-111     Document Type: Article
Times cited : (20)

References (35)
  • 1
    • 84881270200 scopus 로고    scopus 로고
    • Nasopharyngeal carcinoma incidence and mortality in China in 2009
    • 10.5732/cjc.013.10118, 3845582, 23863562
    • Xu ZJ, Zheng RS, Zhang SW, Zou XN, Chen WQ. Nasopharyngeal carcinoma incidence and mortality in China in 2009. Chin J Cancer 2013, 32:453-460. 10.5732/cjc.013.10118, 3845582, 23863562.
    • (2013) Chin J Cancer , vol.32 , pp. 453-460
    • Xu, Z.J.1    Zheng, R.S.2    Zhang, S.W.3    Zou, X.N.4    Chen, W.Q.5
  • 2
    • 79751509698 scopus 로고    scopus 로고
    • Most common cancers in Asia-Pacific region: nasopharyngeal carcinoma
    • Asian Pacific Organization for Cancer Prevention
    • Cho WC. Most common cancers in Asia-Pacific region: nasopharyngeal carcinoma. Cancer report of Asian-Pacific region 2010 2010, 284-289. Asian Pacific Organization for Cancer Prevention.
    • (2010) Cancer report of Asian-Pacific region 2010 , pp. 284-289
    • Cho, W.C.1
  • 4
    • 79957556359 scopus 로고    scopus 로고
    • How does intensity-modulated radiotherapy versus conventional two-dimensional radiotherapy influence the treatment results in nasopharyngeal carcinoma patients?
    • 10.1016/j.ijrobp.2010.03.024, 20643517
    • Lai SZ, Li WF, Chen L, Luo W, Chen YY, Liu LZ, Sun Y, Lin AH, Liu MZ, Ma J. How does intensity-modulated radiotherapy versus conventional two-dimensional radiotherapy influence the treatment results in nasopharyngeal carcinoma patients?. Int J Radiat Oncol Biol Phys 2011, 80:661-668. 10.1016/j.ijrobp.2010.03.024, 20643517.
    • (2011) Int J Radiat Oncol Biol Phys , vol.80 , pp. 661-668
    • Lai, S.Z.1    Li, W.F.2    Chen, L.3    Luo, W.4    Chen, Y.Y.5    Liu, L.Z.6    Sun, Y.7    Lin, A.H.8    Liu, M.Z.9    Ma, J.10
  • 5
    • 84878567392 scopus 로고    scopus 로고
    • Progress report of a randomized trial comparing long-term survival and late toxicity of concurrent chemoradiotherapy with adjuvant chemotherapy versus radiotherapy alone in patients with stage III to IVB nasopharyngeal carcinoma from endemic regions of China
    • 10.1002/cncr.28049, 23576020
    • Chen Y, Sun Y, Liang SB, Zong JF, Li WF, Chen M, Chen L, Mao YP, Tang LL, Guo Y, Lin AH, Liu MZ, Ma J. Progress report of a randomized trial comparing long-term survival and late toxicity of concurrent chemoradiotherapy with adjuvant chemotherapy versus radiotherapy alone in patients with stage III to IVB nasopharyngeal carcinoma from endemic regions of China. Cancer 2013, 119:2230-2238. 10.1002/cncr.28049, 23576020.
    • (2013) Cancer , vol.119 , pp. 2230-2238
    • Chen, Y.1    Sun, Y.2    Liang, S.B.3    Zong, J.F.4    Li, W.F.5    Chen, M.6    Chen, L.7    Mao, Y.P.8    Tang, L.L.9    Guo, Y.10    Lin, A.H.11    Liu, M.Z.12    Ma, J.13
  • 8
    • 84867039610 scopus 로고    scopus 로고
    • CIP2A signature reveals the MYC dependency of CIP2A-regulated phenotypes and its clinical association with breast cancer subtypes
    • 10.1038/onc.2011.599, 22249265
    • Niemelä M, Kauko O, Sihto H, Mpindi JP, Nicorici D, Pernilä P, Kallioniemi OP, Joensuu H, Hautaniemi S, Westermarck J. CIP2A signature reveals the MYC dependency of CIP2A-regulated phenotypes and its clinical association with breast cancer subtypes. Oncogene 2012, 31:4266-4278. 10.1038/onc.2011.599, 22249265.
    • (2012) Oncogene , vol.31 , pp. 4266-4278
    • Niemelä, M.1    Kauko, O.2    Sihto, H.3    Mpindi, J.P.4    Nicorici, D.5    Pernilä, P.6    Kallioniemi, O.P.7    Joensuu, H.8    Hautaniemi, S.9    Westermarck, J.10
  • 10
    • 52449121851 scopus 로고    scopus 로고
    • CIP2A is overexpressed in gastric cancer and its depletion leads to impaired clonogenicity, senescence, or differentiation of tumor cells
    • 10.1158/1078-0432.CCR-07-4137, 18559589
    • Li W, Ge Z, Liu C, Liu Z, Björkholm M, Jia J, Xu D. CIP2A is overexpressed in gastric cancer and its depletion leads to impaired clonogenicity, senescence, or differentiation of tumor cells. Clin Cancer Res 2008, 14:3722-3728. 10.1158/1078-0432.CCR-07-4137, 18559589.
    • (2008) Clin Cancer Res , vol.14 , pp. 3722-3728
    • Li, W.1    Ge, Z.2    Liu, C.3    Liu, Z.4    Björkholm, M.5    Jia, J.6    Xu, D.7
  • 11
    • 84895750890 scopus 로고    scopus 로고
    • CIP2A oncoprotein controls cell growth and autophagy through TORC1 activation
    • 10.1083/jcb.201304012, 24590173
    • Puustinen P, Rytter A, Mortensen M, Kohonen P, Moreira JM, Jäättelä M. CIP2A oncoprotein controls cell growth and autophagy through TORC1 activation. J Cell Biol 2014, 204:713-727. 10.1083/jcb.201304012, 24590173.
    • (2014) J Cell Biol , vol.204 , pp. 713-727
    • Puustinen, P.1    Rytter, A.2    Mortensen, M.3    Kohonen, P.4    Moreira, J.M.5    Jäättelä, M.6
  • 12
    • 79955739210 scopus 로고    scopus 로고
    • CIP2A is overexpressed in non-small cell lung cancer and correlates with poor prognosis
    • 10.1245/s10434-010-1313-8, 20842459
    • Dong QZ, Wang Y, Dong XJ, Li ZX, Tang ZP, Cui QZ, Wang EH. CIP2A is overexpressed in non-small cell lung cancer and correlates with poor prognosis. Ann Surg Oncol 2011, 18:857-865. 10.1245/s10434-010-1313-8, 20842459.
    • (2011) Ann Surg Oncol , vol.18 , pp. 857-865
    • Dong, Q.Z.1    Wang, Y.2    Dong, X.J.3    Li, Z.X.4    Tang, Z.P.5    Cui, Q.Z.6    Wang, E.H.7
  • 14
    • 84874643751 scopus 로고    scopus 로고
    • Clinical implications of CIP2A protein expression in breast cancer
    • Yu G, Liu G, Dong J, Jin Y. Clinical implications of CIP2A protein expression in breast cancer. Med Oncol 2013, 30:524.
    • (2013) Med Oncol , vol.30 , pp. 524
    • Yu, G.1    Liu, G.2    Dong, J.3    Jin, Y.4
  • 16
    • 84856019028 scopus 로고    scopus 로고
    • Expression of CIP2A in renal cell carcinomas correlates with tumour invasion, metastasis and patients' survival
    • 10.1038/bjc.2011.492, 3251889, 22075943
    • Ren J, Li W, Yan L, Jiao W, Tian S, Li D, Tang Y, Gu G, Liu H, Xu Z. Expression of CIP2A in renal cell carcinomas correlates with tumour invasion, metastasis and patients' survival. Br J Cancer 2011, 105:1905-1911. 10.1038/bjc.2011.492, 3251889, 22075943.
    • (2011) Br J Cancer , vol.105 , pp. 1905-1911
    • Ren, J.1    Li, W.2    Yan, L.3    Jiao, W.4    Tian, S.5    Li, D.6    Tang, Y.7    Gu, G.8    Liu, H.9    Xu, Z.10
  • 20
    • 79959252521 scopus 로고    scopus 로고
    • Cancerous inhibitor of PP2A (CIP2A) at diagnosis of chronic myeloid leukemia is a critical determinant of disease progression
    • 10.1182/blood-2010-08-304477, 21490338
    • Lucas CM, Harris RJ, Giannoudis A, Copland M, Slupsky JR, Clark RE. Cancerous inhibitor of PP2A (CIP2A) at diagnosis of chronic myeloid leukemia is a critical determinant of disease progression. Blood 2011, 117:6660-6668. 10.1182/blood-2010-08-304477, 21490338.
    • (2011) Blood , vol.117 , pp. 6660-6668
    • Lucas, C.M.1    Harris, R.J.2    Giannoudis, A.3    Copland, M.4    Slupsky, J.R.5    Clark, R.E.6
  • 21
    • 84888337350 scopus 로고    scopus 로고
    • Cancerous inhibitor of protein phosphatase 2A, an emerging human oncoprotein and a potential cancer therapy target
    • 10.1158/0008-5472.CAN-13-1994, 24204027
    • Khanna A, Pimanda JE, Westermarck J. Cancerous inhibitor of protein phosphatase 2A, an emerging human oncoprotein and a potential cancer therapy target. Cancer Res 2013, 73:6548-6553. 10.1158/0008-5472.CAN-13-1994, 24204027.
    • (2013) Cancer Res , vol.73 , pp. 6548-6553
    • Khanna, A.1    Pimanda, J.E.2    Westermarck, J.3
  • 22
    • 12344308021 scopus 로고    scopus 로고
    • PP2A: the expected tumor suppressor
    • 10.1016/j.gde.2004.12.004, 15661531
    • Jansens V, Goris J, Hoof C. PP2A: the expected tumor suppressor. Curr Opin Genet Dev 2005, 15:34-41. 10.1016/j.gde.2004.12.004, 15661531.
    • (2005) Curr Opin Genet Dev , vol.15 , pp. 34-41
    • Jansens, V.1    Goris, J.2    Hoof, C.3
  • 23
    • 4344646902 scopus 로고    scopus 로고
    • Species- and cell type-specific requirements for cellular transformation
    • 10.1016/j.ccr.2004.07.009, 15324700
    • Rangarajan A, Hong SJ, Gifford A, Weinberg RA. Species- and cell type-specific requirements for cellular transformation. Cancer Cell 2004, 6:171-183. 10.1016/j.ccr.2004.07.009, 15324700.
    • (2004) Cancer Cell , vol.6 , pp. 171-183
    • Rangarajan, A.1    Hong, S.J.2    Gifford, A.3    Weinberg, R.A.4
  • 24
    • 78649511007 scopus 로고    scopus 로고
    • CIP2A mediates effects of bortezomib on phospho-Akt and apoptosis in hepatocellular carcinoma cells
    • 10.1038/onc.2010.357, 20729919
    • Chen KF, Liu CY, Lin YC, Yu HC, Liu TH, Hou DR, Chen PJ, Cheng AL. CIP2A mediates effects of bortezomib on phospho-Akt and apoptosis in hepatocellular carcinoma cells. Oncogene 2010, 29:6257-6266. 10.1038/onc.2010.357, 20729919.
    • (2010) Oncogene , vol.29 , pp. 6257-6266
    • Chen, K.F.1    Liu, C.Y.2    Lin, Y.C.3    Yu, H.C.4    Liu, T.H.5    Hou, D.R.6    Chen, P.J.7    Cheng, A.L.8
  • 26
    • 84860130283 scopus 로고    scopus 로고
    • CIP2A is a target of bortezomib in human triple negative breast cancer cells
    • 10.1186/bcr3175, 3446403, 22537901
    • Tseng LM, Liu CY, Chang KC, Chu PY, Shiau CW, Chen KF. CIP2A is a target of bortezomib in human triple negative breast cancer cells. Breast Cancer Res 2012, 14:R68. 10.1186/bcr3175, 3446403, 22537901.
    • (2012) Breast Cancer Res , vol.14
    • Tseng, L.M.1    Liu, C.Y.2    Chang, K.C.3    Chu, P.Y.4    Shiau, C.W.5    Chen, K.F.6
  • 27
    • 84888380323 scopus 로고    scopus 로고
    • CIP2A modulates cell cycle progression in human cancer cells by regulating the stability and activity of PLK1
    • 10.1158/0008-5472.CAN-13-0888, 23983103
    • Kim JS, Kim EJ, Oh JS, Park IC, Hwang SG. CIP2A modulates cell cycle progression in human cancer cells by regulating the stability and activity of PLK1. Cancer Res 2013, 73:6667-6678. 10.1158/0008-5472.CAN-13-0888, 23983103.
    • (2013) Cancer Res , vol.73 , pp. 6667-6678
    • Kim, J.S.1    Kim, E.J.2    Oh, J.S.3    Park, I.C.4    Hwang, S.G.5
  • 29
    • 79952916409 scopus 로고    scopus 로고
    • ETS2 mediates MEK1/2-dependent overexpression of cancerous inhibitor of protein phosphatase 2A (CIP2A) in human cancer cells
    • 10.1371/journal.pone.0017979, 3062549, 21445343
    • Khanna A, Okkeri J, Bilgen T, Tiirikka T, Vihinen M, Visakirpi T, Westermarck J. ETS2 mediates MEK1/2-dependent overexpression of cancerous inhibitor of protein phosphatase 2A (CIP2A) in human cancer cells. PLoS One 2011, 6:e17979. 10.1371/journal.pone.0017979, 3062549, 21445343.
    • (2011) PLoS One , vol.6
    • Khanna, A.1    Okkeri, J.2    Bilgen, T.3    Tiirikka, T.4    Vihinen, M.5    Visakirpi, T.6    Westermarck, J.7
  • 31
    • 84855347756 scopus 로고    scopus 로고
    • Interfacial inhibitors: targeting macromolicular complexes
    • Pommier Y, Marchand C. Interfacial inhibitors: targeting macromolicular complexes. Nat Rev Drug Discov 2012, 11:25-36.
    • (2012) Nat Rev Drug Discov , vol.11 , pp. 25-36
    • Pommier, Y.1    Marchand, C.2
  • 33
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • 10.1006/meth.2001.1262, 11846609
    • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001, 25:402-408. 10.1006/meth.2001.1262, 11846609.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 34
    • 84872026528 scopus 로고    scopus 로고
    • Reduced expression of Dicer1 is associated with poor prognosis in patients with nasopharyngeal carcinoma
    • Liu N, Cui RX, He QM, Huang BJ, Sun Y, Xie D, Zeng J, Wang HY, Ma J. Reduced expression of Dicer1 is associated with poor prognosis in patients with nasopharyngeal carcinoma. Med Oncol 2013, 30:360.
    • (2013) Med Oncol , vol.30 , pp. 360
    • Liu, N.1    Cui, R.X.2    He, Q.M.3    Huang, B.J.4    Sun, Y.5    Xie, D.6    Zeng, J.7    Wang, H.Y.8    Ma, J.9
  • 35
    • 84872500497 scopus 로고    scopus 로고
    • MiR-29c suppresses invasion and metastasis by targeting TIAM1 in nasopharyngeal carcinoma
    • 10.1016/j.canlet.2012.10.032, 23142282
    • Liu N, Tang LL, Sun Y, Cui RX, Wang HY, Huang BJ, He QM, Jiang W, Ma J. MiR-29c suppresses invasion and metastasis by targeting TIAM1 in nasopharyngeal carcinoma. Cancer Lett 2013, 329:181-188. 10.1016/j.canlet.2012.10.032, 23142282.
    • (2013) Cancer Lett , vol.329 , pp. 181-188
    • Liu, N.1    Tang, L.L.2    Sun, Y.3    Cui, R.X.4    Wang, H.Y.5    Huang, B.J.6    He, Q.M.7    Jiang, W.8    Ma, J.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.