Fabrication of Microscale Hydrogels for Tissue Engineering Applications

Biofabrication: Micro- and Nano-fabrication, Printing, Patterning and Assemblies

Volumn , Issue , 2013, Pages 59-80

  Camci Unal, Gulden ^a,b   Zorlutuna, Pinar ^a,b   Khademhosseini, Ali ^a,b,c  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c HARVARD UNIVERSITY   (United States)

Author keywords

Fabrication; Hydrogels; Microscale; Tissue engineering

Indexed keywords

FABRICATION; HYDROGELS; TISSUE;

CELLULAR BEHAVIORS; FABRICATION TECHNIQUE; FUNCTIONAL TISSUE; MICROSCALE; PHYSICAL AND CHEMICAL PROPERTIES; THREE DIMENSIONAL (3D) STRUCTURES; TISSUE CONSTRUCTS; TISSUE ENGINEERING APPLICATIONS;

TISSUE ENGINEERING;

EID: 84902023076     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-1-4557-2852-7.00004-4     Document Type: Chapter

References (93)

1. Khademhosseini A., Langer R. Microengineered hydrogels for tissue engineering. Biomaterials 2007, 28:5087-5092.
2. Khademhosseini A., Du Y., Rajalingam B., Vacanti J.P., Langer R. Microscale technologies for tissue engineering In: Polak J, editor. Advances in tissue engineering 2007, Imperial College Press, London. 1st ed.
3. Kaji H., Camci-Unal G., Langer R., Khademhosseini A. Engineering systems for the generation of patterned co-cultures for controlling cell-cell interactions. Biochim Biophys Acta 2011, 1810:239-250.
4. Rivest C., Morrison D.W.G., Ni B., Rubin J., Yadav V., et al. Microscale hydrogels for medicine and biology: synthesis, characteristics and applications. J Mech Mater Struct 2007, 2:1103-1119.
5. Slaughter B.V., Khurshid S.S., Fisher O.Z., Khademhosseini A., Peppas N.A. Hydrogels in regenerative medicine. Adv Mater 2009, 21:3307-3329.
6. Chiellini F., Bizzarri R., Ober C.K., Schmaljiohann D., Yu T., et al. Surface patterning and biological evaluation of semi-interpenetrated poly(HEMA)/poly(alkyl β-malolactonate)s. Macromol Symp 2003, 197:369-380.
7. Di Benedetto F., Biasco A., Pisignano D., Cingolani R. Patterning polyacrylamide hydrogels by soft lithography. Nanotechnology 2005, 16:S165-S170.
8. Liu V.A., Bhatia S.N. Three-dimensional photopatterning of hydrogels containing living cells. Biomed Microdevices 2002, 4:257-266.
9. Yeh J., Ling Y., Karp J.M., Gantz J., Chandawarkar A., et al. Micromolding of shape-controlled, harvestable cell-laden hydrogels. Biomaterials 2006, 27:5391-5398.
10. Bryant S.J., Cuy J.L., Hauch K.D., Ratner B.D. Photo-patterning of porous hydrogels for tissue engineering. Biomaterials 2007, 28:2978-2986.
11. Ivanov I., Schaab C., Planitzer S., Teichmann U., Machl A., et al. DNA microarray technology and antimicrobial drug discovery. Pharmacogenomics 2000, 1:169-178.
12. Khademhosseini A., May M.H., Sefton M.V. Conformal coating of mammalian cells immobilized onto magnetically driven beads. Tissue Eng 2005, 11:1797-1806.
13. Malafaya P.B., Silva G.A., Reis R.L. Natural-origin polymers as carriers and scaffolds for biomolecules and cell delivery in tissue engineering applications. Adv Drug Deliv Rev 2007, 59:207-233.
14. Sakiyama S.E., Schense J.C., Hubbell J.A. Incorporation of heparin-binding peptides into fibrin gels enhances neurite extension: an example of designer matrices in tissue engineering. Faseb J 1999, 13:2214-2224.
15. Burdick J.A., Chung C., Jia X.Q., Randolph M.A., Langer R. Controlled degradation and mechanical behavior of photopolymerized hyaluronic acid networks. Biomacromolecules 2005, 6:386-391.
16. Lee C.J., Blumenkranz M.S., Fishman H.A., Bent S.F. Controlling cell adhesion on human tissue by soft lithography. Langmuir 2004, 20:4155-4161.
17. Kim P, Du Y, Khademhosseini A, Langer R, Suh KY. Unconventional patterning methods forbionems. In: Rogers, JA, Lee, HH, editors. Unconventional nanopatterning techniques and applications. 1st ed. Hoboken, New Jersey: John Wiley & Sons, Inc.; 2008.
18. Kane R.S., Takayama S., Ostuni E., Ingber D.E., Whitesides G.M. Patterning proteins and cells using soft lithography. Biomaterials 1999, 20:2363-2376.
19. Shin H. Fabrication methods of an engineered microenvironment for analysis of cell-biomaterial interactions. Biomaterials 2007, 28:126-133.
20. Whitesides G.M., Ostuni E., Takayama S., Jiang X., Ingber D.E. Soft lithography in biology and biochemistry. Annu Rev Biomed Eng 2001, 3:335-373.
21. Franzesi G.T., Ni B., Ling Y.B., Khademhosseini A. A controlled-release strategy for the generation of cross-linked hydrogel microstructures. J Am Chem Soc 2006, 128:15064-15065.
22. Xia Y.N., Whitesides G.M. Soft lithography. Annu Rev Mater Sci 1998, 28:153-184.
23. Cheng C.-M., LeDuc P.R. Micropatterning polyvinyl alcohol as a biomimetic material through soft lithography with cell culture. Mol Biosyst 2006, 2:299-304.
24. Song S.J., Choi J., Park Y.D., Lee J.J., Hong S.Y., et al. A three-dimensional bioprinting system for use with a hydrogel-based biomaterial and printing parameter characterization. Artif Organs 2010, 34:1044-1048.
25. Khalil S., Sun W. Bioprinting endothelial cells with alginate for 3D tissue constructs. J Biomech Eng 2009, 131:111002.
26. Ovsianikov A., Gruene M., Pflaum M., Koch L., Maiorana F., et al. Laser printing of cells into 3D scaffolds. Biofabrication 2010, 2. 0141041-7.
27. Buyukhatipoglu K., Chang R., Sun W., Clyne A.M. Bioprinted nanoparticles for tissue engineering applications. Tissue Eng Part C-Methods 2010, 16:631-642.
28. Guillotin B., Guillemot F. Cell patterning technologies for organotypic tissue fabrication. Trends Biotechnol 2011, 29:183-190.
29. Varghese D., Deshpande M., Xu T., Kesari P., Ohri S., et al. Advances in tissue engineering: cell printing. J Thorac Cardiovasc Surg 2005, 129:470-472.
30. Boland T., Mironov V., Gutowska A., Roth E.A., Markwald R.R. Cell and organ printing 2: fusion of cell aggregates in three-dimensional gels. Anat Rec Part A-Discov Mol Cell Evol Biol 2003, 272A:497-502.
31. Cui X.F., Boland T. Human microvasculature fabrication using thermal inkjet printing technology. Biomaterials 2009, 30:6221-6227.
32. Mironov V., Prestwich G., Forgacs G. Bioprinting living structures. J Mater Chem 2007, 17:2054-2060.
33. Yan Y.N., Xiong Z., Hu Y.Y., Wang S.G., Zhang R.J., et al. Layered manufacturing of tissue engineering scaffolds via multi-nozzle deposition. Mater Lett 2003, 57:2623-2628.
34. Ang T.H., Sultana F.S.A., Hutmacher D.W., Wong Y.S., Fuh J.Y.H., et al. Fabrication of 3D chitosan-hydroxyapatite scaffolds using a robotic dispensing system. Mater Sci Eng C-Biomim Supramol Syst 2002, 20:35-42.
35. Gruene M., Deiwick A., Koch L., Schlie S., Unger C., et al. Laser printing of stem cells for biofabrication of scaffold-free autologous grafts. Tissue Eng Part C-Methods 2010, 17:79-87.
36. Othon C.M., Wu X.J., Anders J.J., Ringeisen B.R. Single-cell printing to form three-dimensional lines of olfactory ensheathing cells. Biomed Mater 2008, 3. 034101.
37. Catros S., Guillotin B., Bacakova M., Fricain J.C., Guillemot F. Effect of laser energy, substrate film thickness and bioink viscosity on viability of endothelial cells printed by laser-assisted bioprinting. Appl Surf Sci 2010, 257:5142-5147.
38. Wu P.K., Ringeisen B.R. Development of human umbilical vein endothelial cell (HUVEC) and human umbilical vein smooth muscle cell (HUVSMC) branch/stem structures on hydrogel layers via biological laser printing (BioLP). Biofabrication 2010, 2. 014111.
39. Ringeisen B.R., Kim H., Barron J.A., Krizman D.B., Chrisey D.B., et al. Laser printing of pluripotent embryonal carcinoma cells. Tissue Eng 2004, 10:483-491.
40. Cohen D.L., Malone E., Lipson H., Bonassar L.J. Direct freeform fabrication of seeded hydrogels in arbitrary geometries. Tissue Eng 2006, 12:1325-1335.
41. Wang X.H., Yan Y.N., Pan Y.Q., Xiong Z., Liu H.X., et al. Generation of three-dimensional hepatocyte/gelatin structures with rapid prototyping system. Tissue Eng 2006, 12:83-90.
42. Guillemot F., Souquet A., Catros S., Guillotin B. Laser-assisted cell printing: principle, physical parameters versus cell fate and perspectives in tissue engineering. Nanomedicine 2010, 5:507-515.
43. Skardal A., Zhang J.X., McCoard L., Xu X.Y., Oottamasathien S., et al. Photocrosslinkable hyaluronan-gelatin hydrogels for two-step bioprinting. Tissue Eng Part A 2010, 16:2675-2685.
44. Lee W., Pinckney J., Lee V., Lee J.H., Fischer K., et al. Three-dimensional bioprinting of rat embryonic neural cells. Neuroreport 2009, 20:798-803.
45. Guillotin B., Souquet A., Catros S., Duocastella M., Pippenger B., et al. Laser assisted bioprinting of engineered tissue with high cell density and microscale organization. Biomaterials 2010, 31:7250-7256.
46. Buyukhatipoglu K, Chang R, Sun W, Clyne AM. Bioprinted nanoparticles for tissue engineering. Tissue Eng Part C-Methods 2010;16:631-42.
47. Kini G.C., Lai J., Wong M.S., Biswal S.L. Microfluidic formation of ionically cross-linked polyamine gels. Langmuir 2010, 26:6650-6656.
48. Kang E., Jeong G.S., Choi Y.Y., Lee K.H., Khademhosseini A., et al. Digitally tunable physicochemical coding of material composition and topography in continuous microfibres. Nature Mater 2011, 10:877-883.
49. Lo C.W., Jiang H.R. Photopatterning and degradation study of dextran-glycidyl methacrylate hydrogels. Polym Eng Sci 2010, 50:232-239.
50. Burdick J.A., Khademhosseini A., Langer R. Fabrication of gradient hydrogels using a microfluidics/photopolymerization process. Langmuir 2004, 20:5153-5156.
51. Nemir S., Hayenga H.N., West J.L. PEGDA hydrogels with patterned elasticity: novel tools for the study of cell response to substrate rigidity. Biotechnol Bioeng 2010, 105:636-644.
52. Aubin H, Nichol JW, Hutson CB, Bae H, Sieminski AL, et al. Directed 3D cell alignment and elongation in microengineered hydrogels. Biomaterials 2010, 31:6941-6951.
53. Hahn MS, Taite LJ, Moon JJ, Rowland MC, Ruffino KA, et al. Photolithographic patterning of polyethylene glycol hydrogels. Biomaterials 2006, 27:2519-2524.
54. Chiu Y.C., Larson J.C., Perez-Luna V.H., Brey E.A. Formation of microchannels in poly(ethylene glycol) hydrogels by selective degradation of patterned microstructures. Chem Mater 2009, 21:1677-1682.
55. Albrecht D.R., Underhill G.H., Wassermann T.B., Sah R.L., Bhatia S.N. Probing the role of multicellular organization in three-dimensional microenvironments. Nature Methods 2006, 3:369-375.
56. Ayala P., Lopez J.I., Desai T.A. Microtopographical cues in 3D attenuate fibrotic phenotype and extracellular matrix deposition: implications for tissue regeneration. Tissue Eng Part A 2010, 16:2519-2527.
57. Tsang V.L., Chen A.A., Cho L.M., Jadin K.D., Sah R.L., et al. Fabrication of 3D hepatic tissues by additive photopatterning of cellular hydrogels. FASEB J 2007, 21:790-801.
58. Lee S.H., Moon J.J., West J.L. Three-dimensional micropatterning of bioactive hydrogels via two-photon laser scanning photolithography for guided 3D cell migration. Biomaterials 2008, 29:2962-2968.
59. Hoffmann J.C., West J.L. Three-dimensional photolithographic patterning of multiple bioactive ligands in poly(ethylene glycol) hydrogels. Soft Matter 2010, 6:5056-5063.
60. Du Y., Lo E., Vidula M.K., Khabiry M., Khademhosseini A. Method of bottom-up directed assembly of cell-laden microgels. Cell Mol Bioeng 2008, 1:157-162.
61. Zamanian B., Masaeli M., Nichol J.W., Khabiry M., Hancock M.J., et al. Interface directed self assembly of cell-laden microgels. Small 2010, 6:937-44.
62. Du Y., Ghodousi M., Lo E., Vidula M.K., Emiroglu O., et al. Surface-directed assembly of cell-laden microgels. Biotechnol Bioeng 2010, 105:655-662.
63. Du Y., Lo E., Ali S., Khademhosseini A. Directed assembly of cell-laden microgels for fabrication of 3D tissue constructs. Proc Natl Acad Sci USA 2008, 105:9522-9527.
64. Chandra D., Taylor J.A., Yang S. Replica molding of high-aspect-ratio (sub-)micron hydrogel pillar arrays and their stability in air and solvents. Soft Matter 2008, 4:979-984.
65. Geissler M., Xia Y Patterning: principles and some new developments. Adv Mater 2004, 16:1249-1269.
66. Raghavan S., Nelson C.M., Baranski J.D., Lim E., Chen C.S. Geometrically controlled endothelial tubulogenesis in micropatterned gels. Tissue Eng Part A 2010, 16:2255-2263.
67. Nichol J.W., Koshy S.T., Bae H., Hwang C.M., Yamanlar S., et al. Cell-laden microengineered gelatin methacrylate hydrogels. Biomaterials 2010, 31:5536-5544.
68. Khademhosseini A., Eng G., Yeh J., Fukuda J., Blumling J., et al. Micromolding of photocrosslinkable hyaluronic acid for cell encapsulation and entrapment. J Biomed Mater Res A 2006, 79:522-532.
69. Suh K.Y., Khademhosseini A., Yang J.M., Eng G., Langer R. Soft lithographic patterning of hyaluronic acid on hydrophilic substrates using molding and printing. Adv Mater 2004, 16:584-588.
70. Revzin A., Russell R.J., Yadavalli V.K., Koh W.G., Deister C., et al. Fabrication of poly(ethylene glycol) hydrogel microstructures using photolithography. Langmuir 2001, 17:5440-5447.
71. Albrecht D.R., Tsang V.L., Sah R.L., Bhatia S.N. Photo- and electropatterning of hydrogel-encapsulated living cell arrays. Lab Chip 2005, 5:111-118.
72. Karp J.M., Yeh J., Eng G., Fukuda J., Blumling J., et al. Controlling size, shape and homogeneity of embryoid bodies using poly(ethylene glycol) microwells. Lab Chip 2007, 7:786-794.
73. Moeller H.C., Mian M.K., Shrivastava S., Chung B.G., Khademhosseini A. A microwell array system for stem cell culture. Biomaterials 2008, 29:752-763.
74. Choi Y.Y., Chung B.G., Lee D.H., Khademhosseini A., Kim J.H., et al. Controlled-size embryoid body formation in concave microwell arrays. Biomaterials 2010, 31:4296-4303.
75. Hwang YS, Chung BG, Ortmann D., Hattori N., Moeller HC, et al. Microwell-mediated control of embryoid body size regulates embryonic stem cell fate via differential expression of WNT5a and WNT11. Proc Natl Acad Sci USA 2009, 106:16978-16983.
76. Napolitano A.P., Chai P., Dean D.M., Morgan J.R. Dynamics of the self-assembly of complex cellular aggregates on micromolded nonadhesive hydrogels. Tissue Eng 2007, 13:2087-2094.
77. Park J.H., Chung B.G., Lee W.G., Kim J., Brigham M.D., et al. Microporous cell-laden hydrogels for engineered tissue constructs. Biotechnol Bioeng 2010, 106:138-148.
78. Yan Y.N., Wang X.H., Pan Y.Q., Liu H.X., Cheng J., et al. Fabrication of viable tissue-engineered constructs with 3D cell-assembly technique. Biomaterials 2005, 26:5864-5871.
79. Moon S., Hasan S.K., Song Y.S., Xu F., Keles H.O., et al. Layer by layer three-dimensional tissue epitaxy by cell-laden hydrogel droplets. Tissue Eng Part C-Methods 2010, 16:157-166.
80. Guillemot F., Souquet A., Catros S., Guillotin B., Lopez J., et al. High-throughput laser printing of cells and biomaterials for tissue engineering. Acta Biomater 2010, 6:2494-2500.
81. Khalil S., Nam J., Sun W. Multi-nozzle deposition for construction of 3D biopolymer tissue scaffolds. Rapid Prototyping J 2005, 11:9-17.
82. Lee W., Debasitis J.C., Lee V.K., Lee J.H., Fischer K., et al. Multi-layered culture of human skin fibroblasts and keratinocytes through three-dimensional freeform fabrication. Biomaterials 2009, 30:1587-1595.
83. Mironov V., Reis N., Derby B. Bioprinting: a beginning. Tissue Eng 2006, 12:631-634.
84. Zhang H., Tumarkin E., Sullan R.M.A., Walker G.C., Kumacheva E. Exploring microfluidic routes to microgels of biological polymers. Macromol Rapid Commun 2007, 28:527-538.
85. Tan W.H., Takeuchi S. Monodisperse alginate hydrogel microbeads for cell encapsulation. Adv Mater 2007, 19:2696-2701.
86. Tan W., Desai T.A. Layer-by-layer microfluidics for biomimetic three-dimensional structures. Biomaterials 2004, 25:1355-1364.
87. Cheung Y.K., Gillette B.M., Zhong M., Ramcharan S., Sia S.K. Direct patterning of composite biocompatible microstructures using microfluidics. Lab Chip 2007, 7:574-579.
88. Panda P., Ali S., Lo E., Chung B.G., Hatton T.A., et al. Stop-flow lithography to generate cell-laden microgel particles. Lab Chip 2008, 8:1056-1061.
89. Batorsky A., Liao J.H., Lund A.W., Plopper G.E., Stegemann J.P. Encapsulation of adult human mesenchymal stem cells within collagen-agarose microenvironments. Biotechnol Bioeng 2005, 92:492-500.
90. Wang C.M., Gong Y.H., Lin Y.M., Shen J.B., Wang D.A. A novel gellan gel-based microcarrier for anchorage-dependent cell delivery. Acta Biomaterialia 2008, 4:1226-1234.
91. Wang C.M., Gong Y.H., Zhong Y., Yao Y.C., Su K., et al. The control of anchorage-dependent cell behavior within a hydrogel/microcarrier system in an osteogenic model. Biomaterials 2009, 30:2259-2269.
92. Dang S.M., Gerecht-Nir S., Chen J., Itskovitz-Eldor J., Zandstra P.W. Controlled, scalable embryonic stem cell differentiation culture. Stem Cells 2004, 22:275-282.
93. Magyar JP, Nemir M, Ehler E, Suter N, Perriard JC, et al. Mass production of embryoid bodies in microbeads. Ann N Y Acad Sci 2001;944:135-43.