Scaling up antiretroviral treatment and improving patient retention in care: Lessons from Ethiopia, 2005-2013

Globalization and Health

Volumn 10, Issue 1, 2014, Pages

  Assefa, Yibeltal ^a   Alebachew, Achamyeleh ^b   Lera, Meskele ^b   Lynen, Lut ^c   Wouters, Edwin ^d   Van Damme, Wim ^c,e  

^a ETHIOPIAN PUBLIC HEALTH INSTITUTE   (Ethiopia)

^b Federal HIV/AIDS Prevention and Control Office   (Ethiopia)

^c INSTITUTE OF TROPICAL MEDICINE   (Belgium)

^d UNIVERSITY OF ANTWERP   (Belgium)

^e UNIVERSITY OF THE WESTERN CAPE   (South Africa)

Author keywords

Antiretroviral treatment; Resource limited settings; Retention in care; Scaling up

Indexed keywords

ANTIRETROVIRUS AGENT; EFAVIRENZ; LAMIVUDINE; NEVIRAPINE; TENOFOVIR; ZIDOVUDINE;

HEALTH CARE; PUBLIC HEALTH; QUALITATIVE ANALYSIS;

ARTICLE; COMMUNITY CARE; DRUG UTILIZATION; ETHIOPIA; FEMALE; HEALTH CARE SYSTEM; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; MALE; PATIENT CARE; PATIENT PARTICIPATION; PRIORITY JOURNAL; PUBLIC HEALTH SERVICE; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; SCALE UP; ACQUIRED IMMUNODEFICIENCY SYNDROME; CAPACITY BUILDING; HEALTH CARE DELIVERY; HIV INFECTIONS; MEDICAL RECORD; ORGANIZATION AND MANAGEMENT; PATIENT COMPLIANCE; PROGRAM EVALUATION; SOCIAL WORK; SUPPLY AND DISTRIBUTION;

ETHIOPIA;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ANTI-RETROVIRAL AGENTS; CAPACITY BUILDING; ETHIOPIA; HEALTH SERVICES ACCESSIBILITY; HIV INFECTIONS; HUMANS; MEDICAL RECORDS; PATIENT COMPLIANCE; PROGRAM EVALUATION; PUBLIC HEALTH PRACTICE; SOCIAL WORK;

EID: 84901979907     PISSN: None     EISSN: 17448603     Source Type: Journal    
DOI: 10.1186/1744-8603-10-43     Document Type: Article

References (65)

1. Chan KC, Wong KH, Lee SS. Universal decline in mortality in patients with advanced HIV-1 disease in various demographic subpopulations after the introduction of HAART in Hong Kong, from 1993 to 2002. HIV Med 2006, 7:186-192. 10.1111/j.1468-1293.2006.00352.x, 16494633.
2. Braitstein P, Brinkhof MW, Dabis F, Schechter M, Boulle A, Miotti P, Wood R, Laurent C, Sprinz E, Seyler C, Bangsberg DR, Balestre E, Sterne JA, May M, Egger M. Mortality of HIV-1-infected patients in the first year of antiretroviral therapy: comparison between low-income and high-income countries. Lancet 2006, 367(9513):817-824.
3. Palella FJ, Delaney KM, Moorman AC, Loveless MO, Fuhrer J, Satten GA, Aschman DJ, Holmberg SD. Declining morbidity and mortality among patients with advanced human immune deficiency virus infection HIV Outpatient Study Investigators. N Engl J Med 1998, 338:853-860. 10.1056/NEJM199803263381301, 9516219.
4. Mocroft A, Vella S, Benfield TL. Changing patterns of mortality across Europe in patients infected with HIV-1 EuroSIDA Study Group. Lancet 1998, 352:1725-1730. 10.1016/S0140-6736(98)03201-2, 9848347.
5. UNAIDS UNAIDS Report on the global AIDS epidemic | 2012 2012, Geneva, Switzerland: UNAIDS, UNAIDS.
6. UNAIDS UNAIDS Report on the global AIDS epidemic | 2013 2013, Geneva, Switzerland: UNAIDS, UNAIDS.
7. WHO Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection: recommendations for a public health approach 2013, Geneva, Switzerland: WHO, WHO.
8. Rosen S, Fox MP, Gill CJ. Patient retention in antiretroviral therapy programs in Sub-Saharan Africa: a systematic review. PLoS Med 2007, 4(10):e298. doi:10.1371/journal.pmed.0040298.e, 10.1371/journal.pmed.0040298, 2020494, 17941716.
9. WHO Retention in HIV programmes: Defining the challenges and identifying solutions 2012, Geneva, Switzerland: WHO, WHO.
10. Assefa Y, Van Damme W, Mariam DH, Kloos H. Toward Universal Access to HIV Counseling and Testing and Antiretroviral Treatment in Ethiopia: Looking Beyond HIV Testing and ART Initiation. AIDS Patient Care and STDs 2010, 24(8). doi:10.1089/apc.2009.0286.
11. Assefa Y, Jerene D, Luelseged S, Ooms G, Van Damme W. Rapid Scale-up of Antiretroviral Treatment in Ethiopia: Successes and System-wide Effects. PLoS Med 2009, 6(4):e1000056. doi:10.1371/journal.pmed.1000056, 10.1371/journal.pmed.1000056, 2667265, 19399154.
12. Assefa Y, Kloos H. The public health approach to ART service scale-up in Ethiopia: the first two years of free ART, 2005-2007. Ethiop Med J 2008, 46(4):401-406.
13. Federal Ministry of Health of Ethiopia Guidelines for implementation of HIV/AIDS case management in Ethiopia 2010, Addis Ababa, Ethiopia: FMOH, Federal Ministry of Health of Ethiopia.
14. Federal HIV/AIDS Prevention and Control Office Monitoring and Evaluation Report, 2011/2012 2013, Addis Ababa, Ethiopia: FHAPCO, Federal HIV/AIDS Prevention and Control Office.
15. Federal HIV/AIDS Prevention and Control Office Country Progress Report on HIV/AIDS Response, 2012 2013, Addis Ababa, Ethiopia: FHAPCO, Federal HIV/AIDS Prevention and Control Office.
16. Kloos H, Assefa Y, Adugna A, Mulatu MS, Mariam DH. Utilization of antiretroviral treatment in Ethiopia between February and December 2006: spatial, temporal, and demographic patterns. Int J Health Geograph 2007, 6:45. doi:10.1186/1476-072×-6-45.
17. Assefa Y, Kiflie A, Tekle B, Mariam DH, Laga M, Van Damme W. Effectiveness and acceptability of delivery of antiretroviral treatment in health centres by health officers and nurses in Ethiopia. J Health Serv Res Policy 2012, 17(1):24-29. doi:10.1258/jhsrp.2011.010135, 10.1258/jhsrp.2011.010135, 22096081.
18. Federal Ministry of Health of Ethiopia Health Center Construction Progress Report 2013, Addis Ababa, Ethiopia: FMOH, Federal Ministry of Health of Ethiopia.
19. Pharmaceuticals Fund and Supply Agency Progress report 2013, Addis Ababa, Ethiopia: PFSA, Pharmaceuticals Fund and Supply Agency.
20. Ethiopian Health and Nutrition Research Institute Progress report 2013, Addis Ababa, Ethiopia: EHNRI, Ethiopian Health and Nutrition Research Institute.
21. Federal Ministry of Health of Ethiopia Health and Health related Indicators 2013, Addis Ababa, Ethiopia: FMOH, Federal Ministry of Health of Ethiopia.
22. Posse M, Baltussen R. Barriers to Access to Antiretroviral Treatment in Mozambique, as Perceived by Patients and Health Workers in Urban and Rural settings. AIDS Patients Care and STDs 2009, 23(10):867-875.
23. Gilks CF, Crowley S, Ekpini R, Gove S, Perriens J, Souteyrand Y, Sutherland D, Vitoria M, Guerma T, De Cock K. The WHO public-health approach to antiretroviral treatment against HIV in resource-limited settings. Lancet 2006, 368(9534):505-510. 10.1016/S0140-6736(06)69158-7, 16890837.
24. WHO Towards Universal Access: Scaling Up Priority HIV/AIDS Interventions in the health sector. Progress Report, 2010 2011, Geneva, Switzerland: WHO, WHO.
25. WHO Task shifting: Rational redistribution of tasks among health workforce teams. Global recommendations and Guidelines 2007, Geneva, Switzerland: WHO, WHO.
26. Assefa Y, Worku A, Wouters E, Koole O, Haile Mariam D, Van Damme W. Simplified Tools for Measuring Retention in Care in Antiretroviral Treatment Program in Ethiopia: Cohort and Current Retention in Care. PLoS One 2012, 7(6):e38555. doi:10.1371/journal.pone.0038555, 10.1371/journal.pone.0038555, 3372511, 22701663.
27. Assefa Y, Kiflie A, Tesfaye D, Mariam DH, Kloos H, Edwin W, Laga M, Van Damme W. Outcomes of antiretroviral treatment program in Ethiopia: Retention of patients in care is a major challenge and varies across health facilities. BMC Health Serv Res. 2011, 11:81. doi:10.1186/1472-6963-11-81, 10.1186/1472-6963-11-81, 3094207, 21501509.
28. Bedelu M, Ford N, Hilderbrand K, Reuter H. Implementing antiretroviral therapy in rural communities: the Lusikisiki model of decentralized HIV/AIDS care. J Infect Dis 2007, 196(Suppl 3):S464-S468.
29. Massaquoi M, Zachariah R, Manzi M, Pasulani O, Misindi D, Mwagomba B, Bauernfeind A, Harries AD. Patient retention and attrition on antiretroviral treatment at district level in rural Malawi. Trans R Soc Trop Med Hyg 2009, 103:594-600. 10.1016/j.trstmh.2009.02.012, 19298993.
30. Nash D, Korves C, Saito S. Characteristics of facilities and programs delivering HIV care and treatment services are associated with loss to follow-up rates in programs from 7 Sub-Saharan African countries 2008, Montreal, Canada: 15th Conference on Retroviruses and Opportunistic Infections.
31. Chan AK, Mateyu G, Jahn A, Schouten E, Arora P, Mlotha W, Kambanji M, van Lettow M. Outcome Assessment of decentralization of antiretroviral therapy provision in a rural district of Malawi using an integrated primary care model. Trop Med Int Health 2010, 15(suppl. 1):90-97.
32. Mutevedzi PC, Lessells RJ, Heller T, Bärnighausen T, Cooke GS, Newell ML. Scale-up of a decentralized HIV treatment programme in rural KwaZulu-Natal, South Africa: does rapid expansion affect patient outcomes?. Bull World Health Organ 2010, 88(8):593-600. 10.2471/BLT.09.069419, 2908968, 20680124.
33. Mdege ND, Chindove S, Ali S. The effectiveness and cost implications of task-shifting in the delivery of antiretroviral therapy to HIV-infected patients: a systematic review. Health Policy Plan 2012, doi:10.1093/heapol/czs058.
34. Callaghan M, Ford N, Schneider H. A systematic review of task- shifting for HIV treatment and care in Africa. Hum Resour Health 2010, 8:8. doi:10.1186/1478-4491-8-8, 10.1186/1478-4491-8-8, 2873343, 20356363.
35. Fairall L, Bachmann MO, Lombard C, Timmerman V, Uebel K, Zwarenstein M, Boulle A, Georgeu D, Colvin CJ, Lewin S, Faris G, Cornick R, Draper B, Tshabalala M, Kotze E, Van Vuuren C, Steyn D, Chapman R, Bateman E. Task shifting of antiretroviral treatment from doctors to primary-care nurses in South Africa (STRETCH): a pragmatic, parallel, cluster-randomised trial. Lancet 2012, 380(9845):889-898. doi:10.1016/S0140-6736(12)60730-2. Epub 2012 Aug 15, 10.1016/S0140-6736(12)60730-2, 3442223, 22901955.
36. Boullé C, Kouanfack C, Laborde-Balen G, Carrieri MP, Dontsop M, Boyer S, Aghokeng AF, Spire B, Koulla-Shiro S, Delaporte E, Laurent C., Stratall ANRSESTHER Study Group Task shifting HIV care in rural district hospitals in Cameroon: evidence of comparable antiretroviral treatment related outcomes between nurses and physicians in the Stratall ANRS/ESTHER trial. J Acquir Immune Defic Syndr 2013, [Epub ahead of print], Stratall ANRSESTHER Study Group.
37. Shumbusho F, van Griensven J, Lowrance D, Turate I, Weaver MA, Price J, Binagwaho A. Task Shifting for Scale-up of HIV Care: Evaluation of Nurse-Centered Antiretroviral Treatment at Rural Health Centers in Rwanda. PLoS Med 2009, 6(10):e1000163. doi:10.1371/journal.pmed.1000163, 10.1371/journal.pmed.1000163, 2752160, 19823569.
38. Kranzer K, Zeinecker J, Ginsberg P, Orrell C, Kalawe NN, Lawn SD, Bekker LG, Wood R. Linkage to HIV care and antiretroviral therapy in Cape Town, South Africa. PLoS One 2010, 5(11):e13801. doi:10.1371/journal.pone.0013801, 10.1371/journal.pone.0013801, 2970551, 21072191.
39. Rosen S, Fox MP. Retention in HIV Care between Testing and Treatment in Sub-Saharan Africa: A Systematic Review. PLoS Med 2011, 8(7):e1001056. doi:10.1371/journal.pmed.1001056, 10.1371/journal.pmed.1001056, 3139665, 21811403.
40. Cohen MS, Chen YQ, McCauley M, Gamble T, Hosseinipour MC, Kumarasamy N, Hakim JG, Kumwenda J, Grinsztejn B, Pilotto JH, Godbole SV, Mehendale S, Chariyalertsak S, Santos BR, Mayer KH, Hoffman IF, Eshleman SH, Piwowar-Manning E, Wang L, Makhema J, Mills LA, de Bruyn G, Sanne I, Eron J, Gallant J, Havlir D, Swindells S, Ribaudo H, Elharrar V, Burns D, et al. Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med 2011, 365:493-505. 10.1056/NEJMoa1105243, 3200068, 21767103.
41. Cain LE, Logan R, Robins JM, Sterne JA, Sabin C, Bansi L, Justice A, Goulet J, Van Sighem A, De Wolf F, Bucher HC, Von Wyl V, Esteve A, Casabona J, del Amo J, Moreno S, Seng R, Meyer L, Perez-Hoyos S, Muga R, Lodi S, Lanoy E, Costagliola D, Hernan MA., HIV-CAUSAL Collaboration When to initiate combined antiretroviral therapy to reduce mortality and AIDS-defining illness in HIV-infected persons in developed countries: an observational study. Ann Intern Med 2011, 154:509-515. 3610527, 21502648, HIV-CAUSAL Collaboration.
42. Writing Committee for the CASCADE Collaboration Timing of HAART initiation and clinical outcomes in human immunodeficiency virus type 1 seroconverters. Arch Intern Med 2011, 171:1560-1569. 10.1001/archinternmed.2011.401, 3960856, 21949165, Writing Committee for the CASCADE Collaboration.
43. Ulett KB, Willig JH, Lin HY, Routman JS, Abroms S, Allison J, Chatham A, Raper JL, Saag MS, Mugavero MJ. The Therapeutic Implications of Timely Linkage and Early Retention in HIV Care. AIDS Patient Care STDS 2009, 23(1):41-49. doi:10.1089/apc.2008.0132, 10.1089/apc.2008.0132, 2733237,2733237, 19055408.
44. WHO Service delivery approaches to HIV testing and counseling (HTC): A strategic policy framework 2012, Geneva, Switzerland: WHO, WHO.
45. WHO The treatment 2.0 framework for action: catalysing the next phase of treatment, care and support 2011, Geneva, Switzerland: WHO, WHO.
46. Deribe K, Hailekiros F, Biadgilign S, Amberbir A, Beyene BK. Defaulters from antiretroviral treatment in Jimma University Specialized Hospital Southwest Ethiopia. Trop Med Int Health 2008, 13(3):328-333. 10.1111/j.1365-3156.2008.02006.x, 18298607.
47. Geng E, Nash D, Kambugu A, Zhang Y, Braitstein P, Christopoulos KA, Muyindike W, Bwana MB, Yiannoutsos CT, Petersen ML, Martin JN. Retention in care among HIV-infected patients in resource-limited settings: emerging insights and new directions. Curr HIV/AIDS Rep 2010, 7(4):234-244. doi:10.1007/s11904-010-0061-5.
48. Geng E, Bangsberg DR, Musinguzi NBA, Emenyonu N, Bwana MB, Yiannoutsos CT, Glidden DV, Deeks SG, Martin JN. Understanding Reasons for and Outcomes of Patients Lost to Follow-Up in Antiretroviral Therapy Programs in Africa Through a Sampling-Based Approach. JAIDS 2010, 53:405-411. doi:10.1097/QAI.0b013e3181b843f0, 3606953, 19745753.
49. Tuller DM, Bangsberg DR, Senkungu J, Ware NC, Emenyonu N, Weiser SD. Transportation Costs Impede Sustained Adherence and Access to HAART in a Clinic Population in Southwestern Uganda: A Qualitative Study. AIDS Behav 2010, 14(4):778-784. doi:10.1007/s10461-009-9533-2, 10.1007/s10461-009-9533-2, 2888948,2888948, 19283464.
50. Yu JK, Chen SC, Wang KY, Chang CS, Makombe SD, Schouten EJ, Harries AD. True outcomes for patients on antiretroviral therapy who are " lost to follow-up" in Malawi. Bull World Health Organ. 2009, 85:501-568.
51. Raguenaud ME, Isaakidis P, Vonthanak S. Good ART patient outcomes and survival achieved in a six-year HIV/AIDS program in Cambodia 2009, Cape Town, South Africa: 5th IAS Conference on HIV Pathogenesis, Treatment, and Prevention.
52. Joshi K, Jhanwar S, Mathur A. Barriers in adherence of ART (antiretroviral treatment): a experience of ART Centre of Western Rajasthan, India 2008, Mexico City, Mexico: 7th International AIDS Conference.
53. Maskew M, MacPhail P, Menezes C, Rubel D. Lost to follow up: contributing factors and challenges in South African patients on antiretroviral therapy. S Afr Med J 2007, 97(9):853-857.
54. Dalal RP, Macphail C, Mqhayi M, Wing J, Feldman C, Chersich MF, Venter WD. Characteristics and outcomes of adult patients lost to follow-up at an antiretroviral treatment clinic in Johannesburg, South Africa. J Acquir Immune Defic Syndr 2008, 47(1):101-107. 10.1097/QAI.0b013e31815b833a, 17971708.
55. Emenyonu N, Thirumurthy H, Muyindike W. Cash transfers to cover clinic transportation costs improve adherence and retention in care in an HIV treatment program in rural Uganda. Program and abstracts of the 17th Conference on Retroviruses and Opportunistic Infections 2010, San Francisco: Abstract 831.
56. McGuire M, Munyenyembe T, Szumilin E, Heinzelmann A, Le Paih M, Bouithy N, Pujades-Rodríguez M. Vital status of pre-ART and ART patients defaulting from care in rural Malawi. Trop Med Int Health 2010, 15:55-62.
57. Wanyama J, Castelnuovo B, Wandera B, Mwebaze P, Kambugu A, Bangsberg DR, Kamya MR. Belief in divine healing can be a barrier to antiretroviral therapy adherence in Uganda. AIDS 2007, 21:1486-1487. 10.1097/QAD.0b013e32823ecf7f, 17589198.
58. Etienne M, Burrows L, Osotimehin B, Macharia T, Hossain B, Redfield RR, Amoroso A. Situational analysis of varying models of adherence support and loss to follow up rates; findings from 27 treatment facilities in eight resource limited countries. Trop Med Int Health 2010, 15:76-81.
59. Wouters E, Van Damme W, van Rensburg D, Masquillier C, Meulemans H. Impact of community-based support services on antiretroviral treatment programme delivery and outcomes in resource-limited countries: a synthetic review. BMC Health Serv Res 2012, 12:194. doi:10.1186/1472-6963-12-194, 10.1186/1472-6963-12-194, 3476429, 22776682.
60. Ware NC, Idoko J, Kaaya S, Biraro IA, Wyatt MA, Agbaji O, Chalamilla G, Bangsberg DR. Explaining Adherence Success in Sub-Saharan Africa: An Ethnographic Study. PLoS Med 2009, 6(1):e1000011. doi:10.1371/journal.pmed.1000011.
61. Rabkin M, Austin J, Nash D. High patient retention rates in a multinational HIV/AIDS treatment program: The Columbia University Mother-to-Child-Plus Experience 2010, San Francisco, CA: 17th Conference on Retroviruses and Opportunistic Infections.
62. Wringe A, Roura M, Urassa M, Busza J, Athanas V, Zaba B. Doubts, denial and divine intervention: understanding delayed attendance and poor retention rates at a HIV treatment programme in rural Tanzania. AIDS Care 2009, 21:632-637. 10.1080/09540120802385629, 19444672.
63. Ochieng-Ooko V, Ochieng D, Sidle JE, Holdsworth M, Wools-Kaloustian K, Siika AM, Yiannoutsos CT, Owiti M, Kimaiyo S, Braitstein P. Influence of gender on loss to follow-up in a large HIV treatment programme in Western Kenya. Bull World Health Organ 2010, 88:681-688. doi:10.2471/BLT.09.064329, 10.2471/BLT.09.064329, 2930357, 20865073.
64. Forster M, Bailey C, Brinkhof MW, Graber C, Boulle A, Spohr M, Balestre E, May M, Keiser O, Jahn A, Egger M., ART-LINC collaboration of International Epidemiological Databases to Evaluate AIDS Electronic medical record systems, data quality and loss to follow-up: survey of antiretroviral theray programmes in resource-limited settings. Bull World Health Org 2008, 86:939-947. 10.2471/BLT.07.049908, 2649575,2649575, 19142294, ART-LINC collaboration of International Epidemiological Databases to Evaluate AIDS.
65. Amuron B, Namara G, Birungi J, Nabiryo C, Levin J, Grosskurth H, Coutinho A, Jaffar S. Mortality and loss-to-follow-up during the pre-treatment period in an antiretroviral therapy programme under normal health service conditions in Uganda. BMC Public Health 2009, 9:290. doi:10.1186/1471-2458-9-290, 10.1186/1471-2458-9-290, 2734853, 19671185.