Scale-up of a decentralized HIV treatment programme in rural Kwazulu-Natal, South Africa: Does rapid expansion affect patient outcomes?;Ampliación de un programa descentralizado de tratamiento del VIH en zones rurales de KwaZulu-Natal, Sudáfrica: ¿afecta su rápida expansión a los resultados de pacientes?

Bulletin of the World Health Organization

Volumn 88, Issue 8, 2010, Pages 593-600

  Mutevedzi, Portia C ^a   Lessells, Richard J ^a   Heller, Tom ^b   Bänighausen, Till ^a   Cooke, Graham S ^a   Newell, Marie Louise ^a  

^a AFRICA HEALTH RESEARCH INSTITUTE   (South Africa)

^b Hlabisa Hospital   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; EFAVIRENZ; LAMIVUDINE; NEVIRAPINE; STAVUDINE;

DISEASE CONTROL; DISEASE TREATMENT; HEALTH CARE; HEALTH SERVICES; HUMAN IMMUNODEFICIENCY VIRUS; MORTALITY; RURAL AREA;

ADOLESCENT; ADULT; ARTICLE; CD4 LYMPHOCYTE COUNT; CONTROLLED STUDY; DECENTRALIZATION; FEMALE; HEALTH CARE DELIVERY; HEALTH CARE QUALITY; HEALTH CARE SYSTEM; HEALTH PROGRAM; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; MALE; MORTALITY; PATIENT INFORMATION; PHARMACEUTICAL CARE; PREGNANT WOMAN; PRIMARY HEALTH CARE; RURAL AREA; SCALE UP; SOUTH AFRICA; TREATMENT OUTCOME; VIRUS LOAD;

ADULT; ANTI-RETROVIRAL AGENTS; FEMALE; HIV INFECTIONS; HUMANS; LONGITUDINAL STUDIES; MALE; MEDICAL AUDIT; QUALITY OF HEALTH CARE; RURAL HEALTH SERVICES; SOUTH AFRICA;

KWAZULU-NATAL; SOUTH AFRICA;

EID: 77955994252     PISSN: 00429686     EISSN: 15640604     Source Type: Journal    
DOI: 10.2471/BLT.09.069419     Document Type: Article

References (37)

1. Report on the global HIV/AIDS epidemic 2008. Geneva: Joint United Nations Programme on HIV/AIDS; 2008.
2. Towards universal access: scaling up priority HIV/AIDS interventions in the health sector. Geneva: World Health Organization; 2008.
3. HIV & AIDS and STI national strategic plan 2007-2011. Pretoria: South African Department of Health; 2007.
4. Walensky RP, Wood R, Weinstein MC, Martinson NA, Losina E, Fofana MO et al. Scaling up antiretroviral therapy in South Africa: the impact of speed on survival. J Infect Dis 2008;197:1324-32. doi:10.1086/587184 PMID:18422445
5. Keiser O, Orrell C, Egger M, Wood R, Brinkhof MW, Furrer H et al. Public-health and individual approaches to antiretroviral therapy: township South Africa and Switzerland compared. PLoS Med 2008;5:e148. doi:10.1371/journal.pmed.0050148 PMID:18613745
6. Bekker LG, Myer L, Orrell C, Lawn S, Wood R. Rapid scale-up of a community-based HIV treatment service: programme performance over 3 consecutive years in Guguletu, South Africa. S Afr Med J 2006;96:315-20. PMID:16670804
7. Coetzee D, Hildebrand K, Boulle A, Maartens G, Louis F, Labatala V et al. Outcomes after two years of providing antiretroviral treatment in Khayelitsha, South Africa. AIDS 2004;18:887-95. doi:10.1097/00002030-200404090-00006 PMID:15060436
8. Boulle A, Bock P, Osler M, Cohen K, Channing L, Hilderbrand K et al. Antiretroviral therapy and early mortality in South Africa. Bull World Health Organ 2008;86:678-87. doi:10.2471/BLT.07.045294 PMID:18797643
9. Fairall LR, Bachmann MO, Louqagie GM, van Vuuren C, Chikobvu P, Steyn D et al. Effectiveness of antiretroviral treatment in a South African program: a cohort study. Arch Intern Med 2008;168:86-93. doi:10.1001/archinternmed.2007.10 PMID:18195200
10. Stringer JSA, Zulu I, Levy J, Stringer EM, Mwango A, Chi BH et al. Rapid scale-up of antiretroviral therapy at primary care sites in Zambia. Feasibility and early outcomes. JAMA 2006;296:782-93. doi:10.1001/jama.296.7.782 PMID:16905784
11. Bussmann H, Wester CW, Ndwapi N, Grundmann N, Gaolathe T, Puvimanasinghe J et al. Five-year outcomes of initial patients treated in Botswana's national antiretroviral treatment program. AIDS 2008;22:2303-11. doi:10.1097/QAD.0b013e3283129db0 PMID:18981769
12. Lowrance DW, Makombe S, Harries AD, Shiraishi RW, Hochgesang M, Aberle-Grasse J et al. A public health approach to rapid scale-up of antiretroviral treatment in Malawi during 2004-2006. J Acquir Immune Defic Syndr 2008;49:287-93. doi:10.1097/QAI.0b013e3181893ef0 PMID:18845953
13. Wilson DP, Blower S. How far will we need to go to reach HIV-infected people in rural South Africa? BMC Med 2007;5:16. doi:10.1186/1741-7015-5-16 PMID:17577418
14. Gilks CF, Crowley S, Ekpini R, Gove S, Perriens J, Souteyrand Y et al. The WHO public-health approach to antiretroviral treatment against HIV in resource-limited settings. Lancet 2006;368:505-10. doi:10.1016/S0140-6736(06)69158-7 PMID:16890837
15. Bedelu M, Ford N, Hilderbrand K, Reuter H. Implementing antiretroviral therapy in rural communities: the Lusikisiki model of decentralized HIV/AIDS care. J Infect Dis 2007;196(Suppl 3):S464-8. doi:10.1086/521114 PMID:18181695
16. Fredlund VG, Nash J. How far should they walk? Increasing antiretroviral therapy access in a rural community in northern KwaZulu-Natal, South Africa. J Infect Dis 2007;196(Suppl 3):S469-73. doi:10.1086/521115 PMID:18181696
17. Boulle A, Ford N. Scaling up antiretroviral therapy in developing countries: what are the benefits and challenges? Postgrad Med J 2008;84:225-7. doi:10.1136/sti.2007.027748 PMID:18508978
18. Keiser O, Anastos K, Schechter M, Balestre E, Myer L, Boulle A et al. Antiretroviral therapy in resource-limited settings 1996 to 2006: patient characteristics, treatment regiments and monitoring in sub-Saharan Africa, Asia and Latin America. Trop Med Int Health 2008;13:870-9. PMID:18373510
19. Calmy A, Ford N, Hirschel B, Reynolds SJ, Lynen L, Goemaere E et al. HIV viral load monitoring in resource-limited regions: optional or necessary? Clin Infect Dis 2007;44:128-34. doi:10.1086/510073 PMID:17143828
20. Operational plan for comprehensive HIV and AIDS care, management and treatment for South Africa. Pretoria: South African Department of Health; 2003.
21. Tanser F. Methodology for optimising location of new primary health care facilities in rural communities: a case study in KwaZulu-Natal, South Africa. J Epidemiol Community Health 2006;60:846-50. doi:10.1136/jech.2005.043265 PMID:16973529
22. Welz T, Hosegood V, Jaffar S, Bätzing-Feigenbaum J, Herbst K, Newell ML. Continued very high prevalence of HIV infection in rural KwaZulu-Natal, South Africa: a population-based longitudinal study. AIDS 2007;21:1467-72. doi:10.1097/QAD.0b013e3280ef6af2 PMID:17589193
23. Antiretroviral therapy for HIV infection in adults and adolescents: recommendations for a public health approach, 2006 revision. Geneva: World Health Organization; 2006.
24. WHO case definitions of HIV for surveillance and revised clinical staging and immunological classification of HIV-related disease in adults and children. Geneva: World Health Organization; 2007.
25. National antiretroviral treatment guidelines. Pretoria: South African Department of Health; 2004.
26. Tanser F, Hosegood V, Bänighausen T, Herbst K, Nyirenda M, Muhwava W et al. Cohort profile: Africa Centre Demographic Information System (ACDIS) and population-based HIV survey. Int J Epidemiol 2008;37:956-62. doi:10.1093/ije/dym211 PMID:17998242
27. Baker SG, Fitzmaurice GM, Freedman LS, Kramer BS. Simple adjustments for randomized trials with nonrandomly missing or censored outcomes arising from informative covariates. Biostatistics 2006;7:29-40. doi:10.1093/biostatistics/kxi038 PMID:15923407
28. Moss RR, Humphries KH, Gao M, Thompson CR, Abel JG, Fradet G et al. Outcome of mitral valve repair or replacement: a comparison by propensity score analysis. Circulation 2003;108(Suppl 1):II-90-7. PMID:12970215 doi:10.1161/01.cir.0000089182.44963.bb
29. Lawn SD, Myer L, Orrell C, Bekker LG, Wood R. Early mortality among adults accessing a community-based antiretroviral service in South Africa: implications for programme design. AIDS 2005;19:2141-8. doi:10.1097/01. aids.0000194802.89540.e1 PMID:16284464
30. Lawn SD, Myer L, Harling G, Orrell C, Bekker LG, Wood R. Determinants of mortality and nondeath losses from an antiretroviral treatment service in South Africa: implications for program evaluation. AIDS 2006;43:770-6. PMID: 16912954doi:10.1086/507095.
31. Braitstein P, Brinkhof MWG, Dabis F, Schechter M, Boulle A, Miotti P et al. Mortality of HIV-1-infected patients in the first year of antiretroviral therapy: comparison between low-income and high-income countries. Lancet 2006;367:817-24. doi:10.1016/S0140-6736(06)68337-2 PMID:16530575
32. Lawn SD, Harries AD, Anglaret X, Myer L, Wood R. Early mortality among adults accessing antiretroviral treatment programmes in sub-Saharan Africa. AIDS 2008;22:1897-908. doi:10.1097/QAD.0b013e32830007cd PMID:18784453
33. Abaasa AM, Todd J, Ekoru K, Kalyango JN, Levin J, Odeke E et al. Good adherence to HAART and improved survival in a community HIV/AIDS treatment and care programme: the experience of The AIDS Support Organization (TASO), Kampala, Uganda. BMC Health Serv Res 2008;8:241. doi:10.1186/1472-6963-8-241 PMID:19021908
34. Dalal RP, MacPhail C, Mqhayi M, Wing J, Feldman C, Chersich MF et al. Characteristics and outcomes of adult patients lost to follow-up at an antiretroviral treatment clinic in Johannesburg, South Africa. J Acquir Immune Defic Syndr 2008;47:101-7. doi:10.1097/QAI.0b013e31815b833a PMID:17971708
35. Yu JK, Chen SC, Wang KY, Chang CS, Makombe SD, Schouten EJ et al. True outcomes for patients on antiretroviral therapy who are "lost to follow-up" in Malawi. Bull World Health Organ 2007;85:550-4. doi:10.2471/BLT.06.037739 PMID:17768504
36. Hamers RL, Derdelinckx I, van Vugt M, Stevens W, Rinke de With TF, Schuurman R. The status of HIV-1 resistance to antiretroviral drugs in sub-Saharan Africa. Antivir Ther 2008;13:625-39. PMID:18771046
37. Orrell C, Harling G, Lawn SD, Kaplan R, McNally M, Bekker LG et al. Conservation of first-line antiretroviral treatment regimen where therapeutic options are limited. Antivir Ther 2007;12:83-8. PMID:17503751