Task shifting of antiretroviral treatment from doctors to primary-care nurses in South Africa (STRETCH): A pragmatic, parallel, cluster-randomised trial

The Lancet

Volumn 380, Issue 9845, 2012, Pages 889-898

  Fairall, Lara ^a   Bachmann, Max O ^a   Lombard, Carl ^c,d   Timmerman, Venessa ^a   Uebel, Kerry ^d,k   Zwarenstein, Merrick ^e,f,g   Boulle, Andrew ^b   Georgeu, Daniella ^a   Colvin, Christopher J ^b   Lewin, Simon ^h   Faris, Gill ^a   Cornick, Ruth ^b   Draper, Beverly ^a   Tshabalala, Mvula ^b   Kotze, Eduan ^a   Van Vuuren, Cloete ^g   Steyn, Dewald ^l   Chapman, Ronald ^i,j   Bateman, Eric ^a  

^a Department of Medicine ^*  (South Africa)

^b School of Public Health and Family Medicine   (South Africa)

^c UNIVERSITY OF CAPE TOWN   (South Africa)

^d UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^e SOUTH AFRICAN MEDICAL RESEARCH COUNCIL   (South Africa)

^f UNIVERSITY OF TORONTO   (Canada)

^g KAROLINSKA INSTITUTE   (Sweden)

^h UNIVERSITY OF WESTERN ONTARIO   (Canada)

ⁱ Norwegian Knowledge Centre for Health Services   (Norway)

^j Free State Department of Health   (South Africa)

^k Informatics Department of Medicine   (South Africa)

^l UNIVERSITY OF THE FREE STATE   (South Africa)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT;

ADULT; ATTRIBUTABLE RISK; CD4 LYMPHOCYTE COUNT; CLUSTER ANALYSIS; CONFIDENCE INTERVAL; CONTROLLED STUDY; DATA ANALYSIS; FEMALE; FOLLOW UP; HAZARD RATIO; HEALTH CARE QUALITY; HEALTH EDUCATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INTENTION TO TREAT ANALYSIS; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTICENTER STUDY; NURSE; NURSE TRAINING; OUTCOME ASSESSMENT; PHYSICIAN; PRESCRIPTION; PRIMARY MEDICAL CARE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REVIEW; SOUTH AFRICA; VIRUS LOAD;

EID: 84865783160     PISSN: 01406736     EISSN: 1474547X     Source Type: Journal    
DOI: 10.1016/S0140-6736(12)60730-2     Document Type: Article

References (26)

1. WHO. Task shifting: global recommendations and guidelines. 2008. http://www.who.int/workforcealliance/knowledge/resources/taskshifting- guidelines/en/index.html (accessed June 25, 2012).
2. Callaghan M, Ford N, Schneider H. A systematic review of task-shifting for HIV treatment and care in Africa. Hum Resour Health 2010; 8: 8.
3. Jaff ar S, Amuron B, Foster S, et al. Rates of virological failure in patients treated in a home-based versus a facility-based HIV-care model in Jinja, southeast Uganda: a cluster-randomised equivalence trial. Lancet 2009; 374: 2080-89.
4. Sanne I, Orrell C, Fox MP, et al. Nurse versus doctor management of HIV-infected patients receiving antiretroviral therapy (CIPRA-SA): a randomised non-inferiority trial. Lancet 2010; 376: 33-40.
5. Fairall LR, Bachmann MO, Louwagie G, et al. Eff ectiveness of antiretroviral treatment in a South African program: cohort study. Arch Intern Med 2008; 168: 86-93.
6. Ingle S, May M, Uebel K, et al. Outcomes in patients waiting for antiretroviral treatment in the Free State Province, South Africa: prospective linkage study. AIDS 2010; 24: 2717-25.
7. Fairall L, Zwarenstein M, Bateman ED, et al. Educational outreach to nurses improves tuberculosis case detection and primary care of respiratory illness: a pragmatic cluster randomised controlled trial. BMJ 2005; 331: 750-54.
8. Zwarenstein M, Fairall LR, Lombard C, et al. Outreach education integrates HIV/AIDS/ART and tuberculosis care in South African primary care clinics: a pragmatic cluster randomized trial. BMJ 2011; 342: d2022.
9. Bachmann MO, Fairall LR, Lombard C, et al. Eff ect on tuberculosis outcomes of educational outreach to South African clinics during two randomised trials. Int J Tuberculosis Lung Dis 2010; 14: 311-17.
10. Fairall LR, Bachmann MO, Zwarenstein MF, et al. Streamlining tasks and roles to expand treatment and care for HIV: randomised controlled trial protocol. Trials 2008; 9: 21.
11. Medical Research Council. Cluster Randomised Trials: methodological and ethical considerations. Nov 11, 2002. http://www. mrc.ac.uk/Utilities/ Documentrecord/index.htm?d=MRC002406 (accessed Aug 10, 2011).
12. Haines A, Ashcroft R, Coggon D, et al. Personal information in medical research. Oct 9, 2000. http://www.mrc.ac.uk/Utilities/Documentrecord/index.htm? d=MRC002452 (accessed Aug 10, 2011).
13. South African National Department of Health. National antiretroviral treatment guidelines: 1st edn. 2004. http://www.doh. gov.za/docs/facts/2004/ intro.pdf (accessed June 25, 2012).
14. Knowledge Translation Unit, University of Cape Town Lung Institute. Practical Approach to Lung Health and HIV/AIDS (PALSA PLUS) Guidelines. Cape Town: Knowledge Translation Unit, 2006.
15. Uebel KU, Fairall LR, van Rensburg HCJ, et al. Task shifting and integration of HIV care into primary care in South Africa: the development and content of the streamlining tasks and roles to expand treatment and care of HIV (STRETCH) intervention. Implement Sci 2011; 6: 86.
16. Statistics South Africa. Mortality and causes of death in South Africa, 1997-2003: fi ndings from death notifi cation. Pretoria: Statistics South Africa, 2005.
17. Donner A. Approaches to sample size estimation in the design of clinical trials-a review. Stat Med 1998; 3: 199-214.
18. Vickers AJ, Altman D.G. Analysing controlled trials with baseline and follow up measurements. BMJ 2001; 323: 1123-24.
19. Colvin CJ, Fairall L, Lewin S, et al. Expanding access to ART in South Africa: the role of nurse initiated treatment. S Afr Med J 2010; 100: 210-11.
20. Bateman C. Free State ARV crisis-central government blamed. S Afr Med J 2009; 99: 284-87.
21. Boseley S. Crisis looms as Global Fund forced to cut back on AIDS, malaria and TB grants. Nov 23, 2011. http://www.guardian.co.uk/society/sarah- boseley-global-health/2011/nov/23/aids-tuberculosis (accessed April 11, 2012).
22. Selke HM, Kimaiyo S, Sidle JE, et al. Task-shifting of antiretroviral delivery from health care workers to persons with HIV/AIDS: clinical outcomes of a community-based program in Kenya. J Acquir Immune Defi c Syndr 2010; 55: 483-90.
23. Chang LW, Kagaayi J, Nakigozi G, et al. Eff ect of peer health workers on AIDS care in Rakai, Uganda: a cluster-randomised trial. PLoS One 2010; 5: e10923.
24. Cornell M, Grimsrud A, Fairall L, et al. Temporal changes in programme outcomes among adult patients initiating antiretroviral therapy across South Africa, 2002-2007. AIDS 2010; 24: 2263-70.
25. Schull MJ, Cornick R, Thompson S, et al. From PALSA PLUS to PALM PLUS: adapting and developing a South African guideline and training intervention to better integrate HIV/AIDS care with primary care in rural health centers in Malawi. Implement Sci 2011; 6: 82.
26. Schull MJ, Banda H, Kathyola D, et al. Strengthening health human resources and improving clinical outcomes through an integrated guideline and educational outreach in resource-poor settings: a cluster-randomized trial. Trials 2010; 11: 118.