-
1
-
-
78650793157
-
Bile acids induce inflammatory genes in hepatocytes: a novel mechanism of inflammation during obstructive cholestasis
-
Allen K, Jaeschke H, Copple BL (2011) Bile acids induce inflammatory genes in hepatocytes: a novel mechanism of inflammation during obstructive cholestasis. Am J Pathol 178:175-186.
-
(2011)
Am J Pathol
, vol.178
, pp. 175-186
-
-
Allen, K.1
Jaeschke, H.2
Copple, B.L.3
-
2
-
-
43449094989
-
Bile acid levels are increased in the liver of patients with steatohepatitis
-
Aranha MM, Cortez-Pinto H, Costa A, da Silva IB, Camilo ME, de Moura MC, Rodrigues CM (2008) Bile acid levels are increased in the liver of patients with steatohepatitis. Eur J Gastroenterol Hepatol 20:519-525.
-
(2008)
Eur J Gastroenterol Hepatol
, vol.20
, pp. 519-525
-
-
Aranha, M.M.1
Cortez-Pinto, H.2
Costa, A.3
da Silva, I.B.4
Camilo, M.E.5
de Moura, M.C.6
Rodrigues, C.M.7
-
3
-
-
32044437966
-
Anti-TGF-beta strategies for the treatment of chronic liver disease
-
Breitkopf K, Haas S, Wiercinska E, Singer MV, Dooley S (2005a) Anti-TGF-beta strategies for the treatment of chronic liver disease. Alcohol Clin Exp Res 29:121S-131S.
-
(2005)
Alcohol Clin Exp Res
, vol.29
-
-
Breitkopf, K.1
Haas, S.2
Wiercinska, E.3
Singer, M.V.4
Dooley, S.5
-
4
-
-
17644407086
-
Thrombospondin 1 acts as a strong promoter of transforming growth factor beta effects via two distinct mechanisms in hepatic stellate cells
-
Breitkopf K, Sawitza I, Westhoff JH, Wickert L, Dooley S, Gressner AM (2005b) Thrombospondin 1 acts as a strong promoter of transforming growth factor beta effects via two distinct mechanisms in hepatic stellate cells. Gut 54:673-681.
-
(2005)
Gut
, vol.54
, pp. 673-681
-
-
Breitkopf, K.1
Sawitza, I.2
Westhoff, J.H.3
Wickert, L.4
Dooley, S.5
Gressner, A.M.6
-
5
-
-
0037115736
-
Acetaldehyde stimulates the activation of latent transforming growth factor-beta1 and induces expression of the type II receptor of the cytokine in rat cultured hepatic stellate cells
-
Chen A (2002) Acetaldehyde stimulates the activation of latent transforming growth factor-beta1 and induces expression of the type II receptor of the cytokine in rat cultured hepatic stellate cells. Biochem J 368:683-693.
-
(2002)
Biochem J
, vol.368
, pp. 683-693
-
-
Chen, A.1
-
7
-
-
2542454565
-
Be fit or be sick: peroxisome proliferator-activated receptors are down the road
-
Desvergne B, Michalik L, Wahli W (2004) Be fit or be sick: peroxisome proliferator-activated receptors are down the road. Mol Endocrinol 18:1321-1332.
-
(2004)
Mol Endocrinol
, vol.18
, pp. 1321-1332
-
-
Desvergne, B.1
Michalik, L.2
Wahli, W.3
-
8
-
-
0036017170
-
Liver disease in alcohol abusers: clinical perspective
-
Diehl AM (2002) Liver disease in alcohol abusers: clinical perspective. Alcohol 27:7-11.
-
(2002)
Alcohol
, vol.27
, pp. 7-11
-
-
Diehl, A.M.1
-
9
-
-
0028351428
-
Hepatocyte proliferation as an indicator of outcome in acute alcoholic hepatitis
-
Fang JW, Bird GL, Nakamura T, Davis GL, Lau JY (1994) Hepatocyte proliferation as an indicator of outcome in acute alcoholic hepatitis. Lancet 343:820-823.
-
(1994)
Lancet
, vol.343
, pp. 820-823
-
-
Fang, J.W.1
Bird, G.L.2
Nakamura, T.3
Davis, G.L.4
Lau, J.Y.5
-
10
-
-
0042847330
-
Peroxisome proliferator-activated receptor alpha (PPARalpha) agonist treatment reverses PPARalpha dysfunction and abnormalities in hepatic lipid metabolism in ethanol-fed mice
-
Fischer M, You M, Matsumoto M, Crabb DW (2003) Peroxisome proliferator-activated receptor alpha (PPARalpha) agonist treatment reverses PPARalpha dysfunction and abnormalities in hepatic lipid metabolism in ethanol-fed mice. J Biol Chem 278:27997-28004.
-
(2003)
J Biol Chem
, vol.278
, pp. 27997-28004
-
-
Fischer, M.1
You, M.2
Matsumoto, M.3
Crabb, D.W.4
-
11
-
-
0035808410
-
The transcriptional and DNA binding activity of peroxisome proliferator-activated receptor alpha is inhibited by ethanol metabolism. A novel mechanism for the development of ethanol-induced fatty liver
-
Galli A, Pinaire J, Fischer M, Dorris R, Crabb DW (2001) The transcriptional and DNA binding activity of peroxisome proliferator-activated receptor alpha is inhibited by ethanol metabolism. A novel mechanism for the development of ethanol-induced fatty liver. J Biol Chem 276:68-75.
-
(2001)
J Biol Chem
, vol.276
, pp. 68-75
-
-
Galli, A.1
Pinaire, J.2
Fischer, M.3
Dorris, R.4
Crabb, D.W.5
-
12
-
-
0343648748
-
Experimental cirrhosis of the liver in rabbits induced by gastric instillation of desiccated whole bile
-
Holsti P (1956) Experimental cirrhosis of the liver in rabbits induced by gastric instillation of desiccated whole bile. Acta Pathol Microbiol Scand Suppl 39:1-66.
-
(1956)
Acta Pathol Microbiol Scand Suppl
, vol.39
, pp. 1-66
-
-
Holsti, P.1
-
13
-
-
33749253713
-
Predominant role of sterol response element binding proteins (SREBP) lipogenic pathways in hepatic steatosis in the murine intragastric ethanol feeding model
-
Ji C, Chan C, Kaplowitz N (2006) Predominant role of sterol response element binding proteins (SREBP) lipogenic pathways in hepatic steatosis in the murine intragastric ethanol feeding model. J Hepatol 45:717-724.
-
(2006)
J Hepatol
, vol.45
, pp. 717-724
-
-
Ji, C.1
Chan, C.2
Kaplowitz, N.3
-
14
-
-
0032699670
-
Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting
-
Kersten S, Seydoux J, Peters JM, Gonzalez FJ, Desvergne B, Wahli W (1999) Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting. J Clin Invest 103:1489-1498.
-
(1999)
J Clin Invest
, vol.103
, pp. 1489-1498
-
-
Kersten, S.1
Seydoux, J.2
Peters, J.M.3
Gonzalez, F.J.4
Desvergne, B.5
Wahli, W.6
-
15
-
-
84863804104
-
Metabolomics reveals an essential role for peroxisome proliferator-activated receptor alpha in bile acid homeostasis
-
Li F, Patterson AD, Krausz KW, Tanaka N, Gonzalez FJ (2012) Metabolomics reveals an essential role for peroxisome proliferator-activated receptor alpha in bile acid homeostasis. J Lipid Res 53:1625-1635.
-
(2012)
J Lipid Res
, vol.53
, pp. 1625-1635
-
-
Li, F.1
Patterson, A.D.2
Krausz, K.W.3
Tanaka, N.4
Gonzalez, F.J.5
-
17
-
-
0027495479
-
Alcohol consumption enhances fatty acid omega-oxidation, with a greater increase in male than in female rats
-
Ma X, Baraona E, Lieber CS (1993) Alcohol consumption enhances fatty acid omega-oxidation, with a greater increase in male than in female rats. Hepatology 18:1247-1253.
-
(1993)
Hepatology
, vol.18
, pp. 1247-1253
-
-
Ma, X.1
Baraona, E.2
Lieber, C.S.3
-
18
-
-
0023025701
-
Histologic spectrum of alcoholic liver disease
-
MacSween RN, Burt AD (1986) Histologic spectrum of alcoholic liver disease. Semin Liver Dis 6:221-232.
-
(1986)
Semin Liver Dis
, vol.6
, pp. 221-232
-
-
MacSween, R.N.1
Burt, A.D.2
-
19
-
-
84891788820
-
MetaboLyzer: a novel statistical workflow for analyzing postprocessed LC-MS metabolomics data
-
Mak TD, Laiakis EC, Goudarzi M, Fornace AJJ (2014) MetaboLyzer: a novel statistical workflow for analyzing postprocessed LC-MS metabolomics data. Anal Chem 86:506-513.
-
(2014)
Anal Chem
, vol.86
, pp. 506-513
-
-
Mak, T.D.1
Laiakis, E.C.2
Goudarzi, M.3
Fornace, A.J.J.4
-
20
-
-
77955463490
-
Identification of noninvasive biomarkers for alcohol-induced liver disease using urinary metabolomics and the Ppara-null mouse
-
Manna SK, Patterson AD, Yang Q, Krausz KW, Li H, Idle JR, Fornace AJJ, Gonzalez FJ (2010) Identification of noninvasive biomarkers for alcohol-induced liver disease using urinary metabolomics and the Ppara-null mouse. J Proteome Res 9:4176-4188.
-
(2010)
J Proteome Res
, vol.9
, pp. 4176-4188
-
-
Manna, S.K.1
Patterson, A.D.2
Yang, Q.3
Krausz, K.W.4
Li, H.5
Idle, J.R.6
Fornace, A.J.J.7
Gonzalez, F.J.8
-
21
-
-
0029783407
-
Expression of hepatocyte growth factor, transforming growth factor alpha, and transforming growth factor beta 1 messenger RNA in various human liver diseases and correlation with hepatocyte proliferation
-
Masuhara M, Yasunaga M, Tanigawa K, Tamura F, Yamashita S, Sakaida I, Okita K (1996) Expression of hepatocyte growth factor, transforming growth factor alpha, and transforming growth factor beta 1 messenger RNA in various human liver diseases and correlation with hepatocyte proliferation. Hepatology 24:323-329.
-
(1996)
Hepatology
, vol.24
, pp. 323-329
-
-
Masuhara, M.1
Yasunaga, M.2
Tanigawa, K.3
Tamura, F.4
Yamashita, S.5
Sakaida, I.6
Okita, K.7
-
22
-
-
77953246434
-
Profiling of promoter occupancy by PPARalpha in human hepatoma cells via ChIP-chip analysis
-
van der Meer DL, Degenhardt T, Vaisanen S, de Groot PJ, Heinaniemi M, de Vries SC, Muller M, Carlberg C, Kersten S (2010) Profiling of promoter occupancy by PPARalpha in human hepatoma cells via ChIP-chip analysis. Nucleic Acids Res 38:2839-2850.
-
(2010)
Nucleic Acids Res
, vol.38
, pp. 2839-2850
-
-
van der Meer, D.L.1
Degenhardt, T.2
Vaisanen, S.3
de Groot, P.J.4
Heinaniemi, M.5
de Vries, S.C.6
Muller, M.7
Carlberg, C.8
Kersten, S.9
-
23
-
-
72349100164
-
Peroxisome proliferator-activated receptor and retinoic × receptor in alcoholic liver disease
-
Mello T, Polvani S, Galli A (2009) Peroxisome proliferator-activated receptor and retinoic × receptor in alcoholic liver disease. PPAR Res 2009:748174.
-
(2009)
PPAR Res
, vol.2009
, pp. 748174
-
-
Mello, T.1
Polvani, S.2
Galli, A.3
-
24
-
-
0034784358
-
Pathogenesis, diagnosis, and treatment of alcoholic liver disease
-
Menon KV, Gores GJ, Shah VH (2001) Pathogenesis, diagnosis, and treatment of alcoholic liver disease. Mayo Clin Proc 76:1021-1029.
-
(2001)
Mayo Clin Proc
, vol.76
, pp. 1021-1029
-
-
Menon, K.V.1
Gores, G.J.2
Shah, V.H.3
-
25
-
-
4644353364
-
Peroxisome proliferator-activated receptor alpha protects against alcohol-induced liver damage
-
Nakajima T, Kamijo Y, Tanaka N, Sugiyama E, Tanaka E, Kiyosawa K, Fukushima Y, Peters JM, Gonzalez FJ, Aoyama T (2004) Peroxisome proliferator-activated receptor alpha protects against alcohol-induced liver damage. Hepatology 40:972-980.
-
(2004)
Hepatology
, vol.40
, pp. 972-980
-
-
Nakajima, T.1
Kamijo, Y.2
Tanaka, N.3
Sugiyama, E.4
Tanaka, E.5
Kiyosawa, K.6
Fukushima, Y.7
Peters, J.M.8
Gonzalez, F.J.9
Aoyama, T.10
-
26
-
-
84873264109
-
Activation of peroxisome proliferator activated receptor alpha ameliorates ethanol mediated liver fibrosis in mice
-
Nan YM, Kong LB, Ren WG, Wang RQ, Du JH, Li WC, Zhao SX, Zhang YG, Wu WJ, Di HL, Li Y, Yu J (2013) Activation of peroxisome proliferator activated receptor alpha ameliorates ethanol mediated liver fibrosis in mice. Lipids Health Dis 12:11.
-
(2013)
Lipids Health Dis
, vol.12
, pp. 11
-
-
Nan, Y.M.1
Kong, L.B.2
Ren, W.G.3
Wang, R.Q.4
Du, J.H.5
Li, W.C.6
Zhao, S.X.7
Zhang, Y.G.8
Wu, W.J.9
Di, H.L.10
Li, Y.11
Yu, J.12
-
27
-
-
0031952238
-
Peroxisome proliferator activated receptor-alpha expression in human liver
-
Palmer CN, Hsu MH, Griffin KJ, Raucy JL, Johnson EF (1998) Peroxisome proliferator activated receptor-alpha expression in human liver. Mol Pharmacol 53:14-22.
-
(1998)
Mol Pharmacol
, vol.53
, pp. 14-22
-
-
Palmer, C.N.1
Hsu, M.H.2
Griffin, K.J.3
Raucy, J.L.4
Johnson, E.F.5
-
28
-
-
0023414856
-
Fatty acid-binding protein: a major contributor to the ethanol-induced increase in liver cytosolic proteins in the rat
-
Pignon JP, Bailey NC, Baraona E, Lieber CS (1987) Fatty acid-binding protein: a major contributor to the ethanol-induced increase in liver cytosolic proteins in the rat. Hepatology 7:865-871.
-
(1987)
Hepatology
, vol.7
, pp. 865-871
-
-
Pignon, J.P.1
Bailey, N.C.2
Baraona, E.3
Lieber, C.S.4
-
29
-
-
0033061334
-
Bile acids modulate the interferon signalling pathway
-
Podevin P, Rosmorduc O, Conti F, Calmus Y, Meier PJ, Poupon R (1999) Bile acids modulate the interferon signalling pathway. Hepatology 29:1840-1847.
-
(1999)
Hepatology
, vol.29
, pp. 1840-1847
-
-
Podevin, P.1
Rosmorduc, O.2
Conti, F.3
Calmus, Y.4
Meier, P.J.5
Poupon, R.6
-
30
-
-
0035570381
-
Fibrates suppress bile acid synthesis via peroxisome proliferator-activated receptor-alpha-mediated downregulation of cholesterol 7alpha-hydroxylase and sterol 27-hydroxylase expression
-
Post SM, Duez H, Gervois PP, Staels B, Kuipers F, Princen HM (2001) Fibrates suppress bile acid synthesis via peroxisome proliferator-activated receptor-alpha-mediated downregulation of cholesterol 7alpha-hydroxylase and sterol 27-hydroxylase expression. Arterioscler Thromb Vasc Biol 21:1840-1845.
-
(2001)
Arterioscler Thromb Vasc Biol
, vol.21
, pp. 1840-1845
-
-
Post, S.M.1
Duez, H.2
Gervois, P.P.3
Staels, B.4
Kuipers, F.5
Princen, H.M.6
-
31
-
-
0025905345
-
A probable defect in the beta-oxidation of lipids in rats fed alcohol for 6 months
-
Rabinowitz JL, Staeffen J, Hall CL, Brand JG (1991) A probable defect in the beta-oxidation of lipids in rats fed alcohol for 6 months. Alcohol 8:241-246.
-
(1991)
Alcohol
, vol.8
, pp. 241-246
-
-
Rabinowitz, J.L.1
Staeffen, J.2
Hall, C.L.3
Brand, J.G.4
-
32
-
-
28844489800
-
Bile salt-induced apoptosis involves NADPH oxidase isoform activation
-
Reinehr R, Becker S, Keitel V, Eberle A, Grether-Beck S, Haussinger D (2005) Bile salt-induced apoptosis involves NADPH oxidase isoform activation. Gastroenterology 129:2009-2031.
-
(2005)
Gastroenterology
, vol.129
, pp. 2009-2031
-
-
Reinehr, R.1
Becker, S.2
Keitel, V.3
Eberle, A.4
Grether-Beck, S.5
Haussinger, D.6
-
33
-
-
0025247125
-
Hepatic injury induced by bile salts: correlation between biochemical and morphological events
-
Schmucker DL, Ohta M, Kanai S, Sato Y, Kitani K (1990) Hepatic injury induced by bile salts: correlation between biochemical and morphological events. Hepatology 12:1216-1221.
-
(1990)
Hepatology
, vol.12
, pp. 1216-1221
-
-
Schmucker, D.L.1
Ohta, M.2
Kanai, S.3
Sato, Y.4
Kitani, K.5
-
34
-
-
84867356237
-
Lipidomic profiling reveals protective function of fatty acid oxidation in cocaine-induced hepatotoxicity
-
Shi X, Yao D, Gosnell BA, Chen C (2012) Lipidomic profiling reveals protective function of fatty acid oxidation in cocaine-induced hepatotoxicity. J Lipid Res 53:2318-2330.
-
(2012)
J Lipid Res
, vol.53
, pp. 2318-2330
-
-
Shi, X.1
Yao, D.2
Gosnell, B.A.3
Chen, C.4
-
36
-
-
84878012189
-
Intrahepatic biliary ablation with pure ethanol: an experimental model of biliary atresia
-
Tatekawa Y, Nakada A, Nakamura T (2013) Intrahepatic biliary ablation with pure ethanol: an experimental model of biliary atresia. Surg Today 43:661-669.
-
(2013)
Surg Today
, vol.43
, pp. 661-669
-
-
Tatekawa, Y.1
Nakada, A.2
Nakamura, T.3
-
37
-
-
0033171439
-
Cholestasis and alcoholic liver disease
-
Tung BY, Carithers RLJ (1999) Cholestasis and alcoholic liver disease. Clin Liver Dis 3:585-601.
-
(1999)
Clin Liver Dis
, vol.3
, pp. 585-601
-
-
Tung, B.Y.1
Carithers, R.L.J.2
-
38
-
-
0028869502
-
Expression of the peroxisome proliferator-activated receptor gene is decreased in experimental alcoholic liver disease
-
Wan YJ, Morimoto M, Thurman RG, Bojes HK, French SW (1995) Expression of the peroxisome proliferator-activated receptor gene is decreased in experimental alcoholic liver disease. Life Sci 56:307-317.
-
(1995)
Life Sci
, vol.56
, pp. 307-317
-
-
Wan, Y.J.1
Morimoto, M.2
Thurman, R.G.3
Bojes, H.K.4
French, S.W.5
-
39
-
-
0035134831
-
Regulation of peroxisome proliferator activated receptor alpha-mediated pathways in alcohol fed cytochrome P450 2E1 deficient mice
-
Wan YY, Cai Y, Li J, Yuan Q, French B, Gonzalez FJ, French S (2001) Regulation of peroxisome proliferator activated receptor alpha-mediated pathways in alcohol fed cytochrome P450 2E1 deficient mice. Hepatol Res 19:117-130.
-
(2001)
Hepatol Res
, vol.19
, pp. 117-130
-
-
Wan, Y.Y.1
Cai, Y.2
Li, J.3
Yuan, Q.4
French, B.5
Gonzalez, F.J.6
French, S.7
-
40
-
-
0037047284
-
Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP)
-
You M, Fischer M, Deeg MA, Crabb DW (2002) Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP). J Biol Chem 277:29342-29347.
-
(2002)
J Biol Chem
, vol.277
, pp. 29342-29347
-
-
You, M.1
Fischer, M.2
Deeg, M.A.3
Crabb, D.W.4
|