Identifying early urinary metabolic changes with long-term environmental exposure to cadmium by mass-spectrometry-based metabolomics

Environmental Science and Technology

Volumn 48, Issue 11, 2014, Pages 6409-6418

  Gao, Yanhong ^a   Lu, Yonghai ^b   Huang, Shaomin ^b   Gao, Liang ^b   Liang, Xuxia ^a   Wu, Yongning ^c   Wang, Jing ^a   Huang, Qiong ^a   Tang, Liuying ^d   Wang, Guian ^d   Yang, Fei ^d   Hu, Shuguang ^a   Chen, Zihui ^d   Wang, Ping ^e   Jiang, Qi ^e   Huang, Rui ^e   Xu, Yinghua ^a   Yang, Xingfen ^a   Ong, Choon Nam ^b  

^a GUANGZHOU CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c CHINA NATIONAL CENTER FOR FOOD SAFETY RISK ASSESSMENT   (China)

^d JINAN UNIVERSITY   (China)

^e Guangdong Provincial Institute of Nephrology   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CADMIUM; GAS CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; PHYSIOLOGY; UREA;

AMINO ACID METABOLISM; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL POLLUTANTS; GALACTOSE METABOLISM; GAS CHROMATOGRAPHY-MASS SPECTROMETRIES (GC-MS); METABOLIC CHANGES; PYROGLUTAMIC ACIDS; QUADRUPOLE TIME OF FLIGHT MASS SPECTROMETRY;

AMINO ACIDS;

CADMIUM; CORTICOSTERONE; CREATINE; CYSTINE; DEOXYADENOSINE PHOSPHATE; ESTRONE; GALACTOSE; GLUTAMINE; HIPPURIC ACID; HISTIDINE; HISTIDINOL DEHYDROGENASE; HYDROXYPROGESTERONE; INOSITOL; PYROGLUTAMIC ACID; TAURINE; TETRAHYDROCORTISONE; TYROSINE; UREA; XANTHINE; BIOLOGICAL MARKER;

ASSESSMENT METHOD; BIOMARKER; CADMIUM; CONCENTRATION (COMPOSITION); MASS SPECTROMETRY; METABOLISM; ORGANIC COMPOUND; POLLUTION EXPOSURE; STEROID;

ADULT; AGED; AMINO ACID METABOLISM; ARTICLE; CONTROLLED STUDY; CREATININE URINE LEVEL; ENVIRONMENTAL EXPOSURE; FEMALE; HORMONE SYNTHESIS; HUMAN; LIQUID CHROMATOGRAPHY; LONG TERM EXPOSURE; MAJOR CLINICAL STUDY; MALE; MASS FRAGMENTOGRAPHY; MASS SPECTROMETRY; METABOLOMICS; NEPHROTOXICITY; PURINE METABOLISM; QUADRUPOLE MASS SPECTROMETRY; TIME OF FLIGHT MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; URINALYSIS; ANALYSIS; CADMIUM POISONING; CHEMICALLY INDUCED; CHEMISTRY; DRUG EFFECTS; KIDNEY; KIDNEY DISEASE; METABOLISM; METABOLOME; MIDDLE AGED; PROCEDURES; URINE;

ADULT; AGED; BIOLOGICAL MARKERS; CADMIUM; CADMIUM POISONING; ENVIRONMENTAL EXPOSURE; FEMALE; HUMANS; KIDNEY; KIDNEY DISEASES; MASS SPECTROMETRY; METABOLOME; METABOLOMICS; MIDDLE AGED;

EID: 84901935454     PISSN: 0013936X     EISSN: 15205851     Source Type: Journal    
DOI: 10.1021/es500750w     Document Type: Article

References (58)

1. Anetor, J. I. Rising environmental cadmium levels in developing countries: Threat to genome stability and health Niger. J. Physiol. Sci. 2012, 27 (2) 103-115
2. Bernard, A. Renal dysfunction induced by cadmium: Biomarkers of critical effects BioMetals 2004, 17 (5) 519-523
3. Liang, Y.; Lei, L.; Nilsson, J.; Li, H.; Nordberg, M.; Bernard, A.; Nordberg, G. F.; Bergdahl, I. A.; Jin, T. Renal function after reduction in cadmium exposure: An 8-year follow-up of residents in cadmium-polluted areas Environ. Health Perspect. 2012, 120 (2) 223-228
4. Satarug, S.; Garrett, S. H.; Sens, M. A.; Sens, D. A. Cadmium, environmental exposure, and health outcomes Environ. Health Perspect. 2010, 118 (2) 182-190
5. Chaumont, A.; Voisin, C.; Deumer, G.; Haufroid, V.; Annesi-Maesano, I.; Roels, H.; Thijs, L.; Staessen, J.; Bernard, A. Associations of urinary cadmium with age and urinary proteins: Further evidence of physiological variations unrelated to metal accumulation and toxicity Environ. Health Perspect. 2013, 121 (9) 1047-1053
6. Ikeda, M.; Moriguchi, J.; Sakuragi, S.; Ohashi, F. Association of past diseases with levels of cadmium and tubular dysfunction markers in urine of adult women in non-polluted areas in Japan Int. Arch. Occup. Environ. Health 2013, 86 (3) 343-355
7. Gallagher, C. M.; Kovach, J. S.; Meliker, J. R. Urinary cadmium and osteoporosis in U.S. women ≥50 years of age: NHANES 1988-1994 and 1999-2004 Environ. Health Perspect. 2008, 116 (10) 1338-1343
8. Lin, Y. S.; Caffrey, J. L.; Chang, M. H.; Dowling, N.; Lin, J. W. Cigarette smoking, cadmium exposure, and zinc intake on obstructive lung disorder Respir. Res. 2010, 11, 53
9. Huff, J.; Lunn, R. M.; Waalkes, M. P.; Tomatis, L.; Infante, P. F. Cadmium-induced cancers in animals and in humans Int. J. Occup. Environ. Health 2007, 13 (2) 202-212
10. Adams, S. V.; Newcomb, P. A. Urinary cadmium as a marker of exposure in epidemiological studies Environ. Health Perspect. 2013, 121 (10) A296
11. World Health Organization (WHO). Cadmium. International Programme on Chemical Safety: Environmental Health Criteria (EHC); WHO: Geneva, Switzerland, 1992; Vol. 134.
12. Frost, S.; Ho, M. Cadmium poisoning: A case study of gold peak batteries in China Corp. Soc. Responsib. Environ. Manage. 2005, 12 (4) 220-226
13. Zhang, G.; Lindars, E.; Chao, Z.; Bai, Y.; Spickett, J. Biological monitoring of cadmium exposed workers in a nickel-cadmium battery factory in China J. Occup. Health 2002, 44 (1) 15-21
14. Järup, L.; Berglund, M.; Elinder, C. G.; Nordberg, G.; Vanter, M. Health effects of cadmium exposure-A review of the literature and a risk estimate Scand. J. Work, Environ. Health 1998, 1-51
15. Cui, L.; Lee, Y. H.; Kumar, Y.; Xu, F.; Lu, K.; Ooi, E. E.; Tannenbaum, S. R.; Ong, C. N. Serum metabolome and lipidome changes in adult patients with primary dengue infection PLoS Neglected Trop. Dis. 2013, 7 (8) e2373
16. Lu, Y.; Wang, C.; Chen, Z.; Zhao, H.; Chen, J.; Liu, X.; Kwan, Y.; Lin, H.; Ngai, S. Serum metabolomics for the diagnosis and classification of myasthenia gravis Metabolomics 2012, 8 (4) 704-713
17. Lankadurai, B. P.; Nagato, E. G.; Simpson, M. J. Environmental metabolomics: An emerging approach to study organism responses to environmental stressors Environ. Rev. 2013, 21 (3) 180-205
18. Bundy, J. G.; Davey, M. P.; Viant, M. R. Environmental metabolomics: A critical review and future perspectives Metabolomics 2009, 5 (1) 3-21
19. Ellis, J. K.; Athersuch, T. J.; Thomas, L. D.; Teichert, F.; Pérez-Trujillo, M.; Svendsen, C.; Spurgeon, D. J.; Singh, R.; Järup, L.; Bundy, J. G. Metabolic profiling detects early effects of environmental and lifestyle exposure to cadmium in a human population BMC Med. 2012, 10 (1) 61
20. Suvagandha, D.; Nishijo, M.; Swaddiwudhipong, W.; Honda, R.; Ohse, M.; Kuhara, T.; Nakagawa, H.; Ruangyuttikarn, W. A biomarker found in cadmium exposed residents of Thailand by metabolome analysis Int. J. Environ. Res. Public Health 2014, 11 (4) 3661-3677
21. Lu, Y.; Lam, H.; Pi, E.; Zhan, Q.; Tsai, S.; Wang, C.; Kwan, Y.; Ngai, S. Comparative metabolomics in Glycine max and Glycine soja under salt stress to reveal the phenotypes of their offspring J. Agric. Food Chem. 2013, 61 (36) 8711-8721
22. Xu, F.; Zou, L.; Liu, Y.; Zhang, Z.; Ong, C. N. Enhancement of the capabilities of liquid chromatography-mass spectrometry with derivatization: General principles and applications Mass Spectrom. Rev. 2011, 30 (6) 1143-1172
23. Gika, H. G.; Theodoridis, G. A.; Wingate, J. E.; Wilson, I. D. Within-day reproducibility of an HPLC-MS-based method for metabonomic analysis: Application to human urine J. Proteome Res. 2007, 6 (8) 3291-3303
24. Wagner, S.; Scholz, K.; Donegan, M.; Burton, L.; Wingate, J.; Völkel, W. Metabonomics and biomarker discovery: LC-MS metabolic profiling and constant neutral loss scanning combined with multivariate data analysis for mercapturic acid analysis Anal. Chem. 2006, 78 (4) 1296-1305
25. Wen, T.; Gao, L.; Wen, Z.; Wu, C.; Tan, C. S.; Toh, W. Z.; Ong, C. N. Exploratory investigation of plasma metabolomics in human lung adenocarcinoma Mol. Biosyst. 2013, 9 (9) 2370-2378
26. Li, J.; Wu, G. Atlas of the Ecological Environmental Geochemistry of China; Geological Publishing House: Beijing, China, 1999.
27. Wang, M.; Liu, X.; Wang, Z. Studies on national surveillance system for food contaminations and foodborne diseases in China Chin. J. Food Hyg. 2006, 6, 002
28. Paschal, D.; Burt, V.; Caudill, S.; Gunter, E.; Pirkle, J.; Sampson, E.; Miller, D.; Jackson, R. Exposure of the US population aged 6 years and older to cadmium: 1988-1994 Arch. Environ. Contam. Toxicol. 2000, 38 (3) 377-383
29. Waikar, S. S.; Sabbisetti, V. S.; Bonventre, J. V. Normalization of urinary biomarkers to creatinine during changes in glomerular filtration rate Kidney Int. 2010, 78 (5) 486-494
30. Miller, R. C.; Brindle, E.; Holman, D. J.; Shofer, J.; Klein, N. A.; Soules, M. R.; O'Connor, K. A. Comparison of specific gravity and creatinine for normalizing urinary reproductive hormone concentrations Clin. Chem. 2004, 50 (5) 924-932
31. Kanter, M.; Aksu, B.; Akpolat, M.; Tarladacalisir, Y. T.; Aktas, C.; Uysal, H. Vitamin E protects against oxidative damage caused by cadmium in the blood of rats Eur. J. Gen. Med. 2009, 6 (3) 154-160
32. Kataranovski, M.; Janković, S.; Kataranovski, D.; Stosić, J.; Bogojević, D. Gender differences in acute cadmium-induced systemi inflammation in rats Biomed. Environ. Sci. 2009, 22 (1) 1-7
33. Perrone, R. D.; Madias, N. E.; Levey, A. S. Serum creatinine as an index of renal function: New insights into old concepts Clin. Chem. 1992, 38 (10) 1933-1953
34. Deguchi, T.; Takemoto, M.; Uehara, N.; Lindup, W. E.; Suenaga, A.; Otagiri, M. Renal clearance of endogenous hippurate correlates with expression levels of renal organic anion transporters in uremic rats J. Pharmacol. Exp. Ther. 2005, 314 (2) 932-938
35. Boelaert, J.; Lynen, F.; Glorieux, G.; Eloot, S.; Van Landschoot, M.; Waterloos, M. A.; Sandra, P.; Vanholder, R. A novel UPLC-MS-MS method for simultaneous determination of seven uremic retention toxins with cardiovascular relevance in chronic kidney disease patients Anal. Bioanal. Chem. 2013, 405 (6) 1937-1947
36. Gargah, T.; Essid, A.; Labassi, A.; Hamzaoui, M.; Lakhoua, M. Xanthine urolithiasis Saudi J. Kidney Dis. Transplant. 2010, 21 (2) 328
37. Cuypers, A.; Plusquin, M.; Remans, T.; Jozefczak, M.; Keunen, E.; Gielen, H.; Opdenakker, K.; Nair, A. R.; Munters, E.; Artois, T. J. Cadmium stress: An oxidative challenge BioMetals 2010, 23 (5) 927-940
38. Yang, C.; Shen, H.; Shen, Y.; Zhuang, Z.; Ong, C. N. Cadmium-induced oxidative cellular damage in human fetal lung fibroblasts (MRC-5 cells) Environ. Health Perspect. 1997, 105 (7) 712-714
39. Pederzolli, C. D.; Sgaravatti, Â. M.; Braum, C. A.; Prestes, C. C.; Zorzi, G. K.; Sgarbi, M. B.; Wyse, A. T.; Wannmacher, C. M.; Wajner, M.; Dutra-Filho, C. S. 5-Oxoproline reduces non-enzymatic antioxidant defenses in vitro in rat brain Metab. Brain Dis. 2007, 22 (1) 51-65
40. DiMarco, T.; Giulivi, C. Current analytical methods for the detection of dityrosine, a biomarker of oxidative stress, in biological samples Mass Spectrom. Rev. 2007, 26 (1) 108-120
41. Liu, J.; Qu, W.; Kadiiska, M. B. Role of oxidative stress in cadmium toxicity and carcinogenesis Toxicol. Appl. Pharmacol. 2009, 238 (3) 209-214
42. Lobo, V.; Patil, A.; Phatak, A.; Chandra, N. Free radicals, antioxidants and functional foods: Impact on human health Pharmacogn. Rev. 2010, 4 (8) 118
43. Amores-Sánchez, M. I.; Medina, M. á. Glutamine, as a precursor of glutathione, and oxidative stress Mol. Genet. Metab. 1999, 67 (2) 100-105
44. Chen, G.; Nan, C.; Tian, J.; Jean-Charles, P.; Li, Y.; Weissbach, H.; Huang, X. Protective effects of taurine against oxidative stress in the heart of MsrA knockout mice J. Cell. Biochem. 2012, 113 (11) 3559-3566
45. Chesney, R. W.; Han, X.; Patters, A. B. Taurine and the renal system J. Biomed. Sci. 2010, 17 (Supplement 1) S4
46. Gukasyan, H. J.; Kannan, R.; Lee, V. H.; Kim, K.-J. Regulation of l -cystine transport and intracellular GSH level by a nitric oxide donor in primary cultured rabbit conjunctival epithelial cell layers Invest. Ophthalmol. Visual Sci. 2003, 44 (3) 1202-1210
47. Chillaron, J.; Font-Llitjos, M.; Fort, J.; Zorzano, A.; Goldfarb, D. S.; Nunes, V.; Palacin, M. Pathophysiology and treatment of cystinuria Nat. Rev. Nephrol. 2010, 6 (7) 424-434
48. Wu, H.; Shiau, C.; Chen, H.; Chiou, T. Antioxidant activities of carnosine, anserine, some free amino acids and their combination J. Food Drug Anal. 2003, 11 (2) 148-153
49. Kang, J. H.; Kim, K. S.; Choi, S. Y.; Kwon, H. Y.; Won, M. H. Oxidative modification of human ceruloplasmin by peroxyl radicals Biochim. Biophys. Acta 2001, 1568 (1) 30-36
50. Shi, X.; Dalal, N.; Kasprzak, K. S. Enhanced generation of hydroxyl radical and sulfur trioxide anion radical from oxidation of sodium sulfite, nickel(II) sulfite, and nickel subsulfide in the presence of nickel(II) complexes Environ. Health Perspect. 1994, 102 (Supplement 3) 91
51. Yi, S.; Selvin, E.; Rohrmann, S.; Basaria, S.; Menke, A.; Rifai, N.; Guallar, E.; Platz, E. A.; Astor, B. Endogenous sex steroid hormones and measures of chronic kidney disease (CKD) in a nationally representative sample of men Clin. Endocrinol. 2009, 71 (2) 246-252
52. Menke, A.; Guallar, E.; Shiels, M. S.; Rohrmann, S.; Basaria, S.; Rifai, N.; Nelson, W. G.; Platz, E. A. The association of urinary cadmium with sex steroid hormone concentrations in a general population sample of US adult men BMC Public Health 2008, 8 (1) 72
53. Nagata, C.; Nagao, Y.; Shibuya, C.; Kashiki, Y.; Shimizu, H. Urinary cadmium and serum levels of estrogens and androgens in postmenopausal Japanese women Cancer Epidemiol., Biomarkers Prev. 2005, 14 (3) 705-708
54. Henson, M. C.; Chedrese, P. J. Endocrine disruption by cadmium, a common environmental toxicant with paradoxical effects on reproduction Exp. Biol. Med. 2004, 229 (5) 383-392
55. Järup, L.; Hellström, L.; Alfvén, T.; Carlsson, M. D.; Grubb, A.; Persson, B.; Pettersson, C.; Spång, G.; Schütz, A.; Elinder, C. G. Low level exposure to cadmium and early kidney damage: The OSCAR study Occup. Environ. Med. 2000, 57 (10) 668-672
56. Bundy, J. G.; Keun, H. C.; Sidhu, J. K.; Spurgeon, D. J.; Svendsen, C.; Kille, P.; Morgan, A. J. Metabolic profile biomarkers of metal contamination in a sentinel terrestrial species are applicable across multiple sites Environ. Sci. Technol. 2007, 41 (12) 4458-4464
57. Bundy, J. G.; Sidhu, J. K.; Rana, F.; Spurgeon, D. J.; Svendsen, C.; Wren, J. F.; Stürzenbaum, S. R.; Morgan, A. J.; Kille, P. 'Systems toxicology' approach identifies coordinated metabolic responses to copper in a terrestrial non-model invertebrate, the earthworm Lumbricus rubellus BMC Biol. 2008, 6, 25
58. Ng, D.; Salim, A.; Liu, Y.; Zou, L.; Xu, F.; Huang, S.; Leong, H.; Ong, C. A metabolomic study of low estimated GFR in non-proteinuric type 2 diabetes mellitus Diabetologia 2012, 55 (2) 499-508