Low level exposure to cadmium and early kidney damage: The OSCAR study

Occupational and Environmental Medicine

Volumn 57, Issue 10, 2000, Pages 668-672

  Järup, Lars ^a,b   Elinder, Carl Gustaf ^j   Hellström, Lennart ^c   Alfvén, Tobias ^a   Carlsson, Margareta D ^d,e   Grubb, Anders ^f   Persson, Bodil ^g   Pettersson, Conny ^h   Spång, Gunnar ⁱ   Schütz, Andrejs ^f  

^a KAROLINSKA INSTITUTE   (Sweden)

^b IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^c Department of Environmental Medicine and Public Health   (Sweden)

^d LINNAEUS UNIVERSITY   (Sweden)

^e Local Government Environmental Protection Board   (Sweden)

^f LUND UNIVERSITY HOSPITAL   (Sweden)

^g LINKÖPING UNIVERSITY   (Sweden)

^h Primary Health Care Unit   (Sweden)

ⁱ Industrial Health Care Unit   (Sweden)

^j KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

more..

Author keywords

Cadmium; Environmental; Tubular damage

Indexed keywords

ALPHA 1 MICROGLOBULIN; CADMIUM;

ADULT; ARTICLE; BATTERY INDUSTRY; CONTROLLED STUDY; DOSE RESPONSE; ENVIRONMENTAL EXPOSURE; FEMALE; HEAVY METAL POISONING; HUMAN; KIDNEY TUBULE DAMAGE; MAJOR CLINICAL STUDY; MALE; OCCUPATIONAL EXPOSURE; PREVALENCE; PRIORITY JOURNAL; PROTEINURIA; URINE LEVEL;

ADULT; AGED; AGED, 80 AND OVER; ALPHA-GLOBULINS; CADMIUM; CHILD; CROSS-SECTIONAL STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; KIDNEY DISEASES; MALE; MIDDLE AGED; OCCUPATIONAL EXPOSURE; ODDS RATIO; PREVALENCE; PROTEINURIA; REGRESSION ANALYSIS; SWEDEN;

EID: 0033832233     PISSN: 13510711     EISSN: None     Source Type: Journal    
DOI: 10.1136/oem.57.10.668     Document Type: Article

References (27)

1. 1 Friberg L, Elinder CG, Kjellstr÷m T, et al. Cadmium and health: a toxicological and epidemiological appraisal. Boca Raton, FL: CRC Press, 1986:2.
2. 2 Cadmium. Environmental health criteria. Geneva: World Health Organisation, 1992.
3. 3 Kido I, Nordberg GF. Cadmium and the kidney. In: De Broe ME, Porter GA, Bennet WM, et al, eds. Clinical nephrotoxins. The Netherlands: Kluwer Academic, 1998:323-50.
4. 4 Elinder CG, Gerhardsson L, Oberdörster G. Biological monitoring of toxic metals: overview. In: Clarkson TW, Friberg L, Nordberg GF, et al, editors. Biological monitoring of toxic metals. London: Plenum Press, 1988:1-71.
5. 5 Lauwerys R, Bernard A, Cardenas A. Monitoring of early nephrotoxic effects of industrial chemicals. Toxicol Lett 1992;64-65:33-42.
6. 6 Wedeen RP, De Broe ME. Heavy metals and the kidney. In: Davison AM, Cameron JS, Grünfeld JP, et al, editors. Oxford textbook of clinical nephrology. 2nd ed. Oxford: Oxford University Press, 1998:1175-90.
7. 7 Järup L, Berglund M, Elinder CG, et al. Health effects of cadmium exposure: a review of the literature and a risk estimate. Scand J Work Environ Health 1998;24(suppl 1):1 51.
8. 8 Kjellström T. Mechanism and epidemiology of bone effects of cadmium. IARC Sci Publ 1992,118:301-10.
9. 9 Buchet JP, Lauwerys R, Roels H, et al. Renal effects of cadmium body burden of the general population published erratum appears in Lancet 1991;337:1554. Lancet 1990; 336:699-702.
10. 10 Kjellström T, Evrin PE, Rahnster B. Dose-response analysis of cadmium-induced tubular proteinuria: a study of urinary β2-microglobulin excretion among workers in a battery factory. Environ Res 1977;13:303-17.
11. 11 Järup L, Elinder CG. Dose-response relations between urinary cadmium and tubular proteinuria in cadmium-exposed workers. Am J Ind Med 1994;26:759-69.
12. 11a Alfrén T, Elinder C-G, Carlsson MD, et al. Low-level cadmium exposure and osteoporosis. J Bone Miner Res 2000;15.
13. 12 Tencer J, Thysell H, Andersson K, et al. Stability of albumin, protein HC, immunoglobulin G, κ- and λ-chain immunoreactivity, orosomucoid and μ 1-antitrypsin in urine stored at various conditions. Scand J Clin Lab Invest 1994;54:199-206.
14. 13 Tencer J, Thysell H, Grubb A. Analysis of proteinuria: reference limits for urine excretion of albumin, protein HC, immunoglobulin G, κ- and λ-immunoreactivity, orosomucoid and μ 1-antitrypsin. Stand J Clin Lab Invest 1996;56: 691-700.
15. 14 Finn WF, Porter GA. Urinary biomarkers and nephrotoxicity. In: De Broe ME, Porter GA, Bennet VM, et al, eds. Clinical nephrotoxins. The Netherlands: Kluwer Academic, 1998:439-63.
16. 15 Kido T, Honda R, Yamada Y, et al. μ1-Microglobulin determination in urine for the early detection of renal tubular dysfunctions caused by exposure to cadmium. Toxicol Lett 1985;24:195-201.
17. 16 Tohyama C, Kobayashi E, Saito H, et al. Urinary μ1-microglobulin as an indicator protein of renal tubular dysfunction caused by environmental cadmium exposure. J Appl Toxicol 1986;6:171-8.
18. 17 Järup L, Persson B, Elinder CG. Blood cadmium as an indicator of dose in a long Term follow up of workers previously exposed to cadmium. Scand J Work Environ Health 1997;23:31-6.
19. 18 Fels LM, Bundschuh I, Gwinner W, et al. Early urinary markers of target nephron segments as studied in cadmium toxicity. Kidney Int Suppl 1994;47:S81-8.
20. 19 Mueller PW, Paschal DC, Hammel RR, et al. Chronic renal effects in three studies of men and women occupationally exposed to cadmium. Arch Environ Contain Toxicol 1992;23:125-36.
21. 20 Yamanaka O, Kobayashi E, Nogawa K, et al. Association between renal effects and cadmium exposure in a cadmium-nonpolluted area in Japan. Environ Res 1998;77: 1-8.
22. 21 Granerus G, Aurell M. Reference values for 51Cr-EDTA clearance as a measure of glomerular filtration rate. Scand J Clin Lab Invest 1981;41:611-6.
23. 22 Niederstadt C, Steinhoff J. The kidneys in ageing (in German). Z Gerontol Geriatr 1997;30:200-7.
24. 23 Kowal NE, Zirkes M. Urinary cadmium and β 2-microglobulin: normal values and concentration adjustment. J Toxicol Environ Health 1983;11:607-24.
25. 24 Nogawa K, Kobayashi E, Honda R. A study of the relationship between cadmium concentrations in urine and renal effects of cadmium. Environ Health Perspect 1979;28: 161-8.
26. 25 Hotz P, Buchet JP, Bernard A, et al. Renal effects of low-level environmental cadmium exposure: 5 year follow up of a subcohort from the Cadmibel study. Lancet 1999;354:1508-13.
27. 26 Staessen JA, Roels HA, Emelianov D, et al. Environmental exposure to cadmium, forearm bone density, and risk of fractures: prospective population study. Lancet 1999;353: 1140-4.