Distinct biochemical properties of human serine hydroxymethyltransferase compared with the Plasmodium enzyme: Implications for selective inhibition

FEBS Journal

Volumn 281, Issue 11, 2014, Pages 2570-2583

  Pinthong, Chatchadaporn ^a   Maenpuen, Somchart ^b   Amornwatcharapong, Watcharee ^a   Yuthavong, Yongyuth ^c   Leartsakulpanich, Ubolsree ^c   Chaiyen, Pimchai ^a  

^a MAHIDOL UNIVERSITY   (Thailand)

^b BURAPHA UNIVERSITY   (Thailand)

^c NATIONAL SCIENCE AND TECHNOLOGY DEVELOPMENT AGENCY   (Thailand)

Author keywords

dTMP cycle; folate metabolism; PLP dependent enzyme; pyridoxal 5 phosphate; serine hydroxymethyltransferase

Indexed keywords

GLYCINE HYDROXYMETHYLTRANSFERASE;

ARTICLE; BIOCHEMICAL COMPOSITION; BIOPHYSICS; COMPARATIVE STUDY; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; ENZYME KINETICS; ENZYME STABILITY; ENZYME SUBSTRATE; HUMAN; HUMAN VERSUS NONHUMAN DATA; LIGAND BINDING; NONHUMAN; PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION;

DTMP CYCLE; FOLATE METABOLISM; PLP-DEPENDENT ENZYME; PYRIDOXAL-5′-PHOSPHATE; SERINE HYDROXYMETHYLTRANSFERASE;

ANIMALS; GLYCINE HYDROXYMETHYLTRANSFERASE; HUMANS; PLASMODIUM; PYRIDOXAL PHOSPHATE; RECOMBINANT PROTEINS;

EID: 84901922180     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.12803     Document Type: Article

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