CD4+ t cells modified by the endoribonuclease MazF are safe and can persist in SHIV-infected rhesus macaques

Molecular Therapy Nucleic Acids

Volumn 3, Issue , 2014, Pages e168-

  Saito, Naoki ^a   Chono, Hideto ^a   Shibata, Hiroaki ^b   Ageyama, Naohide ^b   Yasutomi, Yasuhiro ^b   Mineno, Junichi ^a  

^a TAKARA BIO INC   (Japan)

^b NATIONAL INSTITUTE OF BIOMEDICAL INNOVATION   (Japan)

Author keywords

Gene therapy; HIV 1; MazF; Primate model; Retroviral vector; Rhesus macaque; SHIV

Indexed keywords

GAMMA INTERFERON; MAZF PROTEIN; RIBONUCLEASE; UNCLASSIFIED DRUG; ZSGREEN1 PROTEIN; MAZF ENDORIBONUCLEASE; SINGLE STRANDED RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN SPECIFICITY; ARTICLE; AUTOTRANSPLANTATION; BODY WEIGHT; CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; CELL FUNCTION; CELL TRANSPLANTATION; CELLULAR IMMUNITY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSPOT ASSAY; GENE THERAPY; HISTOPATHOLOGY; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMORAL IMMUNITY; IN VIVO STUDY; NONHUMAN; PLASMA; PRIORITY JOURNAL; RHESUS MONKEY; SIMIAN HUMAN IMMUNODEFICIENCY VIRUS; SIMIAN HUMAN IMMUNODEFICIENCY VIRUS INFECTION; VIRUS LOAD; ANTIBODY PRODUCTION; GIBBON APE LEUKEMIA VIRUS; LIMIT OF DETECTION; MEMORY CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN EXPRESSION; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; SIMIAN IMMUNODEFICIENCY VIRUS; VIRUS REPLICATION;

EID: 84901919285     PISSN: None     EISSN: 21622531     Source Type: Journal    
DOI: 10.1038/mtna.2014.20     Document Type: Article

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