메뉴 건너뛰기




Volumn , Issue , 2012, Pages 157-179

Cancer Chemotherapy

Author keywords

[No Author keywords available]

Indexed keywords


EID: 84901886588     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-1-4377-2362-5.00011-6     Document Type: Chapter
Times cited : (46)

References (294)
  • 1
    • 78349301150 scopus 로고    scopus 로고
    • Cancer chemotherapy: an annotated history
    • Morrison WB Cancer chemotherapy: an annotated history. J Vet Intern Med 2010, 24:1249.
    • (2010) J Vet Intern Med , vol.24 , pp. 1249
    • Morrison, W.B.1
  • 2
    • 11144242211 scopus 로고    scopus 로고
    • Timeline: Chemotherapy and the war on cancer
    • Chabner BA, Roberts TG Timeline: Chemotherapy and the war on cancer. Nat Rev Cancer 2005, 5:65.
    • (2005) Nat Rev Cancer , vol.5 , pp. 65
    • Chabner, B.A.1    Roberts, T.G.2
  • 3
    • 55349136976 scopus 로고    scopus 로고
    • A history of cancer chemotherapy
    • De Vita VT, Chu E A history of cancer chemotherapy. Cancer Res 2008, 68:8643.
    • (2008) Cancer Res , vol.68 , pp. 8643
    • De Vita, V.T.1    Chu, E.2
  • 4
    • 33749011163 scopus 로고    scopus 로고
    • The NCI60 human tumour cell line anticancer drug screen
    • Shoemaker RH The NCI60 human tumour cell line anticancer drug screen. Nat Rev Cancer 2006, 6:813.
    • (2006) Nat Rev Cancer , vol.6 , pp. 813
    • Shoemaker, R.H.1
  • 5
    • 77949957365 scopus 로고    scopus 로고
    • Cell line-based platforms to evaluate the therapeutic efficacy of candidate anticancer agents
    • Sharma SV, Haber DA, Settleman J Cell line-based platforms to evaluate the therapeutic efficacy of candidate anticancer agents. Nat Rev Cancer 2010, 10:241.
    • (2010) Nat Rev Cancer , vol.10 , pp. 241
    • Sharma, S.V.1    Haber, D.A.2    Settleman, J.3
  • 6
    • 80052508310 scopus 로고    scopus 로고
    • Masitinib as a chemosensitizer of canine tumor cell lines: A proof of concept study
    • Thamm DH, Rose B, Kow K, et al. Masitinib as a chemosensitizer of canine tumor cell lines: A proof of concept study. Vet J 2011, 191(1):131-134.
    • (2011) Vet J , vol.191 , Issue.1 , pp. 131-134
    • Thamm, D.H.1    Rose, B.2    Kow, K.3
  • 7
    • 0018771948 scopus 로고
    • Evidence for active transport of melphalan by two amino acid carriers in L5178Y lymphoblasts in vitro
    • Begleiter A, Lam H-YP, Grover J, et al. Evidence for active transport of melphalan by two amino acid carriers in L5178Y lymphoblasts in vitro. Cancer Res 1979, 39:353.
    • (1979) Cancer Res , vol.39 , pp. 353
    • Begleiter, A.1    Lam, H.-Y.P.2    Grover, J.3
  • 8
    • 0019147613 scopus 로고
    • Cytotoxicity as an indicator for transport mechanism: evidence that murine bone marrow progenitor cells lack a high-affinity leucine carrier that transports melphalan in murine L1210 leukemia cells
    • Vistica D Cytotoxicity as an indicator for transport mechanism: evidence that murine bone marrow progenitor cells lack a high-affinity leucine carrier that transports melphalan in murine L1210 leukemia cells. Blood 1980, 56:427.
    • (1980) Blood , vol.56 , pp. 427
    • Vistica, D.1
  • 9
    • 0020072941 scopus 로고
    • Cytosine arabinoside influx and nucleoside transport sites in acute leukemia
    • Wiley JS, Jones SP, Sawyer WH, et al. Cytosine arabinoside influx and nucleoside transport sites in acute leukemia. J Clin Invest 1982, 69:479.
    • (1982) J Clin Invest , vol.69 , pp. 479
    • Wiley, J.S.1    Jones, S.P.2    Sawyer, W.H.3
  • 10
    • 0032188825 scopus 로고    scopus 로고
    • Functional nucleoside transporters are required for gemcitabine influx and manifestation of toxicity in cancer cell lines
    • Mackey JR, Mani RS, Selner M, et al. Functional nucleoside transporters are required for gemcitabine influx and manifestation of toxicity in cancer cell lines. Cancer Res 1998, 58:4349.
    • (1998) Cancer Res , vol.58 , pp. 4349
    • Mackey, J.R.1    Mani, R.S.2    Selner, M.3
  • 11
    • 0014410041 scopus 로고
    • Carrier-mediated transport of the folic acid analogue, methotrexate, in the L1210 leukemia cell
    • Goldman ID, Lichtenstein NS, Oliverio VT Carrier-mediated transport of the folic acid analogue, methotrexate, in the L1210 leukemia cell. J Biol Chem 1968, 243:5007.
    • (1968) J Biol Chem , vol.243 , pp. 5007
    • Goldman, I.D.1    Lichtenstein, N.S.2    Oliverio, V.T.3
  • 12
    • 0029781038 scopus 로고    scopus 로고
    • Selection of a subpopulation with fewer DNA topoisomerase II alpha gene copies in a doxorubicin-resistant cell line panel
    • Withoff S, Keith WN, Knol AJ, et al. Selection of a subpopulation with fewer DNA topoisomerase II alpha gene copies in a doxorubicin-resistant cell line panel. Br J Cancer 1996, 74:502.
    • (1996) Br J Cancer , vol.74 , pp. 502
    • Withoff, S.1    Keith, W.N.2    Knol, A.J.3
  • 13
    • 0031577472 scopus 로고    scopus 로고
    • Decreased CP-1 (NF-Y) activity results in transcriptional down-regulation of topoisomerase IIalpha in a doxorubicin-resistant variant of human multiple myeloma RPMI 8226
    • Wang H, Jiang Z, Wong YW, et al. Decreased CP-1 (NF-Y) activity results in transcriptional down-regulation of topoisomerase IIalpha in a doxorubicin-resistant variant of human multiple myeloma RPMI 8226. Biochem Biophys Res Commun 1997, 237:217.
    • (1997) Biochem Biophys Res Commun , vol.237 , pp. 217
    • Wang, H.1    Jiang, Z.2    Wong, Y.W.3
  • 14
    • 0642319762 scopus 로고
    • Biochemical determinants of tumor sensitivity to 5-fluorouracil: ultrasensitive methods for the determination of 5-fluoro-2′-deoxyuridylate, 2′-deoxyuridylate, and thymidylate synthetase
    • Moran RG, Spears CP, Heidelberger C Biochemical determinants of tumor sensitivity to 5-fluorouracil: ultrasensitive methods for the determination of 5-fluoro-2′-deoxyuridylate, 2′-deoxyuridylate, and thymidylate synthetase. Proc Natl Acad Sci U S A 1979, 76:1456.
    • (1979) Proc Natl Acad Sci U S A , vol.76 , pp. 1456
    • Moran, R.G.1    Spears, C.P.2    Heidelberger, C.3
  • 15
    • 0028533694 scopus 로고
    • DNA damage tolerance, mismatch repair and genome instability
    • Karran P, Bignami M DNA damage tolerance, mismatch repair and genome instability. BioEssays 1994, 16:833.
    • (1994) BioEssays , vol.16 , pp. 833
    • Karran, P.1    Bignami, M.2
  • 16
    • 14644407525 scopus 로고    scopus 로고
    • The role of apoptosis in cancer development and treatment response
    • Brown JM, Attardi LD The role of apoptosis in cancer development and treatment response. Nat Rev Cancer 2005, 5:231.
    • (2005) Nat Rev Cancer , vol.5 , pp. 231
    • Brown, J.M.1    Attardi, L.D.2
  • 17
    • 0036547417 scopus 로고    scopus 로고
    • Death and anti-death: tumour resistance to apoptosis
    • Igney FH, Krammer PH Death and anti-death: tumour resistance to apoptosis. Nat Rev Cancer 2002, 2:277.
    • (2002) Nat Rev Cancer , vol.2 , pp. 277
    • Igney, F.H.1    Krammer, P.H.2
  • 18
    • 0028054687 scopus 로고
    • Regulation of chemoresistance by the bcl-2 oncoprotein in non-Hodgkin's lymphoma and lymphocytic leukemia cell lines
    • Reed JC, Kitada S, Takayama S, et al. Regulation of chemoresistance by the bcl-2 oncoprotein in non-Hodgkin's lymphoma and lymphocytic leukemia cell lines. Ann Oncol 1994, 5(Suppl 1):61.
    • (1994) Ann Oncol , vol.5 , Issue.SUPPL.1 , pp. 61
    • Reed, J.C.1    Kitada, S.2    Takayama, S.3
  • 19
    • 0033826530 scopus 로고    scopus 로고
    • Genetic analysis of chemoresistance in primary murine lymphomas
    • Schmitt CA, Rosenthal CT, Lowe SW Genetic analysis of chemoresistance in primary murine lymphomas. Nat Med 2000, 6:1029.
    • (2000) Nat Med , vol.6 , pp. 1029
    • Schmitt, C.A.1    Rosenthal, C.T.2    Lowe, S.W.3
  • 20
    • 0030746636 scopus 로고    scopus 로고
    • A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma
    • Ambrosini G, Adida C, Altieri DC A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat Med 1997, 3:917.
    • (1997) Nat Med , vol.3 , pp. 917
    • Ambrosini, G.1    Adida, C.2    Altieri, D.C.3
  • 21
    • 8944262192 scopus 로고    scopus 로고
    • Clinical significance of bcl2 and p53 protein expression in diffuse large B-cell lymphoma: a population-based study
    • Kramer M, Hermans J, Parker J, et al. Clinical significance of bcl2 and p53 protein expression in diffuse large B-cell lymphoma: a population-based study. J Clin Oncol 1996, 14:2131.
    • (1996) J Clin Oncol , vol.14 , pp. 2131
    • Kramer, M.1    Hermans, J.2    Parker, J.3
  • 22
    • 0037609669 scopus 로고    scopus 로고
    • Prognostic significance of bcl-2, bax, and p53 expression in diffuse large B-cell lymphoma
    • Sohn SK, Jung JT, Kim DH, et al. Prognostic significance of bcl-2, bax, and p53 expression in diffuse large B-cell lymphoma. Am J Hematol 2003, 73:101.
    • (2003) Am J Hematol , vol.73 , pp. 101
    • Sohn, S.K.1    Jung, J.T.2    Kim, D.H.3
  • 23
    • 47849118398 scopus 로고    scopus 로고
    • Comparative analysis of survivin expression in untreated and relapsed canine lymphoma
    • Rebhun RB, Lana SE, Ehrhart EJ, et al. Comparative analysis of survivin expression in untreated and relapsed canine lymphoma. J Vet Intern Med 2008, 22:989.
    • (2008) J Vet Intern Med , vol.22 , pp. 989
    • Rebhun, R.B.1    Lana, S.E.2    Ehrhart, E.J.3
  • 24
    • 0027422392 scopus 로고
    • Decreased melphalan accumulation in a human breast cancer cell line selected for resistance to melphalan
    • Moscow JA, Swanson CA, Cowan KH Decreased melphalan accumulation in a human breast cancer cell line selected for resistance to melphalan. Br J Cancer 1993, 68:732.
    • (1993) Br J Cancer , vol.68 , pp. 732
    • Moscow, J.A.1    Swanson, C.A.2    Cowan, K.H.3
  • 25
    • 0027469593 scopus 로고
    • Decreased expression of the human folate receptor mediates transport-defective methotrexate resistance in KB cells
    • Saikawa Y, Knight CB, Saikawa T, et al. Decreased expression of the human folate receptor mediates transport-defective methotrexate resistance in KB cells. J Biol Chem 1993, 268:5293.
    • (1993) J Biol Chem , vol.268 , pp. 5293
    • Saikawa, Y.1    Knight, C.B.2    Saikawa, T.3
  • 26
    • 0028106016 scopus 로고
    • Glutathione-associated enzymes in anticancer drug resistance
    • Tew KD Glutathione-associated enzymes in anticancer drug resistance. Cancer Res 1994, 54:4313.
    • (1994) Cancer Res , vol.54 , pp. 4313
    • Tew, K.D.1
  • 27
    • 0021889194 scopus 로고
    • Increased glutathione-S-transferase activity in a cell line with acquired resistance to nitrogen mustards
    • Wang AL, Tew KD Increased glutathione-S-transferase activity in a cell line with acquired resistance to nitrogen mustards. Cancer Treat Rep 1985, 69:677.
    • (1985) Cancer Treat Rep , vol.69 , pp. 677
    • Wang, A.L.1    Tew, K.D.2
  • 28
    • 0345083688 scopus 로고
    • Amplification and increased expression of alpha class glutathione S-transferase-encoding genes associated with resistance to nitrogen mustards
    • Lewis AD, Hickson ID, Robson CN, et al. Amplification and increased expression of alpha class glutathione S-transferase-encoding genes associated with resistance to nitrogen mustards. Proc Natl Acad Sci U S A 1988, 85:8511.
    • (1988) Proc Natl Acad Sci U S A , vol.85 , pp. 8511
    • Lewis, A.D.1    Hickson, I.D.2    Robson, C.N.3
  • 29
    • 0028097137 scopus 로고
    • A role for dihydropyrimidine dehydrogenase and thymidylate synthase in tumour sensitivity to fluorouracil
    • Beck A, Etienne MC, Cheradame S, et al. A role for dihydropyrimidine dehydrogenase and thymidylate synthase in tumour sensitivity to fluorouracil. Eur J Cancer 1994, 30A:1517.
    • (1994) Eur J Cancer , vol.30 A , pp. 1517
    • Beck, A.1    Etienne, M.C.2    Cheradame, S.3
  • 30
    • 0032945491 scopus 로고    scopus 로고
    • Dihydropyrimidine dehydrogenase activity and messenger RNA level may be related to the antitumor effect of 5-fluorouracil on human tumor xenografts in nude mice
    • Ishikawa Y, Kubota T, Otani Y, et al. Dihydropyrimidine dehydrogenase activity and messenger RNA level may be related to the antitumor effect of 5-fluorouracil on human tumor xenografts in nude mice. Clin Cancer Res 1999, 5:883.
    • (1999) Clin Cancer Res , vol.5 , pp. 883
    • Ishikawa, Y.1    Kubota, T.2    Otani, Y.3
  • 31
    • 0034088857 scopus 로고    scopus 로고
    • A gene expression database for the molecular pharmacology of cancer
    • Scherf U, Ross DT, Waltham M, et al. A gene expression database for the molecular pharmacology of cancer. Nat Genet 2000, 24:236.
    • (2000) Nat Genet , vol.24 , pp. 236
    • Scherf, U.1    Ross, D.T.2    Waltham, M.3
  • 32
    • 0023187085 scopus 로고
    • Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine, and bile
    • Heggie GD, Sommadossi JP, Cross DS, et al. Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine, and bile. Cancer Res 1987, 47:2203.
    • (1987) Cancer Res , vol.47 , pp. 2203
    • Heggie, G.D.1    Sommadossi, J.P.2    Cross, D.S.3
  • 33
    • 0025049372 scopus 로고
    • Inhibition of ribonucleotide reduction in CCRF-CEM cells by 2′,2′-difluorodeoxycytidine
    • Heinemann V, Xu YZ, Chubb S, et al. Inhibition of ribonucleotide reduction in CCRF-CEM cells by 2′,2′-difluorodeoxycytidine. Mol Pharmacol 1990, 38:567.
    • (1990) Mol Pharmacol , vol.38 , pp. 567
    • Heinemann, V.1    Xu, Y.Z.2    Chubb, S.3
  • 34
    • 0026324313 scopus 로고
    • Action of 2′,2′-difluorodeoxycytidine on DNA synthesis
    • Huang P, Chubb S, Hertel LW, et al. Action of 2′,2′-difluorodeoxycytidine on DNA synthesis. Cancer Res 1991, 51:6110.
    • (1991) Cancer Res , vol.51 , pp. 6110
    • Huang, P.1    Chubb, S.2    Hertel, L.W.3
  • 35
    • 0023783698 scopus 로고
    • Comparison of the cellular pharmacokinetics and toxicity of 2′,2′-difluorodeoxycytidine and 1-beta-D-arabinofuranosylcytosine
    • Heinemann V, Hertel LW, Grindey GB, et al. Comparison of the cellular pharmacokinetics and toxicity of 2′,2′-difluorodeoxycytidine and 1-beta-D-arabinofuranosylcytosine. Cancer Res 1988, 48:4024.
    • (1988) Cancer Res , vol.48 , pp. 4024
    • Heinemann, V.1    Hertel, L.W.2    Grindey, G.B.3
  • 36
    • 0027197028 scopus 로고
    • Kinetic studies on 2′,2′-difluorodeoxycytidine (Gemcitabine) with purified human deoxycytidine kinase and cytidine deaminase
    • Bouffard DY, Laliberte J, Momparler RL Kinetic studies on 2′,2′-difluorodeoxycytidine (Gemcitabine) with purified human deoxycytidine kinase and cytidine deaminase. Biochem Pharmacol 1993, 45:1857.
    • (1993) Biochem Pharmacol , vol.45 , pp. 1857
    • Bouffard, D.Y.1    Laliberte, J.2    Momparler, R.L.3
  • 37
    • 49049100257 scopus 로고    scopus 로고
    • Down-regulation of deoxycytidine kinase enhances acquired resistance to gemcitabine in pancreatic cancer
    • Ohhashi S, Ohuchida K, Mizumoto K, et al. Down-regulation of deoxycytidine kinase enhances acquired resistance to gemcitabine in pancreatic cancer. Anticancer Res 2008, 28:2205.
    • (2008) Anticancer Res , vol.28 , pp. 2205
    • Ohhashi, S.1    Ohuchida, K.2    Mizumoto, K.3
  • 38
    • 33846816556 scopus 로고    scopus 로고
    • Gemcitabine chemoresistance and molecular markers associated with gemcitabine transport and metabolism in human pancreatic cancer cells
    • Nakano Y, Tanno S, Koizumi K, et al. Gemcitabine chemoresistance and molecular markers associated with gemcitabine transport and metabolism in human pancreatic cancer cells. Br J Cancer 2007, 96:457.
    • (2007) Br J Cancer , vol.96 , pp. 457
    • Nakano, Y.1    Tanno, S.2    Koizumi, K.3
  • 39
    • 0025997529 scopus 로고
    • Mechanisms of resistance to etoposide and teniposide in acquired resistant human colon and lung carcinoma cell lines
    • Long BH, Wang L, Lorico A, et al. Mechanisms of resistance to etoposide and teniposide in acquired resistant human colon and lung carcinoma cell lines. Cancer Res 1991, 51:5275.
    • (1991) Cancer Res , vol.51 , pp. 5275
    • Long, B.H.1    Wang, L.2    Lorico, A.3
  • 40
    • 0021240783 scopus 로고
    • Inhibition of the DNA catenation activity of type II topoisomerase by VP16-213 and VM26
    • Minocha A, Long BH Inhibition of the DNA catenation activity of type II topoisomerase by VP16-213 and VM26. Biochem Biophys Res Commun 1984, 122:165.
    • (1984) Biochem Biophys Res Commun , vol.122 , pp. 165
    • Minocha, A.1    Long, B.H.2
  • 41
    • 0021749639 scopus 로고
    • Nonintercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II
    • Chen GL, Yang L, Rowe TC, et al. Nonintercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II. J Biol Chem 1984, 259:13560.
    • (1984) J Biol Chem , vol.259 , pp. 13560
    • Chen, G.L.1    Yang, L.2    Rowe, T.C.3
  • 42
    • 0017807188 scopus 로고
    • Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells
    • Alt FW, Kellems RE, Bertino JR, et al. Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells. J Biol Chem 1978, 253:1357.
    • (1978) J Biol Chem , vol.253 , pp. 1357
    • Alt, F.W.1    Kellems, R.E.2    Bertino, J.R.3
  • 43
    • 0030758777 scopus 로고    scopus 로고
    • Paclitaxel-resistant human ovarian cancer cells have mutant β-tubulins that exhibit impaired paclitaxel-driven polymerization
    • Giannakakou P, Sackett DL, Kang Y-K, et al. Paclitaxel-resistant human ovarian cancer cells have mutant β-tubulins that exhibit impaired paclitaxel-driven polymerization. J Biol Chem 1997, 272:17118.
    • (1997) J Biol Chem , vol.272 , pp. 17118
    • Giannakakou, P.1    Sackett, D.L.2    Kang, Y.-K.3
  • 44
    • 0023395222 scopus 로고
    • Characterization of a mammalian mutant with a camptothecin-resistant DNA topoisomerase I
    • Andoh T, Ishii K, Suzuki Y, et al. Characterization of a mammalian mutant with a camptothecin-resistant DNA topoisomerase I. Proc Natl Acad Sci U S A 1987, 84:5565.
    • (1987) Proc Natl Acad Sci U S A , vol.84 , pp. 5565
    • Andoh, T.1    Ishii, K.2    Suzuki, Y.3
  • 45
    • 0029762815 scopus 로고    scopus 로고
    • DNA repair: Enzymatic mechanisms and relevance to drug response
    • Chaney SG, Sancar A DNA repair: Enzymatic mechanisms and relevance to drug response. J Natl Cancer Inst 1996, 88:1346.
    • (1996) J Natl Cancer Inst , vol.88 , pp. 1346
    • Chaney, S.G.1    Sancar, A.2
  • 46
    • 0023111825 scopus 로고
    • Characterization of a cis-diamminedichloroplatinum(II)-resistant human ovarian cancer cell line and its use in evaluation of platinum analogues
    • Behrens BC, Hamilton TC, Masuda H, et al. Characterization of a cis-diamminedichloroplatinum(II)-resistant human ovarian cancer cell line and its use in evaluation of platinum analogues. Cancer Res 1987, 47:414.
    • (1987) Cancer Res , vol.47 , pp. 414
    • Behrens, B.C.1    Hamilton, T.C.2    Masuda, H.3
  • 47
    • 0025271094 scopus 로고
    • Increased removal of DNA-bound platinum in a human ovarian cancer cell line resistant to cis-diamminedichloroplatinum(II)
    • Masuda H, Tanaka T, Matsuda H, et al. Increased removal of DNA-bound platinum in a human ovarian cancer cell line resistant to cis-diamminedichloroplatinum(II). Cancer Res 1990, 50:1863.
    • (1990) Cancer Res , vol.50 , pp. 1863
    • Masuda, H.1    Tanaka, T.2    Matsuda, H.3
  • 48
    • 0025775323 scopus 로고
    • Acquired cisplatin resistance in human ovarian cancer cells is associated with enhanced repair of cisplatin-DNA lesions and reduced drug accumulation
    • Parker RJ, Eastman A, Bostick-Bruton F, et al. Acquired cisplatin resistance in human ovarian cancer cells is associated with enhanced repair of cisplatin-DNA lesions and reduced drug accumulation. J Clin Invest 1991, 87:772.
    • (1991) J Clin Invest , vol.87 , pp. 772
    • Parker, R.J.1    Eastman, A.2    Bostick-Bruton, F.3
  • 49
    • 29244435019 scopus 로고    scopus 로고
    • Multiple repair pathways mediate tolerance to chemotherapeutic cross-linking agents in vertebrate cells
    • Nojima K, Hochegger H, Saberi A, et al. Multiple repair pathways mediate tolerance to chemotherapeutic cross-linking agents in vertebrate cells. Cancer Res 2005, 65:11704.
    • (2005) Cancer Res , vol.65 , pp. 11704
    • Nojima, K.1    Hochegger, H.2    Saberi, A.3
  • 50
    • 0036074018 scopus 로고    scopus 로고
    • Mammalian ABC transporters in health and disease
    • Borst P, Elferink RO Mammalian ABC transporters in health and disease. Annu Rev Biochem 2002, 71:537.
    • (2002) Annu Rev Biochem , vol.71 , pp. 537
    • Borst, P.1    Elferink, R.O.2
  • 51
    • 75149143363 scopus 로고    scopus 로고
    • ABC transporters in cancer: more than just drug efflux pumps
    • Fletcher JI, Haber M, Henderson MJ, et al. ABC transporters in cancer: more than just drug efflux pumps. Nat Rev Cancer 2010, 10:147.
    • (2010) Nat Rev Cancer , vol.10 , pp. 147
    • Fletcher, J.I.1    Haber, M.2    Henderson, M.J.3
  • 52
    • 0029965253 scopus 로고    scopus 로고
    • P-glycoprotein expression in canine lymphoma: a relevant, intermediate model of multidrug resistance
    • Lee JJ, Hughes CS, Fine RL, et al. P-glycoprotein expression in canine lymphoma: a relevant, intermediate model of multidrug resistance. Cancer 1996, 77:1892.
    • (1996) Cancer , vol.77 , pp. 1892
    • Lee, J.J.1    Hughes, C.S.2    Fine, R.L.3
  • 53
    • 67651225458 scopus 로고    scopus 로고
    • Expression of ABC-transport proteins in canine mammary cancer: Consequences for chemotherapy
    • Honscha KU, Schirmer A, Reischauer A, et al. Expression of ABC-transport proteins in canine mammary cancer: Consequences for chemotherapy. Reprod Domest Anim 2009, 44(Suppl 2):218.
    • (2009) Reprod Domest Anim , vol.44 , Issue.SUPPL.2 , pp. 218
    • Honscha, K.U.1    Schirmer, A.2    Reischauer, A.3
  • 54
    • 77953750709 scopus 로고    scopus 로고
    • Immunohistochemical detection of proteins associated with multidrug resistance to anti-cancer drugs in canine and feline primary pulmonary carcinoma
    • Hifumi T, Miyoshi N, Kawaguchi H, et al. Immunohistochemical detection of proteins associated with multidrug resistance to anti-cancer drugs in canine and feline primary pulmonary carcinoma. J Vet Med Sci 2010, 72:665.
    • (2010) J Vet Med Sci , vol.72 , pp. 665
    • Hifumi, T.1    Miyoshi, N.2    Kawaguchi, H.3
  • 55
    • 70350060139 scopus 로고    scopus 로고
    • Expression of breast cancer resistance protein (BCRP-1) in canine mammary adenocarcinomas and adenomas
    • Nowak M, Madej JA, Dziegiel P Expression of breast cancer resistance protein (BCRP-1) in canine mammary adenocarcinomas and adenomas. In Vivo 2009, 23:705.
    • (2009) In Vivo , vol.23 , pp. 705
    • Nowak, M.1    Madej, J.A.2    Dziegiel, P.3
  • 56
    • 0035793123 scopus 로고    scopus 로고
    • Sequencing and tissue distribution of the canine MRP2 gene compared with MRP1 and MDR1
    • Conrad S, Viertelhaus A, Orzechowski A, et al. Sequencing and tissue distribution of the canine MRP2 gene compared with MRP1 and MDR1. Toxicology 2001, 156:81.
    • (2001) Toxicology , vol.156 , pp. 81
    • Conrad, S.1    Viertelhaus, A.2    Orzechowski, A.3
  • 57
    • 58749099991 scopus 로고    scopus 로고
    • Cloning of the dog bile salt export pump (BSEP; ABCB11) and functional comparison with the human and rat proteins
    • Yabuuchi H, Tanaka K, Maeda M, et al. Cloning of the dog bile salt export pump (BSEP; ABCB11) and functional comparison with the human and rat proteins. Biopharm Drug Dispos 2008, 29:441.
    • (2008) Biopharm Drug Dispos , vol.29 , pp. 441
    • Yabuuchi, H.1    Tanaka, K.2    Maeda, M.3
  • 58
    • 78751627527 scopus 로고    scopus 로고
    • Molecular genetic basis for fluoroquinolone-induced retinal degeneration in cats
    • Ramirez CJ, Minch JD, Gay JM, et al. Molecular genetic basis for fluoroquinolone-induced retinal degeneration in cats. Pharmacogenet Genomics 2011, 21:66.
    • (2011) Pharmacogenet Genomics , vol.21 , pp. 66
    • Ramirez, C.J.1    Minch, J.D.2    Gay, J.M.3
  • 59
    • 0002918044 scopus 로고
    • Clinical strategies for cancer treatment: the role of drugs
    • JB Lippincott, Philadelphia, B.A. Chabner, J.M. Collins (Eds.)
    • Chabner BA Clinical strategies for cancer treatment: the role of drugs. Cancer chemotherapy: Principles and practice 1990, JB Lippincott, Philadelphia. B.A. Chabner, J.M. Collins (Eds.).
    • (1990) Cancer chemotherapy: Principles and practice
    • Chabner, B.A.1
  • 60
    • 0026516919 scopus 로고
    • Phase III evaluation of doxorubicin and whole-body hyperthermia in dogs with lymphoma
    • Page RL, Macy DW, Ogilvie GK, et al. Phase III evaluation of doxorubicin and whole-body hyperthermia in dogs with lymphoma. Int J Hyperthermia 1992, 8:187.
    • (1992) Int J Hyperthermia , vol.8 , pp. 187
    • Page, R.L.1    Macy, D.W.2    Ogilvie, G.K.3
  • 61
    • 0023233177 scopus 로고
    • Chemotherapy of canine lymphoma with histopathological correlation- doxorubicin alone compared to COP as 1st treatment regimen
    • Carter RF, Harris CK, Withrow SJ, et al. Chemotherapy of canine lymphoma with histopathological correlation- doxorubicin alone compared to COP as 1st treatment regimen. J Am Anim Hosp Assoc 1987, 23:587.
    • (1987) J Am Anim Hosp Assoc , vol.23 , pp. 587
    • Carter, R.F.1    Harris, C.K.2    Withrow, S.J.3
  • 63
    • 0031043680 scopus 로고    scopus 로고
    • Doxorubicin alone or in combination with asparaginase, followed by cyclophosphamide, vincristine, and prednisone for treatment of multicentric lymphoma in dogs: 121 cases (1987-1995)
    • Valerius KD, Ogilvie GK, Mallinckrodt CH, et al. Doxorubicin alone or in combination with asparaginase, followed by cyclophosphamide, vincristine, and prednisone for treatment of multicentric lymphoma in dogs: 121 cases (1987-1995). J Am Vet Med Assoc 1997, 210:512.
    • (1997) J Am Vet Med Assoc , vol.210 , pp. 512
    • Valerius, K.D.1    Ogilvie, G.K.2    Mallinckrodt, C.H.3
  • 64
    • 0037097388 scopus 로고    scopus 로고
    • Evaluation of treatment with doxorubicin and piroxicam or doxorubicin alone for multicentric lymphoma in dogs
    • Mutsaers AJ, Glickman NW, De Nicola DB, et al. Evaluation of treatment with doxorubicin and piroxicam or doxorubicin alone for multicentric lymphoma in dogs. J Am Vet Med Assoc 2002, 220:1813.
    • (2002) J Am Vet Med Assoc , vol.220 , pp. 1813
    • Mutsaers, A.J.1    Glickman, N.W.2    De Nicola, D.B.3
  • 65
    • 0020638702 scopus 로고
    • Treatment of lymphoma and leukemia with cyclophosphamide, vincristine, and prednisone. 1. Treatment of Dogs
    • Cotter SM Treatment of lymphoma and leukemia with cyclophosphamide, vincristine, and prednisone. 1. Treatment of Dogs. J Am Anim Hosp Assoc 1983, 19:159.
    • (1983) J Am Anim Hosp Assoc , vol.19 , pp. 159
    • Cotter, S.M.1
  • 66
    • 0019574157 scopus 로고
    • Cyclic combination chemotherapy of canine lymphosarcoma
    • Mac Ewen EG, Brown NO, Patnaik AK, et al. Cyclic combination chemotherapy of canine lymphosarcoma. J Am Vet Med Assoc 1981, 178:1178.
    • (1981) J Am Vet Med Assoc , vol.178 , pp. 1178
    • Mac Ewen, E.G.1    Brown, N.O.2    Patnaik, A.K.3
  • 67
    • 0023302908 scopus 로고
    • Evaluation of some prognostic factors for advanced multicentric lymphosarcoma in the dog-147 Cases (1978-1981)
    • Mac Ewen EG, Hayes AA, Matus RE, et al. Evaluation of some prognostic factors for advanced multicentric lymphosarcoma in the dog-147 Cases (1978-1981). J Am Vet Med Assoc 1987, 190:564.
    • (1987) J Am Vet Med Assoc , vol.190 , pp. 564
    • Mac Ewen, E.G.1    Hayes, A.A.2    Matus, R.E.3
  • 68
    • 0031727130 scopus 로고    scopus 로고
    • Randomized controlled trial of doxorubicin versus dactinomycin in a multiagent protocol for treatment of dogs with malignant lymphoma
    • Khanna C, Lund EM, Redic KA, et al. Randomized controlled trial of doxorubicin versus dactinomycin in a multiagent protocol for treatment of dogs with malignant lymphoma. J Am Vet Med Assoc 1998, 213:985.
    • (1998) J Am Vet Med Assoc , vol.213 , pp. 985
    • Khanna, C.1    Lund, E.M.2    Redic, K.A.3
  • 69
    • 0025292613 scopus 로고
    • Lymphomas in dogs. A morphologic, immunologic, and clinical study
    • Greenlee PG, Filippa DA, Quimby FW, et al. Lymphomas in dogs. A morphologic, immunologic, and clinical study. Cancer 1990, 66:480.
    • (1990) Cancer , vol.66 , pp. 480
    • Greenlee, P.G.1    Filippa, D.A.2    Quimby, F.W.3
  • 70
    • 0025727985 scopus 로고
    • Comparison of 2 protocols for induction of remission in dogs with lymphoma
    • Stone MS, Goldstein MA, Cotter SM Comparison of 2 protocols for induction of remission in dogs with lymphoma. J Am Anim Hosp Assoc 1991, 27:315.
    • (1991) J Am Anim Hosp Assoc , vol.27 , pp. 315
    • Stone, M.S.1    Goldstein, M.A.2    Cotter, S.M.3
  • 71
    • 0031262068 scopus 로고    scopus 로고
    • Evaluation of a multidrug chemotherapy protocol (ACOPA II) in dogs with lymphoma
    • Myers NC, Moore AS, Rand WM, et al. Evaluation of a multidrug chemotherapy protocol (ACOPA II) in dogs with lymphoma. J Vet Intern Med 1997, 11:333.
    • (1997) J Vet Intern Med , vol.11 , pp. 333
    • Myers, N.C.1    Moore, A.S.2    Rand, W.M.3
  • 72
    • 0033818756 scopus 로고    scopus 로고
    • Treatment of canine lymphoma with COPLA/LVP
    • Boyce KL, Kitchell BE Treatment of canine lymphoma with COPLA/LVP. J Am Anim Hosp Assoc 2000, 36:395.
    • (2000) J Am Anim Hosp Assoc , vol.36 , pp. 395
    • Boyce, K.L.1    Kitchell, B.E.2
  • 73
    • 33748372619 scopus 로고    scopus 로고
    • A combination chemotherapy protocol with MOPP and CCNU consolidation (Tufts VELCAP-SC) for the treatment of canine lymphoma
    • Morrison-Collister KE, Rassnick KM, Northrup NC, et al. A combination chemotherapy protocol with MOPP and CCNU consolidation (Tufts VELCAP-SC) for the treatment of canine lymphoma. Vet Comp Oncol 2003, 1:180.
    • (2003) Vet Comp Oncol , vol.1 , pp. 180
    • Morrison-Collister, K.E.1    Rassnick, K.M.2    Northrup, N.C.3
  • 74
    • 0032199325 scopus 로고    scopus 로고
    • A combination chemotherapy protocol (VELCAP-L) for dogs with lymphoma
    • Zemann BI, Moore AS, Rand WM, et al. A combination chemotherapy protocol (VELCAP-L) for dogs with lymphoma. J Vet Intern Med 1998, 12:465.
    • (1998) J Vet Intern Med , vol.12 , pp. 465
    • Zemann, B.I.1    Moore, A.S.2    Rand, W.M.3
  • 75
    • 0027653667 scopus 로고
    • Evaluation of prognostic factors and sequential combination chemotherapy with doxorubicin for canine lymphoma
    • Keller ET, Mac Ewen EG, Rosenthal RC, et al. Evaluation of prognostic factors and sequential combination chemotherapy with doxorubicin for canine lymphoma. J Vet Intern Med 1993, 7:289.
    • (1993) J Vet Intern Med , vol.7 , pp. 289
    • Keller, E.T.1    Mac Ewen, E.G.2    Rosenthal, R.C.3
  • 76
    • 0036836122 scopus 로고    scopus 로고
    • Evaluation of a 6-month chemotherapy protocol with no maintenance therapy for dogs with lymphoma
    • Garrett LD, Thamm DH, Chun R, et al. Evaluation of a 6-month chemotherapy protocol with no maintenance therapy for dogs with lymphoma. J Vet Intern Med 2002, 16:704.
    • (2002) J Vet Intern Med , vol.16 , pp. 704
    • Garrett, L.D.1    Thamm, D.H.2    Chun, R.3
  • 78
    • 9444220180 scopus 로고    scopus 로고
    • Effect of glomerular filtration rate on clearance and myelotoxicity of carboplatin in cats with tumors
    • Bailey DB, Rassnick KM, Erb HN, et al. Effect of glomerular filtration rate on clearance and myelotoxicity of carboplatin in cats with tumors. Am J Vet Res 2004, 65:1502.
    • (2004) Am J Vet Res , vol.65 , pp. 1502
    • Bailey, D.B.1    Rassnick, K.M.2    Erb, H.N.3
  • 79
    • 47849115022 scopus 로고    scopus 로고
    • ABCB1-1Delta polymorphism can predict hematologic toxicity in dogs treated with vincristine
    • Mealey KL, Fidel J, Gay JM, et al. ABCB1-1Delta polymorphism can predict hematologic toxicity in dogs treated with vincristine. J Vet Intern Med 2008, 22:996.
    • (2008) J Vet Intern Med , vol.22 , pp. 996
    • Mealey, K.L.1    Fidel, J.2    Gay, J.M.3
  • 80
    • 77956578921 scopus 로고    scopus 로고
    • Description of current practices of empiric chemotherapy dose adjustment in obese adult patients
    • Thompson LA, Lawson AP, Sutphin SD, et al. Description of current practices of empiric chemotherapy dose adjustment in obese adult patients. J Oncol Pract 2010, 6:141.
    • (2010) J Oncol Pract , vol.6 , pp. 141
    • Thompson, L.A.1    Lawson, A.P.2    Sutphin, S.D.3
  • 81
    • 58549091067 scopus 로고    scopus 로고
    • Dosing chemotherapy in obese patients: actual versus assigned body surface area (BSA)
    • Hunter RJ, Navo MA, Thaker PH, et al. Dosing chemotherapy in obese patients: actual versus assigned body surface area (BSA). Cancer Treat Rev 2009, 35:69.
    • (2009) Cancer Treat Rev , vol.35 , pp. 69
    • Hunter, R.J.1    Navo, M.A.2    Thaker, P.H.3
  • 82
    • 69249245375 scopus 로고    scopus 로고
    • Supporting the veterinary cancer patient on chemotherapy: neutropenia and gastrointestinal toxicity
    • Vail DM Supporting the veterinary cancer patient on chemotherapy: neutropenia and gastrointestinal toxicity. Top Companion Anim Med 2009, 24:122.
    • (2009) Top Companion Anim Med , vol.24 , pp. 122
    • Vail, D.M.1
  • 83
    • 23644447249 scopus 로고    scopus 로고
    • Are health care providers who work with cancer drugs at an increased risk for toxic events? A systematic review and meta-analysis of the literature
    • Dranitsaris G, Johnston M, Poirier S, et al. Are health care providers who work with cancer drugs at an increased risk for toxic events? A systematic review and meta-analysis of the literature. J Oncol Pharm Pract 2005, 11:69.
    • (2005) J Oncol Pharm Pract , vol.11 , pp. 69
    • Dranitsaris, G.1    Johnston, M.2    Poirier, S.3
  • 84
    • 77957025805 scopus 로고    scopus 로고
    • Determination of drug residues in urine of dogs receiving anti-cancer chemotherapy by liquid chromatography-electrospray ionization- tandem mass spectrometry: is there an environmental or occupational risk?
    • Hamscher G, Mohring SA, Knobloch A, et al. Determination of drug residues in urine of dogs receiving anti-cancer chemotherapy by liquid chromatography-electrospray ionization- tandem mass spectrometry: is there an environmental or occupational risk?. J Anal Toxicol 2010, 34:142.
    • (2010) J Anal Toxicol , vol.34 , pp. 142
    • Hamscher, G.1    Mohring, S.A.2    Knobloch, A.3
  • 85
    • 0024360395 scopus 로고
    • Clinical pharmacokinetics-pharmacodynamics of anticancer drugs
    • Evans WE, Relling MV Clinical pharmacokinetics-pharmacodynamics of anticancer drugs. Clin Pharmacokinet 1989, 16:327.
    • (1989) Clin Pharmacokinet , vol.16 , pp. 327
    • Evans, W.E.1    Relling, M.V.2
  • 86
    • 0019297470 scopus 로고
    • Mechanisms of adverse drug-reactions and interactions in veterinary-medicine
    • Eckhoff GA Mechanisms of adverse drug-reactions and interactions in veterinary-medicine. J Am Vet Med Assoc 1980, 176:1131.
    • (1980) J Am Vet Med Assoc , vol.176 , pp. 1131
    • Eckhoff, G.A.1
  • 87
    • 77956807615 scopus 로고    scopus 로고
    • Effects of herbal products on the metabolism and transport of anticancer agents
    • He SM, Yang AK, Li XT, et al. Effects of herbal products on the metabolism and transport of anticancer agents. Expert Opin Drug Metab Toxicol 2010, 6:1195.
    • (2010) Expert Opin Drug Metab Toxicol , vol.6 , pp. 1195
    • He, S.M.1    Yang, A.K.2    Li, X.T.3
  • 89
    • 8344244484 scopus 로고    scopus 로고
    • Therapeutic implications of the MDR-1 gene
    • Mealey KL Therapeutic implications of the MDR-1 gene. J Vet Pharmacol Ther 2004, 27:257.
    • (2004) J Vet Pharmacol Ther , vol.27 , pp. 257
    • Mealey, K.L.1
  • 90
    • 0020038042 scopus 로고
    • Reduction of doxorubicin cardiotoxicity by prolonged continuous intravenous infusion
    • Legha SS, Benjamin RS, Mackay B, et al. Reduction of doxorubicin cardiotoxicity by prolonged continuous intravenous infusion. Ann Intern Med 1982, 96:133.
    • (1982) Ann Intern Med , vol.96 , pp. 133
    • Legha, S.S.1    Benjamin, R.S.2    Mackay, B.3
  • 91
    • 0035344035 scopus 로고    scopus 로고
    • Doxorubicin cardiotoxicity in children: reduced incidence of cardiac dysfunction associated with continuous-infusion schedules
    • Berrak SG, Ewer MS, Jaffe N, et al. Doxorubicin cardiotoxicity in children: reduced incidence of cardiac dysfunction associated with continuous-infusion schedules. Oncol Rep 2001, 8:611.
    • (2001) Oncol Rep , vol.8 , pp. 611
    • Berrak, S.G.1    Ewer, M.S.2    Jaffe, N.3
  • 92
    • 0021353428 scopus 로고
    • Relationship between plasma adriamycin levels and the outcome of remission induction therapy for acute nonlymphocytic leukemia
    • Preisler HD, Gessner T, Azarnia N, et al. Relationship between plasma adriamycin levels and the outcome of remission induction therapy for acute nonlymphocytic leukemia. Cancer Chemother Pharmacol 1984, 12:125.
    • (1984) Cancer Chemother Pharmacol , vol.12 , pp. 125
    • Preisler, H.D.1    Gessner, T.2    Azarnia, N.3
  • 93
    • 0027299421 scopus 로고
    • Pharmacokinetics and pharmacodynamics of doxorubicin in patients with small cell lung cancer
    • Piscitelli SC, Rodvold KA, Rushing DA, et al. Pharmacokinetics and pharmacodynamics of doxorubicin in patients with small cell lung cancer. Clin Pharmacol Ther 1993, 53:555.
    • (1993) Clin Pharmacol Ther , vol.53 , pp. 555
    • Piscitelli, S.C.1    Rodvold, K.A.2    Rushing, D.A.3
  • 94
    • 0036310616 scopus 로고    scopus 로고
    • Pharmacokinetic-pharmacodynamic relationships of the anthracycline anticancer drugs
    • Danesi R, Fogli S, Gennari A, et al. Pharmacokinetic-pharmacodynamic relationships of the anthracycline anticancer drugs. Clin Pharmacokinet 2002, 41:431.
    • (2002) Clin Pharmacokinet , vol.41 , pp. 431
    • Danesi, R.1    Fogli, S.2    Gennari, A.3
  • 95
    • 0027961089 scopus 로고
    • Comparison of body surface area-based and weight-based dosage protocols for doxorubicin administration in dogs
    • Arrington KA, Legendre AM, Tabeling GS, et al. Comparison of body surface area-based and weight-based dosage protocols for doxorubicin administration in dogs. Am J Vet Res 1994, 55:1587.
    • (1994) Am J Vet Res , vol.55 , pp. 1587
    • Arrington, K.A.1    Legendre, A.M.2    Tabeling, G.S.3
  • 96
    • 26844522727 scopus 로고    scopus 로고
    • Veterinary co-operative oncology group-common terminology criteria for adverse events (VCOG-CTCAE) following chemotherapy or biological antineoplastic therapy in dogs and cats v1.0
    • Veterinary co-operative oncology group-common terminology criteria for adverse events (VCOG-CTCAE) following chemotherapy or biological antineoplastic therapy in dogs and cats v1.0. Vet Comp Oncol 2004, 2:195.
    • (2004) Vet Comp Oncol , vol.2 , pp. 195
  • 97
    • 57149096686 scopus 로고    scopus 로고
    • Phase I dose escalation of single-agent vinblastine in dogs
    • Bailey DB, Rassnick KM, Kristal O, et al. Phase I dose escalation of single-agent vinblastine in dogs. J Vet Intern Med 2008, 22:1397.
    • (2008) J Vet Intern Med , vol.22 , pp. 1397
    • Bailey, D.B.1    Rassnick, K.M.2    Kristal, O.3
  • 98
    • 37349092699 scopus 로고    scopus 로고
    • Impact of chemotherapeutic dose intensity and hematologic toxicity on first remission duration in dogs with lymphoma treated with a chemoradiotherapy protocol
    • Vaughan A, Johnson JL, Williams LE Impact of chemotherapeutic dose intensity and hematologic toxicity on first remission duration in dogs with lymphoma treated with a chemoradiotherapy protocol. J Vet Intern Med 2007, 21:1332.
    • (2007) J Vet Intern Med , vol.21 , pp. 1332
    • Vaughan, A.1    Johnson, J.L.2    Williams, L.E.3
  • 99
    • 0023948933 scopus 로고
    • Study of histamine release induced by acute administration of antitumor agents in dogs
    • Eschalier A, Lavarenne J, Burtin C, et al. Study of histamine release induced by acute administration of antitumor agents in dogs. Cancer Chemother Pharmacol 1988, 21:246.
    • (1988) Cancer Chemother Pharmacol , vol.21 , pp. 246
    • Eschalier, A.1    Lavarenne, J.2    Burtin, C.3
  • 100
    • 1642312441 scopus 로고    scopus 로고
    • Efficacy and toxicity of paclitaxel (Taxol) for the treatment of canine malignant tumors
    • Poirier VJ, Hershey AE, Burgess KE, et al. Efficacy and toxicity of paclitaxel (Taxol) for the treatment of canine malignant tumors. J Vet Intern Med 2004, 18:219.
    • (2004) J Vet Intern Med , vol.18 , pp. 219
    • Poirier, V.J.1    Hershey, A.E.2    Burgess, K.E.3
  • 101
    • 78249277673 scopus 로고
    • Nitrogen mustard therapy; use of methyl-bis (beta-chloroethyl) amine hydrochloride and tris (beta-chloroethyl) amine hydrochloride for Hodgkin's disease, lymphosarcoma, leukemia and certain allied and miscellaneous disorders
    • Goodman LS, Wintrobe MM, et al. Nitrogen mustard therapy; use of methyl-bis (beta-chloroethyl) amine hydrochloride and tris (beta-chloroethyl) amine hydrochloride for Hodgkin's disease, lymphosarcoma, leukemia and certain allied and miscellaneous disorders. J Am Med Assoc 1946, 132:126.
    • (1946) J Am Med Assoc , vol.132 , pp. 126
    • Goodman, L.S.1    Wintrobe, M.M.2
  • 102
    • 84864054302 scopus 로고
    • Studies on the effect of methyl bis (beta-chloroethyl) amine hydrochloride on diseases of the hemopoietic system
    • Jacobson LO, Spurr CL, et al. Studies on the effect of methyl bis (beta-chloroethyl) amine hydrochloride on diseases of the hemopoietic system. J Clin Invest 1946, 25:909.
    • (1946) J Clin Invest , vol.25 , pp. 909
    • Jacobson, L.O.1    Spurr, C.L.2
  • 103
    • 84872635316 scopus 로고
    • Nitrogen mustards in the treatment of neoplastic disease; official statement
    • Rhoads CP Nitrogen mustards in the treatment of neoplastic disease; official statement. J Am Med Assoc 1946, 131:656.
    • (1946) J Am Med Assoc , vol.131 , pp. 656
    • Rhoads, C.P.1
  • 104
    • 0013936069 scopus 로고
    • Inter-strand crosslinking of DNA by nitrogen mustard
    • Kohn KW, Spears CL, Doty P Inter-strand crosslinking of DNA by nitrogen mustard. J Mol Biol 1966, 19:266.
    • (1966) J Mol Biol , vol.19 , pp. 266
    • Kohn, K.W.1    Spears, C.L.2    Doty, P.3
  • 105
    • 84965189423 scopus 로고
    • Over-all tracer studies with C14 labeled nitrogen mustard in normal and leukemic mice
    • Skipper HE, Bennett LL, Langham WH Over-all tracer studies with C14 labeled nitrogen mustard in normal and leukemic mice. Cancer 1951, 4:1025.
    • (1951) Cancer , vol.4 , pp. 1025
    • Skipper, H.E.1    Bennett, L.L.2    Langham, W.H.3
  • 106
    • 0014849350 scopus 로고
    • Evidence for a transport carrier of nitrogen mustard in nitrogen mustard-sensitive and -resistant L5178Y lymphoblasts
    • Goldenberg GJ, Vanstone CL, Israels LG, et al. Evidence for a transport carrier of nitrogen mustard in nitrogen mustard-sensitive and -resistant L5178Y lymphoblasts. Cancer Res 1970, 30:2285.
    • (1970) Cancer Res , vol.30 , pp. 2285
    • Goldenberg, G.J.1    Vanstone, C.L.2    Israels, L.G.3
  • 107
    • 0041737061 scopus 로고    scopus 로고
    • MOPP chemotherapy for treatment of resistant lymphoma in dogs: a retrospective study of 117 cases
    • Rassnick KM, Mauldin GE, Al-Sarraf R, et al. MOPP chemotherapy for treatment of resistant lymphoma in dogs: a retrospective study of 117 cases. J Vet Intern Med 2002, 16:1989-2000.
    • (2002) J Vet Intern Med , vol.16 , pp. 1989-2000
    • Rassnick, K.M.1    Mauldin, G.E.2    Al-Sarraf, R.3
  • 108
    • 78349259283 scopus 로고    scopus 로고
    • Comparison between L-CHOP and an L-CHOP protocol with interposed treatments of CCNU and MOPP (L-CHOP-CCNU-MOPP) for lymphoma in dogs
    • Rassnick KM, Bailey DB, Malone EK, et al. Comparison between L-CHOP and an L-CHOP protocol with interposed treatments of CCNU and MOPP (L-CHOP-CCNU-MOPP) for lymphoma in dogs. Vet Comp Oncol 2010, 8:243.
    • (2010) Vet Comp Oncol , vol.8 , pp. 243
    • Rassnick, K.M.1    Bailey, D.B.2    Malone, E.K.3
  • 111
    • 0014836063 scopus 로고
    • Enzymatic basis of cyclophosphamide activation by hepatic microsomes of the rat
    • Cohen JL, Jao JY Enzymatic basis of cyclophosphamide activation by hepatic microsomes of the rat. J Pharmacol Exp Ther 1970, 174:206.
    • (1970) J Pharmacol Exp Ther , vol.174 , pp. 206
    • Cohen, J.L.1    Jao, J.Y.2
  • 112
    • 0017285853 scopus 로고
    • Alkylating properties of phosphoramide mustard
    • Colvin M, Brundrett RB, Kan MN, et al. Alkylating properties of phosphoramide mustard. Cancer Res 1976, 36:1121.
    • (1976) Cancer Res , vol.36 , pp. 1121
    • Colvin, M.1    Brundrett, R.B.2    Kan, M.N.3
  • 113
    • 79960566218 scopus 로고    scopus 로고
    • Pharmacokinetics of cyclophosphamide after oral and intravenous administration to dogs with lymphoma
    • Warry E, Hansen RJ, Gustafson DL, et al. Pharmacokinetics of cyclophosphamide after oral and intravenous administration to dogs with lymphoma. J Vet Intern Med 2011, 25:903.
    • (2011) J Vet Intern Med , vol.25 , pp. 903
    • Warry, E.1    Hansen, R.J.2    Gustafson, D.L.3
  • 114
    • 0019991581 scopus 로고
    • Vomiting induced by cyclophosphamide and phosphoramide mustard in cats
    • Fetting JH, McCarthy LE, Borison HL, et al. Vomiting induced by cyclophosphamide and phosphoramide mustard in cats. Cancer Treat Rep 1982, 66:1625.
    • (1982) Cancer Treat Rep , vol.66 , pp. 1625
    • Fetting, J.H.1    McCarthy, L.E.2    Borison, H.L.3
  • 115
    • 77955263075 scopus 로고    scopus 로고
    • Doxorubicin and cyclophosphamide for the treatment of canine lymphoma: a randomized, placebo-controlled study
    • Lori JC, Stein TJ, Thamm DH Doxorubicin and cyclophosphamide for the treatment of canine lymphoma: a randomized, placebo-controlled study. Vet Comp Oncol 2010, 8:188.
    • (2010) Vet Comp Oncol , vol.8 , pp. 188
    • Lori, J.C.1    Stein, T.J.2    Thamm, D.H.3
  • 116
    • 40549103488 scopus 로고    scopus 로고
    • Efficacy and toxicosis of VELCAP-C treatment of lymphoma in cats
    • Hadden AG, Cotter SM, Rand W, et al. Efficacy and toxicosis of VELCAP-C treatment of lymphoma in cats. J Vet Intern Med 2008, 22:153.
    • (2008) J Vet Intern Med , vol.22 , pp. 153
    • Hadden, A.G.1    Cotter, S.M.2    Rand, W.3
  • 118
    • 0017097821 scopus 로고
    • Studies on the metabolism of isopnosphamide (NSC-109724) in man
    • Norpoth K Studies on the metabolism of isopnosphamide (NSC-109724) in man. Cancer Treat Rep 1976, 60:437.
    • (1976) Cancer Treat Rep , vol.60 , pp. 437
    • Norpoth, K.1
  • 119
    • 0025285270 scopus 로고
    • The effect of route of administration and fractionation of dose on the metabolism of ifosfamide
    • Lind MJ, Roberts HL, Thatcher N, et al. The effect of route of administration and fractionation of dose on the metabolism of ifosfamide. Cancer Chemother Pharmacol 1990, 26:105.
    • (1990) Cancer Chemother Pharmacol , vol.26 , pp. 105
    • Lind, M.J.1    Roberts, H.L.2    Thatcher, N.3
  • 120
    • 0034183434 scopus 로고    scopus 로고
    • Evaluation of ifosfamide for treatment of various canine neoplasms
    • Rassnick KM, Frimberger AE, Wood CA, et al. Evaluation of ifosfamide for treatment of various canine neoplasms. J Vet Intern Med 2000, 14:271.
    • (2000) J Vet Intern Med , vol.14 , pp. 271
    • Rassnick, K.M.1    Frimberger, A.E.2    Wood, C.A.3
  • 121
    • 33646372989 scopus 로고    scopus 로고
    • Phase I trial and pharmacokinetic analysis of ifosfamide in cats with sarcomas
    • Rassnick KM, Moore AS, Northrup NC, et al. Phase I trial and pharmacokinetic analysis of ifosfamide in cats with sarcomas. Am J Vet Res 2006, 67:510.
    • (2006) Am J Vet Res , vol.67 , pp. 510
    • Rassnick, K.M.1    Moore, A.S.2    Northrup, N.C.3
  • 122
    • 33646348741 scopus 로고    scopus 로고
    • Results of a phase II clinical trial on the use of ifosfamide for treatment of cats with vaccine-associated sarcomas
    • Rassnick KM, Rodriguez CO, Khanna C, et al. Results of a phase II clinical trial on the use of ifosfamide for treatment of cats with vaccine-associated sarcomas. Am J Vet Res 2006, 67:517.
    • (2006) Am J Vet Res , vol.67 , pp. 517
    • Rassnick, K.M.1    Rodriguez, C.O.2    Khanna, C.3
  • 123
    • 0020660468 scopus 로고
    • Uptake and decomposition of chlorambucil by L5178Y lymphoblasts in vitro
    • Begleiter A, Goldenberg GJ Uptake and decomposition of chlorambucil by L5178Y lymphoblasts in vitro. Biochem Pharmacol 1983, 32:535.
    • (1983) Biochem Pharmacol , vol.32 , pp. 535
    • Begleiter, A.1    Goldenberg, G.J.2
  • 124
    • 0024421132 scopus 로고
    • Lack of drug-induced DNA cross-links in chlorambucil-resistant Chinese hamster ovary cells
    • Jiang BZ, Bank BB, Hsiang YH, et al. Lack of drug-induced DNA cross-links in chlorambucil-resistant Chinese hamster ovary cells. Cancer Res 1989, 49:5514.
    • (1989) Cancer Res , vol.49 , pp. 5514
    • Jiang, B.Z.1    Bank, B.B.2    Hsiang, Y.H.3
  • 125
    • 0017327582 scopus 로고
    • Metabolic disposition of chlorambucil in rats
    • Mitoma C, Onodera T, Takegoshi T, et al. Metabolic disposition of chlorambucil in rats. Xenobiotica 1977, 7:205.
    • (1977) Xenobiotica , vol.7 , pp. 205
    • Mitoma, C.1    Onodera, T.2    Takegoshi, T.3
  • 126
    • 0020075568 scopus 로고
    • Inhibition of human tumour clonogenicity by chlorambucil and its metabolites
    • Goodman GE, McLean A, Alberts DS, et al. Inhibition of human tumour clonogenicity by chlorambucil and its metabolites. Br J Cancer 1982, 45:621.
    • (1982) Br J Cancer , vol.45 , pp. 621
    • Goodman, G.E.1    McLean, A.2    Alberts, D.S.3
  • 127
    • 78649312302 scopus 로고    scopus 로고
    • Treatment of feline gastrointestinal small-cell lymphoma with chlorambucil and glucocorticoids
    • Stein TJ, Pellin M, Steinberg H, et al. Treatment of feline gastrointestinal small-cell lymphoma with chlorambucil and glucocorticoids. J Am Anim Hosp Assoc 2010, 46:413.
    • (2010) J Am Anim Hosp Assoc , vol.46 , pp. 413
    • Stein, T.J.1    Pellin, M.2    Steinberg, H.3
  • 128
    • 0017598095 scopus 로고
    • Mechanism of uptake of nitrosoureas by L5178Y lymphoblasts in vitro
    • Begleiter A, Lam HP, Goldenberg GJ Mechanism of uptake of nitrosoureas by L5178Y lymphoblasts in vitro. Cancer Res 1977, 37:1022.
    • (1977) Cancer Res , vol.37 , pp. 1022
    • Begleiter, A.1    Lam, H.P.2    Goldenberg, G.J.3
  • 129
    • 0014109802 scopus 로고
    • The modes of decomposition of 1,3-bis(2-chloroethyl)-1-nitrosourea and related compounds
    • Montgomery JA, James R, McCaleb GS, et al. The modes of decomposition of 1,3-bis(2-chloroethyl)-1-nitrosourea and related compounds. J Med Chem 1967, 10:668.
    • (1967) J Med Chem , vol.10 , pp. 668
    • Montgomery, J.A.1    James, R.2    McCaleb, G.S.3
  • 130
    • 84886638520 scopus 로고
    • A chemical basis for the antitumor activity of chloroethylnitrosoureas
    • Colvin M, Brundrett RB, Cowens W, et al. A chemical basis for the antitumor activity of chloroethylnitrosoureas. Biochem Pharmacol 1976, 25:695.
    • (1976) Biochem Pharmacol , vol.25 , pp. 695
    • Colvin, M.1    Brundrett, R.B.2    Cowens, W.3
  • 131
    • 0017641428 scopus 로고
    • Interstrand cross-linking of DNA by 1,3-bis(2-chloroethyl)-1-nitrosourea and other 1-(2-haloethyl)-1-nitrosoureas
    • Kohn KW Interstrand cross-linking of DNA by 1,3-bis(2-chloroethyl)-1-nitrosourea and other 1-(2-haloethyl)-1-nitrosoureas. Cancer Res 1977, 37:1450.
    • (1977) Cancer Res , vol.37 , pp. 1450
    • Kohn, K.W.1
  • 132
  • 135
    • 79952778923 scopus 로고    scopus 로고
    • CCNU (lomustine) toxicity in dogs: a retrospective study (2002-07)
    • Heading KL, Brockley LK, Bennett PF CCNU (lomustine) toxicity in dogs: a retrospective study (2002-07). Aust Vet J 2011, 89:109.
    • (2011) Aust Vet J , vol.89 , pp. 109
    • Heading, K.L.1    Brockley, L.K.2    Bennett, P.F.3
  • 136
    • 70450064740 scopus 로고    scopus 로고
    • Prevalence of elevated alanine transaminase activity in dogs treated with CCNU (Lomustine)
    • Hosoya K, Lord LK, Lara-Garcia A, et al. Prevalence of elevated alanine transaminase activity in dogs treated with CCNU (Lomustine). Vet Comp Oncol 2009, 7:244.
    • (2009) Vet Comp Oncol , vol.7 , pp. 244
    • Hosoya, K.1    Lord, L.K.2    Lara-Garcia, A.3
  • 137
    • 79960556328 scopus 로고    scopus 로고
    • Prospective randomized clinical trial assessing the efficacy of denamarin for prevention of CCNU-induced hepatopathy in tumor-bearing dogs
    • Skorupski KA, Hammond GM, Irish AM, et al. Prospective randomized clinical trial assessing the efficacy of denamarin for prevention of CCNU-induced hepatopathy in tumor-bearing dogs. J Vet Intern Med 2011, 25:838.
    • (2011) J Vet Intern Med , vol.25 , pp. 838
    • Skorupski, K.A.1    Hammond, G.M.2    Irish, A.M.3
  • 138
    • 0015010131 scopus 로고
    • Mode of action of streptozotocin
    • Reusser F Mode of action of streptozotocin. J Bacteriol 1971, 105:580.
    • (1971) J Bacteriol , vol.105 , pp. 580
    • Reusser, F.1
  • 139
    • 0014821362 scopus 로고
    • The action of streptozotocin on mammalian cells
    • Bhuyan BK The action of streptozotocin on mammalian cells. Cancer Res 1970, 30:2017.
    • (1970) Cancer Res , vol.30 , pp. 2017
    • Bhuyan, B.K.1
  • 140
    • 0028604486 scopus 로고
    • STZ transport and cytotoxicity. Specific enhancement in GLUT2-expressing cells
    • Schnedl WJ, Ferber S, Johnson JH, et al. STZ transport and cytotoxicity. Specific enhancement in GLUT2-expressing cells. Diabetes 1994, 43:1326.
    • (1994) Diabetes , vol.43 , pp. 1326
    • Schnedl, W.J.1    Ferber, S.2    Johnson, J.H.3
  • 141
    • 0035930973 scopus 로고    scopus 로고
    • Differential sensitivity of GLUT1- and GLUT2-expressing beta cells to streptozotocin
    • Hosokawa M, Dolci W, Thorens B Differential sensitivity of GLUT1- and GLUT2-expressing beta cells to streptozotocin. Biochem Biophys Res Commun 2001, 289:1114.
    • (2001) Biochem Biophys Res Commun , vol.289 , pp. 1114
    • Hosokawa, M.1    Dolci, W.2    Thorens, B.3
  • 142
    • 0017644043 scopus 로고
    • Preliminary pharmacokinetics of streptozotocin, an antineoplastic antibiotic
    • Adolphe AB, Glasofer ED, Troetel WM, et al. Preliminary pharmacokinetics of streptozotocin, an antineoplastic antibiotic. J Clin Pharmacol 1977, 17:379.
    • (1977) J Clin Pharmacol , vol.17 , pp. 379
    • Adolphe, A.B.1    Glasofer, E.D.2    Troetel, W.M.3
  • 143
    • 0014183930 scopus 로고
    • The use of nicotinamide to modify the toxicity of streptozotocin diabetes without loss of antitumor activity
    • Schein PS, Cooney DA, Vernon ML The use of nicotinamide to modify the toxicity of streptozotocin diabetes without loss of antitumor activity. Cancer Res 1967, 27:2324.
    • (1967) Cancer Res , vol.27 , pp. 2324
    • Schein, P.S.1    Cooney, D.A.2    Vernon, M.L.3
  • 144
    • 0015632916 scopus 로고
    • Streptozotocin diabetes in monkeys and dogs, and its prevention by nicotinamide
    • Schein PS, Rakieten N, Cooney DA, et al. Streptozotocin diabetes in monkeys and dogs, and its prevention by nicotinamide. Proc Soc Exp Biol Med 1973, 143:514.
    • (1973) Proc Soc Exp Biol Med , vol.143 , pp. 514
    • Schein, P.S.1    Rakieten, N.2    Cooney, D.A.3
  • 145
    • 0014528223 scopus 로고
    • 1-methyl-1-nitrosourea and dialkylnitrosamine depression of nicotinamide adenine dinucleotide
    • Schein PS 1-methyl-1-nitrosourea and dialkylnitrosamine depression of nicotinamide adenine dinucleotide. Cancer Res 1969, 29:1226.
    • (1969) Cancer Res , vol.29 , pp. 1226
    • Schein, P.S.1
  • 146
    • 0017654852 scopus 로고
    • Structure-activity studies of methylnitrosourea antitumor agents with reduced murine bone marrow toxicity
    • Panasci LC, Fox PA, Schein PS Structure-activity studies of methylnitrosourea antitumor agents with reduced murine bone marrow toxicity. Cancer Res 1977, 37:3321.
    • (1977) Cancer Res , vol.37 , pp. 3321
    • Panasci, L.C.1    Fox, P.A.2    Schein, P.S.3
  • 147
    • 0037105752 scopus 로고    scopus 로고
    • Streptozocin for treatment of pancreatic islet cell tumors in dogs: 17 cases (1989-1999)
    • Moore AS, Nelson RW, Henry CJ, et al. Streptozocin for treatment of pancreatic islet cell tumors in dogs: 17 cases (1989-1999). J Am Vet Med Assoc 2002, 221:811.
    • (2002) J Am Vet Med Assoc , vol.221 , pp. 811
    • Moore, A.S.1    Nelson, R.W.2    Henry, C.J.3
  • 148
    • 0015896739 scopus 로고
    • Studies on the mechanism of action of the tumour inhibitory triazenes
    • Audette RC, Connors TA, Mandel HG, et al. Studies on the mechanism of action of the tumour inhibitory triazenes. Biochem Pharmacol 1973, 22:1855.
    • (1973) Biochem Pharmacol , vol.22 , pp. 1855
    • Audette, R.C.1    Connors, T.A.2    Mandel, H.G.3
  • 149
    • 0032784651 scopus 로고    scopus 로고
    • Metabolic activation of dacarbazine by human cytochromes P450: the role of CYP1A1, CYP1A2, and CYP2E1
    • Reid JM, Kuffel MJ, Miller JK, et al. Metabolic activation of dacarbazine by human cytochromes P450: the role of CYP1A1, CYP1A2, and CYP2E1. Clin Cancer Res 1999, 5:2192.
    • (1999) Clin Cancer Res , vol.5 , pp. 2192
    • Reid, J.M.1    Kuffel, M.J.2    Miller, J.K.3
  • 150
    • 0016224077 scopus 로고
    • The mechanism of alkylation of DNA by 5-(3-methyl-1-triazeno)imidazole-4-carboxamide (MIC), a metabolite of DIC (NSC-45388). Non-involvement of diazomethane
    • Nagasawa HT, Shirota FN, Mizuno NS The mechanism of alkylation of DNA by 5-(3-methyl-1-triazeno)imidazole-4-carboxamide (MIC), a metabolite of DIC (NSC-45388). Non-involvement of diazomethane. Chem Biol Interact 1974, 8:403.
    • (1974) Chem Biol Interact , vol.8 , pp. 403
    • Nagasawa, H.T.1    Shirota, F.N.2    Mizuno, N.S.3
  • 151
    • 0017133762 scopus 로고
    • Interaction of the carcinogen 3,3-dimethyl-1-phenyltriazene with nucleic acids of various rat tissues and the effect of a protein-free diet
    • Kleihues P, Kolar GF, Margison GP Interaction of the carcinogen 3,3-dimethyl-1-phenyltriazene with nucleic acids of various rat tissues and the effect of a protein-free diet. Cancer Res 1976, 36:2189.
    • (1976) Cancer Res , vol.36 , pp. 2189
    • Kleihues, P.1    Kolar, G.F.2    Margison, G.P.3
  • 152
    • 70350405389 scopus 로고    scopus 로고
    • Dacarbazine as single-agent therapy for relapsed lymphoma in dogs
    • Griessmayr PC, Payne SE, Winter JE, et al. Dacarbazine as single-agent therapy for relapsed lymphoma in dogs. J Vet Intern Med 2009, 23:1227.
    • (2009) J Vet Intern Med , vol.23 , pp. 1227
    • Griessmayr, P.C.1    Payne, S.E.2    Winter, J.E.3
  • 153
    • 40549103821 scopus 로고    scopus 로고
    • Combination of CCNU and DTIC chemotherapy for treatment of resistant lymphoma in dogs
    • Flory AB, Rassnick KM, Al-Sarraf R, et al. Combination of CCNU and DTIC chemotherapy for treatment of resistant lymphoma in dogs. J Vet Intern Med 2008, 22:164.
    • (2008) J Vet Intern Med , vol.22 , pp. 164
    • Flory, A.B.1    Rassnick, K.M.2    Al-Sarraf, R.3
  • 154
    • 0014102191 scopus 로고
    • Studies of the mode of action of N-isopropyl-alpha-(2-methylhydrazino)-p-toluamide
    • Gale GR, Simpson JG, Smith AB Studies of the mode of action of N-isopropyl-alpha-(2-methylhydrazino)-p-toluamide. Cancer Res 1967, 27:1186.
    • (1967) Cancer Res , vol.27 , pp. 1186
    • Gale, G.R.1    Simpson, J.G.2    Smith, A.B.3
  • 155
    • 0021992540 scopus 로고
    • Metabolic activation of the terminal N-methyl group of N-isopropyl-alpha-(2-methylhydrazino)-p-toluamide hydrochloride (procarbazine)
    • Moloney SJ, Wiebkin P, Cummings SW, et al. Metabolic activation of the terminal N-methyl group of N-isopropyl-alpha-(2-methylhydrazino)-p-toluamide hydrochloride (procarbazine). Carcinogenesis 1985, 6:397.
    • (1985) Carcinogenesis , vol.6 , pp. 397
    • Moloney, S.J.1    Wiebkin, P.2    Cummings, S.W.3
  • 156
    • 0024478384 scopus 로고
    • O6-alkylguanine-DNA alkyltransferase and sensitivity to procarbazine in human brain-tumor xenografts
    • Schold SC, Brent TP, von Hofe E, et al. O6-alkylguanine-DNA alkyltransferase and sensitivity to procarbazine in human brain-tumor xenografts. J Neurosurg 1989, 70:573.
    • (1989) J Neurosurg , vol.70 , pp. 573
    • Schold, S.C.1    Brent, T.P.2    von Hofe, E.3
  • 157
    • 0020264415 scopus 로고
    • Quantitative analysis of procarbazine, procarbazine metabolites and chemical degradation products with application to pharmacokinetic studies
    • Shiba DA, Weinkam RJ Quantitative analysis of procarbazine, procarbazine metabolites and chemical degradation products with application to pharmacokinetic studies. J Chromatogr 1982, 229:397.
    • (1982) J Chromatogr , vol.229 , pp. 397
    • Shiba, D.A.1    Weinkam, R.J.2
  • 158
    • 0009803192 scopus 로고
    • Some pharmacologic properties of a new antitumor agent, N-isopropyl-alpha-(2-methylhydrazino)-p-toluamide, hydrochloride (Nsc-77213)
    • Oliverio VT, Denham C, Devita VT, et al. Some pharmacologic properties of a new antitumor agent, N-isopropyl-alpha-(2-methylhydrazino)-p-toluamide, hydrochloride (Nsc-77213). Cancer Chemother Rep 1964, 42:1.
    • (1964) Cancer Chemother Rep , vol.42 , pp. 1
    • Oliverio, V.T.1    Denham, C.2    Devita, V.T.3
  • 159
    • 0015807041 scopus 로고
    • High-dose intermittent intravenous infusion of procarbazine (NSC-77213)
    • Chabner BA, Sponzo R, Hubbard S, et al. High-dose intermittent intravenous infusion of procarbazine (NSC-77213). Cancer Chemother Rep 1973, 57:361.
    • (1973) Cancer Chemother Rep , vol.57 , pp. 361
    • Chabner, B.A.1    Sponzo, R.2    Hubbard, S.3
  • 160
    • 0016851896 scopus 로고
    • The inhibition in vitro of DNA polymerase and RNA polymerase by daunomycin and Adriamycin
    • Zunino F, Gambetta R, Di Marco A The inhibition in vitro of DNA polymerase and RNA polymerase by daunomycin and Adriamycin. Biochem Pharmacol 1975, 24:309.
    • (1975) Biochem Pharmacol , vol.24 , pp. 309
    • Zunino, F.1    Gambetta, R.2    Di Marco, A.3
  • 161
    • 0021192054 scopus 로고
    • Intercalative anti-tumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase
    • Tewey KM, Chen GI, Nelson EM, et al. Intercalative anti-tumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase. J Biol Chem 1984, 259:9182.
    • (1984) J Biol Chem , vol.259 , pp. 9182
    • Tewey, K.M.1    Chen, G.I.2    Nelson, E.M.3
  • 162
    • 0029840013 scopus 로고    scopus 로고
    • Alkylation of DNA by the anthracycline, antitumor drugs adriamycin and daunomycin
    • Taatjes DJ, Gaudiano G, Resing K, et al. Alkylation of DNA by the anthracycline, antitumor drugs adriamycin and daunomycin. J Med Chem 1996, 39:4135.
    • (1996) J Med Chem , vol.39 , pp. 4135
    • Taatjes, D.J.1    Gaudiano, G.2    Resing, K.3
  • 163
    • 0001213485 scopus 로고
    • Role of hydrogen peroxide and hydroxyl radical in the killing of ehrlich tumor cells by anticancer quinones
    • Doroshow JH Role of hydrogen peroxide and hydroxyl radical in the killing of ehrlich tumor cells by anticancer quinones. Proc Natl Acad Sci U S A 1985, 83:4514.
    • (1985) Proc Natl Acad Sci U S A , vol.83 , pp. 4514
    • Doroshow, J.H.1
  • 164
    • 0018194637 scopus 로고
    • A general mechanism for microsomal activation of quinone anticancer agents to free radicals
    • Bachur NR, Gordon SL, Gee MV A general mechanism for microsomal activation of quinone anticancer agents to free radicals. Cancer Res 1978, 38:1745.
    • (1978) Cancer Res , vol.38 , pp. 1745
    • Bachur, N.R.1    Gordon, S.L.2    Gee, M.V.3
  • 165
    • 0025193578 scopus 로고
    • Anthraquinone-sensitized Ca + release channel from rat cardiac sarcoplasmic reticulum: possible receptor-mediated mechanism of doxorubicin cardiomyopathy
    • Pessah IN, Durie EL, Schiedt MJ, et al. Anthraquinone-sensitized Ca + release channel from rat cardiac sarcoplasmic reticulum: possible receptor-mediated mechanism of doxorubicin cardiomyopathy. Mol Pharmacol 1990, 37:503.
    • (1990) Mol Pharmacol , vol.37 , pp. 503
    • Pessah, I.N.1    Durie, E.L.2    Schiedt, M.J.3
  • 166
    • 0025237624 scopus 로고
    • Doxorubicin blocks the increase in intracellular Ca ++, part of a second messenger system in N1E-115 murine neuroblastoma cells
    • Oakes SG, Schlager JJ, Santone KS, et al. Doxorubicin blocks the increase in intracellular Ca ++, part of a second messenger system in N1E-115 murine neuroblastoma cells. J Pharmacol Exp Ther 1990, 252:979.
    • (1990) J Pharmacol Exp Ther , vol.252 , pp. 979
    • Oakes, S.G.1    Schlager, J.J.2    Santone, K.S.3
  • 167
    • 0026505778 scopus 로고
    • Inhibition of cellular thioredoxin reductase by diaziquone and doxorubicin: relationship to the inhibition of cell proliferation and decreased ribonucleotide reductase activity
    • Mau BL, Powis G Inhibition of cellular thioredoxin reductase by diaziquone and doxorubicin: relationship to the inhibition of cell proliferation and decreased ribonucleotide reductase activity. Biochem Pharmacol 1992, 43:1621.
    • (1992) Biochem Pharmacol , vol.43 , pp. 1621
    • Mau, B.L.1    Powis, G.2
  • 168
    • 0030777179 scopus 로고    scopus 로고
    • Is the drug-responsive NADH oxidase of the cancer cell plasma membrane a molecular target for adriamycin?
    • Morre DJ, Kim C, Paulik M, et al. Is the drug-responsive NADH oxidase of the cancer cell plasma membrane a molecular target for adriamycin?. J Bioenerg Biomembr 1997, 29:269.
    • (1997) J Bioenerg Biomembr , vol.29 , pp. 269
    • Morre, D.J.1    Kim, C.2    Paulik, M.3
  • 169
    • 0019988094 scopus 로고
    • Experimental evidence of characteristic tissue distribution of Adriamycin: tissue DNA concentration as a determinant
    • Terasaki T, Iga T, Sugiyama Y, et al. Experimental evidence of characteristic tissue distribution of Adriamycin: tissue DNA concentration as a determinant. J Pharm Pharmacol 1982, 34:597.
    • (1982) J Pharm Pharmacol , vol.34 , pp. 597
    • Terasaki, T.1    Iga, T.2    Sugiyama, Y.3
  • 170
    • 0021742903 scopus 로고
    • The interaction of adriamycin with cardiolipin in model and rat liver mitochondrial membranes
    • Nicolay K, Timmers RJM, Spoelstra E, et al. The interaction of adriamycin with cardiolipin in model and rat liver mitochondrial membranes. Biochim Biophys Acta 1984, 778:359.
    • (1984) Biochim Biophys Acta , vol.778 , pp. 359
    • Nicolay, K.1    Timmers, R.J.M.2    Spoelstra, E.3
  • 171
    • 0019221914 scopus 로고
    • Evidence of a specific complex between adriamycin and negatively-charged phospholipids
    • Goormaghtigh E, Chatelain P, Caspers J, et al. Evidence of a specific complex between adriamycin and negatively-charged phospholipids. Biochim Biophys Acta 1980, 597:1.
    • (1980) Biochim Biophys Acta , vol.597 , pp. 1
    • Goormaghtigh, E.1    Chatelain, P.2    Caspers, J.3
  • 172
    • 0036282896 scopus 로고    scopus 로고
    • Doxorubicin pharmacokinetics: macromolecule binding, metabolism and elimination in the context of a physiological model
    • Gustafson DL, Rastatter JC, Colombo T, et al. Doxorubicin pharmacokinetics: macromolecule binding, metabolism and elimination in the context of a physiological model. J Pharm Sci 2002, 91:1488.
    • (2002) J Pharm Sci , vol.91 , pp. 1488
    • Gustafson, D.L.1    Rastatter, J.C.2    Colombo, T.3
  • 173
    • 0019432786 scopus 로고
    • Daunorubicin reduction mediated by aldehyde and ketone reductases
    • Ahmed NK, Felsted RL, Bachur NR Daunorubicin reduction mediated by aldehyde and ketone reductases. Xenobiotica 1981, 11:131.
    • (1981) Xenobiotica , vol.11 , pp. 131
    • Ahmed, N.K.1    Felsted, R.L.2    Bachur, N.R.3
  • 174
    • 0018865202 scopus 로고
    • Xanthine oxidase catalyzed reductive cleavage of anthracycline antibiotics and free radical formation
    • Pan SS, Bachur NR Xanthine oxidase catalyzed reductive cleavage of anthracycline antibiotics and free radical formation. Mol Pharmacol 1980, 17:95.
    • (1980) Mol Pharmacol , vol.17 , pp. 95
    • Pan, S.S.1    Bachur, N.R.2
  • 176
    • 0027652774 scopus 로고
    • Systemic toxicity associated with doxorubicin administration in cats
    • O'Keefe DA, Sisson DD, Gelberg HB, et al. Systemic toxicity associated with doxorubicin administration in cats. J Vet Intern Med 1993, 7:309.
    • (1993) J Vet Intern Med , vol.7 , pp. 309
    • O'Keefe, D.A.1    Sisson, D.D.2    Gelberg, H.B.3
  • 177
    • 33947187195 scopus 로고    scopus 로고
    • Aftershocks of cancer chemotherapy: managing adverse effects
    • Thamm DH, Vail DM Aftershocks of cancer chemotherapy: managing adverse effects. J Am Anim Hosp Assoc 2007, 43:1.
    • (2007) J Am Anim Hosp Assoc , vol.43 , pp. 1
    • Thamm, D.H.1    Vail, D.M.2
  • 178
    • 0020060120 scopus 로고
    • DNA-binding specificity and RNA polymerase inhibitory activity of bis(aminoalkyl)anthraquinones and bis(methylthio)vinylquinolinium iodides
    • Foye WO, Vajragupta O, Sengupta SK DNA-binding specificity and RNA polymerase inhibitory activity of bis(aminoalkyl)anthraquinones and bis(methylthio)vinylquinolinium iodides. J Pharm Sci 1982, 71:253.
    • (1982) J Pharm Sci , vol.71 , pp. 253
    • Foye, W.O.1    Vajragupta, O.2    Sengupta, S.K.3
  • 179
    • 0022481289 scopus 로고
    • Mitoxantrone affects topoisomerase activities in human breast cancer cells
    • Crespi MD, Ivanier SE, Genovese J, et al. Mitoxantrone affects topoisomerase activities in human breast cancer cells. Biochem Biophys Res Commun 1986, 136:521.
    • (1986) Biochem Biophys Res Commun , vol.136 , pp. 521
    • Crespi, M.D.1    Ivanier, S.E.2    Genovese, J.3
  • 180
    • 0020676390 scopus 로고
    • 1,4-Bis(2-[(2-hydroxyethyl)amino]ethylamino)-9,10-anthracenedione, an anthraquinone antitumour agent that does not cause lipid peroxidation in vivo; comparison with daunorubicin
    • Patterson LH, Gandecha BM, Brown JR 1,4-Bis(2-[(2-hydroxyethyl)amino]ethylamino)-9,10-anthracenedione, an anthraquinone antitumour agent that does not cause lipid peroxidation in vivo; comparison with daunorubicin. Biochem Biophys Res Commun 1983, 110:399.
    • (1983) Biochem Biophys Res Commun , vol.110 , pp. 399
    • Patterson, L.H.1    Gandecha, B.M.2    Brown, J.R.3
  • 181
    • 0025261039 scopus 로고
    • Mechanism(s) for the metabolism of mitoxantrone: electron spin resonance and electrochemical studies
    • Nguyen B, Gutierrez PL Mechanism(s) for the metabolism of mitoxantrone: electron spin resonance and electrochemical studies. Chem Biol Interact 1990, 74:139.
    • (1990) Chem Biol Interact , vol.74 , pp. 139
    • Nguyen, B.1    Gutierrez, P.L.2
  • 182
    • 0021880217 scopus 로고
    • Disposition of mitoxantrone in cancer patients
    • Alberts DS, Peng YM, Leigh S, et al. Disposition of mitoxantrone in cancer patients. Cancer Res 1985, 45:1879.
    • (1985) Cancer Res , vol.45 , pp. 1879
    • Alberts, D.S.1    Peng, Y.M.2    Leigh, S.3
  • 183
    • 0021242371 scopus 로고
    • Pharmacological disposition of 1,4-dihydroxy-5-8-bis[[2 [(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione dihydrochloride in the dog
    • Lu K, Savaraj N, Loo TL Pharmacological disposition of 1,4-dihydroxy-5-8-bis[[2 [(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione dihydrochloride in the dog. Cancer Chemother Pharmacol 1984, 13:63.
    • (1984) Cancer Chemother Pharmacol , vol.13 , pp. 63
    • Lu, K.1    Savaraj, N.2    Loo, T.L.3
  • 184
    • 0022533438 scopus 로고
    • Identification of human urinary mitoxantrone metabolites
    • Chiccarelli FS, Morrison JA, Cosulich DB, et al. Identification of human urinary mitoxantrone metabolites. Cancer Res 1986, 46:4858.
    • (1986) Cancer Res , vol.46 , pp. 4858
    • Chiccarelli, F.S.1    Morrison, J.A.2    Cosulich, D.B.3
  • 185
    • 0037314711 scopus 로고    scopus 로고
    • Clinical evaluation of mitoxantrone and piroxicam in a canine model of human invasive urinary bladder carcinoma
    • Henry CJ, McCaw DL, Turnquist SE, et al. Clinical evaluation of mitoxantrone and piroxicam in a canine model of human invasive urinary bladder carcinoma. Clin Cancer Res 2003, 9:906.
    • (2003) Clin Cancer Res , vol.9 , pp. 906
    • Henry, C.J.1    McCaw, D.L.2    Turnquist, S.E.3
  • 186
    • 0020064754 scopus 로고
    • The structure of a pseudo intercalated complex between actinomycin and the DNA binding sequence d(GpC)
    • Takusagawa F, Dabrow M, Neidle S, et al. The structure of a pseudo intercalated complex between actinomycin and the DNA binding sequence d(GpC). Nature 1982, 296:466.
    • (1982) Nature , vol.296 , pp. 466
    • Takusagawa, F.1    Dabrow, M.2    Neidle, S.3
  • 187
    • 0021337228 scopus 로고
    • Crystallization and preliminary X-ray study of a complex between d(ATGCAT) and actinomycin D
    • Takusagawa F, Goldstein BM, Youngster S, et al. Crystallization and preliminary X-ray study of a complex between d(ATGCAT) and actinomycin D. J Biol Chem 1984, 259:4714.
    • (1984) J Biol Chem , vol.259 , pp. 4714
    • Takusagawa, F.1    Goldstein, B.M.2    Youngster, S.3
  • 188
    • 0021326732 scopus 로고
    • Aqueous solution structure of an intercalated actinomycin D-dATGCAT complex by two-dimensional and one-dimensional proton NMR
    • Brown SC, Mullis K, Levenson C, et al. Aqueous solution structure of an intercalated actinomycin D-dATGCAT complex by two-dimensional and one-dimensional proton NMR. Biochemistry 1984, 23:403.
    • (1984) Biochemistry , vol.23 , pp. 403
    • Brown, S.C.1    Mullis, K.2    Levenson, C.3
  • 189
    • 0026055736 scopus 로고
    • Actinomycin D and 7-aminoactinomycin D binding to single-stranded DNA
    • Wadkins RM, Jovin TM Actinomycin D and 7-aminoactinomycin D binding to single-stranded DNA. Biochemistry 1991, 30:9469.
    • (1991) Biochemistry , vol.30 , pp. 9469
    • Wadkins, R.M.1    Jovin, T.M.2
  • 190
    • 0000912747 scopus 로고
    • Basis of actinomycin action. I. DNA binding and inhibition of RNA-polymerase synthetic reactions by actinomycin
    • Goldberg IH, Rabinowitz M, Reich E Basis of actinomycin action. I. DNA binding and inhibition of RNA-polymerase synthetic reactions by actinomycin. Proc Natl Acad Sci U S A 1962, 48:2094.
    • (1962) Proc Natl Acad Sci U S A , vol.48 , pp. 2094
    • Goldberg, I.H.1    Rabinowitz, M.2    Reich, E.3
  • 192
    • 0014236441 scopus 로고
    • Uptake in vivo and in vitro of actinomycin D by mouse leukemias as factors in survival
    • Kessel D, Wodinsky I Uptake in vivo and in vitro of actinomycin D by mouse leukemias as factors in survival. Biochem Pharmacol 1968, 17:161.
    • (1968) Biochem Pharmacol , vol.17 , pp. 161
    • Kessel, D.1    Wodinsky, I.2
  • 193
    • 0017697254 scopus 로고
    • Decreased retention of actinomycin D as the basis for cross-resistance in anthracycline-resistant sublines of P388 leukemia
    • Inaba M, Johnson RK Decreased retention of actinomycin D as the basis for cross-resistance in anthracycline-resistant sublines of P388 leukemia. Cancer Res 1977, 37:4629.
    • (1977) Cancer Res , vol.37 , pp. 4629
    • Inaba, M.1    Johnson, R.K.2
  • 194
    • 0023512992 scopus 로고
    • Characterization of actinomycin-D-resistant CHO cell lines exhibiting a multidrug-resistance phenotype and amplified DNA sequences
    • Diddens H, Gekeler V, Neumann M, et al. Characterization of actinomycin-D-resistant CHO cell lines exhibiting a multidrug-resistance phenotype and amplified DNA sequences. Int J Cancer 1987, 40:635.
    • (1987) Int J Cancer , vol.40 , pp. 635
    • Diddens, H.1    Gekeler, V.2    Neumann, M.3
  • 195
    • 0016571824 scopus 로고
    • Tissue disposition of 3H-actinomycin D (NSC-3053) in the rat, monkey, and dog
    • Galbraith WM, Mellett LB Tissue disposition of 3H-actinomycin D (NSC-3053) in the rat, monkey, and dog. Cancer Chemother Rep 1975, 59:1601.
    • (1975) Cancer Chemother Rep , vol.59 , pp. 1601
    • Galbraith, W.M.1    Mellett, L.B.2
  • 196
    • 0014341101 scopus 로고
    • Inhibition of mammalian DNA polymerase by the 5′-triphosphate of 1-beta-d-arabinofuranosylcytosine and the 5′-triphosphate of 9-beta-d-arabinofuranoxyladenine
    • Furth JJ, Cohen SS Inhibition of mammalian DNA polymerase by the 5′-triphosphate of 1-beta-d-arabinofuranosylcytosine and the 5′-triphosphate of 9-beta-d-arabinofuranoxyladenine. Cancer Res 1968, 28:2061.
    • (1968) Cancer Res , vol.28 , pp. 2061
    • Furth, J.J.1    Cohen, S.S.2
  • 197
    • 0019131198 scopus 로고
    • Correlation of cytotoxicity with incorporation of ara-C into DNA
    • Kufe DW, Major PP, Egan EM, et al. Correlation of cytotoxicity with incorporation of ara-C into DNA. J Biol Chem 1980, 255:8997.
    • (1980) J Biol Chem , vol.255 , pp. 8997
    • Kufe, D.W.1    Major, P.P.2    Egan, E.M.3
  • 198
    • 0019986283 scopus 로고
    • Effect of ARA-C incorporation on deoxyribonucleic acid synthesis in cells
    • Major PP, Egan EM, Herrick DJ, et al. Effect of ARA-C incorporation on deoxyribonucleic acid synthesis in cells. Biochem Pharmacol 1982, 31:2937.
    • (1982) Biochem Pharmacol , vol.31 , pp. 2937
    • Major, P.P.1    Egan, E.M.2    Herrick, D.J.3
  • 199
    • 0023677076 scopus 로고
    • Functional consequences of the arabinosylcytosine structural lesion in DNA
    • Mikita T, Beardsley GP Functional consequences of the arabinosylcytosine structural lesion in DNA. Biochemistry 1988, 27:4698.
    • (1988) Biochemistry , vol.27 , pp. 4698
    • Mikita, T.1    Beardsley, G.P.2
  • 200
    • 0022853614 scopus 로고
    • Terminal erythroid differentiation in the K-562 cell line by 1-beta-D-arabinofuranosylcytosine: accompaniment by c-myc messenger RNA decrease
    • Bianchi Scarra GL, Romani M, Coviello DA, et al. Terminal erythroid differentiation in the K-562 cell line by 1-beta-D-arabinofuranosylcytosine: accompaniment by c-myc messenger RNA decrease. Cancer Res 1986, 46:6327.
    • (1986) Cancer Res , vol.46 , pp. 6327
    • Bianchi Scarra, G.L.1    Romani, M.2    Coviello, D.A.3
  • 201
    • 0017847558 scopus 로고
    • Transport and metabolism of deoxycytidine and 1-beta-D-arabinofuranosylcytosine into cultured Novikoff rat hepatoma cells, relationship to phosphorylation, and regulation of triphosphate synthesis
    • Plagemann PG, Marz R, Wohlhueter RM Transport and metabolism of deoxycytidine and 1-beta-D-arabinofuranosylcytosine into cultured Novikoff rat hepatoma cells, relationship to phosphorylation, and regulation of triphosphate synthesis. Cancer Res 1978, 38:978.
    • (1978) Cancer Res , vol.38 , pp. 978
    • Plagemann, P.G.1    Marz, R.2    Wohlhueter, R.M.3
  • 203
    • 0015147420 scopus 로고
    • Clinical pharmacology of 1-beta-d-arabinofuranosyl cytosine
    • Ho DH, Frei E Clinical pharmacology of 1-beta-d-arabinofuranosyl cytosine. Clin Pharmacol Ther 1971, 12:944.
    • (1971) Clin Pharmacol Ther , vol.12 , pp. 944
    • Ho, D.H.1    Frei, E.2
  • 204
    • 41449102630 scopus 로고    scopus 로고
    • Treatment of 11 dogs with meningoencephalomyelitis of unknown origin with a combination of prednisolone and cytosine arabinoside
    • Menaut P, Landart J, Behr S, et al. Treatment of 11 dogs with meningoencephalomyelitis of unknown origin with a combination of prednisolone and cytosine arabinoside. Vet Rec 2008, 162:241.
    • (2008) Vet Rec , vol.162 , pp. 241
    • Menaut, P.1    Landart, J.2    Behr, S.3
  • 205
    • 67449093608 scopus 로고    scopus 로고
    • Comparison of two regimens for the treatment of meningoencephalomyelitis of unknown etiology
    • Smith PM, Stalin CE, Shaw D, et al. Comparison of two regimens for the treatment of meningoencephalomyelitis of unknown etiology. J Vet Intern Med 2009, 23:520.
    • (2009) J Vet Intern Med , vol.23 , pp. 520
    • Smith, P.M.1    Stalin, C.E.2    Shaw, D.3
  • 206
    • 61749098480 scopus 로고    scopus 로고
    • Cytosine arabinoside in addition to VCAA-based protocols for the treatment of canine lymphoma with bone marrow involvement: does it make the difference?
    • Marconato L, Bonfanti U, Stefanello D, et al. Cytosine arabinoside in addition to VCAA-based protocols for the treatment of canine lymphoma with bone marrow involvement: does it make the difference?. Vet Comp Oncol 2008, 6:80.
    • (2008) Vet Comp Oncol , vol.6 , pp. 80
    • Marconato, L.1    Bonfanti, U.2    Stefanello, D.3
  • 207
    • 0022970777 scopus 로고
    • The effect of methotrexate on intracellular folate pools in human MCF-7 breast cancer cells. Evidence for direct inhibition of purine synthesis
    • Allegra CJ, Fine RL, Drake JC, et al. The effect of methotrexate on intracellular folate pools in human MCF-7 breast cancer cells. Evidence for direct inhibition of purine synthesis. J Biol Chem 1986, 261:6478.
    • (1986) J Biol Chem , vol.261 , pp. 6478
    • Allegra, C.J.1    Fine, R.L.2    Drake, J.C.3
  • 208
    • 0022262215 scopus 로고
    • Enhanced inhibition of thymidylate synthase by methotrexate polyglutamates
    • Allegra CJ, Chabner BA, Drake JC, et al. Enhanced inhibition of thymidylate synthase by methotrexate polyglutamates. J Biol Chem 1985, 260:9720.
    • (1985) J Biol Chem , vol.260 , pp. 9720
    • Allegra, C.J.1    Chabner, B.A.2    Drake, J.C.3
  • 209
    • 0021167732 scopus 로고
    • Polyglutamylation, an important element in methotrexate cytotoxicity and selectivity in tumor versus murine granulocytic progenitor cells in vitro
    • Fabre I, Fabre G, Goldman ID Polyglutamylation, an important element in methotrexate cytotoxicity and selectivity in tumor versus murine granulocytic progenitor cells in vitro. Cancer Res 1984, 44:3190.
    • (1984) Cancer Res , vol.44 , pp. 3190
    • Fabre, I.1    Fabre, G.2    Goldman, I.D.3
  • 210
    • 0016288809 scopus 로고
    • Effect of route of administration and effusions on methotrexate pharmacokinetics
    • Wan SH, Huffman DH, Azarnoff DL, et al. Effect of route of administration and effusions on methotrexate pharmacokinetics. Cancer Res 1974, 34:3487.
    • (1974) Cancer Res , vol.34 , pp. 3487
    • Wan, S.H.1    Huffman, D.H.2    Azarnoff, D.L.3
  • 212
    • 0032188825 scopus 로고    scopus 로고
    • Functional nucleoside transporters are required for gemcitabine influx and manifestation of toxicity in cancer cell lines
    • Mackey JR, Mani RS, Selner M, et al. Functional nucleoside transporters are required for gemcitabine influx and manifestation of toxicity in cancer cell lines. Cancer Res 1998, 58:4349.
    • (1998) Cancer Res , vol.58 , pp. 4349
    • Mackey, J.R.1    Mani, R.S.2    Selner, M.3
  • 213
    • 0025295958 scopus 로고
    • Modulatory activity of 2′,2′-difluorodeoxycytidine on the phosphorylation and cytotoxicity of arabinosyl nucleosides
    • Gandhi V, Plunkett W Modulatory activity of 2′,2′-difluorodeoxycytidine on the phosphorylation and cytotoxicity of arabinosyl nucleosides. Cancer Res 1990, 50:3675.
    • (1990) Cancer Res , vol.50 , pp. 3675
    • Gandhi, V.1    Plunkett, W.2
  • 214
    • 0029782426 scopus 로고    scopus 로고
    • Excision of 2′,2′-difluorodeoxycytidine (gemcitabine) monophosphate residues from DNA
    • Gandhi V, Legha J, Chen F, et al. Excision of 2′,2′-difluorodeoxycytidine (gemcitabine) monophosphate residues from DNA. Cancer Res 1996, 56:4453.
    • (1996) Cancer Res , vol.56 , pp. 4453
    • Gandhi, V.1    Legha, J.2    Chen, F.3
  • 215
    • 0029060757 scopus 로고
    • Fludarabine- and gemcitabine-induced apoptosis: incorporation of analogs into DNA is a critical event
    • Huang P, Plunkett W Fludarabine- and gemcitabine-induced apoptosis: incorporation of analogs into DNA is a critical event. Cancer Chemother Pharmacol 1995, 36:181.
    • (1995) Cancer Chemother Pharmacol , vol.36 , pp. 181
    • Huang, P.1    Plunkett, W.2
  • 216
    • 47949113797 scopus 로고    scopus 로고
    • New insights into the pharmacology and cytotoxicity of gemcitabine and 2′,2′-difluorodeoxyuridine
    • Veltkamp SA, Pluim D, van Eijndhoven MA, et al. New insights into the pharmacology and cytotoxicity of gemcitabine and 2′,2′-difluorodeoxyuridine. Mol Cancer Ther 2008, 7:2415.
    • (2008) Mol Cancer Ther , vol.7 , pp. 2415
    • Veltkamp, S.A.1    Pluim, D.2    van Eijndhoven, M.A.3
  • 217
    • 47949130807 scopus 로고    scopus 로고
    • Oral administration of gemcitabine in patients with refractory tumors: a clinical and pharmacologic study
    • Veltkamp SA, Jansen RS, Callies S, et al. Oral administration of gemcitabine in patients with refractory tumors: a clinical and pharmacologic study. Clin Cancer Res 2008, 14:3477.
    • (2008) Clin Cancer Res , vol.14 , pp. 3477
    • Veltkamp, S.A.1    Jansen, R.S.2    Callies, S.3
  • 218
    • 47949115416 scopus 로고    scopus 로고
    • Extensive metabolism and hepatic accumulation of gemcitabine after multiple oral and intravenous administration in mice
    • Veltkamp SA, Pluim D, van Tellingen O, et al. Extensive metabolism and hepatic accumulation of gemcitabine after multiple oral and intravenous administration in mice. Drug Metab Dispos 2008, 36:1606.
    • (2008) Drug Metab Dispos , vol.36 , pp. 1606
    • Veltkamp, S.A.1    Pluim, D.2    van Tellingen, O.3
  • 219
    • 0142121290 scopus 로고    scopus 로고
    • Randomized phase II comparison of dose-intense gemcitabine: thirty-minute infusion and fixed dose rate infusion in patients with pancreatic adenocarcinoma
    • Tempero M, Plunkett W, Ruiz Van Haperen V, et al. Randomized phase II comparison of dose-intense gemcitabine: thirty-minute infusion and fixed dose rate infusion in patients with pancreatic adenocarcinoma. J Clin Oncol 2003, 21:3402.
    • (2003) J Clin Oncol , vol.21 , pp. 3402
    • Tempero, M.1    Plunkett, W.2    Ruiz Van Haperen, V.3
  • 220
    • 33845771202 scopus 로고    scopus 로고
    • Single agent gemcitabine chemotherapy in dogs with spontaneously occurring lymphoma
    • Turner AI, Hahn KA, Rusk A, et al. Single agent gemcitabine chemotherapy in dogs with spontaneously occurring lymphoma. J Vet Intern Med 2006, 20:1384.
    • (2006) J Vet Intern Med , vol.20 , pp. 1384
    • Turner, A.I.1    Hahn, K.A.2    Rusk, A.3
  • 221
    • 7244221409 scopus 로고    scopus 로고
    • Unexpected toxicity following use of gemcitabine as a radiosensitizer in head and neck carcinomas: a veterinary radiation therapy oncology group pilot study
    • Le Blanc AK, La Due TA, Turrel JM, et al. Unexpected toxicity following use of gemcitabine as a radiosensitizer in head and neck carcinomas: a veterinary radiation therapy oncology group pilot study. Vet Radiol Ultrasound 2004, 45:466.
    • (2004) Vet Radiol Ultrasound , vol.45 , pp. 466
    • Le Blanc, A.K.1    La Due, T.A.2    Turrel, J.M.3
  • 222
    • 67449094428 scopus 로고    scopus 로고
    • Tolerability of gemcitabine and carboplatin doublet therapy in cats with carcinomas
    • Martinez-Ruzafa I, Dominguez PA, Dervisis NG, et al. Tolerability of gemcitabine and carboplatin doublet therapy in cats with carcinomas. J Vet Intern Med 2009, 23:570.
    • (2009) J Vet Intern Med , vol.23 , pp. 570
    • Martinez-Ruzafa, I.1    Dominguez, P.A.2    Dervisis, N.G.3
  • 223
    • 0141731181 scopus 로고    scopus 로고
    • Gemcitabine as a radiosensitizer for nonresectable feline oral squamous cell carcinoma
    • Jones PD, de Lorimier LP, Kitchell BE, et al. Gemcitabine as a radiosensitizer for nonresectable feline oral squamous cell carcinoma. J Am Anim Hosp Assoc 2003, 39:463.
    • (2003) J Am Anim Hosp Assoc , vol.39 , pp. 463
    • Jones, P.D.1    de Lorimier, L.P.2    Kitchell, B.E.3
  • 224
    • 61349146549 scopus 로고    scopus 로고
    • Combined gemcitabine and carboplatin therapy for carcinomas in dogs
    • Dominguez PA, Dervisis NG, Cadile CD, et al. Combined gemcitabine and carboplatin therapy for carcinomas in dogs. J Vet Intern Med 2009, 23:130.
    • (2009) J Vet Intern Med , vol.23 , pp. 130
    • Dominguez, P.A.1    Dervisis, N.G.2    Cadile, C.D.3
  • 225
    • 61749098352 scopus 로고    scopus 로고
    • Adjuvant gemcitabine after surgical removal of aggressive malignant mammary tumours in dogs
    • Marconato L, Lorenzo RM, Abramo F, et al. Adjuvant gemcitabine after surgical removal of aggressive malignant mammary tumours in dogs. Vet Comp Oncol 2008, 6:90.
    • (2008) Vet Comp Oncol , vol.6 , pp. 90
    • Marconato, L.1    Lorenzo, R.M.2    Abramo, F.3
  • 226
    • 79955617143 scopus 로고    scopus 로고
    • Toxic effects and antitumor response of gemcitabine in combination with piroxicam treatment in dogs with transitional cell carcinoma of the urinary bladder
    • Marconato L, Zini E, Lindner D, et al. Toxic effects and antitumor response of gemcitabine in combination with piroxicam treatment in dogs with transitional cell carcinoma of the urinary bladder. J Am Vet Med Assoc 2011, 238:1004.
    • (2011) J Am Vet Med Assoc , vol.238 , pp. 1004
    • Marconato, L.1    Zini, E.2    Lindner, D.3
  • 227
    • 79955522391 scopus 로고    scopus 로고
    • Adjuvant carboplatin and gemcitabine combination chemotherapy postamputation in canine appendicular osteosarcoma
    • McMahon M, Mathie T, Stingle N, et al. Adjuvant carboplatin and gemcitabine combination chemotherapy postamputation in canine appendicular osteosarcoma. J Vet Intern Med 2011, 25:511.
    • (2011) J Vet Intern Med , vol.25 , pp. 511
    • McMahon, M.1    Mathie, T.2    Stingle, N.3
  • 228
    • 0019277437 scopus 로고
    • Facilitated transport of uracil and 5-fluorouracil, and permeation of orotic acid into cultured mammalian cells
    • Wohlhueter RM, McIvor RS, Plagemann PG Facilitated transport of uracil and 5-fluorouracil, and permeation of orotic acid into cultured mammalian cells. J Cell Physiol 1980, 104:309.
    • (1980) J Cell Physiol , vol.104 , pp. 309
    • Wohlhueter, R.M.1    McIvor, R.S.2    Plagemann, P.G.3
  • 229
    • 0014512198 scopus 로고
    • The synthesis of 5-fluorouridine 5′-phosphate by a pyrimidine phosphoribosyltransferase of mammalian origin. I. Some properties of the enzyme from P1534J mouse leukemic cells
    • Reyes P The synthesis of 5-fluorouridine 5′-phosphate by a pyrimidine phosphoribosyltransferase of mammalian origin. I. Some properties of the enzyme from P1534J mouse leukemic cells. Biochemistry 1969, 8:2057.
    • (1969) Biochemistry , vol.8 , pp. 2057
    • Reyes, P.1
  • 230
    • 0020563004 scopus 로고
    • Elucidation of pathways of 5-fluorouracil metabolism in xenografts of human colorectal adenocarcinoma
    • Houghton JA, Houghton PJ Elucidation of pathways of 5-fluorouracil metabolism in xenografts of human colorectal adenocarcinoma. Eur J Cancer Clin Oncol 1983, 19:807.
    • (1983) Eur J Cancer Clin Oncol , vol.19 , pp. 807
    • Houghton, J.A.1    Houghton, P.J.2
  • 231
    • 77958166547 scopus 로고    scopus 로고
    • Toxic effects of fluorouracil cream ingestion on dogs and cats
    • Snavely NR, Snavely DA, Wilson BB Toxic effects of fluorouracil cream ingestion on dogs and cats. Arch Dermatol 2010, 146:1195.
    • (2010) Arch Dermatol , vol.146 , pp. 1195
    • Snavely, N.R.1    Snavely, D.A.2    Wilson, B.B.3
  • 232
    • 0019807257 scopus 로고
    • 5-Fluorouracil incorporation into human breast carcinoma RNA correlates with cytotoxicity
    • Kufe DW, Major PP 5-Fluorouracil incorporation into human breast carcinoma RNA correlates with cytotoxicity. J Biol Chem 1981, 256:9802.
    • (1981) J Biol Chem , vol.256 , pp. 9802
    • Kufe, D.W.1    Major, P.P.2
  • 233
    • 0019813027 scopus 로고
    • 5-Fluoro-2′-deoxyuridine incorporation in L1210 DNA
    • Kufe DW, Major PP, Egan EM, et al. 5-Fluoro-2′-deoxyuridine incorporation in L1210 DNA. J Biol Chem 1981, 256:8885.
    • (1981) J Biol Chem , vol.256 , pp. 8885
    • Kufe, D.W.1    Major, P.P.2    Egan, E.M.3
  • 234
    • 0019501567 scopus 로고
    • Utilization of 5-fluoro-2′-deoxyuridine triphosphate and 5-fluoro-2′-deoxycytidine triphosphate in DNA synthesis by DNA polymerases alpha and beta from calf thymus
    • Tanaka M, Yoshida S, Saneyoshi M, et al. Utilization of 5-fluoro-2′-deoxyuridine triphosphate and 5-fluoro-2′-deoxycytidine triphosphate in DNA synthesis by DNA polymerases alpha and beta from calf thymus. Cancer Res 1981, 41:4132.
    • (1981) Cancer Res , vol.41 , pp. 4132
    • Tanaka, M.1    Yoshida, S.2    Saneyoshi, M.3
  • 235
    • 0015962412 scopus 로고
    • Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate
    • Santi DV, McHenry CS, Sommer H Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate. Biochemistry 1974, 13:471.
    • (1974) Biochemistry , vol.13 , pp. 471
    • Santi, D.V.1    McHenry, C.S.2    Sommer, H.3
  • 236
    • 0022400840 scopus 로고
    • Enzymes of uracil catabolism in normal and neoplastic human tissues
    • Naguib FN, El Kouni MH, Cha S Enzymes of uracil catabolism in normal and neoplastic human tissues. Cancer Res 1985, 45:5405.
    • (1985) Cancer Res , vol.45 , pp. 5405
    • Naguib, F.N.1    El Kouni, M.H.2    Cha, S.3
  • 237
    • 0002548405 scopus 로고    scopus 로고
    • 5-fluoropyrimidines
    • Lippincott Williams & Wilkins, Philadelphia, B.A. Chabner, D.L. Longo (Eds.)
    • Grem JL 5-fluoropyrimidines. Cancer chemotherapy & biotherapy: principles and practice 2001, Lippincott Williams & Wilkins, Philadelphia. B.A. Chabner, D.L. Longo (Eds.).
    • (2001) Cancer chemotherapy & biotherapy: principles and practice
    • Grem, J.L.1
  • 238
    • 0018387446 scopus 로고
    • Promotion of microtubule assembly in vitro by taxol
    • Schiff PB, Fant J, Horwitz SB Promotion of microtubule assembly in vitro by taxol. Nature 1979, 277:665.
    • (1979) Nature , vol.277 , pp. 665
    • Schiff, P.B.1    Fant, J.2    Horwitz, S.B.3
  • 239
    • 0000297058 scopus 로고
    • Taxol stabilizes microtubules in mouse fibroblast cells
    • Schiff PB, Horwitz SB Taxol stabilizes microtubules in mouse fibroblast cells. Proc Natl Acad Sci U S A 1980, 77:1561.
    • (1980) Proc Natl Acad Sci U S A , vol.77 , pp. 1561
    • Schiff, P.B.1    Horwitz, S.B.2
  • 240
    • 0026428123 scopus 로고
    • Studies with RP 56976 (taxotere): a semisynthetic analogue of taxol
    • Ringel I, Horwitz SB Studies with RP 56976 (taxotere): a semisynthetic analogue of taxol. J Natl Cancer Inst 1991, 83:288.
    • (1991) J Natl Cancer Inst , vol.83 , pp. 288
    • Ringel, I.1    Horwitz, S.B.2
  • 241
    • 0027360552 scopus 로고
    • Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations
    • Jordan MA, Toso RJ, Thrower D, et al. Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations. Proc Natl Acad Sci U S A 1993, 90:9552.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 9552
    • Jordan, M.A.1    Toso, R.J.2    Thrower, D.3
  • 242
    • 0026425674 scopus 로고
    • Experimental antitumor activity of taxotere (RP 56976, NSC 628503), a taxol analogue
    • Bissery MC, Guenard D, Gueritte-Voegelein F, et al. Experimental antitumor activity of taxotere (RP 56976, NSC 628503), a taxol analogue. Cancer Res 1991, 51:4845.
    • (1991) Cancer Res , vol.51 , pp. 4845
    • Bissery, M.C.1    Guenard, D.2    Gueritte-Voegelein, F.3
  • 243
    • 0027467778 scopus 로고
    • Assembly of purified GDP-tubulin into microtubules induced by taxol and taxotere: reversibility, ligand stoichiometry, and competition
    • Diaz JF, Andreu JM Assembly of purified GDP-tubulin into microtubules induced by taxol and taxotere: reversibility, ligand stoichiometry, and competition. Biochemistry 1993, 32:2747.
    • (1993) Biochemistry , vol.32 , pp. 2747
    • Diaz, J.F.1    Andreu, J.M.2
  • 244
    • 8344252959 scopus 로고    scopus 로고
    • Enhanced bioavailability of oral docetaxel by co-administration of cyclosporin A in dogs and rats
    • McEntee M, Silverman JA, Rassnick K, et al. Enhanced bioavailability of oral docetaxel by co-administration of cyclosporin A in dogs and rats. Vet Comp Oncol 2003, 1:105.
    • (2003) Vet Comp Oncol , vol.1 , pp. 105
    • McEntee, M.1    Silverman, J.A.2    Rassnick, K.3
  • 245
    • 33845706632 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic evaluation of the combination of orally administered docetaxel and cyclosporin A in tumor-bearing cats
    • McEntee MC, Rassnick KM, Bailey DB, et al. Phase I and pharmacokinetic evaluation of the combination of orally administered docetaxel and cyclosporin A in tumor-bearing cats. J Vet Intern Med 2006, 20:1370.
    • (2006) J Vet Intern Med , vol.20 , pp. 1370
    • McEntee, M.C.1    Rassnick, K.M.2    Bailey, D.B.3
  • 246
    • 33745675665 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic evaluation of the combination of orally administered docetaxel and cyclosporin A in tumor-bearing dogs
    • McEntee MC, Rassnick KM, Lewis LD, et al. Phase I and pharmacokinetic evaluation of the combination of orally administered docetaxel and cyclosporin A in tumor-bearing dogs. Am J Vet Res 2006, 67:1057.
    • (2006) Am J Vet Res , vol.67 , pp. 1057
    • McEntee, M.C.1    Rassnick, K.M.2    Lewis, L.D.3
  • 247
    • 80955178784 scopus 로고    scopus 로고
    • Intravenous administration of docetaxel to cats with cancer
    • Shiu KB, McCartan L, Kubicek L, et al. Intravenous administration of docetaxel to cats with cancer. J Vet Intern Med 2011, 25:916.
    • (2011) J Vet Intern Med , vol.25 , pp. 916
    • Shiu, K.B.1    McCartan, L.2    Kubicek, L.3
  • 248
    • 0026319932 scopus 로고
    • Effects of antimitotic agents on tubulin-nucleotide interactions
    • Correia JJ Effects of antimitotic agents on tubulin-nucleotide interactions. Pharmacol Ther 1991, 52:127.
    • (1991) Pharmacol Ther , vol.52 , pp. 127
    • Correia, J.J.1
  • 249
    • 0019977155 scopus 로고
    • Interaction of vinblastine with steady-state microtubules in vitro
    • Wilson L, Jordan MA, Morse A, et al. Interaction of vinblastine with steady-state microtubules in vitro. J Mol Biol 1982, 159:125.
    • (1982) J Mol Biol , vol.159 , pp. 125
    • Wilson, L.1    Jordan, M.A.2    Morse, A.3
  • 250
    • 0013798203 scopus 로고
    • Effects of vinblastine on the proliferative capacity of L cells and their progress through the division cycle
    • Bruchovsky N, Owen AA, Becker AJ, et al. Effects of vinblastine on the proliferative capacity of L cells and their progress through the division cycle. Cancer Res 1965, 25:1232.
    • (1965) Cancer Res , vol.25 , pp. 1232
    • Bruchovsky, N.1    Owen, A.A.2    Becker, A.J.3
  • 251
    • 0017753733 scopus 로고
    • Correlation of cytotoxicity and mitotic spindle dissolution by vinblastine in mammalian cells
    • Tucker RW, Owellen RJ, Harris SB Correlation of cytotoxicity and mitotic spindle dissolution by vinblastine in mammalian cells. Cancer Res 1977, 37:4346.
    • (1977) Cancer Res , vol.37 , pp. 4346
    • Tucker, R.W.1    Owellen, R.J.2    Harris, S.B.3
  • 253
    • 61749104434 scopus 로고    scopus 로고
    • Dose-escalating vinblastine for the treatment of canine mast cell tumour
    • Vickery KR, Wilson H, Vail DM, et al. Dose-escalating vinblastine for the treatment of canine mast cell tumour. Vet Comp Oncol 2008, 6:111.
    • (2008) Vet Comp Oncol , vol.6 , pp. 111
    • Vickery, K.R.1    Wilson, H.2    Vail, D.M.3
  • 254
    • 42449147096 scopus 로고    scopus 로고
    • A phase II clinical trial of vinorelbine in dogs with cutaneous mast cell tumors
    • Grant IA, Rodriguez CO, Kent MS, et al. A phase II clinical trial of vinorelbine in dogs with cutaneous mast cell tumors. J Vet Intern Med 2008, 22:388.
    • (2008) J Vet Intern Med , vol.22 , pp. 388
    • Grant, I.A.1    Rodriguez, C.O.2    Kent, M.S.3
  • 255
    • 4243200414 scopus 로고    scopus 로고
    • Toxicity, dosage, and efficacy of vinorelbine (Navelbine) in dogs with spontaneous neoplasia
    • Poirier VJ, Burgess KE, Adams WM, et al. Toxicity, dosage, and efficacy of vinorelbine (Navelbine) in dogs with spontaneous neoplasia. J Vet Intern Med 2004, 18:536.
    • (2004) J Vet Intern Med , vol.18 , pp. 536
    • Poirier, V.J.1    Burgess, K.E.2    Adams, W.M.3
  • 256
    • 0021240783 scopus 로고
    • Inhibition of the DNA catenation activity of type II topoisomerase by VP16-213 and VM26
    • Minocha A, Long BH Inhibition of the DNA catenation activity of type II topoisomerase by VP16-213 and VM26. Biochem Biophys Res Commun 1984, 122:165.
    • (1984) Biochem Biophys Res Commun , vol.122 , pp. 165
    • Minocha, A.1    Long, B.H.2
  • 257
    • 0021749639 scopus 로고
    • Nonintercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II
    • Chen GL, Yang L, Rowe TC, et al. Nonintercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II. J Biol Chem 1984, 259:13560.
    • (1984) J Biol Chem , vol.259 , pp. 13560
    • Chen, G.L.1    Yang, L.2    Rowe, T.C.3
  • 258
    • 0021864097 scopus 로고
    • Single- and double-strand DNA breakage and repair in human lung adenocarcinoma cells exposed to etoposide and teniposide
    • Long BH, Musial ST, Brattain MG Single- and double-strand DNA breakage and repair in human lung adenocarcinoma cells exposed to etoposide and teniposide. Cancer Res 1985, 45:3106.
    • (1985) Cancer Res , vol.45 , pp. 3106
    • Long, B.H.1    Musial, S.T.2    Brattain, M.G.3
  • 259
    • 0023275078 scopus 로고
    • Proliferation-dependent topoisomerase II content as a determinant of antineoplastic drug action in human, mouse, and Chinese hamster ovary cells
    • Sullivan DM, Latham MD, Ross WE Proliferation-dependent topoisomerase II content as a determinant of antineoplastic drug action in human, mouse, and Chinese hamster ovary cells. Cancer Res 1987, 47:3973.
    • (1987) Cancer Res , vol.47 , pp. 3973
    • Sullivan, D.M.1    Latham, M.D.2    Ross, W.E.3
  • 260
    • 56049116967 scopus 로고    scopus 로고
    • Oral bioavailability of etoposide after administration of a single dose to tumor-bearing dogs
    • Flory AB, Rassnick KM, Balkman CE, et al. Oral bioavailability of etoposide after administration of a single dose to tumor-bearing dogs. Am J Vet Res 2008, 69:1316.
    • (2008) Am J Vet Res , vol.69 , pp. 1316
    • Flory, A.B.1    Rassnick, K.M.2    Balkman, C.E.3
  • 261
    • 0038027882 scopus 로고    scopus 로고
    • Topoisomerase II inhibitors: epipodophyllotoxins, acridines, ellipticines, and bisdioxopiperazines
    • Lippincott Williams & Wilkins, Philadelphia, B.A. Chabner, D.L. Longo (Eds.)
    • Pommier YG, Goldwasser F, Strumberg D Topoisomerase II inhibitors: epipodophyllotoxins, acridines, ellipticines, and bisdioxopiperazines. Cancer chemotherapy & biotherapy: principles and practice 2001, Lippincott Williams & Wilkins, Philadelphia. B.A. Chabner, D.L. Longo (Eds.).
    • (2001) Cancer chemotherapy & biotherapy: principles and practice
    • Pommier, Y.G.1    Goldwasser, F.2    Strumberg, D.3
  • 262
    • 0015223972 scopus 로고
    • Glucocorticoid receptors in lymphoma cells in culture: relationship to glucocorticoid killing activity
    • Baxter JD, Harris AW, Tomkins GM, et al. Glucocorticoid receptors in lymphoma cells in culture: relationship to glucocorticoid killing activity. Science 1971, 171:189.
    • (1971) Science , vol.171 , pp. 189
    • Baxter, J.D.1    Harris, A.W.2    Tomkins, G.M.3
  • 263
    • 0036278515 scopus 로고    scopus 로고
    • Mechanisms of glucocorticoid-mediated apoptosis in hematological malignancies
    • Greenstein S, Ghias K, Krett NL, et al. Mechanisms of glucocorticoid-mediated apoptosis in hematological malignancies. Clin Cancer Res 2002, 8:1681.
    • (2002) Clin Cancer Res , vol.8 , pp. 1681
    • Greenstein, S.1    Ghias, K.2    Krett, N.L.3
  • 264
    • 0028067889 scopus 로고
    • Glucocorticoid receptors and resistance to glucocorticoids in hematologic malignancies
    • Moalli PA, Rosen ST Glucocorticoid receptors and resistance to glucocorticoids in hematologic malignancies. Leuk Lymphoma 1994, 15:363.
    • (1994) Leuk Lymphoma , vol.15 , pp. 363
    • Moalli, P.A.1    Rosen, S.T.2
  • 265
    • 0021894582 scopus 로고
    • Adducts of the antitumor drug cis-diamminedichloroplatinum(II) with DNA: formation, identification, and quantitation
    • Fichtinger-Schepman AM, van der Veer JL, Den Hartog JH, et al. Adducts of the antitumor drug cis-diamminedichloroplatinum(II) with DNA: formation, identification, and quantitation. Biochemistry 1985, 24:707.
    • (1985) Biochemistry , vol.24 , pp. 707
    • Fichtinger-Schepman, A.M.1    van der Veer, J.L.2    den Hartog, J.H.3
  • 266
    • 0018771949 scopus 로고
    • DNA-protein and DNA interstrand cross-linking by cis- and trans-platinum(II) diamminedichloride in L1210 mouse leukemia cells and relation to cytotoxicity
    • Zwelling LA, Anderson T, Kohn KW DNA-protein and DNA interstrand cross-linking by cis- and trans-platinum(II) diamminedichloride in L1210 mouse leukemia cells and relation to cytotoxicity. Cancer Res 1979, 39:365.
    • (1979) Cancer Res , vol.39 , pp. 365
    • Zwelling, L.A.1    Anderson, T.2    Kohn, K.W.3
  • 268
    • 0024440650 scopus 로고
    • Carboplatin dosage: prospective evaluation of a simple formula based on renal function
    • Calvert AH, Newell DR, Gumbrell LA, et al. Carboplatin dosage: prospective evaluation of a simple formula based on renal function. J Clin Oncol 1989, 7:1748.
    • (1989) J Clin Oncol , vol.7 , pp. 1748
    • Calvert, A.H.1    Newell, D.R.2    Gumbrell, L.A.3
  • 269
    • 9444220180 scopus 로고    scopus 로고
    • Effect of glomerular filtration rate on clearance and myelotoxicity of carboplatin in cats with tumors
    • Bailey DB, Rassnick KM, Erb HN, et al. Effect of glomerular filtration rate on clearance and myelotoxicity of carboplatin in cats with tumors. Am J Vet Res 2004, 65:1502.
    • (2004) Am J Vet Res , vol.65 , pp. 1502
    • Bailey, D.B.1    Rassnick, K.M.2    Erb, H.N.3
  • 270
    • 40549115331 scopus 로고    scopus 로고
    • Phase I clinical evaluation of carboplatin in tumor-bearing cats: a Veterinary Cooperative Oncology Group study
    • Kisseberth WC, Vail DM, Yaissle J, et al. Phase I clinical evaluation of carboplatin in tumor-bearing cats: a Veterinary Cooperative Oncology Group study. J Vet Intern Med 2008, 22:83.
    • (2008) J Vet Intern Med , vol.22 , pp. 83
    • Kisseberth, W.C.1    Vail, D.M.2    Yaissle, J.3
  • 271
    • 0022578537 scopus 로고
    • Evidence that the antitumor agent hydroxyurea enters mammalian cells by a diffusion mechanism
    • Morgan JS, Creasey DC, Wright JA Evidence that the antitumor agent hydroxyurea enters mammalian cells by a diffusion mechanism. Biochem Biophys Res Commun 1986, 134:1254.
    • (1986) Biochem Biophys Res Commun , vol.134 , pp. 1254
    • Morgan, J.S.1    Creasey, D.C.2    Wright, J.A.3
  • 272
    • 0014028243 scopus 로고
    • Meso-alpha, beta-diphenylsuccinate and hydroxyurea as inhibitors of deoxycytidylate synthesis in extracts of Ehrlich ascites and L cells
    • Turner MK, Abrams R, Lieberman I Meso-alpha, beta-diphenylsuccinate and hydroxyurea as inhibitors of deoxycytidylate synthesis in extracts of Ehrlich ascites and L cells. J Biol Chem 1966, 241:5777.
    • (1966) J Biol Chem , vol.241 , pp. 5777
    • Turner, M.K.1    Abrams, R.2    Lieberman, I.3
  • 273
    • 0015025261 scopus 로고
    • Effects of hydroxyurea and 1-beta-D-arabinofuranosyl-cytosine on deoxyribonucleotide pools in mouse embryo cells
    • Skoog L, Nordenskjold B Effects of hydroxyurea and 1-beta-D-arabinofuranosyl-cytosine on deoxyribonucleotide pools in mouse embryo cells. Eur J Biochem 1971, 19:81.
    • (1971) Eur J Biochem , vol.19 , pp. 81
    • Skoog, L.1    Nordenskjold, B.2
  • 274
    • 0020580432 scopus 로고
    • Inhibitor evidence for allosteric interaction in the replitase multienzyme complex
    • Veer Reddy GP, Pardee AB Inhibitor evidence for allosteric interaction in the replitase multienzyme complex. Nature 1983, 304:86.
    • (1983) Nature , vol.304 , pp. 86
    • Veer Reddy, G.P.1    Pardee, A.B.2
  • 275
    • 0023025598 scopus 로고
    • Changes of deoxyribonucleoside triphosphate pools induced by hydroxyurea and their relation to DNA synthesis
    • Bianchi V, Pontis E, Reichard P Changes of deoxyribonucleoside triphosphate pools induced by hydroxyurea and their relation to DNA synthesis. J Biol Chem 1986, 261:16037.
    • (1986) J Biol Chem , vol.261 , pp. 16037
    • Bianchi, V.1    Pontis, E.2    Reichard, P.3
  • 276
    • 77953948181 scopus 로고    scopus 로고
    • Phase II open-label study of single-agent hydroxyurea for treatment of mast cell tumours in dogs
    • Rassnick KM, Al-Sarraf R, Bailey DB, et al. Phase II open-label study of single-agent hydroxyurea for treatment of mast cell tumours in dogs. Vet Comp Oncol 2010, 8:103.
    • (2010) Vet Comp Oncol , vol.8 , pp. 103
    • Rassnick, K.M.1    Al-Sarraf, R.2    Bailey, D.B.3
  • 279
    • 0035887459 scopus 로고    scopus 로고
    • Molecular classification of human carcinomas by use of gene expression signatures
    • Su AI, Welsh JB, Sapinoso LM, et al. Molecular classification of human carcinomas by use of gene expression signatures. Cancer Res 2001, 61:7388.
    • (2001) Cancer Res , vol.61 , pp. 7388
    • Su, A.I.1    Welsh, J.B.2    Sapinoso, L.M.3
  • 280
    • 0033569406 scopus 로고    scopus 로고
    • Molecular classification of cancer: class discovery and class prediction by gene expression monitoring
    • Golub TR, Slonim DK, Tamayo P, et al. Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science 1999, 286:531.
    • (1999) Science , vol.286 , pp. 531
    • Golub, T.R.1    Slonim, D.K.2    Tamayo, P.3
  • 281
    • 0018179158 scopus 로고
    • The use of antiestrogens tamoxifen and nafoxidine in the treatment of human breast cancer in correlation with estrogen receptor values. A phase II study
    • Moseson DL, Sasaki GH, Kraybill WG, et al. The use of antiestrogens tamoxifen and nafoxidine in the treatment of human breast cancer in correlation with estrogen receptor values. A phase II study. Cancer 1978, 41:797.
    • (1978) Cancer , vol.41 , pp. 797
    • Moseson, D.L.1    Sasaki, G.H.2    Kraybill, W.G.3
  • 282
    • 77956030786 scopus 로고    scopus 로고
    • Inhibition of mutated, activated BRAF in metastatic melanoma
    • Flaherty KT, Puzanov I, Kim KB, et al. Inhibition of mutated, activated BRAF in metastatic melanoma. N Engl J Med 2010, 363:809.
    • (2010) N Engl J Med , vol.363 , pp. 809
    • Flaherty, K.T.1    Puzanov, I.2    Kim, K.B.3
  • 283
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy
    • Paez JG, Janne PA, Lee JC, et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 2004, 304:1497.
    • (2004) Science , vol.304 , pp. 1497
    • Paez, J.G.1    Janne, P.A.2    Lee, J.C.3
  • 284
    • 0022923890 scopus 로고
    • The mdr1 gene, responsible for multidrug-resistance, codes for P-glycoprotein
    • Ueda K, Cornwell MM, Gottesman MM, et al. The mdr1 gene, responsible for multidrug-resistance, codes for P-glycoprotein. Biochem Biophys Res Commun 1986, 141:956.
    • (1986) Biochem Biophys Res Commun , vol.141 , pp. 956
    • Ueda, K.1    Cornwell, M.M.2    Gottesman, M.M.3
  • 285
    • 0023996269 scopus 로고
    • Efficacy and toxicity of doxorubicin and cyclophosphamide used in the treatment of selected malignant tumors in 23 cats
    • Mauldin G, Matus R, Patnaik A, et al. Efficacy and toxicity of doxorubicin and cyclophosphamide used in the treatment of selected malignant tumors in 23 cats. J Vet Intern Med 1988, 2:60.
    • (1988) J Vet Intern Med , vol.2 , pp. 60
    • Mauldin, G.1    Matus, R.2    Patnaik, A.3
  • 286
    • 77954086743 scopus 로고    scopus 로고
    • Chemosensitivity testing with ChemoFx and overall survival in primary ovarian cancer
    • e1
    • Herzog TJ, Krivak TC, Fader AN, et al. Chemosensitivity testing with ChemoFx and overall survival in primary ovarian cancer. Am J Obstet Gynecol 2010, 203:68. e1.
    • (2010) Am J Obstet Gynecol , vol.203 , pp. 68
    • Herzog, T.J.1    Krivak, T.C.2    Fader, A.N.3
  • 287
    • 77955709396 scopus 로고    scopus 로고
    • Complete response of anaplastic pancreatic carcinoma to paclitaxel treatment selected by chemosensitivity testing
    • Wakatsuki T, Irisawa A, Imamura H, et al. Complete response of anaplastic pancreatic carcinoma to paclitaxel treatment selected by chemosensitivity testing. Int J Clin Oncol 2010, 15:310.
    • (2010) Int J Clin Oncol , vol.15 , pp. 310
    • Wakatsuki, T.1    Irisawa, A.2    Imamura, H.3
  • 288
    • 33749364367 scopus 로고    scopus 로고
    • In vitro drug sensitivity predicts response and survival after individualized sensitivity-directed chemotherapy in metastatic melanoma: a multicenter phase II trial of the Dermatologic Cooperative Oncology Group
    • Ugurel S, Schadendorf D, Pfohler C, et al. In vitro drug sensitivity predicts response and survival after individualized sensitivity-directed chemotherapy in metastatic melanoma: a multicenter phase II trial of the Dermatologic Cooperative Oncology Group. Clin Cancer Res 2006, 12:5454.
    • (2006) Clin Cancer Res , vol.12 , pp. 5454
    • Ugurel, S.1    Schadendorf, D.2    Pfohler, C.3
  • 289
    • 15944422808 scopus 로고    scopus 로고
    • Prediction of individual response to chemotherapy in patients with acute myeloid leukaemia using the chemosensitivity index Ci
    • Staib P, Staltmeier E, Neurohr K, et al. Prediction of individual response to chemotherapy in patients with acute myeloid leukaemia using the chemosensitivity index Ci. Br J Haematol 2005, 128:783.
    • (2005) Br J Haematol , vol.128 , pp. 783
    • Staib, P.1    Staltmeier, E.2    Neurohr, K.3
  • 290
    • 34548799629 scopus 로고    scopus 로고
    • A strategy for predicting the chemosensitivity of human cancers and its application to drug discovery
    • Lee JK, Havaleshko DM, Cho H, et al. A strategy for predicting the chemosensitivity of human cancers and its application to drug discovery. Proc Natl Acad Sci U S A 2007, 104:13086.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 13086
    • Lee, J.K.1    Havaleshko, D.M.2    Cho, H.3
  • 292
    • 78651246674 scopus 로고    scopus 로고
    • Retraction: Genomic signatures to guide the use of chemotherapeutics
    • Potti A, Dressman HK, Bild A, et al. Retraction: Genomic signatures to guide the use of chemotherapeutics. Nat Med 2011, 17:135.
    • (2011) Nat Med , vol.17 , pp. 135
    • Potti, A.1    Dressman, H.K.2    Bild, A.3
  • 293
    • 79251528216 scopus 로고    scopus 로고
    • Retraction-Validation of gene signatures that predict the response of breast cancer to neoadjuvant chemotherapy: a substudy of the EORTC 10994/BIG 00-01 clinical trial
    • Bonnefoi H, Potti A, Delorenzi M, et al. Retraction-Validation of gene signatures that predict the response of breast cancer to neoadjuvant chemotherapy: a substudy of the EORTC 10994/BIG 00-01 clinical trial. Lancet Oncol 2011, 12:116.
    • (2011) Lancet Oncol , vol.12 , pp. 116
    • Bonnefoi, H.1    Potti, A.2    Delorenzi, M.3
  • 294
    • 77951163222 scopus 로고    scopus 로고
    • Deriving chemosensitivity from cell lines: Forensic bioinformatics and reproducible research in high-throughput biology
    • Baggerly KA, Coombes KR Deriving chemosensitivity from cell lines: Forensic bioinformatics and reproducible research in high-throughput biology. Ann Appl Stat 2009, 3:1309.
    • (2009) Ann Appl Stat , vol.3 , pp. 1309
    • Baggerly, K.A.1    Coombes, K.R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.