A piperidine alkaloid and limonoids from arisaema decipiens, a traditional antitumor herb used by the dong people

Archives of Pharmacal Research

Volumn 33, Issue 11, 2010, Pages 1735-1739

  Zhao, Fu Wei ^a,b   Luo, Min ^c   Wang, Yue Hu ^a   Li, Ma Lin ^c   Tang, Gui Hua ^a,b   Long, Chun Lin ^a,d  

^a KUNMING INSTITUTE OF BOTANY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c KUNMING MEDICAL UNIVERSITY   (China)

^d MINZU UNIVERSITY OF CHINA   (China)

Author keywords

( ) (2R; ) N,2 Dimethyl 3 hydroxy 6 (9 phenylnonyl); ,3S; ,6S; Antitumor activity; Araceae; Arisaema decipiens Schott; Limonoids

Indexed keywords

28 DEOXONIMBOLIDE; 6 DEACETYLNIMBIN; ARISAEMA DECIPIENS EXTRACT; DOXORUBICIN; LIMONOID; N 2 DIMETHYL 3 HYDROXY 6 (9 PHENYLNONYL)PIPERIDINE; NIMBIN; PIPERIDINE DERIVATIVE; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARISAEMA; ARISAEMA DECIPIENS; ARTICLE; CANCER CELL CULTURE; CHINA; CONTROLLED STUDY; CYTOTOXICITY; DRUG ISOLATION; ETHNIC GROUP; HERB; HUMAN; HUMAN CELL; IC 50; RHIZOME;

ALKALOIDS; ANTINEOPLASTIC AGENTS; ARISAEMA; BREAST NEOPLASMS; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; DRUGS, CHINESE HERBAL; ETHNIC GROUPS; FEMALE; HUMANS; LIMONINS; MAGNETIC RESONANCE IMAGING; OVARIAN NEOPLASMS; PIPERIDINES; RHIZOME;

EID: 78751659287     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-010-1104-6     Document Type: Article

References (26)

1. Akhila, A. and Rani, K., Chemistry of the neem tree (Azadir-achta indica A Juss). In: H. W. (Ed.), Progress in the Chem-istry of Organic Natural Products. Springer-Verlag Wien, New York, pp. 47-149, (1999).
2. Akhila, A. and Rani, K., Biosynthesis of some biologically active limonoids in the leaves of Azadirachta indica (the Indian neem tree). Indian J. Heterocycl. Chem. 11, 299-302 (2002).
3. Bokel, M., Cramer, R., Gutzeit, H., Reeb, S., and Kraus, W., Tetranortriterpenoids related to nimbin and nimbolide from Azadirachta indica A. Juss (Meliaceae). Tetrahedron, 46, 775-782 (1990).
4. Chinese Pharmacopoeia Committee (Ed.), Chinese Pharma-copoeia. Chemical Industry Press, Beijing, (2005).
5. Cohen, E., Quistad, G. B., and Casida, J. E., Cytotoxicity of nimbolide, epoxyazadiradione and other limonoids from neem insecticide. Life Sci., 58, 1075-1081 (1996a).
6. Cohen, E., Quistad, G. B., Jefferies, P. R., and Casida, J. E., Nimbolide is the principal cytotoxic component of neem-seed insecticide preparations. Pestic Sci., 48, 135-140 (1996b).
7. Cui, B. L., Chai, H., Constant, H. L., Santisuk, T., Reutrakul, V., Beecher, C. W. W., Farnsworth, N. R., and Cordell, G. A., Limonoids from Azadirachta excelsa. Phytochemistry, 47, 1283-1287 (1998).
8. Dhuna, V., Singh, J., Saxena, A. K., and Kamboj, S. S., Puri-fication and characterization of a novel monocot lectin with mitogenic and in vitro anti-proliferative activity from Arisaema curvatum. Eur. J. Cancer, Suppl. 6, 42 (2008).
9. Garrido, L., Zubia, E., Ortega, M. J., and Salva, J., Haou-amines A and B: A new class of alkaloids from the asci-dian Aplidium haouarianum. J. Org. Chem., 68, 293-299 (2003).
10. Jung, J. H., Jee, H., and Kang, S. S., Diacylglycerylgalacto-sides from Arisaema amurense. Phytochemistry, 42, 447-452 (1996a).
11. Jung, J. H., Lee, C. O., Kim, Y. C., and Kang, S. S., New-bioactive cerebrosides from Arisaema amurense. J. Nat Prod., 59, 319-322 (1996b).
12. Kaur, M., Singh, K., Rup, P. J., Saxena, A. K, Khan, R. H., Ashraf, M. T., Kamboj, S. S., and Singh, J., A tuber lectin from Arisaema helleborifolium Schott with anti-insect activity against melon fruit fly, Bactrocera cucurbitae (Coquillett) and anti-cancer effect on human cancer cell lines. Arch. Biochem. Biophys., 445, 156-165 (2006).
13. Kigodi, P. G. K, Blasko, G., Thebtaranonth, Y., Pezzuto, J. M., and Cordell, G. A., Spectroscopic and biological in-vestigation of nimbolide and 28-deoxonimbolide from Azadirachta indica. J. Nat Prod., 52, 1246-1251 (1989).
14. Lai, C. S, Mas, R. H. M. H, Nair, N. K., Mansor, S. M, and Navaratnam, V., Chemical constituents and in vitro anticancer activity of Typhonium flagelliforme (Araceae). J. Ethnopharmacol., 127, 486-494 (2010).
15. Li, H. (Ed.), Flora of China (volume 13). Science Press, Beijing, (1979).
16. Li, H. and Long, C. L., A preliminary revision of Araceae of China. Acta Bot. Yunnan., Suppl. XI, 12-23 (1998).
17. Luo, X. D., Wu, S. H., Ma, Y. B., and Wu, D. G., Tetranortriterpenoids from insecticidal fraction of Azadirachta indica. Nat Prod. Res. Dev., 13, 9-13 (2001).
18. Melhaoui, A., Jossang, A., and Bodo, B., Structure of irniine, a pyrrolidine alkaloid from Arisarum vulgare. J. Nat Prod., 55, 950-952 (1992).
19. Melhaoui, A. and Bodo, B., Irnigaine and N-Methylirnigaine, two new piperidinol alkaloids from the tubers of Arisarum vulgare. Nat Prod. Lett., 7, 101-108 (1995).
20. Melhaoui, A. and Belouali, H., DNA affinity of active alkaloids from Arisarum vulgare Targ. J. Ethnopharmacol., 62, 67-71 (1998).
21. Morita, H., Yoshida, N., and Kobayashi, J., Daphnezomines A and B, novel alkaloids with an aza-adamantane core from Daphniphyllum humile. J. Org. Chem., 64, 7208-7212 (1999).
22. Pezzuto, J. M., Che, C.-T., McPherson, D. D., Zhu, J.-P., Topcu, G., Erdelmeier, C. A. J., and Cordell, G. A., DNA as an affinity probe useful in the detection and isolation of biologically active natural products. J. Nat Prod., 54, 1522-1530 (1991).
23. Roy, A. and Saraf, S., Limonoids: Overview of significant bioactive triterpenes distributed in plants kingdom. Biol. Pharm. Bull., 29, 191-201 (2006).
24. Singh, J., Singh, J., and Kamboj, S. S., A novel mitogenic and antiproliferative lectin from a wild cobra lily, Arisaema flavum. Biochem. Biophys. Res. Commun., 318, 1057-1065 (2004).
25. th Academic Lecture of College of Science and Technology, Nihon University, College of Science and Technology, Nihon University, Tokyo, pp. 1150-1151, (2009).
26. Vichai, V. and Kirtikara, K., Sulforhodamine B colorimetric assay for cytotoxicity screening. Nat Protoc, 1, 1112-1116 (2006).