Ethnobotanical approach versus random approach in the search for new bioactive compounds: Support of a hypothesis

Pharmaceutical Biology

Volumn 50, Issue 1, 2012, Pages 30-41

  Gyllenhaal, C ^a   Kadushin, M R ^a,b   Southavong, B ^c   Sydara, K ^c   Bouamanivong, S ^d   Xaiveu, M ^c   Xuan, L T ^e   Hiep, N T ^e   Hung, N V ^e   Loc, P K ^e   Dac, L X ^e   Bich, T Q ^f   Cuong, N M ^f   Ly, H M ^g   Zhang, H J ^a   Franzblau, S G ^a   Xie, H ^a   Riley, M C ^a   Elkington, B G ^a   Nguyen, H T ^a   Waller, D P ^a   Ma, C Y ^h   Tamez, P ⁱ   Tan, G T ^j   Pezzuto, J M ^j   Soejarto, D D ^a,b   more..

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b FIELD MUSEUM OF NATURAL HISTORY   (United States)

^c Ministry of Health   (Laos)

^d National Science Council   (Laos)

^e GRADUATE UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Viet Nam)

^f Cuc Phuong National Park   (Viet Nam)

^g National Institute of Health and Epidemics   (Viet Nam)

^h US Pharmacopoeia   (United States)

ⁱ UNIVERSITY OF NOTRE DAME   (United States)

^j UNIVERSITY OF HAWAII AT HILO   (United States)

more..

Author keywords

Cancer; Chemoprevention; Drug discovery; HIV; Laos; Malaria; Screening; Traditional medicine; Tuberculosis; Vietnam

Indexed keywords

PLANT EXTRACT;

ARTICLE; BIOASSAY; CANCER PREVENTION; CONTROLLED STUDY; DRUG DETERMINATION; DRUG RESEARCH; DRUG SCREENING; ETHNOBOTANY; HUMAN IMMUNODEFICIENCY VIRUS; LAOS; MALARIA; MEDICINAL PLANT; TRADITIONAL MEDICINE; TUBERCULOSIS; VIET NAM;

BIOLOGICAL ASSAY; DRUG DISCOVERY; ETHNOBOTANY; ETHNOPHARMACOLOGY; HUMANS; LAOS; MEDICINE, TRADITIONAL; PLANT EXTRACTS; PLANTS, MEDICINAL; VIETNAM;

EID: 84555196624     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.3109/13880209.2011.634424     Document Type: Article

References (33)

1. Cragg GM, Grothaus PG, Newman DJ. (2009). Impact of natural products on developing new anti-cancer agents. Chem Rev, 109, 3012-3043.
2. Elkington BG, Southavong B, Sydara K, Souliya O, Vanthanouvong M, Nettavong K, Tammachack B, Pak DH, Riley MC, Franzblau SG, Soejarto DD. (2009). Biological evaluation of plants of Laos used in the treatment of tuberculosis in Lao traditional medicine. Pharm Biol, 47, 26-33.
3. Farnsworth NR. (1994). Ethnopharmacology and drug development. Ciba Found Symp, 185, 42-51; discussion 51.
4. Gertsch J. (2009). How scientifc is the science in ethnopharmacology? Historical perspectives and epistemological problems. J Ethnopharmacol, 122, 177-183.
5. He ZD, Ma CY, Zhang HJ, Tan GT, Tamez P, Sydara K, Bouamanivong S, Southavong B, Soejarto DD, Pezzuto JM, Fong HH. (2005). Antimalarial constituents from Nauclea orientalis (L.) L. Chem Biodivers, 2, 1378-1386. (Pubitemid 41645372)
6. He ZD, Ma CY, Tan GT, Sydara K, Tamez P, Southavong B, Bouamanivong S, Soejarto DD, Pezzuto JM, Fong HH, Zhang HJ. (2006). Rourinoside and rouremin, antimalarial constituents from Rourea minor. Phytochemistry, 67, 1378-1384. (Pubitemid 44137288)
7. Jutiviboonsuk A, Zhang H, Tan GT, Ma C, Van Hung N, Manh Cuong N, Bunyapraphatsara N, Soejarto DD, Fong HH. (2005). Bioactive constituents from roots of Bursera tonkinensis. Phytochemistry, 66, 2745-2751. (Pubitemid 41727661)
8. Leonti M. (2011). Te future is written: Impact of scripts on the cognition, selection, knowledge and transmission of medicinal plant use and its implications for ethnobotany and ethnopharmacology. J Ethnopharmacol, 134, 542-555.
9. Ma C, Case RJ, Wang Y, Zhang HJ, Tan GT, Van Hung N, Cuong NM, Franzblau SG, Soejarto DD, Fong HH, Pauli G F. (2005). Anti-tuberculosis constituents from the stem bark of Micromelum hirsutum. Planta Med, 71, 261-267. (Pubitemid 40476784)
10. Ma C, Zhang HJ, Tan GT, Hung NV, Cuong NM, Soejarto DD, Fong HH. (2006). Antimalarial compounds from Grewia bilamellata. J Nat Prod, 69, 346-350.
11. Ma CY, Musoke SF, Tan GT, Sydara K, Bouamanivong S, Southavong B, Soejarto DD, Fong HH, Zhang HJ. (2008). Study of antimalarial activity of chemical constituents from Diospyros quaesita. Chem Biodivers, 5, 2442-2448.
12. Moerman DE, Pemberton RW, Kiefer D, Berlin B. (1999). A comparative analysis of fve medicinal foras. J Ethnobiol, 19, 49-67.
13. Nguyen QC, Nguyen VH, Santarsiero BD, Mesecar AD, Nguyen MC, Soejarto DD, Pezzuto JM, Fong HH, Tan GT. (2004). New 3-O-acyl betulinic acids from Strychnos vanprukii Craib. J Nat Prod, 67, 994-998. (Pubitemid 38823332)
14. Preacher KJ. (2001). Calculation for the chi-square test: An interactive calculation tool for Chi-square tests of goodness of ft and independence Computer software. Available at http://quantpsy. org and http://quantpsy.org/ chisq/chisq.htm. Accessed on 9/22/2011.
15. Riley MC. (2001). Traditional Medicine Research Center (TMRC): A potential tool for protecting Traditional and Tribal Medicinal knowledge in Laos. Cultural Survival Quart, 24, 21-24.
16. Soejarto DD, Gyllenhaal C, Regalado JC, Pezzuto JM, Fong HHS, Tan GT, Hiep NT, Xuan LT, Binh DQ, Hung NV, Bich TQ, Tin NN, Loc PK, Vu BM., Southavong BH, Sydara K, Bouamanivong S, O'Neill MJ, Lewis J, Xie X, Dietzman G. (1999). Studies on biodiversity of Vietnam and Laos: A UIC-based ICBG Program. Pharm Biol, 37 (Supplement), 1-14. Available online at http://www.uic.edu/pharmacy/ depts/ICBG/UIC-ICBG-Pbiol-1999-.pdf. Accessed on 9/22/2011.
17. Soejarto DD, Gyllenhaal C, Regalado JC, Pezzuto JM, Fong HHS, Tan GT, Hiep NT, Xuan,LT, Hung NV, Bich TQ, Loc PK, Vu BM, Southavong BH, Sydara K, Bouamanivong S, O'Neill MJ, Dietzman G. (2002). An international collaborative program to discover new drugs from tropical biodiversity of Vietnam and Laos. Nat Prod Sci, 8, 1-15. (Pubitemid 34408000)
18. Soejarto DD, Hiep NT, Loc PK, Cuong NM, Bien LK, Dai TD, Kadushin, MR. (2004a) Seed Plants of Cuc Phuong National Park, Vietnam. A Documented Checklist. Published by Cuc Phuong National Park, Ninh Binh, Vietnam. Agricultural Publishing House, Hanoi, Vietnam, i-xxxiv, 1-760, plates I-XCIX.
19. Soejarto DD, Gyllenhaal C, Fong HH, Xuan LT, Hiep NT, Hung NV, Bich TQ, Southavong B, Sydara K, Pezzuto JM. (2004b). Te UIC ICBG (University of Illinois at Chicago International Cooperative Biodiversity Group) Memorandum of Agreement: A model of beneft-sharing arrangement in natural products drug discovery and development. J Nat Prod, 67, 294-299. (Pubitemid 38282921)
20. Soejarto DD, Fong HHS, Tan GT, Zhang HJ, Ma CY, Franzblau SG, Gyllenhaal C, Riley MC, Kadushin MR, Pezzuto JM, Xuan LT, Hiep NT, Hung NV, Vu BM, Loc PK, Dac LX, Binh LT, Chien NQ, Hai NV, Bich TQ, Cuong NM, Southavong B, Sydara K, Bouamanivong S, Ly HM, Tuy T V, Rose WC, Dietzman GR. (2006). Studies on Biodiversity of Vietnam and Laos 1998-2005: Examining the impact. J Nat Prod, 69 (Special Issue), 473-481. Available online at http://pubget.com/paper/16562860. Accessed on 9/22/2011.
21. Soejarto DD, Gyllenhaal C, Tarzian Sorensen JA, Fong HHS, Xuan LT, Binh LT, Hiep NT, Hung NV, Bich TQ, Vu BM, Southavong BV, Sydara K, Pezzuto JM, Riley MC. (2007). Bioprospecting Arrangements: Cooperation Between the North and the South. In: Intellectual Property Management in Health and Agricultural Innovation: A Handbook of Best Practices, Krattiger A, Mahoney RT, Nelsen L, et al., Eds. MIHR: Oxford, U.K., and PIPRA: Davis, U.S.A. Available online at www.ipHandbook.org. Accessed on 9/22/2011.
22. Soejarto DD, Southavong B, Sydara K, Bouamanivong S, Riley MC, Libman A, Kadushin MR, Gyllenhaal C. (2009). Studies on medicinal plants of Laos: A collaborative program between the University of Illinois at Chicago (UIC) and the Traditional Medicine Research Center (TMRC), Lao PDR: Accomplishments. In: Contemporary Lao Studies: Research on Development, Culture, Language, and Traditional Medicine, pp. 307-323. Center for Laos Studies, San Francisco, and Center for Southeast Asian Studies, Norhern Illinois University, De Kalb, Illinois. Selected Papers from the First International Conference on Lao Studies, De Kalb, Illinois, May 20-22, 2005.
23. Soejarto DD, Gyllenhaal C, Kadushin MR, Southavong B, Sydara K, Bouamanivong S, Xaiveu M, Zhang HJ, Rong L, Franzblau SG, Fong HHS, Riley MC, Elkington BG, Waller DP. (2012). An ethnobotanical survey of medicinal plants of Laos toward the discovery of bioactive compounds as potential candidates for pharmaceutical development. Pharm Biol 50.
24. Spjut RW. (2005). Relationships between plant folklore and antitumor activity: An historical review. Sida, 2, 2205-2241. (Pubitemid 43111579)
25. Svetaz L, Zuljan F, Derita M, Petenatti E, Tamayo G, Cáceres A, Cechinel Filho V, Giménez A, Pinzón R, Zacchino SA, Gupta M. (2010). Value of the ethnomedical information for the discovery of plants with antifungal properties. A survey among seven Latin American countries. J Ethnopharmacol, 127, 137-158.
26. Tan AC, Konczak I, Sze DM, Ramzan I. (2011). Molecular pathways for cancer chemoprevention by dietary phytochemicals. Nutr Cancer, 63, 495-505.
27. Truong NB, Pham CV, Doan HT, Nguyen HV, Nguyen CM, Nguyen HT, Zhang HJ, Fong HH, Franzblau SG, Soejarto DD, Chau MV. (2011). Antituberculosis cycloartane triterpenoids from Radermachera boniana. J Nat Prod, 74, 1318-1322.
28. Yuan J, Johnson RL, Huang R, Wichterman J, Jiang H, Hayton K, Fidock DA, Wellems TE, Inglese J, Austin CP, Su XZ. (2009). Genetic mapping of targets mediating diferential chemical phenotypes in Plasmodium falciparum. Nat Chem Biol, 5, 765-771.
29. Zhang HJ, Tamez PA, Aydogmus Z, Tan GT, Saikawa Y, Hashimoto K, Nakata M, Hung NV, Xuan le T, Cuong NM, Soejarto DD, Pezzuto JM, Fong HH. (2002). Antimalarial agents from plants. III. Trichothecenes from Ficus fstulosa and Rhaphidophora decursiva. Planta Med, 68, 1088-1091. (Pubitemid 36140313)
30. Zhang H-J, Tan GT, Hoang VD, Hung NV, Cuong NM, Soejarto DD, Pezzuto JM, Fong HHS. (2003a). Natural anti-HIV agents. Part III. Litseaverticillols A-H, novel sesquiterpenes from Litsea verticillata. Tetrahedron 59, 141-148. (Pubitemid 36015757)
31. Zhang HJ, Tan GT, Hoang VD, Hung NV, Cuong NM, Soejarto DD, Pezzuto JM, Fong HH. (2003b). Natural anti-HIV agents. Part IV. Anti-HIV constituents from Vatica cinerea. J Nat Prod, 66, 263-268. (Pubitemid 36278242)
32. Zhang HJ, Sydara K, Tan GT, Ma C, Southavong B, Soejarto DD, Pezzuto JM, Fong HH. (2004). Bioactive constituents from Asparagus cochinchinensis. J Nat Prod, 67, 194-200. (Pubitemid 38282908)
33. Zhang HJ, Ma C, Nguyen VH, Nguyen MC, Tan GT, Santarsiero BD, Mesecar AD, Soejarto DD, Pezzuto JM, Fong HH. (2006). Miliusanes, a class of cytotoxic agents from Miliusa sinensis. J Med Chem, 49, 693-708. (Pubitemid 43157499)