Infection of human islets of langerhans with two strains of coxsackie B virus serotype 1: Assessment of virus replication, degree of cell death and induction of genes involved in the innate immunity pathway

Journal of Medical Virology

Volumn 86, Issue 8, 2014, Pages 1402-1411

  Anagandula, Mahesh ^a   Richardson, Sarah J ^b   Oberste, M Steven ^c   Sioofy Khojine, Amir Babak ^d   Hyöty, Heikki ^d,e   Morgan, Noel G ^b   Korsgren, Olle ^a   Frisk, Gun ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b UNIVERSITY OF EXETER MEDICAL SCHOOL   (United Kingdom)

^c CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^d TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^e PIRKANMAA HOSPITAL DISTRICT   (Finland)

Author keywords

Enterovirus; Human pancreatic islets; Innate immunity; RNA sensors; Type 1 diabetes

Indexed keywords

2',5' OLIGOADENYLATE SYNTHETASE; BETA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GLUCAGON; HELICASE; INSULIN; INTERFERON; INTERFERON INDUCED WITH HELICASE C DOMAIN 1; RANTES; RETINOIC ACID INDUCIBLE PROTEIN I; TOLL LIKE RECEPTOR 3; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DEATH; CONTROLLED STUDY; COXSACKIE VIRUS B; CYTOPATHOGENIC EFFECT; DISEASE PREDISPOSITION; DONOR; GENE EXPRESSION; GENE INDUCTION; GENETIC VARIABILITY; HORMONE SYNTHESIS; HUMAN; HUMAN TISSUE; INNATE IMMUNITY; INSULIN DEPENDENT DIABETES MELLITUS; ISOLATED PANCREAS ISLET; NONHUMAN; PANCREAS ISLET; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; PURIFICATION; SEROTYPE; VIRUS INFECTION; VIRUS REPLICATION; VIRUS STRAIN; BIOSYNTHESIS; ENTEROVIRUS; GENE EXPRESSION PROFILING; HOST PATHOGEN INTERACTION; IMMUNOLOGY; PHYSIOLOGY; VIRAL TROPISM; VIROLOGY;

CELL DEATH; CYTOPATHOGENIC EFFECT, VIRAL; ENTEROVIRUS B, HUMAN; GENE EXPRESSION PROFILING; GLUCAGON; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNITY, INNATE; INSULIN; ISLETS OF LANGERHANS; VIRAL TROPISM; VIRUS REPLICATION;

EID: 84901842522     PISSN: 01466615     EISSN: 10969071     Source Type: Journal    
DOI: 10.1002/jmv.23835     Document Type: Article

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