Fission reactor-based irradiation facilities for neutron capture therapy

Neutron Capture Therapy: Principles and Applications

Volumn 9783642313349, Issue , 2012, Pages 19-40

  Harling, Otto K ^a   Riley, Kent J ^b  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84901821781     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-3-642-31334-9_2     Document Type: Chapter

References (59)

1. Akutsu H, Yamamoto T, Matsumura A, Shibata Y, Nakai K, Yasuda S, Matsushita A, Nose T, Yamamoto K, Kumada H, Hori N, Torii Y (2000) In: 9th international symposium on neutron capture therapy. International Society for Neutron Capture Therapy, Osaka, 2000, pp 199-200
2. Auterinen I, Hiismäki P, Kotiluoto P, Rosenberg RJ, Salmenhara S, Seppälä T, Seren T, Tanner V, Aschan C, Kortesniemi M, Kosunen A, Lampinen J, Savolainen S, Toivonen M, Välimäki P (2001) Metamorphosis of a 35 year-old TRIGA reactor into a modern BNCT facility. In: Hawthorne MF (ed) Frontiers in neutron capture therapy, vol I. Kluwer Academic/Plenum Publishers, New York, pp 267-275
3. Auterinen I, Kotiluoto P, Hippelaïnen E, Kortesniemi M, Seppälä T, Serén T, Mannila V, Poÿry P, Kankaanranta L, Collan J, Kouri M, Joensuu H, Savolainen S (2004) Design and construction of shoulder recesses into the beam aperture shields for improved patient positioning at thefiR1 BNCT facility. Appl Radiat Isot 61:799-803
4. Binns PJ, Riley KJ, Harling OK (2005) Epithermal neutron beams for clinical studies of boron neutron capture therapy: a dosimetric comparison of seven beams. Radiat Res 164:212-220
5. Binns PJ, Riley KJ, Ostrovsky Y, Gao W, Albritton JR, Kiger WS III, Harling OK (2007) Improved dose targeting for a clinical epithermal neutron capture beam using optional 6 Li fi ltration. Int J Radiat Oncol Biol Phys 67:1484-1491
6. Bisceglie E, Colangelo P, Colonna N, Santorelli P, Variale V (2000) On the optimal energy of epithermal neutron beams for BNCT. Phys Med Biol 45:49-58
7. Blaumann HR, Calzetta-Larrieu O, Longhino JM, Albornoz AF (2001) NCT facility development and beam characterization at the RA-6 reactor. In: Hawthorne MF, Shelly K, Wiersema RJ (eds) Frontiers in neutron capture therapy, 1st edn. Kluwer Academic/Plenum Publishers, New York, pp 313-317
8. Bleuel DL, Donahue RJ, Ludewigt BA, Vujic J (1998) Designing accelerator-based epithermal neutron beams for boron neutron capture therapy. Med Phys 25:1725-1734
9. Brugger RM, Constantine G, Harling OK, Wheeler FJ (1990) Rapporteurs' report. In: Harling OK, Bernard JA, Zamenhof RG (eds) Neutron beam, design, development and performancefor neutron capture therapy. Plenum Press, New York, p 54
10. Burlon AA, Kreiner AJ (2008) A comparison between a TESQ accelerator and a reactor as a neutron sources for BNCT. Nucl Instrum Methods Phys Res B 266:763-771
11. Burn KW, Casalini L, Martini S, Mazzini M, Nava E, Petrovich E, Rosi G, Sarotto M, Tinti R (2004) An epithermal facility for treating brain gliomas at the TAPIRO reactor. Appl Radiat Isot 61:987-991
12. Capala JA, Stenstam BH, Sköld K, Munckaf Rosenschöld P, Giusti V, Persson C, Wallin E, Brun A, Franzen L, Carlsson J, Salford L, Ceberg C, Persson B, Pellettieri L, Henriksson R (2003) Boron neutron capture therapy for glioblastoma multiforme: clinical studies in Sweden. J Neurooncol 62:135-144
13. Clement SD, Choi JR, Zamenhof RG, Harling OK (1990) Monte Carlo methods of neutron beam design for neutron capture therapy at the MITR-II. In: Harling OK, Bernard JA, Zamenhof RG (eds) Neutron beam, design, development and performancefor neutron capture therapy. Plenum Press, New York, pp 51-70
14. Coderre JA, Makar MS, Micca PL, Nawrocky MM, Liu HB, Joel DD, Slatkin DN, Amols HI (1993) Derivations of relative biological effectiveness for the high-LET radiations produced during boron neutron capture irradiations of the 9L rat gliosarcoma in vitro and in vivo. Radiat Res 27:1121-1129
15. Culbertson CN, Green S, Mason AJ, Picton D, Baugh G, Hugtenburg RP, Yin Z, Scott MC, Nelson JM (2004) In-phantom characterization studies at the Birmingham acceleratorgenerated epithermal neutron source (BAGINS) BNCT facility. Appl Radiat Isot 61: 734-738
16. Farr LE, Sweet WH, Robertson JS, Foster CG, Locksley HB, Sutherland DL, Mendelsohn ML, Stickley EE (1954) Neutron capture therapy with boron in the treatment of glioblastoma multiforme. Am J Roentgenol Radium Ther Nucl Med 71:279-293
17. Godel JB (1960) Description of facilities and mechanical components, medical research reactor (MRR) Brookhaven National laboratory, BNL-600, Brookhaven National Laboratory, Upton.
18. Goorley JT, Kiger WS III, Zamenhof RG (2002) Reference dosimetry calculations for neutron capture therapy with comparison of analytical and voxel models. Med Phys 29:145-156
19. Guotu K, Ziyong, S, Feng, S (2009) The study of physics and thermal characteristics for in hospital neutron irradiator (IHNI). Appl Radiat Isot 67:S234-S7
20. Harling OK, Riley KJ (2003) Fission reactor neutron sources for neutron capture therapy-a critical review. J Neurooncol 62:7-17
21. Harling OK, Moulin SJ, Chabeuf JM, Solares GS (1995) On-line beam monitoring for neutron capture therapy at the MIT research reactor. Nucl Instrum Methods Phys Res B 101:464
22. Harling OK, Riley KJ, Newton TH, Wilson BA, Bernard JA, Hu LW, Fonteneau EJ, Menadier PT, Ali SJ, Sutharsan B, Kohse GE, Ostrovsky Y, Stahle PW, Binns PJ, Kiger WS III, Busse PM (2002) Thefi ssion converter based epithermal neutron irradiation facility at the Massachusetts Institute of Technology reactor. Nucl Sci Eng 140:223-240
23. Harling OK, Kohse GE, Riley KJ (2002) Irradiation performance of polytetrafluoroethylene (Tefl on ® ) in a mixed fast neutron and gamma radiation field. J Nucl Mater 304:83-85
24. Hatanaka H (1975) A revised boron-neutron capture therapy for malignant brain tumors. II. Interim clinical result with the patients excluding previous treatments. J Neurol 209:81-94
25. Kiger WS III, Sakamoto S, Harling OK (1999) Neutronic design of a fi ssion converter-based epithermal neutron beam for neutron capture therapy. Nucl Sci Eng 131:1-22
26. Kiger WS III, Lu XQ, Harling OK, Riley KJ, Binns PJ, Kaplan J, Patel H, Zamenhof RG, Shibata Y, Kaplan ID, Busse PM, Palmer MR (2004) Preliminary treatment planning and dosimetry for a clinical trial of neutron capture therapy using a fi ssion converter epithermal neutron beam. Appl Radiat Isot 61:1075-1081
27. Kobayashi T, Sakurai Y, Kanda K (2001) Characteristics of neutron irradiation facility and dose estimation method for neutron capture therapy at Kyoto University Research Reactor Institute. In: Current status of neutron capture therapy, IAEA Tecdoc 1223, IAEA, Vienna, 2001, pp 175-185
28. Kononov OE, Kononov VN, Bokhovko MV, Korobeynikov VV, Soloviev AN, Sysoev AS, Gulidov IA, Chu WT, Nigg DW (2004) Optimization of an accelerator-based epithermal neutron sourcefor neutron capture therapy. Appl Radiat Isot 61:1009-1013
29. Kortesniemi M (2002) Solutions for clinical implementation of boron neutron capture therapy in Finland. Ph.D. thesis, University of Helsinki, Helsinki, ISBN 951-45-8955-6; http://ethesis. helsinki. fi , pp 54-68
30. Liu HB (1995) Design of neutron beams for neutron capture therapy using a 300 kw slab TRIGA reactor. Nucl Technol 109:314-326
31. Liu HB, Brugger RM (1994) Conceptual designs of epithermal neutron beams for boron neutron capture therapy from low-power reactors. Nucl Technol 108:151-156
32. Liu HB, Brugger RM, Rorer DC, Tichler PR, Hu JP (1994) Design of a high-fl ux epithermal neutron beam using 235U fi ssion plates at the Brookhaven Medical Research Reactor. Med Phys 21:1627-1631
33. Liu HB, Greenberg DD, Capala J, Wheeler FJ (1996) An improved neutron collimator for brain tumor irradiations in clinical boron neutron capture therapy. Med Phys 23:2051-2060
34. Liu HB, Razvi J, Rucker R, Cerbone R, Merrill M, Whittemore W, Newell D, Autry S, Richards W, Boggan J (2001) TRIGA fuel based converter assembly design for a dual-mode neutron beam system at the McClellan Nuclear Radiation Center. In: Hawthorne MF, Shelly K, Wiersema RJ (eds) Frontiers in neutron capture therapy, 1st edn. Kluwer Academic/Plenum Publishers, New York, pp 295-300
35. Liu YWH, Huang TT, Jiang SH, Liu HM (2004) Renovation of epithermal neutron beam for BNCT at THOR. Appl Radiat Isot 61:1039-1043
36. Marek M, Burian J, Rataj J, Polák J, Spurny F (1997) Reactor based epithermal neutron beam enhancement at Rež. Radiat Prot Dosimetry 70:567-570
37. Moss RL, Aizawa O, Beynon D, Brugger R, Constantine G, Harling O, Liu HB, Watkins P (1997) The requirements and development of neutron beams for neutron capture therapy of brain cancer. J Neurooncol 33:27-40
38. Moss RL, Stecher-Rasmussen F, Ravensberg K, Constantine G, Watkins P (1992) Design, construction and installation of an epithermal neutron beam for BNCT at the high fl ux reactor Petten. In: Allen BJ et al. (eds) Progress in Neutron Capture Therapy for Cancer. Plenum Press, New York, pp 63-66
39. Nievaart VA, Moss RL, Kloosterman JL, van der Hagen THJJ, van Dam H (2004) A parameter study to determine the optimal source neutron energy in boron neutron capture therapy of brain tumors. Phys Med Biol 49:4277-4292
40. Nigg DW, Venhuizen JR, Wemple CA, Tripard GE, Sharp S, Fox K (2004) Flux and instrumentation upgradefor the epithermal neutron beam facility at Washington State University. Appl Radiat Isot 61:993-996
41. Raaijmakers CPJ, Nottelman EL, Konijnenberg MBJ (1995) Dose monitoring for boron neutron capture therapy using a reactor-based epithermal neutron beam. Phys Med Biol 41:2789-2797
42. Raaijmakers CPJ, Konijnenberg MW, Mijnheer BJ (1997) Clinical dosimetry of an epithermal neutron beam for neutron capture therapy: dose distributions under reference conditions. Int J Radiat Oncol Biol Phys 37:941-951
43. Rief H, Van Heusden R, Perlini G (1993) Generating epithermal neutron beams for neutron capture therapy in TRIGA reactors. In: Soloway AH, Barth RF, Carpenter DE (eds) Advances in neutron capture therapy. Plenum Press, New York, pp 85-88
44. Riley KJ, Binns PJ, Harling OK (2003) Performance characteristics of the MIT fi ssion converter based epithermal neutron beam. Phys Med Biol 48:943-958
45. Riley KJ, Binns PJ, Harling OK (2004) The design, construction and performance of a variable collimator for epithermal neutron capture therapy beams. Phys Med Biol 49:2015-2028
46. Rogus RD, Harling OK, Yanch JC (1994) Mixed field dosimetry of epithermal neutron beams for boron neutron capture therapy at the MITR-II research reactor. Med Phys 21:1611-1625
47. Sakamoto S, Kiger WS III, Harling OK (1999) Sensitivity studies of beam directionality, beam size and neutron spectrum for a fi ssion converter-based epithermal neutron beam for boron neutron capture therapy. Med Phys 26:979-988
48. Sakurai F, Torii Y, Kishi T, Kumada H, Yamamoto K, Yokoo K, Kaieda K (2001) Medical irradiation facility at JRR-4. In: IAEA-TECDOC-1223 Current Status of Neutron Capture Therapy. International Atomic Energy Agenct, Vienna, pp 142-146
49. Sakurai Y, Kobayashi T (2002) The medical-irradiation characteristics for neutron capture therapy at the heavy water neutron irradiation facility of Kyoto University Research Reactor. Med Phys 29:2328-2337
50. Slatkin DN (1991) A history of boron neutron capture therapy of brain tumors. Brain 114:1609-1629
51. Tanner V, Auterinen I, Helin J, Kosunen A, Savolainen S (1999) On-line beam monitoring of thefinnish BNCT facility. Nucl Instrum Methods Phys Res A 422:101-105
52. Thompson TJ, Benedict M, Cantwell T, Axford RA (1956) Final hazards summary report to the Advisory Committee on reactor safeguards on a research reactor for the Massachusetts Institute of Technology. Published Cambridge, MIT [1956] located in the Institute archives, non-circulating collection 2 TK9202.M36
53. Wallace SA, Mathur JN, Allen BJ (1994) Treatment planning fi gures of merit in thermal and epithermal boron neutron capture therapy of brain tumors. Phys Med Biol 39:897-906
54. Wilson BA, Riley KJ, Harling OK (2000) Automatic control and monitoring of the MIT fi ssion converter beam. In: 9th international symposium on neutron capture therapy. International Society for Neutron Capture Therapy, Osaka, 2000, pp 237
55. Yamamoto T, Matsumura A, Shibata Y, Nose T, Yamamoto K, Kumada H, Hori N, Torii Y, Ono K, Kobayashi T, Sakurai Y (2000) Radiobiological characterization of epithermal and mixed thermal-epithermal beams at JRR-4. In: 9th international symposium on neutron capture therapy. International Society for Neutron Capture Therapy, Osaka, 2000, pp 205-206
56. Yanch JC, Blue TE (2003) Accelerator-based epithermal neutron sources for boron neutron capture therapy of brain tumors. J Neurooncol 62:19-31
57. Yanch JC, Harling OK (1993) Dosimetric effects of beam size and collimation of epithermal neutrons for boron neutron capture therapy. Radiat Res 135:131-145
58. Yanch JC, Zhou XL, Brownell GL (1991) A Monte Carlo investigation of the dosimetric properties of monoenergetic neutron beams for neutron capture therapy. Radiat Res 126:1-20
59. Zamenhof RG, Murray BW, Brownell GL, Wellum GR, Tolpin EI (1975) Boron neutron capture therapy for the treatment of cerebral gliomas. I: theoretical evaluation of the efficacy of various neutron beams. Med Phys 2:47-60