Accelerator-based epithermal neutron sources for boron neutron capture therapy of brain tumors

Journal of Neuro-Oncology

Volumn 62, Issue 1, 2003, Pages 19-31

  Blue, Thomas E ^a   Yanch, Jacquelyn C ^b  

^a Ohio State University   (United States)

^b Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

Accelerator; BNCT; Neutron; Sources

Indexed keywords

BERYLLIUM; BORON; LITHIUM;

BEAM THERAPY; BRAIN TUMOR; COOLING; COST UTILITY ANALYSIS; CYCLOTRON; ELECTRICITY; EQUIPMENT DESIGN; FEASIBILITY STUDY; HEALTH CARE FACILITY; HEALTH PHYSICS; HUMAN; INTERMETHOD COMPARISON; IRRADIATION; LINEAR ACCELERATOR; LOW ENERGY RADIATION; MONTE CARLO METHOD; NEUTRON CAPTURE THERAPY; NEUTRON RADIATION; PARTICLE RADIATION; RADIATION DEPTH DOSE; RADIATION EQUIPMENT; RADIATION FIELD; RADIOFREQUENCY; REACTOR DESIGN; REVIEW; SCALP; SKULL; TARGET CELL; TREATMENT OUTCOME;

EID: 0037693138     PISSN: 0167594X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1023247222043     Document Type: Review

References (46)

1. 7Be direct neutrons: Application to intra-operative BNCT for malignant brain tumors. Phys Med Biol 47: 3011-3032, 2002
2. Nigg D, Wemple C: Modification of the University of Washington Neutron Radiotherapy Facility for optimization of neutron capture enhanced fast neutron therapy. Med Phys 27: 359-367, 2000
3. Blue JW, Roberts WK, Blue TE, Gahbauer RA, Vincent JS: A study of low energy proton accelerators for neutron capture therapy. Neutron Capture Therapy, 1986. Proceedings of the Second International Symposium on Neutron Capture Therapy, Tokyo, Japan, October 1985, 147-158
4. Brownell GL, Kirsch JE, Kehayias J: In: Hatanaka H (Niigata: Nishimura) (ed) Neutron Capture Therapy, 1986. Proceeding of the Second International Symposium on Neutron Capture Therapy, Tokyo, Japan, October 1985, pp 127-138
5. Wang CK, Blue TE, Gahbauer R: A neutronic study of an accelerator-based neutron irradiation facility for boron neutron capture therapy. Nucl Tech 84: 93-107, 1989
6. Dolan TJ, Ottewitte EH, Wills EE, Neuman WA, Woodall DM: Non-Reactor Neutron Sources for BNCT. Idaho National Engineering Laboratory, Informal Report, EGG-BNCT-8319, May 1989
7. Shefer RE, Klinkowstein RE, Yanch JC, Bronwell GL: In: Harling OK and Bernard JA (eds) Neutron Beam Design, Development and Performance for Neutron Capture Therapy, Plenum Press, New York, 1989, pp 259-270
8. Yanch JC, Zhou X-I, Shefer IE, Klinkowstein RE: Accelerator-based epithermal neutron beam design for neutron capture therapy. Med Phys 19: 709-721, 1992
9. Wu T, Bruggr R, Kunze J: Low energy accelerator-based neutron source for neutron capture therapy. In: Barth R, Soloway A (eds) Advances in Neutron Capture Therapy. Plenum Press, New York 1993, pp 105-108
10. Wang CK, Moore BR: Thick beryllium target as an epithermal neutron source for neutron capture therapy. Med Phys 21: 1633-1638, 1994
11. 7Li(p,n) Proton Beam Energy for BNCT Applications. LBL-37983, Rev 1, May 1996
12. Ludewigt BA, Chu WT, Donahue RJ, Kwan J, Phillips TL, Reginato LL, Wells RP: An epithermal neutron source for BNCT based on an ESQ-accelerator. Proceedings of the Topical Meeting on Nuclear Applications of Accelerator Technology, Albuquerque, New Mexico, November 16-20, 1997
13. Bleuel DL, Donahue RJ, Ludewigt BA, Vujic J: Designing accelerator-based epithermal neutron beams for boron neutron capture therapy. Med Phys 25: 1725-1734, 1998
14. 7Be reaction near threshold for accelerator boron neutron capture therapy. Med Phys 27: 192-202, 2000
15. 7Li(p,n) reaction near threshold. Phys Med Biol: 59-67, 2000
16. Yokobori H: Design study on an accelerator-based facility for BNCT and low energy neutron source. Prog Nucl Energy 37(1-4): 321-326, 2000
17. 235U. Phys Med Biol 46: 2681-2695, 2001
18. Avilov MS, Gubin KV, Kh Kot N, Logatchev PV, Martyshkin PV, Morozov SN, Shiyankov SV, Starostenko AA: Project of proton accelerator based target for neutron production. Proceedings of the Second Asian Particle Accelerator Conference, Beijing, China, 2001
19. Montagnini B, Cerullo N, Esposito J, Giusti V, Mattioda F, Varone R: Spectrum shaping of accelerator-based neutron beams for BNCT. Nucl Instrum Meth Phys Res A 476: 2002, 90-98
20. Agosteo S, Curzio G, D'Errico F, Nath R, Tinti R: Characterisation of an Accelerator-based neutron source for BNCT versus beam energy. Nucl Instrum Meth Phys Res A 476: 106-112, 2002
21. Bisceglie E, Colangelo P, Colonna N, Paticchio V, Santorelli V, Variale V: Production of epithermal neutron beams for BNCT. Nucl Instrum Meth Phys Res A 476: 2002, 123-126
22. Allen DA, Beynon TD, Green D, James ND: Toward a final design for the Birmingham boron neutron capture therapy neutron beam. Med Phys 26: 77-82, 1999
23. Allen DA, Beynon TD, Green S: Design for an accelerator-based orthogonal epithermal neutron beam for boron neutron capture therapy. Med Phys 26: 71-76, 1999
24. 7 Be reaction? Med Phys 27: 1113-1118, 2000
25. DOE Workshop on Accelerator-Based BNCT, Boston Massachusetts, 7-8 July, 1999
26. Yanch JC, Shefer RE, Klinkowstein RE, Howard WB, Song H, Blackburn B, Binello E: Research in boron neutron capture therapy at MIT LABA. In: Duggan JL, Morgan IL (ed) Applications of Accelerators in Research and Industry. AIP Press, Woodbury, New York, Part Two, 1996, pp. 1281-1284
27. Gierga DP: Neutron delivery for boron neutron capture synovectomy. Ph.D. Thesis, Massachusetts Istitute of Technology, 2001
28. 7 Be Neutron Source (Canutron), Chalk River Laboratories Report AECL-7413, 1982
29. Wangler TP, Stovall JE, Bhatia TS, Wang CK, Blue TE, Gahbauer RA: Conceptual design of an RFQ accelerator-based neutron source for boron neutron capture therapy. Los Alamos National Laboratory Article LAUR89-912, 1989 Particle Accelerator Conference, Chicago, IL, March 20-23, 1989
30. Cornelius WD: CW operation of the FMIT RFQ accelerator. Nucl Instrum Meth B B10/11, p 859, 1985
31. McMichael GE, Yule TJ, Zhou X-L: The argonne ACWL, a potential accelerator-based neutron source for BNCT. Nucl Instrum Meth Phys Res B B 99: 1995, 847
32. Swenson DA: Compact, linac-based source of epithermal neutrons for BNCT. Eighth International Symposium on Neutron Capture Therapy for Cancer, La Jolla, CA, September 1998
33. Howard WB, Grimes SM, Massey TN, Al-Quaraish SI, Jacobs DK, Brient CE, Yanch JC: Measurement of the thick target 9Be(p,n) neutron energy spectra. Nucl Sci Eng 139: 145-160, 2001
34. Burlon AA, Kreiner AJ, White S, Yanch JC, Blackburn B, Gierga D: In-phantom dosimetry using the 13C(d,n)14N reaction for BNCT. Med Phys 28: 796-803, 2001
35. Dobelbower MC, Blue TE, Garnett RW: Design and shielding of a beam transport system for use in an accelerator-based epithermal neutron source for BNCT. Proceedings of First International Workshop on Accelerator-Based Neutron Sources for Boron Neutron Capture Therapy, Jackson, WY, September 11-14, 1994, INEL Report Conference-940976, 1995, pp 99-110
36. Blackburn BW, Yanch JC, Klinkowstein RE: Development of a high-power water cooled beryllium target for use in accelerator-based boron neutron capture therapy. Med Phys 25: 1967-1974, 1998
37. Blackburn B, Yanch JC: Liquid gallium colling of a high-power beryllium target for use in accelerator boron neutron capture therapy (ABNCT). Proceedings of the 8th Workshop on Target & Target Chemistry, St. Louis, MO, June 23-26, 1999, December 2000
38. Personal communication with Allen DA
39. Harling OK, Riley KJ: Fission reactor neutron sources for neutron capture therapy - A critical review. J Neuro-Oncol 62: 7-17, 2003
40. Woollard JE, Blue TE, Gupta N, Gahbauer RA: Development and application of neutron field optimization parameters for an accelerator-based neutron source for boron neutron capture therapy. Nucl Tech 115: 100-113, 1996
41. Orr MT, Blue TE, Woollard JE: Using DORT to improve the moderator assembly design for the OSU accelerator-based neutron source for boron neutron capture therapy. Proceedings of the Embedded Topl. Mtg. Accelerator Applications/Accelerator Driven Transmutation Technology and Applications '01, Reno, NV, November 11-15, 2001, Am Nucl Soc (CD-ROM)
42. Woollard JE, Gupta N, Blue TE, Gahbauer RA: Neutron field optimization parameters for boron neutron capture therapy. Trans Am Nucl Soc 73: 25-26, 1995
43. Auterinen I, Hiismaki P: Design of an epithermal neutron beam for the TRIGA Reactor in Otaniemi. Proceedings of the CLINCT BNCT Workshop. Helsinki 1993, Helsinki University of Technology Report TKK-F-A718, 1994
44. Nigg DW, Mitchell HE, Harker YD, Harmon JF: Experimental investigation of filtered epithermal photoneutron beams for BNCT. Adv Neutron Capture Therapy 1(Elsevier): 477-482, 1997
45. Wheeler F, Nigg D: Boron neutron capture therapy (BNCT): Implications of neutron beam and boron compound characteristics. Med Phys 26: 1237-1244, 1999
46. Yoon WY, Jones JL, Nigg DW, Harker YD: Accelerator-based neutron source for boron neutron capture therapy (BNCT) and method. U.S. Patent Number 5903622, May 11, 1999