The requirements and development of neutron beams for neutron capture therapy of brain cancer

Journal of Neuro-Oncology

Volumn 33, Issue 1-2, 1997, Pages 27-40

  Moss, R L ^a   Aizawa, O ^b   Beynon, D ^c   Brugger, R ^d   Constantine, G ^e   Harling, O ^f   Liu, H B ^d   Watkins, P ^a  

^a JOINT RESEARCH CENTRE   (Italy)

^b TOKYO CITY UNIVERSITY   (Japan)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^d BROOKHAVEN NATIONAL LABORATORY   (United States)

^e RICARDO UK LTD   (United Kingdom)

^f MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

BNCT; Epithermal neutrons; Neutron beam design

Indexed keywords

BORON DERIVATIVE;

ARTICLE; BRAIN CANCER; CANCER CELL; CLINICAL TRIAL; HUMAN; JAPAN; NEUTRON; NEUTRON CAPTURE THERAPY; NUCLEAR REACTOR; RADIATION BEAM; TREATMENT OUTCOME; UNITED STATES;

EID: 0030966063     PISSN: 0167594X     EISSN: None     Source Type: Journal    
DOI: 10.1023/a:1005704911264     Document Type: Article

References (41)

1. Locher GL: Biological effects and therapeutic possibilities of neutrons. Am J Roentgenol 36: 1-13, 1936
2. Slatkin DN: A history of boron neutron capture therapy of brain tumors. Brain 114: 1609-1629, 1991
3. Hatanaka H et al.: Clinical experience of boron-neutron capture therapy for gliomas - a comparison with conventional chemo-immune-radiotherapy. In: Hatanaka H (ed) Boron-Neuron Capture Therapy for Tumors. Nishimura, Niigata, Japan 1986
4. Coderre JA: BNCT for malignant glioma using BPA. In: Mishima Y (ed) Proc. 6th Int. Symp. on Neutron Capture Therapy, Kobe, Japan, November 1994. Plenum Press, New York 1995
5. Madoc-Jones H, Zamenhof R, Solares R, Harling O: Clinical trial begins at MIT/NEMC. In: Mishima Y (ed) Proc. 6th Int. Symp. on Neutron Capture Therapy, Kobe, Japan, November 1994. Plenum Press, New York 1995
6. Fankhauser H: Proposed patient selection criteria and follow-up. In: Gabel D, Moss RL (eds) Boron Neutron Capture Therapy: Toward Clinical Trials of Glioma Treatment. Plenum Press, New York, 1992
7. 10B in fast neutron therapy. Phys Med Biol 38: 397-410, 1993
8. Allen DA, Beynon TD: A design study for an accelerator-based epithermal neutron beam for BNCT. Phys Med Biol 40: 807-821, 1995
9. Kim JK et al.: Californium-based epithermal neutron beams for neutron capture therapy. In: Soloway A et al. (eds) Advances in Neutron Capture Therapy. Plenum Press, New York, 1993
10. Farr LE et al.: Neutron capture therapy. In: Handbuch der Medizinische Radiologie. Springer, Heidelberg 1971
11. Farr LE et al.: Neutron capture therapy with boron in the treatment of glioblastoma multiforme. Am J Roentgenol 71: 279-293, 1954
12. Soloway AH et al.: Penetration of brain and brain tumor. VII. Tumor-binding sulfhydryl boron compounds. J Med Chem 10: 714-717, 1967
13. Kanda K: Development of neutron field for medial irradiation purposes. J At Energy Soc Japan 17: 582-586, 1975
14. Aizawa O et al.: Remodelling and dosimetry on the neutron irradiation facility of the Musashi Institute of Technology Reactor for boron neutron capture therapy. J Nucl Technol 48: 150-163, 1980
15. Nakagawa Y, Hatanaka H: Recent study of boron neutron capture therapy in patient with malignant tumor. In: Mishima Y (ed) Proc. 6th Int. Symp. on Neutron Capture Therapy, Kobe, Japan, November 1994. Plenum Press, New York 1995
16. Nakagawa Y et al.: Thermal neutron capture therapy for brain stem and skull base tumors: Heavy water and multi-portal neutron delivery. In: Soloway A et al. (eds) Advances in Neutron Capture Therapy. Plenum Press, New York, 1993
17. Hatanaka H, Nakagawa Y: Clinical results of long-surviving brain tumor patients who underwent boron neutron capture therapy. Int J Rad Oncol Biol Phys 28 (5): 1061-1066, 1994
18. 10B-compound. Lancet 2: 388-389, 1989
19. Fairchild RG et al.: Clinical aspects of neutron capture therapy. In: Fairchild RG et al. (eds) Basic Life Sciences, vol 50. Plenum Press, New York, 1989
20. Yanch JC, Harling OK: A comparison of epithermal neutron beams for NCT: Effect of beam collimation on therapy parameters. In: Soloway A et al. (eds) Advances in Neutron Capture Therapy. Plenum Press, New York, 1993
21. 10B-neutron capture therapy: Enhancement of tumor dose via beam filtration and dose rate, and the effects of these parameters on minimum boron content: A theoretical evaluation. Int Rad Oncol Biol Phys 11: 831-840, 1985
22. Rhoades WA, Childs RL: Updated Version of DOT 4 One-and Two-Dimensional Neutron/Photon Transport Code. Oak Ridge National Laboratory, ORNL-5621, July 1980
23. Briesmeister JF (Ed): MCNP - A General Monte Carlo Code for Neutron and Photon Transport. LA-7596-M, Rev. 2, 1986
24. Fairchild RG et al.: An optimized epithermal neutron beam capture therapy (NCT) at the Brookhaven Medical Research Reactor (BMRR). In: Allen BJ (ed) Proc. on Neuron Capture Therapy for Cancer. Plenum Press, New York, 1992
25. Gabel DG: Goals of the European collaboration on boron neutron capture therapy. In: Allen BJ (ed) Proc. on Neutron Capture Therapy for Cancer. Plenum Press, New York, 1992
26. Moss RL et al.: Design, construction and installation of an epithermal neutron beam for BNCT at the High Flux Reactor at Petten. In: Allen BJ (ed) Proc. on Neutron Capture Therapy Cancer. Plnum Press, New York, 1992
27. Auterinen I, Hiismäki P: Construction of the epithermal BNCT station at the FiR 1. In: Mishima Y (ed) Proc. 6th Int. Symp. on Neutron Capture Therapy, Kobe, Japan, November 1994. Plenum Press, New York, 1995
28. Brugger R et al.: An epithermal neutron beam for neutron capture therapy at the Missouri University Research Reactor. J Nucl Tech 98 (3): 322-332, 1992
29. Nigg D, Storr G, Wheeler F: Physics parameters for an epithermal-neutron beam at the Georgia Institute of Technology. In: Soloway A et al. (eds) Advances in Neutron Capture Therapy. Plenum Press, New York, 1993
30. Rief H, Van Heusden R, Perlini G: Generating epithermal neutron beams for BNCT at TRIGA reactors. In: Soloway et al. (eds) Advances in Neutron Capture Therapy. Plenum Press, New York, 1993
31. Harling OK et al.: High intensity fission convertor based epithermal neutron beam for boron neutron capture therapy. In: Mishima Y (ed) Proc. 6th Int. Symp. on Neutron Capture Therapy, Kobe, Japan, November 1994. Plenum Press, New York, 1995
32. 235U fission plates at the Brookhaven Medical Research Reactor. Med Phys 21: 1627-1631, 1994
33. Grusell E et al.: The possible use of a spallation source for neutron capture therapy with epithermal neutrons. In: Proc. of Neutron Beam Design, Development and Performance for Neutron Capture Therapy, Basic Life Sciences, vol 54. Plenum Press, New York, 1990
34. Yanch JC et al.: Accelerator-based epithermal neutron beams for neutron capture therapy. In: Soloway A et al. (eds) Advances in Neutron Capture Therapy. Plenum Press, New York, 1993
35. Rogus RD, Harling OK, Yanch JC: Mixed field dosimetry of epithermal neutron beams used for boron neutron capture therapy at the MIRT-II research reactor. Med Physics 21 (10): 1611-1625, 1994
36. Harling OK et al.: Head phantoms for neutron capture therapy. Med Physics 22 (5): 579-583, 1995
37. Moss RL, Siefert A, Watkins PRD, Constantine G, Philipp K: The Petten BNCT Facility: I - Phantom Dosimetry Techniques used in the Nuclear and Biological Characterisation of the Epithermal Neutron Beam and in the Halthy Tissue Tolerance Studies on the Canine Brain, and II - the Development towards a Treatment Planning System for the Treatment of Glioma Patients by BNCT. In: Harling O et al. (eds) Proc. Int. Workshop on Neutron Beam Design, Development and Performance for Neutron Capture Therapy, MIT Cambridge USA, March 1989, Basic Life Sciences, vol 54. Plenum Press, New York, 1990
38. Harling O et al. (eds) Neutron Beam Design, Development and Performance for Neutron Capture Therapy, MIT Cambridge USA, March 1989, Basic Life Sciences, vol 54. Plenum Press, 1990
39. Moss RL: Review of reactor-based neutron beam development for BNCT applications. In: Soloway A et al. (eds) Advances in Neutron Capture Therapy. Plenum Press, New York, 1993
40. Zamenhof R et al.: Federal and institutional approvals necessary prior to a U.S. clinical trial of neutron capture therapy. In: Soloway A et al. (eds) Advances in Neutron Capture Therapy. Plenum Press, New York, 1993
41. Kanda K: Procedures for the medical application of research reactors. In: Soloway A et al. (eds) Advances in Neutron Capture Therapy. Plenum Press, New York, 1993