The phenotype of a flavin-containing monooyxgenase knockout mouse implicates the drug-metabolizing enzyme FMO1 as a novel regulator of energy balance

Biochemical Pharmacology

Volumn 90, Issue 1, 2014, Pages 88-95

  Veeravalli, Sunil ^a   Omar, Bilal A ^b   Houseman, Lyndsey ^a   Hancock, Matthew ^a   Gonzalez Malagon, Sandra G ^a   Scott, Flora ^a   Janmohamed, Azara ^a   Phillips, Ian R ^a,b   Shephard, Elizabeth A ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Body weight; Endogenous role; Energy; Futile cycle; White adipose tissue

Indexed keywords

ACYL COENZYME A DESATURASE; AQUAPORIN 7; DIMETHYLANILINE MONOOXYGENASE; DIMETHYLANILINE MONOOXYGENASE 1; DIMETHYLANILINE MONOOXYGENASE 2; DIMETHYLANILINE MONOOXYGENASE 4; DRUG METABOLIZING ENZYME; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ETHIONAMIDE; FATTY ACID; GLUCOSE TRANSPORTER 4; GLYCEROL KINASE; GLYCEROPHOSPHATE; HORMONE SENSITIVE LIPASE; IMIPRAMINE; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPROTEIN LIPASE; MAMMALIAN TARGET OF RAPAMYCIN; NEURONAL NITRIC OXIDE SYNTHASE; PERILIPIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHOENOLPYRUVATE; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 1; UNCOUPLING PROTEIN 2; UNCOUPLING PROTEIN 3;

ADIPOCYTE; ADIPOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CALORIC INTAKE; CONTROLLED STUDY; DRUG METABOLISM; DUAL ENERGY X RAY ABSORPTIOMETRY; ENERGY BALANCE; ENERGY EXPENDITURE; ENZYME ACTIVITY; EPIDIDYMIS FAT; EXERCISE; FATTY ACID OXIDATION; GLUCOSE OXIDATION; HOMEOSTASIS; KNOCKOUT MOUSE; LIPID STORAGE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESTING ENERGY EXPENDITURE; SKELETAL MUSCLE; THERMOGENESIS; WHITE ADIPOSE TISSUE;

BODY WEIGHT; ENDOGENOUS ROLE; ENERGY; FUTILE CYCLE; WHITE ADIPOSE TISSUE;

3T3-L1 CELLS; ADIPOCYTES; ADIPOSE TISSUE, BROWN; ADIPOSE TISSUE, WHITE; ADIPOSITY; ANIMALS; BODY WEIGHT; ENERGY METABOLISM; FATTY ACIDS; GENE EXPRESSION REGULATION; KIDNEY; LIVER; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOTOR ACTIVITY; MUSCLE, SKELETAL; OXIDATION-REDUCTION; OXYGEN CONSUMPTION; OXYGENASES; PHENOTYPE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84901818603     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2014.04.007     Document Type: Article

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