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Volumn 8, Issue 3, 2013, Pages 213-218

Parenteral patent drug S/GSK1265744 has the potential to be an effective agent in pre-exposure prophylaxis against HIV infection

Author keywords

GSK 744; HIV; Nanotechnology; Parenteral; Patent drug; Pre exposure prophylaxis

Indexed keywords

CABOTEGRAVIR; DOLUTEGRAVIR; ELVITEGRAVIR; EMTRICITABINE; PLACEBO; RALTEGRAVIR; RILPIVIRINE; TENOFOVIR; TENOFOVIR DISOPROXIL; DELAYED RELEASE FORMULATION; INTEGRASE INHIBITOR; PYRIDONE DERIVATIVE; SUSPENSION;

EID: 84901816437     PISSN: 1574891X     EISSN: 22124071     Source Type: Journal    
DOI: 10.2174/1574891X09666140417154727     Document Type: Article
Times cited : (12)

References (47)
  • 1
    • 84873034364 scopus 로고    scopus 로고
    • Systemic and topical drugs for the prevention of HIV infection: Antiretroviral pre-exposure prophylaxis
    • Baeten J, Celum C. Systemic and topical drugs for the prevention of HIV infection: antiretroviral pre-exposure prophylaxis. Annu Rev Med 2013; 64: 219-32.
    • (2013) Annu Rev Med , vol.64 , pp. 219-232
    • Baeten, J.1    Celum, C.2
  • 3
    • 80054887588 scopus 로고    scopus 로고
    • Topical tenofovir, a microbicide effective against HIV, inhibits herpes simplex virus-2 replication
    • Andrei G, Lisco A, Vanpouille C, Introini A, Balestra E, Van den Ooord J, et al. Topical tenofovir, a microbicide effective against HIV, inhibits herpes simplex virus-2 replication. Cell Host Microbe 2011; 10(4): 379-89.
    • (2011) Cell Host Microbe , vol.10 , Issue.4 , pp. 379-389
    • Andrei, G.1    Lisco, A.2    Vanpouille, C.3    Introini, A.4    Balestra, E.5    Van den Ooord, J.6
  • 4
    • 84868089015 scopus 로고    scopus 로고
    • The potential impact of pre-exposure prophylaxis for HIV prevention among men who have sex with men and transwomen in Lima, Peru: A mathematical modelling study
    • Gomez GB, Borquez A, Caceres CF, Segura ER, Grant RM, Garnett GP, et al. The potential impact of pre-exposure prophylaxis for HIV prevention among men who have sex with men and transwomen in Lima, Peru: A mathematical modelling study. PLoS Med 2012; 9(10): e1001323.
    • (2012) PLoS Med , vol.9 , Issue.10
    • Gomez, G.B.1    Borquez, A.2    Caceres, C.F.3    Segura, E.R.4    Grant, R.M.5    Garnett, G.P.6
  • 5
    • 84866283847 scopus 로고    scopus 로고
    • Emtricitabine-tenofovir concentrations and preexposure prophylaxis efficacy in men who have sex with men
    • 151ra125
    • Anderson PL, Glidden DV, Liu A, Buchbinder S, Lama JR, Guanira JV, et al. Emtricitabine-tenofovir concentrations and preexposure prophylaxis efficacy in men who have sex with men. Sci Transl Med 2012; 4(151): 151ra125.
    • (2012) Sci Transl Med , vol.4 , Issue.151
    • Anderson, P.L.1    Glidden, D.V.2    Liu, A.3    Buchbinder, S.4    Lama, J.R.5    Guanira, J.V.6
  • 6
    • 84155171087 scopus 로고    scopus 로고
    • Tenofovir-based pre-exposure prophylaxis for HIV prevention: Evolving evidence
    • Celum C, Baeten JM. Tenofovir-based pre-exposure prophylaxis for HIV prevention: Evolving evidence. Curr Opin Infect Dis 2011; 25(1): 51-7.
    • (2011) Curr Opin Infect Dis , vol.25 , Issue.1 , pp. 51-57
    • Celum, C.1    Baeten, J.M.2
  • 7
    • 84871855684 scopus 로고    scopus 로고
    • Antiretroviral-based HIV-1 prevention: Antiretroviral treatment and pre-exposure prophylaxis
    • Celum C, Baeten JM. Antiretroviral-based HIV-1 prevention: Antiretroviral treatment and pre-exposure prophylaxis. Antivir Ther 2011; 17(8): 1483-93.
    • (2011) Antivir Ther , vol.17 , Issue.8 , pp. 1483-1493
    • Celum, C.1    Baeten, J.M.2
  • 8
    • 84878885645 scopus 로고    scopus 로고
    • HIV preexposure prophylaxis: New data and potential use
    • Celum C. HIV preexposure prophylaxis: New data and potential use. Topics in antiviral medicine 2011; 19(5): 181-5.
    • (2011) Topics In Antiviral Medicine , vol.19 , Issue.5 , pp. 181-185
    • Celum, C.1
  • 9
    • 84860014826 scopus 로고    scopus 로고
    • Unraveling the divergent results of pre-exposure prophylaxis trials for HIV prevention
    • Van der Straten A, Van Damme L, Haberer JE, Bangsberg DR. Unraveling the divergent results of pre-exposure prophylaxis trials for HIV prevention. AIDS 2012; 26(7): F13-9.
    • (2012) AIDS , vol.26 , Issue.7
    • Van der Straten, A.1    van Damme, L.2    Haberer, J.E.3    Bangsberg, D.R.4
  • 11
    • 78650359074 scopus 로고    scopus 로고
    • Strategies to prevent unintended pregnancy: Increasing use of long-acting reversible contraception
    • Blumenthal PF, Voedisch A, Gemzell-Danielsson K. Strategies to prevent unintended pregnancy: Increasing use of long-acting reversible contraception. Hum Reprod Update 2010; 17(1): 121-37.
    • (2010) Hum Reprod Update , vol.17 , Issue.1 , pp. 121-137
    • Blumenthal, P.F.1    Voedisch, A.2    Gemzell-Danielsson, K.3
  • 12
    • 84869212370 scopus 로고    scopus 로고
    • Development and evaluation of a thermosensitive vaginal gel containing raltegravir+efavirenz loaded nanoparticles for HIV prophylaxis
    • Date AA, Shibata A, Goede M, Sanford B, La Bruzzo K, Belshan M, et al. Development and evaluation of a thermosensitive vaginal gel containing raltegravir+efavirenz loaded nanoparticles for HIV prophylaxis. Antiviral Res 2012; 96(3): 430-6.
    • (2012) Antiviral Res , vol.96 , Issue.3 , pp. 430-436
    • Date, A.A.1    Shibata, A.2    Goede, M.3    Sanford, B.4    la Bruzzo, K.5    Belshan, M.6
  • 13
    • 84858187453 scopus 로고    scopus 로고
    • Stampidine as a promising antiretroviral drug candidate for pre-exposure prophylaxis against sexually transmitted HIV/AIDS
    • Uckun FM, Cahn P, Qazi S, D'Cruz O. Stampidine as a promising antiretroviral drug candidate for pre-exposure prophylaxis against sexually transmitted HIV/AIDS. Expert Opin Investig Drugs 2012; 21(4): 489-500.
    • (2012) Expert Opin Investig Drugs , vol.21 , Issue.4 , pp. 489-500
    • Uckun, F.M.1    Cahn, P.2    Qazi, S.3    D'cruz, O.4
  • 15
    • 73649121308 scopus 로고    scopus 로고
    • Nanoparticle-based vaginal drug delivery systems for HIV prevention
    • Mallipeddi R, Rohan LC. Nanoparticle-based vaginal drug delivery systems for HIV prevention. Expert Opin Drug Deliv 2010; 7(1): 37-48.
    • (2010) Expert Opin Drug Deliv , vol.7 , Issue.1 , pp. 37-48
    • Mallipeddi, R.1    Rohan, L.C.2
  • 16
    • 84886089649 scopus 로고    scopus 로고
    • Long-acting injectable antiretrovirals for HIV treatment and prevention
    • Spreen WR, Margolis DA, Pottage JC Jr. Long-acting injectable antiretrovirals for HIV treatment and prevention. Curr Opin HIV AIDS 2013; 8(6): 565-71.
    • (2013) Curr Opin HIV AIDS , vol.8 , Issue.6 , pp. 565-571
    • Spreen, W.R.1    Margolis, D.A.2    Pottage Jr., J.C.3
  • 17
    • 60149105478 scopus 로고    scopus 로고
    • Targeted delivery of PSC-RANTES for HIV-1 prevention using biodegradable nanoparticles
    • Ham AS, Cost MR, Sassi AB, Dezutti CS, Rohan LC. Targeted delivery of PSC-RANTES for HIV-1 prevention using biodegradable nanoparticles. Pharm Res 2009; 26(3): 502-11.
    • (2009) Pharm Res , vol.26 , Issue.3 , pp. 502-511
    • Ham, A.S.1    Cost, M.R.2    Sassi, A.B.3    Dezutti, C.S.4    Rohan, L.C.5
  • 18
    • 0035937594 scopus 로고    scopus 로고
    • Mucoadhesive nanoparticulate systems for peptide drug delivery
    • Takeuchi H, Yamamoto H, Kawashima Y. Mucoadhesive nanoparticulate systems for peptide drug delivery. Adv Drug Deliv Rev 2001; 47(1): 39-54.
    • (2001) Adv Drug Deliv Rev , vol.47 , Issue.1 , pp. 39-54
    • Takeuchi, H.1    Yamamoto, H.2    Kawashima, Y.3
  • 19
    • 79952116301 scopus 로고    scopus 로고
    • Progress in antiretroviral drug delivery using nanotechnology
    • Mallipeddi R, Rohan LC. Progress in antiretroviral drug delivery using nanotechnology. Int J Nanomed 2010; 5: 533-47.
    • (2010) Int J Nanomed , vol.5 , pp. 533-547
    • Mallipeddi, R.1    Rohan, L.C.2
  • 21
    • 84868124431 scopus 로고    scopus 로고
    • Nanotechnology in therapeutics: A focus on nanoparticles as a drug delivery system
    • Bamrungsap S, Zhao Z, Chen T, Wang L, Li C, Fu T, et al. Nanotechnology in therapeutics: A focus on nanoparticles as a drug delivery system. Nanomedicine 2012; 7(8): 1253-71.
    • (2012) Nanomedicine , vol.7 , Issue.8 , pp. 1253-1271
    • Bamrungsap, S.1    Zhao, Z.2    Chen, T.3    Wang, L.4    Li, C.5    Fu, T.6
  • 22
    • 67149130841 scopus 로고    scopus 로고
    • Prevention of the sexual transmission of HIV-1: Preparing for success
    • Cohen MS, Kaleebu P, Coates T. Prevention of the sexual transmission of HIV-1: preparing for success. J Int AIDS Soc 2008; 11: 4.
    • (2008) J Int AIDS Soc , vol.11 , pp. 4
    • Cohen, M.S.1    Kaleebu, P.2    Coates, T.3
  • 23
    • 84890408873 scopus 로고    scopus 로고
    • Assessing the cost effectiveness of pre-exposure prophylaxis for HIV prevention in the US
    • Hellinger FJ. Assessing the cost effectiveness of pre-exposure prophylaxis for HIV prevention in the US. Pharmaco Econ 2013; 31(12): 1091-104.
    • (2013) Pharmaco Econ , vol.31 , Issue.12 , pp. 1091-1104
    • Hellinger, F.J.1
  • 24
    • 77955930318 scopus 로고    scopus 로고
    • Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women
    • Abdool Karim Q, Abdool Karim SS, Frohlich JA, Grobler AC, Baxter C, Mansoor LE, et al. Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women. Science 2010; 329(5996): 1168-74.
    • (2010) Science , vol.329 , Issue.5996 , pp. 1168-1174
    • Abdool, K.Q.1    Abdool, K.S.S.2    Frohlich, J.A.3    Grobler, A.C.4    Baxter, C.5    Mansoor, L.E.6
  • 27
    • 78650670855 scopus 로고    scopus 로고
    • Identification and characterization of persistent intracellular human immunodeficiency virus type 1 integrase strand transfer inhibitor activity
    • Koh Y, Haim H, Engelman A. Identification and characterization of persistent intracellular human immunodeficiency virus type 1 integrase strand transfer inhibitor activity. Antimicrob Agents Chemother 2010; 55(1): 42-9.
    • (2010) Antimicrob Agents Chemother , vol.55 , Issue.1 , pp. 42-49
    • Koh, Y.1    Haim, H.2    Engelman, A.3
  • 29
    • 84896519296 scopus 로고    scopus 로고
    • Impact of resistance mutations on inhibitor binding to HIV-1 Integrase
    • Chen Q, Buolamwini JK, Smith JC, Li A, Xu Q, Cheng X, et al. Impact of resistance mutations on inhibitor binding to HIV-1 Integrase. J Chem Inf Modeling 2013; 53(12): 3297-307.
    • (2013) J Chem Inf Modeling , vol.53 , Issue.12 , pp. 3297-3307
    • Chen, Q.1    Buolamwini, J.K.2    Smith, J.C.3    Li, A.4    Xu, Q.5    Cheng, X.6
  • 30
    • 52449097240 scopus 로고    scopus 로고
    • Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIVAIDS infection
    • Summa V, Petrocchi A, Bonelli F, Crescenzi B, Donghi M, Ferrara M, et al. Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIVAIDS infection. J Med Chem 2008; 51(18): 5843-55.
    • (2008) J Med Chem , vol.51 , Issue.18 , pp. 5843-5855
    • Summa, V.1    Petrocchi, A.2    Bonelli, F.3    Crescenzi, B.4    Donghi, M.5    Ferrara, M.6
  • 31
    • 84879799713 scopus 로고    scopus 로고
    • Efficacy and safety of raltegravir for treatment of HIV for 5 years in the BENCHMRK studies: Final results of two randomised, placebo-controlled trials
    • Eron JJ, Cooper DA, Steigbigel RT, Clotet B, Gatell JM, Kumar PN, et al. Efficacy and safety of raltegravir for treatment of HIV for 5 years in the BENCHMRK studies: Final results of two randomised, placebo-controlled trials. Lancet Infect Dis 2013; 13(7): 587-96.
    • (2013) Lancet Infect Dis , vol.13 , Issue.7 , pp. 587-596
    • Eron, J.J.1    Cooper, D.A.2    Steigbigel, R.T.3    Clotet, B.4    Gatell, J.M.5    Kumar, P.N.6
  • 32
    • 84873633830 scopus 로고    scopus 로고
    • Safety and efficacy of dolutegravir in treatment-experienced subjects with raltegravir-resistant HIV type 1 infection: 24-week results of the VIKING Study
    • Eron JJ, Clotet B, Durant J, Katlama C, Kumar P, Lazzarin A, et al. Safety and efficacy of dolutegravir in treatment-experienced subjects with raltegravir-resistant HIV type 1 infection: 24-week results of the VIKING Study. J Infect Dis 2012; 207(5): 740-8.
    • (2012) J Infect Dis , vol.207 , Issue.5 , pp. 740-748
    • Eron, J.J.1    Clotet, B.2    Durant, J.3    Katlama, C.4    Kumar, P.5    Lazzarin, A.6
  • 33
    • 84862285709 scopus 로고    scopus 로고
    • The elvitegravir Quad pill: The first once-daily dualtarget anti-HIV tablet
    • Marchand C. The elvitegravir Quad pill: The first once-daily dualtarget anti-HIV tablet. Expert Opin Invest Drugs 2012; 21(7): 901-4.
    • (2012) Expert Opin Invest Drugs , vol.21 , Issue.7 , pp. 901-904
    • Marchand, C.1
  • 35
    • 84856221584 scopus 로고    scopus 로고
    • Dolutegravir--a promising antiretroviral in development
    • Boyd M. Dolutegravir--a promising antiretroviral in development. Lancet Infect Dis 2012; 12(2): 90-1.
    • (2012) Lancet Infect Dis , vol.12 , Issue.2 , pp. 90-91
    • Boyd, M.1
  • 36
    • 84886247956 scopus 로고    scopus 로고
    • In vitro phenotypes to elvitegravir and dolutegravir in primary macrophages and lymphocytes of clonal recombinant viral variants selected in patients failing raltegravir
    • Canducci F, Ceresola ER, Saita D, Castagna A, Gianotti N, Underwood M, et al. In vitro phenotypes to elvitegravir and dolutegravir in primary macrophages and lymphocytes of clonal recombinant viral variants selected in patients failing raltegravir. J Antimicrob Chemother 2013; 68(11): 2525-32
    • (2013) J Antimicrob Chemother , vol.68 , Issue.11 , pp. 2525-2532
    • Canducci, F.1    Ceresola, E.R.2    Saita, D.3    Castagna, A.4    Gianotti, N.5    Underwood, M.6
  • 38
    • 84893057636 scopus 로고    scopus 로고
    • First study of repeat dose co-administration of GSK1265744 and TMC278 long-acting parenteral nanosuspensions: Pharmacokinetics, safety and tolerability in healthy adults
    • Kuala Lumpur, Malyasia, June 30-July 3
    • Spreen W, Margolis PWD, Ford S, Crauwels H, Lou Y, Gould E, et al. First study of repeat dose co-administration of GSK1265744 and TMC278 long-acting parenteral nanosuspensions: Pharmacokinetics, safety and tolerability in healthy adults. Proceedings of the 7th IAS conference on HIV pathogenesis, treatment and prevention. Kuala Lumpur, Malyasia, June 30-July 3, 2013.
    • (2013) Proceedings of the 7th IAS Conference On HIV Pathogenesis, Treatment and Prevention
    • Spreen, W.1    Margolis, P.W.D.2    Ford, S.3    Crauwels, H.4    Lou, Y.5    Gould, E.6
  • 42
  • 43
    • 84877123280 scopus 로고    scopus 로고
    • Next-generation integrase inhibitors: Where to after raltegravir?
    • Karmon SL, Markowitz M. Next-generation integrase inhibitors: Where to after raltegravir?. Drugs 2013; 73(3): 213-28.
    • (2013) Drugs , vol.73 , Issue.3 , pp. 213-228
    • Karmon, S.L.1    Markowitz, M.2
  • 45
    • 84867651801 scopus 로고    scopus 로고
    • Pharmacokinetics, safety and tolerability of the HIV integrase inhibitor S/GSK1265744 long acting parenteral nanosuspension following single dose administration to healthy adults
    • Washington, USA, July 22-27
    • Spreen W, Ford SL, Chen S, Gould E, Wilfret D, Subich D, et al. Pharmacokinetics, safety and tolerability of the HIV integrase inhibitor S/GSK1265744 long acting parenteral nanosuspension following single dose administration to healthy adults. Proceedings of the XIX International AIDS Conference. Washington, USA, July 22-27, 2012.
    • (2012) Proceedings of the XIX International AIDS Conference
    • Spreen, W.1    Ford, S.L.2    Chen, S.3    Gould, E.4    Wilfret, D.5    Subich, D.6
  • 46
    • 84901781622 scopus 로고    scopus 로고
    • FDA Grants Priority Review Designation for ViiV's Dolutegravir. Available at, Accessed on: February 16
    • FDA Grants Priority Review Designation for ViiV's Dolutegravir. Available at: http://www.aidsmeds.com/articles/dolutegravir_priority_1667_234 80.shtml (Accessed on: February 16, 2014)
    • (2014)
  • 47
    • 84879000125 scopus 로고    scopus 로고
    • Antiretroviral prophylaxis for HIV infection in injecting drug users in Bangkok, Thailand (the Bangkok Tenofovir Study): A randomised, double-blind, placebocontrolled phase 3 trial
    • Choopanya K, Martin M, Suntharasamai P, Sangkum U, Mock PA, Leethochawalit M, et al. Antiretroviral prophylaxis for HIV infection in injecting drug users in Bangkok, Thailand (the Bangkok Tenofovir Study): A randomised, double-blind, placebocontrolled phase 3 trial. Lancet 2013; 381(9883): 2083-90.
    • (2013) Lancet , vol.381 , Issue.9883 , pp. 2083-2090
    • Choopanya, K.1    Martin, M.2    Suntharasamai, P.3    Sangkum, U.4    Mock, P.A.5    Leethochawalit, M.6


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