Endothelium-independent vasorelaxant effects of hydroalcoholic extract from nigella sativa seed in rat aorta: The roles of Ca2+ and K + channels

BioMed Research International

Volumn 2014, Issue , 2014, Pages

  Niazmand, Saeed ^a,b   Fereidouni, Elahe ^b   Mahmoudabady, Maryam ^b,c   Mousavi, Seyed Mojtaba ^b  

^a MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL; DILTIAZEM; ENDOTHELIUM DERIVED RELAXING FACTOR; GLIBENCLAMIDE; HEPARIN; INDOMETACIN; N(G) NITROARGININE METHYL ESTER; NIGELLA SATIVA EXTRACT; PHENYLEPHRINE; POTASSIUM CHANNEL; POTASSIUM CHLORIDE; RUTHENIUM RED; TETRYLAMMONIUM CHLORIDE; CALCIUM; PLANT EXTRACT; VASODILATOR AGENT;

AORTA; ARTICLE; BLACK CUMIN; DRUG EFFECT; DRUG MECHANISM; ENDOTHELIUM; MEDICINAL PLANT; NONHUMAN; PLANT SEED; VASODILATATION; ANIMAL; CHEMISTRY; DRUG EFFECTS; METABOLISM; MUSCLE CONTRACTION; RAT; VASCULAR ENDOTHELIUM; WISTAR RAT;

ANIMALS; AORTA; CALCIUM; CALCIUM CHANNELS; ENDOTHELIUM, VASCULAR; MUSCLE CONTRACTION; NG-NITROARGININE METHYL ESTER; NIGELLA SATIVA; PLANT EXTRACTS; POTASSIUM CHANNELS; RATS; RATS, WISTAR; SEEDS; VASODILATION; VASODILATOR AGENTS;

EID: 84901778008     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2014/247054     Document Type: Article

References (42)

1. Ahmad A., Husain A., Mujeeb M., A review on therapeutic potential of Nigella sativa: a miracle herb. Asian Pacific Journal of Tropical Biomedicine 2013 3 5 337 352
2. Ali B. H., Blunden G., Pharmacological and toxicological properties of Nigella sativa. Phytotherapy Research 2003 17 4 299 305 2-s2.0-0038559976 10.1002/ptr.1309 (Pubitemid 36565330)
3. Boskabady M. H., Vahedi N., Amery S., Khakzad M. R., The effect of Nigella sativa alone, and in combination with dexamethasone, on tracheal muscle responsiveness and lung inflammation in sulfur mustard exposed guinea pigs. Journal of Ethnopharmacology 2011 137 2 1028 1034 2-s2.0-80052033521 10.1016/j.jep.2011.07.030
4. Yildiz F., Coban S., Terzi A., Savas M., Bitiren M., Celik H., Aksoy N., Protective effects of Nigella sativa against ischemia-reperfusion injury of kidneys. Renal Failure 2010 32 1 126 131 2-s2.0-76449089573 10.3109/ 08860220903367577
5. Burits M., Bucar F., Antioxidant activity of Nigella sativa essential oil. Phytotherapy Research 2000 14 5 323 328 (Pubitemid 30655515)
6. Aboul Ezz H. S., Khadrawy Y. A., Noor N. A., The neuroprotective effect of curcumin and Nigella sativa oil against oxidative stress in the pilocarpine model of epilepsy: a comparison with valproate. Neurochemical Research 2011 36 11 2195 2204 2-s2.0-80054987695 10.1007/s11064-011-0544-9
7. Noor N. A., Aboul Ezz H. S., Faraag A. R., Khadrawy Y. A., Evaluation of the antiepileptic effect of curcumin and Nigella sativa oil in the pilocarpine model of epilepsy in comparison with valproate. Epilepsy & Behavior 2012 24 2 199 206 2-s2.0-84860581469 10.1016/j.yebeh.2012.03.026
8. Landa P., Marsik P., Havlik J., Kloucek P., Vanek T., Kokoska L., Evaluation of antimicrobial and anti-inflammatory activities of seed extracts from six Nigella species. Journal of Medicinal Food 2009 12 2 408 415 2-s2.0-67649522164 10.1089/jmf.2007.0600
9. Boskabady M. H., Shirmohammadi B., Jandaghi P., Kiani S., Possible mechanism(s) for relaxant effect of aqueous and macerated extracts from Nigella sativa on tracheal chains of guinea pig. BMC Pharmacology 2004 4, article 3 2-s2.0-2642534478 10.1186/1471-2210-4-3 (Pubitemid 38729282)
10. Abdel-Fattah A.-F. M., Matsumoto K., Watanabe H., Antinociceptive effects of Nigella sativa oil and its major component, thymoquinone, in mice. European Journal of Pharmacology 2000 400 1 89 97 2-s2.0-0034648056 10.1016/S0014- 2999(00)00340-X (Pubitemid 30412113)
11. Benhaddou-Andaloussi A., Martineau L., Vuong T., Meddah B., Madiraju P., Settaf A., Haddad P. S., The in vivo antidiabetic activity of Nigella sativa is mediated through activation of the AMPK pathway and increased muscle Glut4 content. Evidence-Based Complementary and Alternative Medicine 2011 2011 9 2-s2.0-79959277526 10.1155/2011/538671 538671
12. Al-Suhaimi E. A., Hepatoprotective and immunological functions of Nigella sativa seed oil against hypervitaminosis A in adult male rats. International Journal for Vitamin and Nutrition Research 2012 82 4 288 297 10.1024/0300-9831/a000121
13. Boskabady M. H., Keyhanmanesh R., Saadatloo M. A. E., Relaxant effects of different fractions from Nigella sativa L. on guinea pig tracheal chains and its possible mechanism(s). Indian Journal of Experimental Biology 2008 46 12 805 810 2-s2.0-67549093936
14. Al-Naqeeb G., Ismail M., Al-Zubairi A. S., Fatty acid profile, α -tocopherol content and total antioxidant activity of oil extracted from Nigella sativa seeds. International Journal of Pharmacology 2009 5 4 244 250 2-s2.0-70449370991 10.3923/ijp.2009.244.250
15. Mezit A., Meziti H., Boudiaf K., Mustapha B., Bouriche H., Polyphenolic profile and antioxidant activities of Nigella sativa seed extracts in vitro and in vivo. World Academy of Science, Engineering & Technology 2012 64 6 24 32
16. Nergiz C., Otles S., Chemical composition of Nigella sativa L. seeds. Food Chemistry 1993 48 3 259 261 2-s2.0-0027323712 10.1016/0308-8146(93)90137-5 (Pubitemid 23249459)
17. Ghosheh O. A., Houdi A. A., Crooks P. A., High performance liquid chromatographic analysis of the pharmacologically active quinones and related compounds in the oil of the black seed (Nigella sativa L.). Journal of Pharmaceutical and Biomedical Analysis 1999 19 5 757 762 2-s2.0-0033120349 10.1016/S0731-7085(98)00300-8 (Pubitemid 29092778)
18. Dehkordi F. R., Kamkhah A. F., Antihypertensive effect of Nigella sativa seed extract in patients with mild hypertension. Fundamental & Clinical Pharmacology 2008 22 4 447 452 2-s2.0-55949121968 10.1111/j.1472-8206.2008. 00607.x
19. Khattab M. M., Nagi M. N., Thymoquinone supplementation attenuates hypertension and renal damage in nitric oxide deficient hypertensive rats. Phytotherapy Research 2007 21 5 410 414 2-s2.0-34248165186 10.1002/ptr.2083 (Pubitemid 46715078)
20. Leong X.-F., Mustafa M. R., Jaarin K., Nigella sativa and its protective role in oxidative stress and hypertension. Evidence-Based Complementary and Alternative Medicine 2013 2013 9 120732 10.1155/2013/120732
21. Tahraoui A., El-Hilaly J., Israili Z. H., Lyoussi B., Ethnopharmacological survey of plants used in the traditional treatment of hypertension and diabetes in south-eastern Morocco (Errachidia province). Journal of Ethnopharmacology 2007 110 1 105 117 2-s2.0-33846852196 10.1016/j.jep.2006.09.011 (Pubitemid 46217839)
22. Mohtashami R., Amini M., Huseini H. F., Ghamarchehre M., Sadeqhi Z., Hajiagaee R., Huseini A. F., Blood glucose lowering effects of Nigella sativa L. seeds oil in healthy volunteers: a randomized, double-blind, placebo-controlled clinical trial. Journal of Medicinal Plants 2011 10 39 90 94 2-s2.0-81255163748
23. Zaoui A., Cherrah Y., Lacaille-Dubois M. A., Settaf A., Amarouch H., Hassar M., Diuretic and hypotensive effects of Nigella sativa on the spontaneously hypertensive rat. Therapie 2000 55 3 379 382 2-s2.0-0034186616 (Pubitemid 30481173)
24. Ahmad S., Beg Z. H., Elucidation of mechanisms of actions of thymoquinone-enriched methanolic and volatile oil extracts from Nigella sativa against cardiovascular risk parameters in experimental hyperlipidemia. Lipids in Health and Disease 2013 12, article 86 10.1186/1476-511X-12-86
25. Hamed A., Alobaidi A., Effect of Nigella sativa and Allium sativum coadminstered with simvastatin in dyslipidemia patients: a prospective, randomized, double-blind trial. Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2014 13 1 68 74
26. Le P. M., Benhaddou-Andaloussi A., Elimadi A., Settaf A., Cherrah Y., Haddad P. S., The petroleum ether extract of Nigella sativa exerts lipid-lowering and insulin-sensitizing actions in the rat. Journal of Ethnopharmacology 2004 94 2-3 251 259 2-s2.0-4344587232 10.1016/j.jep.2004.04. 030 (Pubitemid 39119926)
27. Sabzghabaee A. M., Dianatkhah M., Sarrafzadegan N., Asgary S., Ghannadi A., Clinical evaluation of Nigella sativa seeds for the treatment of hyperlipidemia: a randomized, placebo controlled clinical trial. Medical Archives 2012 66 3 198 200 10.5455/medarh.2012.66.198-200
28. El-Saleh S. C., Al-Sagair O. A., Al-Khalaf M. I., Thymoquinone and Nigella sativa oil protection against methionine-induced hyperhomocysteinemia in rats. International Journal of Cardiology 2004 93 1 19 23 2-s2.0-0347318041 10.1016/S0167-5273(03)00108-6 (Pubitemid 38068504)
29. Idris-Khodja N., Schini-Kerth V., Thymoquinone improves aging-related endothelial dysfunction in the rat mesenteric artery. Naunyn-Schmiedeberg's Archives of Pharmacology 2012 385 7 749 758 2-s2.0-84859452048 10.1007/s00210-012-0749-8
30. Félétou M., Vanhoutte P. M., Endothelial dysfunction: a multifaceted disorder (The Wiggers Award Lecture). American Journal of Physiology: Heart and Circulatory Physiology 2006 291 3 H985 H1002 2-s2.0-33748421398 10.1152/ajpheart.00292.2006 (Pubitemid 44343640)
31. Bello R., Calatayud S., Moreno L., Beltran B., Primo-Yúfera E., Esplugues J., Effects on arterial blood pressure of the methanol extracts from different Teucrium species. Phytotherapy Research 1997 11 4 330 331 (Pubitemid 27250273)
32. Niazmand S., Esparham M., Hassannia T., Derakhshan M., Cardiovascular effects of Teucrium polium L. extract in rabbit. Pharmacognosy Magazine 2011 7 27 260 264 2-s2.0-80052761293 10.4103/0973-1296.84244
33. Lohn M., Furstenau M., Sagach V., Elger M., Schulze W., Luft F. C., Haller H., Gollasch M., Ignition of calcium sparks in arterial and cardiac muscle through caveolae. Circulation Research 2000 87 11 1034 1039 2-s2.0-0034711504
34. 2+-sensitive ion channels. Cell Calcium 2003 34 3 211 229 2-s2.0-0041977092 10.1016/S0143- 4160(03)00124-6 (Pubitemid 37009930)
35. 2+ oscillations. Biophysical Journal 2006 90 1 1 23 2-s2.0-33646162419 10.1529/biophysj.104.058743
36. Nelson M. T., Quayle J. M., Physiological roles and properties of potassium channels in arterial smooth muscle. American Journal of Physiology: Cell Physiology 1995 268 4, part 1 C799 C822 2-s2.0-0029108913
37. Thorneloe K. S., Nelson M. T., Ion channels in smooth muscle: regulators of intracellular calcium and contractility. Canadian Journal of Physiology and Pharmacology 2005 83 3 215 242 2-s2.0-21744452492 10.1139/y05-016 (Pubitemid 40942310)
38. 2+ oscillations and waves in smooth muscle. Biochemical Society Transactions 2003 31 5 920 924 2-s2.0-0142153381 (Pubitemid 37305017)
39. + channels in vascular smooth muscle cells. Journal of Smooth Muscle Research 2008 44 2 65 81 2-s2.0-45749103308 10.1540/jsmr.44.65
40. Côrtes S. F., Rezende B. A., Corriu C., Medeiros I. A., Teixeira M. M., Lopes M. J., Lemos V. S., Pharmacological evidence for the activation of potassium channels as the mechanism involved in the hypotensive and vasorelaxant effect of dioclein in rat small resistance arteries. British Journal of Pharmacology 2001 133 6 849 858 2-s2.0-0034881959 (Pubitemid 32751794)
41. Jackson W. F., Ion channels and vascular tone. Hypertension 2000 35 1, part 2 173 178 2-s2.0-0033977162 (Pubitemid 30054169)
42. Boskabady M. H., Shafei M. N., Parsaee H., Effects of aqueous and macerated extracts from Nigella sativa on guinea pig isolated heart activity. Pharmazie 2005 60 12 943 948 2-s2.0-29244439017 (Pubitemid 41820763)