메뉴 건너뛰기




Volumn 34, Issue 23, 2014, Pages 7754-7762

Critical role of peripheral vasoconstriction in fatal brain hyperthermia induced by MDMA (Ecstasy) under conditions that mimic human drug use

Author keywords

Acute intoxication; Brain temperature; MDMA; Peripheral vasoconstriction; Social interaction; Warm environment

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL TONE; BRAIN HYPERTHERMIA; BRAIN METABOLISM; BRAIN TEMPERATURE; CONTROLLED STUDY....?; DRUG USE; HISTOLOGY; HOMEOSTASIS; HYPERTHERMIA; LOCOMOTION; MALE; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; RAT; SKIN TEMPERATURE; SOCIAL INTERACTION; TEMPERATURE MEASUREMENT; TEMPORALIS MUSCLE; THERMOGENESIS; VASOCONSTRICTION;

EID: 84901744457     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0506-14.2014     Document Type: Article
Times cited : (43)

References (58)
  • 1
    • 80054812680 scopus 로고    scopus 로고
    • Opiate versus psychostimulant addiction: The differences do matter
    • CrossRef Medline
    • Badiani A, Belin D, Epstein D, Calu D, Shaham Y (2011) Opiate versus psychostimulant addiction: the differences do matter. Nat Rev Neurosci 12:685-700. CrossRef Medline
    • (2011) Nat Rev Neurosci , vol.12 , pp. 685-700
    • Badiani, A.1    Belin, D.2    Epstein, D.3    Calu, D.4    Shaham, Y.5
  • 2
    • 71749104455 scopus 로고    scopus 로고
    • Neural and cardiac toxicities associated with 3,4-methylenedioxymethamphetamine (MDMA)
    • CrossRef Medline
    • Baumann MH, Rothman RB (2009) Neural and cardiac toxicities associated with 3,4-methylenedioxymethamphetamine (MDMA). Int Rev Neurobiol 88:257-296. CrossRef Medline
    • (2009) Int Rev Neurobiol , vol.88 , pp. 257-296
    • Baumann, M.H.1    Rothman, R.B.2
  • 3
    • 33751230490 scopus 로고    scopus 로고
    • 3,4-Methylenedioxymethamphetamine(MDMA)neurotoxicity in rats: A reappraisal of past and present findings
    • Medline
    • Baumann MH, Wang X, Rothman RB (2007) 3,4-Methylenedioxymethamphetamine(MDMA)neurotoxicity in rats: a reappraisal of past and present findings. Psychopharmacology 189:407-424. Medline
    • (2007) Psychopharmacology , vol.189 , pp. 407-424
    • Baumann, M.H.1    Wang, X.2    Rothman, R.B.3
  • 4
    • 70350330871 scopus 로고    scopus 로고
    • Effects of dose and route of administration on pharmacokinetics of (+ or-)-3,4-methylenedioxymethamphetamine in the rat
    • CrossRef Medline
    • Baumann MH, Zolkowska D, Kim I, Scheidweiler KB, Rothman RB, Huestis MA (2009) Effects of dose and route of administration on pharmacokinetics of (+ or-)-3,4-methylenedioxymethamphetamine in the rat. Drug Metab Dispos 37:2163-2170. CrossRef Medline
    • (2009) Drug Metab Dispos , vol.37 , pp. 2163-2170
    • Baumann, M.H.1    Zolkowska, D.2    Kim, I.3    Scheidweiler, K.B.4    Rothman, R.B.5    Huestis, M.A.6
  • 5
    • 33744943282 scopus 로고    scopus 로고
    • A review of the acute subjective effects of MDMA/ecstasy
    • CrossRef Medline
    • Baylen CA, Rosenberg H (2006) A review of the acute subjective effects of MDMA/ecstasy. Addiction 101:933-947. CrossRef Medline
    • (2006) Addiction , vol.101 , pp. 933-947
    • Baylen, C.A.1    Rosenberg, H.2
  • 6
    • 0038043717 scopus 로고    scopus 로고
    • Clozapine reverses hyperthermia and sympathetically mediated cutaneous vasconstriction induced by 3,4-methylenedioxymethamphetamine (ecstasy) in rabbits and rats
    • Medline
    • Blessing WW, Seaman B, Pedersen NP, Ootsuka Y (2003) Clozapine reverses hyperthermia and sympathetically mediated cutaneous vasconstriction induced by 3,4-methylenedioxymethamphetamine (ecstasy) in rabbits and rats. J Neurosci 23:6385-6391. Medline
    • (2003) J Neurosci , vol.23 , pp. 6385-6391
    • Blessing, W.W.1    Seaman, B.2    Pedersen, N.P.3    Ootsuka, Y.4
  • 7
    • 55349129950 scopus 로고    scopus 로고
    • MDMA-assisted psychotherapy using low doses in a small sample of women with chronic posttraumatic stress disorder
    • CrossRef Medline
    • Bouso JC, Doblin R, Farré M, Alcázar MA, Gómez-Jarabo G (2008) MDMA-assisted psychotherapy using low doses in a small sample of women with chronic posttraumatic stress disorder. J Psychoactive Drugs 40:225-236. CrossRef Medline
    • (2008) J Psychoactive Drugs , vol.40 , pp. 225-236
    • Bouso, J.C.1    Doblin, R.2    Farré, M.3    Alcázar, M.A.4    Gómez-Jarabo, G.5
  • 8
    • 3142666060 scopus 로고    scopus 로고
    • Brain hyperthermia induced by MDMA(ecstasy): Modulation by environmental conditions
    • CrossRef Medline
    • Brown PL, Kiyatkin EA (2004) Brain hyperthermia induced by MDMA(ecstasy): modulation by environmental conditions. Eur J Neurosci 20:51-58. CrossRef Medline
    • (2004) Eur J Neurosci , vol.20 , pp. 51-58
    • Brown, P.L.1    Kiyatkin, E.A.2
  • 9
    • 0037531195 scopus 로고    scopus 로고
    • Brain hyperthermia is induced by methamphetamine and exacerbated by social interaction
    • Medline
    • Brown PL, Wise RA, Kiyatkin EA (2003) Brain hyperthermia is induced by methamphetamine and exacerbated by social interaction. J Neurosci 23: 3924-3929. Medline
    • (2003) J Neurosci , vol.23 , pp. 3924-3929
    • Brown, P.L.1    Wise, R.A.2    Kiyatkin, E.A.3
  • 10
    • 0036214775 scopus 로고    scopus 로고
    • Effect of 3,4-methylenedioxymethamphetamine ("ecstasy") on body temperature and liver antioxidant status in mice: Influence of ambient temperature
    • CrossRef Medline
    • Carvalho M, Carvalho F, Remião F, de Lourdes Pereira M, Pires-das-Neves R, de Lourdes Bastos M (2002) Effect of 3,4-methylenedioxymethamphetamine ("ecstasy") on body temperature and liver antioxidant status in mice: influence of ambient temperature. Arch Toxicol 76:166-172. CrossRef Medline
    • (2002) Arch Toxicol , vol.76 , pp. 166-172
    • Carvalho, M.1    Carvalho, F.2    Remião, F.3    de Lourdes Pereira, M.4    Pires-das-Neves, R.5    de Lourdes Bastos, M.6
  • 11
    • 2442681827 scopus 로고    scopus 로고
    • Psychedelic drugs: The ups and downs of ecstasy
    • CrossRef Medline
    • Check E (2004) Psychedelic drugs: the ups and downs of ecstasy. Nature 429:126-128. CrossRef Medline
    • (2004) Nature , vol.429 , pp. 126-128
    • Check, E.1
  • 12
    • 84890620696 scopus 로고    scopus 로고
    • Nonlinear pharmacokinetics of ({+/-})3,4-methylenedioxymethamphetamine (MDMA) and its pharmacodynamic consequences in the rat
    • CrossRef Medline
    • Concheiro M, Baumann MH, Scheidweiler KB, Rothman RB, Marrone GF, Huestis MA (2014) Nonlinear pharmacokinetics of ({+/-})3,4-methylenedioxymethamphetamine (MDMA) and its pharmacodynamic consequences in the rat. Drug Metab Dispos 42:119-125. CrossRef Medline
    • (2014) Drug Metab Dispos , vol.42 , pp. 119-125
    • Concheiro, M.1    Baumann, M.H.2    Scheidweiler, K.B.3    Rothman, R.B.4    Marrone, G.F.5    Huestis, M.A.6
  • 13
    • 0023116756 scopus 로고
    • Toxicity of MDA (3,4-methylenedioxyamphetamine) considered for relevance to hazards of MDMA (ecstasy) abuse
    • Medline
    • Davis WM, Hatoum HT, Waters IW (1987) Toxicity of MDA (3,4-methylenedioxyamphetamine) considered for relevance to hazards of MDMA (ecstasy) abuse. Alcohol Drug Res 7:123-134. Medline
    • (1987) Alcohol Drug Res , vol.7 , pp. 123-134
    • Davis, W.M.1    Hatoum, H.T.2    Waters, I.W.3
  • 15
    • 0036325605 scopus 로고    scopus 로고
    • A clinical plan for MDMA (ecstasy) in the treatment of posttraumatic stress disorder (PTSD): Partnering with the FDA
    • CrossRef Medline
    • Doblin R (2002) A clinical plan for MDMA (ecstasy) in the treatment of posttraumatic stress disorder (PTSD): partnering with the FDA. J Psychoactive Drugs 34:185-194. CrossRef Medline
    • (2002) J Psychoactive Drugs , vol.34 , pp. 185-194
    • Doblin, R.1
  • 16
    • 33746796418 scopus 로고    scopus 로고
    • A review of acute effects of 3,4-methylenedioxymethamphetamine in healthy volunteers
    • CrossRef Medline
    • Dumont GJ, Verkes RJ (2006) A review of acute effects of 3,4-methylenedioxymethamphetamine in healthy volunteers. J Psychopharmacol 20:176-187. CrossRef Medline
    • (2006) J Psychopharmacol , vol.20 , pp. 176-187
    • Dumont, G.J.1    Verkes, R.J.2
  • 17
    • 0344061038 scopus 로고    scopus 로고
    • Pharmacological characterization of the effects of 3,4-methylenedioxymethamphetamine ("ecstasy") and its enantiomers on lethality, core temperature, and locomotor activity in singly housed and crowded mice
    • Medline
    • Fantegrossi WE, Godlewski T, Karabenick RL, Stephens JM, Ullrich T, Rice KC, Woods JH (2003) Pharmacological characterization of the effects of 3,4-methylenedioxymethamphetamine ("ecstasy") and its enantiomers on lethality, core temperature, and locomotor activity in singly housed and crowded mice. Psychopharmacology 166:202-211. Medline
    • (2003) Psychopharmacology , vol.166 , pp. 202-211
    • Fantegrossi, W.E.1    Godlewski, T.2    Karabenick, R.L.3    Stephens, J.M.4    Ullrich, T.5    Rice, K.C.6    Woods, J.H.7
  • 18
    • 27744480339 scopus 로고    scopus 로고
    • Thermoregulatory effects of 3,4-methylenedioxymethamphetamine (MDMA) in humans
    • CrossRef Medline
    • Freedman RR, Johanson CE, Tancer ME (2005) Thermoregulatory effects of 3,4-methylenedioxymethamphetamine (MDMA) in humans. Psychopharmacology 183:248-256. CrossRef Medline
    • (2005) Psychopharmacology , vol.183 , pp. 248-256
    • Freedman, R.R.1    Johanson, C.E.2    Tancer, M.E.3
  • 19
    • 34447625084 scopus 로고    scopus 로고
    • Thermophysiological responses to hyperthermic drugs: Extrapolating from rodent to human
    • CrossRef Medline
    • Gordon CJ (2007) Thermophysiological responses to hyperthermic drugs: extrapolating from rodent to human. Prog Brain Res 162:63-79. CrossRef Medline
    • (2007) Prog Brain Res , vol.162 , pp. 63-79
    • Gordon, C.J.1
  • 20
    • 0026081849 scopus 로고
    • Effects of 3,4-methylenedioxymethamphetamine on autonomic thermoregulatory responses of the rat
    • CrossRef Medline
    • Gordon CJ, Watkinson WP, O'Callaghan JP, Miller DB (1991) Effects of 3,4-methylenedioxymethamphetamine on autonomic thermoregulatory responses of the rat. Pharmacol Biochem Behav 38:339-344. CrossRef Medline
    • (1991) Pharmacol Biochem Behav , vol.38 , pp. 339-344
    • Gordon, C.J.1    Watkinson, W.P.2    O'Callaghan, J.P.3    Miller, D.B.4
  • 21
    • 0041466261 scopus 로고    scopus 로고
    • Thepharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine(MDMA, "ecstasy")
    • CrossRef Medline
    • Green AR, Mechan AO, Elliott JM, O'Shea E, Colado MI (2003) Thepharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine(MDMA, "ecstasy"). Pharmacol Rev 55:463-508. CrossRef Medline
    • (2003) Pharmacol Rev , vol.55 , pp. 463-508
    • Green, A.R.1    Mechan, A.O.2    Elliott, J.M.3    O'Shea, E.4    Colado, M.I.5
  • 22
    • 4644320720 scopus 로고    scopus 로고
    • The methamphetamine experience: A NIDA partnership
    • Medline
    • Hanson GR, Rau KS, Fleckenstein AE (2004) The methamphetamine experience: a NIDA partnership. Neuropharmacology 47 [Suppl 1]:92-100. Medline
    • (2004) Neuropharmacology , vol.47 , Issue.SUPPL. 1 , pp. 92-100
    • Hanson, G.R.1    Rau, K.S.2    Fleckenstein, A.E.3
  • 24
    • 0030324856 scopus 로고    scopus 로고
    • Changes in the ultrastructure of human cells related to certain biological responses under hyperthermic culture conditions
    • Medline
    • Iwagami Y (1996) Changes in the ultrastructure of human cells related to certain biological responses under hyperthermic culture conditions. Hum Cell 9:353-366. Medline
    • (1996) Hum Cell , vol.9 , pp. 353-366
    • Iwagami, Y.1
  • 25
    • 0035664224 scopus 로고    scopus 로고
    • The pharmacology and toxicology of "ecstasy" (MDMA) and related drugs
    • Medline
    • Kalant H (2001) The pharmacology and toxicology of "ecstasy" (MDMA) and related drugs. CMAJ 165:917-928. Medline
    • (2001) CMAJ , vol.165 , pp. 917-928
    • Kalant, H.1
  • 26
    • 73249137207 scopus 로고    scopus 로고
    • Brain temperature homeostasis: Physiological fluctuations and pathological shifts
    • CrossRef Medline
    • Kiyatkin EA (2010) Brain temperature homeostasis: physiological fluctuations and pathological shifts. Front Biosci 15:73-92. CrossRef Medline
    • (2010) Front Biosci , vol.15 , pp. 73-92
    • Kiyatkin, E.A.1
  • 27
    • 84873706679 scopus 로고    scopus 로고
    • The hidden side of drug action: Brain temperature changes induced by neuroactive drugs
    • CrossRef Medline
    • Kiyatkin EA (2013) The hidden side of drug action: brain temperature changes induced by neuroactive drugs. Psychopharmacology 225:765-780. CrossRef Medline
    • (2013) Psychopharmacology , vol.225 , pp. 765-780
    • Kiyatkin, E.A.1
  • 28
    • 9744222888 scopus 로고    scopus 로고
    • Modulation of physiological brain hyperthermia by environmental temperature and impaired blood outflow in rats
    • CrossRef Medline
    • Kiyatkin EA, Brown PL (2004) Modulation of physiological brain hyperthermia by environmental temperature and impaired blood outflow in rats. Physiol Behav 83:467-474. CrossRef Medline
    • (2004) Physiol Behav , vol.83 , pp. 467-474
    • Kiyatkin, E.A.1    Brown, P.L.2
  • 29
    • 16844376187 scopus 로고    scopus 로고
    • Brain and body temperature homeostasis during sodium pentobarbital anesthesia with and without body warming in rats
    • CrossRef Medline
    • Kiyatkin EA, Brown PL (2005) Brain and body temperature homeostasis during sodium pentobarbital anesthesia with and without body warming in rats. Physiol Behav 84:563-570. CrossRef Medline
    • (2005) Physiol Behav , vol.84 , pp. 563-570
    • Kiyatkin, E.A.1    Brown, P.L.2
  • 30
    • 67349091117 scopus 로고    scopus 로고
    • Permeability of the blood-brain barrier depends on brain temperature
    • CrossRef Medline
    • Kiyatkin EA, Sharma HS (2009) Permeability of the blood-brain barrier depends on brain temperature. Neuroscience 161:926-939. CrossRef Medline
    • (2009) Neuroscience , vol.161 , pp. 926-939
    • Kiyatkin, E.A.1    Sharma, H.S.2
  • 31
    • 34548301692 scopus 로고    scopus 로고
    • Brain edema and breakdown of the blood-brain barrier during methamphetamine intoxication: Critical role of brain hyperthermia
    • CrossRef Medline
    • Kiyatkin EA, Brown PL, Sharma HS (2007) Brain edema and breakdown of the blood-brain barrier during methamphetamine intoxication: critical role of brain hyperthermia. Eur J Neurosci 26:1242-1253. CrossRef Medline
    • (2007) Eur J Neurosci , vol.26 , pp. 1242-1253
    • Kiyatkin, E.A.1    Brown, P.L.2    Sharma, H.S.3
  • 32
    • 47249166411 scopus 로고    scopus 로고
    • Plasma pharmacokinetics of 3,4-methylenedioxymethamphetamine after controlled oral administration to young adults
    • CrossRef Medline
    • Kolbrich EA, Goodwin RS, Gorelick DA, Hayes RJ, Stein EA, Huestis MA (2008) Plasma pharmacokinetics of 3,4-methylenedioxymethamphetamine after controlled oral administration to young adults. Ther Drug Monit 30:320-332. CrossRef Medline
    • (2008) Ther Drug Monit , vol.30 , pp. 320-332
    • Kolbrich, E.A.1    Goodwin, R.S.2    Gorelick, D.A.3    Hayes, R.J.4    Stein, E.A.5    Huestis, M.A.6
  • 33
    • 0038376295 scopus 로고    scopus 로고
    • Cellular effects of hyperthermia: Relevance to the minimumdose for thermal damage
    • CrossRef Medline
    • Lepock JR (2003) Cellular effects of hyperthermia: relevance to the minimumdose for thermal damage. Int J Hyperthermia 19:252-266. CrossRef Medline
    • (2003) Int J Hyperthermia , vol.19 , pp. 252-266
    • Lepock, J.R.1
  • 34
    • 0034687860 scopus 로고    scopus 로고
    • Cardiovascular effects of 3,4-methylenedioxymethamphetamine. A double-blind, placebo-controlled trial
    • CrossRef Medline
    • Lester SJ, Baggott M, Welm S, Schiller NB, Jones RT, Foster E, Mendelson J (2000) Cardiovascular effects of 3,4-methylenedioxymethamphetamine. A double-blind, placebo-controlled trial. Ann Intern Med 133:969-973. CrossRef Medline
    • (2000) Ann Intern Med , vol.133 , pp. 969-973
    • Lester, S.J.1    Baggott, M.2    Welm, S.3    Schiller, N.B.4    Jones, R.T.5    Foster, E.6    Mendelson, J.7
  • 35
    • 0029846728 scopus 로고    scopus 로고
    • Adverse reactions with 3,4-methylenedioxymethamphetamine (MDMA; 'ecstasy')
    • CrossRef Medline
    • McCann UD, Slate SO, Ricaurte GA (1996) Adverse reactions with 3,4-methylenedioxymethamphetamine (MDMA; 'ecstasy'). Drug Saf 15:107-115. CrossRef Medline
    • (1996) Drug Saf , vol.15 , pp. 107-115
    • McCann, U.D.1    Slate, S.O.2    Ricaurte, G.A.3
  • 36
    • 0036152649 scopus 로고    scopus 로고
    • The pharmacology of the acute hyperthermic response that follows administration of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') to rats
    • CrossRef Medline
    • Mechan AO, Esteban B, O'Shea E, Elliott JM, Colado MI, Green AR (2002) The pharmacology of the acute hyperthermic response that follows administration of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') to rats. Br J Pharmacol 135:170-180. CrossRef Medline
    • (2002) Br J Pharmacol , vol.135 , pp. 170-180
    • Mechan, A.O.1    Esteban, B.2    O'Shea, E.3    Elliott, J.M.4    Colado, M.I.5    Green, A.R.6
  • 37
    • 0037403797 scopus 로고    scopus 로고
    • Elevated environmental temperature and methamphetamine neurotoxicity
    • CrossRef Medline
    • Miller DB, O'Callaghan JP (2003) Elevated environmental temperature and methamphetamine neurotoxicity. Environ Res 92:48-53. CrossRef Medline
    • (2003) Environ Res , vol.92 , pp. 48-53
    • Miller, D.B.1    O'Callaghan, J.P.2
  • 38
    • 79960955212 scopus 로고    scopus 로고
    • 'Ecstasy' associated deaths: What is a fatal concentration? Analysis of a case series
    • CrossRef Medline
    • Milroy CM (2011) "Ecstasy" associated deaths: what is a fatal concentration? Analysis of a case series. Forensic Sci Med Pathol 7:248-252. CrossRef Medline
    • (2011) Forensic Sci Med Pathol , vol.7 , pp. 248-252
    • Milroy, C.M.1
  • 39
    • 84871603204 scopus 로고    scopus 로고
    • Durability of improvement in post-traumatic stress disorder symptoms and absence of harmful effects or drug dependency after 3,4-methylenedioxymethamphetamine-assisted psychotherapy: A prospective long-term follow-up study
    • CrossRef Medline
    • Mithoefer MC, Wagner MT, Mithoefer AT, Jerome L, Martin SF, Yazar-Klosinski B, Michel Y, Brewerton TD, Doblin R (2013) Durability of improvement in post-traumatic stress disorder symptoms and absence of harmful effects or drug dependency after 3,4-methylenedioxymethamphetamine-assisted psychotherapy: a prospective long-term follow-up study. J Psychopharmacol 27:28-39. CrossRef Medline
    • (2013) J Psychopharmacol , vol.27 , pp. 28-39
    • Mithoefer, M.C.1    Wagner, M.T.2    Mithoefer, A.T.3    Jerome, L.4    Martin, S.F.5    Yazar-Klosinski, B.6    Michel, Y.7    Brewerton, T.D.8    Doblin, R.9
  • 40
    • 0019188610 scopus 로고
    • From motivation to action: Functional interface between the limbic system and the motor system
    • CrossRef Medline
    • Mogenson GJ, Jones DL, Yim CY (1980) From motivation to action: functional interface between the limbic system and the motor system. Prog Neurobiol 14:69-97. CrossRef Medline
    • (1980) Prog Neurobiol , vol.14 , pp. 69-97
    • Mogenson, G.J.1    Jones, D.L.2    Yim, C.Y.3
  • 41
    • 0002209037 scopus 로고
    • The use of interspecies scaling in toxicokinetics
    • In: (Yacobi A, Kelly J, Batra V, eds), New York: Pergamon
    • Mordenti J, Chappell W (1989) The use of interspecies scaling in toxicokinetics. In: Toxicokinetics and new drug development (Yacobi A, Kelly J, Batra V, eds), pp 42-96. New York: Pergamon.
    • (1989) Toxicokinetics and new drug development , pp. 42-96
    • Mordenti, J.1    Chappell, W.2
  • 42
    • 84879719261 scopus 로고    scopus 로고
    • Human psychobiology of MDMA or 'ecstasy': An overview of 25 years of empirical research
    • CrossRef Medline
    • Parrott AC (2013) Human psychobiology of MDMA or 'ecstasy': an overview of 25 years of empirical research. Hum Psychopharmacol 28:289-307. CrossRef Medline
    • (2013) Hum Psychopharmacol , vol.28 , pp. 289-307
    • Parrott, A.C.1
  • 44
    • 0035503298 scopus 로고    scopus 로고
    • Cutaneous vasoconstriction contributes to hyperthermia induced by 3,4-methylenedioxymethamphetamine (ecstasy) in conscious rabbits
    • Medline
    • Pedersen NP, Blessing WW (2001) Cutaneous vasoconstriction contributes to hyperthermia induced by 3,4-methylenedioxymethamphetamine (ecstasy) in conscious rabbits. J Neurosci 21:8648-8654. Medline
    • (2001) J Neurosci , vol.21 , pp. 8648-8654
    • Pedersen, N.P.1    Blessing, W.W.2
  • 45
    • 0034767580 scopus 로고    scopus 로고
    • An exploration of the history and controversies surrounding MDMA and MDA
    • CrossRef Medline
    • Pentney AR (2001) An exploration of the history and controversies surrounding MDMA and MDA. J Psychoactive Drugs 33:213-221. CrossRef Medline
    • (2001) J Psychoactive Drugs , vol.33 , pp. 213-221
    • Pentney, A.R.1
  • 46
    • 0037096036 scopus 로고    scopus 로고
    • Reduced (+/+)-3,4-methylenedioxymethamphetamine ("ecstasy") metabolism with cytochrome P450 2D6 inhibitors and pharmacogenetic variants in vitro
    • CrossRef Medline
    • Ramamoorthy Y, Yu AM, Suh N, Haining RL, Tyndale RF, Sellers EM (2002) Reduced (+/+)-3,4-methylenedioxymethamphetamine ("ecstasy") metabolism with cytochrome P450 2D6 inhibitors and pharmacogenetic variants in vitro. Biochem Pharmacol 63:2111-2119. CrossRef Medline
    • (2002) Biochem Pharmacol , vol.63 , pp. 2111-2119
    • Ramamoorthy, Y.1    Yu, A.M.2    Suh, N.3    Haining, R.L.4    Tyndale, R.F.5    Sellers, E.M.6
  • 47
    • 0034900590 scopus 로고    scopus 로고
    • Experimental studies on 3,4-methylenedioxymethamphetamine (MDA, "ecstasy") and its potential to damage brain serotonin neurons
    • CrossRef Medline
    • Ricaurte GA, McCann UD (2001) Experimental studies on 3,4-methylenedioxymethamphetamine (MDA, "ecstasy") and its potential to damage brain serotonin neurons. Neurotox Res 3:85-99. CrossRef Medline
    • (2001) Neurotox Res , vol.3 , pp. 85-99
    • Ricaurte, G.A.1    McCann, U.D.2
  • 48
    • 0033623773 scopus 로고    scopus 로고
    • (+/-)3,4-Methylenedioxymethamphetamine ('ecstasy')-induced serotonin neurotoxicity: Studies in animals
    • CrossRef Medline
    • Ricaurte GA, Yuan J, McCann UD (2000) (+/-)3,4-Methylenedioxymethamphetamine ('ecstasy')-induced serotonin neurotoxicity: studies in animals. Neuropsychobiology 42:5-10. CrossRef Medline
    • (2000) Neuropsychobiology , vol.42 , pp. 5-10
    • Ricaurte, G.A.1    Yuan, J.2    McCann, U.D.3
  • 49
    • 0036085577 scopus 로고    scopus 로고
    • Selected contribution: Ambient temperature for experiments in rats: A new method for determining the zone of thermal neutrality
    • Romanovsky AA, Ivanov AI, Shimansky YP (2002) Selected contribution: ambient temperature for experiments in rats: a new method for determining the zone of thermal neutrality. J Appl Physiol (1985) 92:2667-2679.
    • (2002) J Appl Physiol (1985) , vol.92 , pp. 2667-2679
    • Romanovsky, A.A.1    Ivanov, A.I.2    Shimansky, Y.P.3
  • 50
    • 0020956786 scopus 로고
    • Cardiovascular aspects of human thermoregulation
    • CrossRef Medline
    • Rowell LB (1983) Cardiovascular aspects of human thermoregulation. Circ Res 52:367-379. CrossRef Medline
    • (1983) Circ Res , vol.52 , pp. 367-379
    • Rowell, L.B.1
  • 51
    • 45849097934 scopus 로고    scopus 로고
    • When administered to rats in a cold environment, 3,4-methylenedioxymethamphetamine reduces brown adipose tissue thermogenesis and increases tail blood flow: Effects of pretreatment with 5-HT1A and dopamine D2 antagonists
    • CrossRef Medline
    • Rusyniak DE, Ootsuka Y, Blessing WW (2008) When administered to rats in a cold environment, 3,4-methylenedioxymethamphetamine reduces brown adipose tissue thermogenesis and increases tail blood flow: effects of pretreatment with 5-HT1A and dopamine D2 antagonists. Neuroscience 154:1619-1626. CrossRef Medline
    • (2008) Neuroscience , vol.154 , pp. 1619-1626
    • Rusyniak, D.E.1    Ootsuka, Y.2    Blessing, W.W.3
  • 52
    • 0028764006 scopus 로고
    • Inappropriate antidiuretic hormone secretion and extreme rises in serum creatinine kinase following MDMA ingestion
    • Medline
    • Satchell SC, Connaughton M (1994) Inappropriate antidiuretic hormone secretion and extreme rises in serum creatinine kinase following MDMA ingestion. Br J Hosp Med 51:495. Medline
    • (1994) Br J Hosp Med , vol.51 , pp. 495
    • Satchell, S.C.1    Connaughton, M.2
  • 53
    • 53549134954 scopus 로고    scopus 로고
    • Acute administration of 3,4-methylenedioxymethamphetamine induces profound hyperthermia, blood-brain barrier disruption, brain edema formation, and cell injury
    • CrossRef Medline
    • Sharma HS, Ali SF (2008) Acute administration of 3,4-methylenedioxymethamphetamine induces profound hyperthermia, blood-brain barrier disruption, brain edema formation, and cell injury. Ann N Y Acad Sci 1139:242-258. CrossRef Medline
    • (2008) Ann N Y Acad Sci , vol.1139 , pp. 242-258
    • Sharma, H.S.1    Ali, S.F.2
  • 54
    • 57449112998 scopus 로고    scopus 로고
    • Rapid morphological brain abnormalities during acute methamphetamine intoxication in the rat: An experimental study using light and electron microscopy
    • CrossRef Medline
    • Sharma HS, Kiyatkin EA (2009) Rapid morphological brain abnormalities during acute methamphetamine intoxication in the rat: an experimental study using light and electron microscopy. J Chem Neuroanat 37:18-32. CrossRef Medline
    • (2009) J Chem Neuroanat , vol.37 , pp. 18-32
    • Sharma, H.S.1    Kiyatkin, E.A.2
  • 55
    • 57349159346 scopus 로고    scopus 로고
    • Fluctuations in central and peripheral temperatures associated with feeding behavior in rats
    • CrossRef Medline
    • Smirnov MS, Kiyatkin EA (2008) Fluctuations in central and peripheral temperatures associated with feeding behavior in rats. Am J Physiol Regul Integr Comp Physiol 295:R1415-R1424. CrossRef Medline
    • (2008) Am J Physiol Regul Integr Comp Physiol , vol.295
    • Smirnov, M.S.1    Kiyatkin, E.A.2
  • 57
  • 58
    • 0003042882 scopus 로고
    • The brain and reward
    • In: (Liebman JM, Kooper SJ, eds), Oxford: Oxford UP
    • Wise RA (1989) The brain and reward. In: The neuropharmacological basis of reward (Liebman JM, Kooper SJ, eds), pp 377-424. Oxford: Oxford UP.
    • (1989) The neuropharmacological basis of reward , pp. 377-424
    • Wise, R.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.