An experimental approach to evaluate the impact of impaired transport function on hepatobiliary drug disposition using Mrp2-deficient TR- rat sandwich-cultured hepatocytes in combination with Bcrp knockdown

Molecular Pharmaceutics

Volumn 11, Issue 3, 2014, Pages 766-775

  Yang, Kyunghee ^a   Pfeifer, Nathan D ^a   Hardwick, Rhiannon N ^b   Yue, Wei ^a,c   Stewart, Paul W ^b   Brouwer, Kim L R ^a,b  

^a University of North Carolina at Chapel Hill   (United States)

^b The University of North Carolina at Chapel Hill   (United States)

^c UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

Author keywords

breast cancer resistance protein (BCRP Bcrp); multidrug resistance associated protein 2 (MRP2 Mrp2); RNA interference (RNAi); sandwich cultured hepatocytes (SCH)

Indexed keywords

ADENOVIRUS VECTOR; BREAST CANCER RESISTANCE PROTEIN; CARRIER PROTEIN; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 2; ROSUVASTATIN; SHORT HAIRPIN RNA; TAUROCHOLIC ACID; ABC TRANSPORTER; ABCC2 PROTEIN, RAT; ABCG2 PROTEIN, RAT; DETERGENT; FLUOROBENZENE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MESSENGER RNA; PYRIMIDINE DERIVATIVE; SMALL INTERFERING RNA; SULFONAMIDE;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ARTICLE; BILIARY EXCRETION; CONTROLLED STUDY; DRUG DISPOSITION; ENZYME IMMUNOASSAY; GENE SILENCING; GENE TARGETING; HEPATOBILIARY SYSTEM; IN VITRO STUDY; LIVER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; RAT; RNA INTERFERENCE; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; GENETICS; MALE; METABOLISM; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSPORT AT THE CELLULAR LEVEL; WESTERN BLOTTING; WISTAR RAT;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BILIARY TRACT; BIOLOGICAL TRANSPORT; BLOTTING, WESTERN; CELLS, CULTURED; DETERGENTS; FLUOROBENZENES; HEPATOCYTES; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; PYRIMIDINES; RATS; RATS, WISTAR; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; ROSUVASTATIN CALCIUM; SULFONAMIDES; TAUROCHOLIC ACID;

EID: 84901741247     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp400471e     Document Type: Article

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