메뉴 건너뛰기




Volumn 16, Issue 7, 2014, Pages

Mesenchymal stem cell therapy for cardiac repair

Author keywords

Cardiac injury; Heart disease; Mesenchymal stem cell therapy; Transplantation

Indexed keywords

HEART DISEASE; HEART INJURY; HUMAN; MESENCHYMAL STEM CELL TRANSPLANTATION; NONHUMAN; PLURIPOTENT STEM CELL; REGENERATIVE MEDICINE; REVIEW;

EID: 84901739670     PISSN: 10928464     EISSN: 15343189     Source Type: Journal    
DOI: 10.1007/s11936-014-0323-4     Document Type: Review
Times cited : (45)

References (56)
  • 1
    • 84872054233 scopus 로고    scopus 로고
    • Executive summary: Heart disease and stroke statistics - 2013 Update: A report from the American Heart Association
    • Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Borden WB, et al. Executive summary: heart disease and stroke statistics - 2013 update: a report from the American Heart Association. Circulation. 2013;127(1):143-52.
    • (2013) Circulation , vol.127 , Issue.1 , pp. 143-152
    • Go, A.S.1    Mozaffarian, D.2    Roger, V.L.3    Benjamin, E.J.4    Berry, J.D.5    Borden, W.B.6
  • 2
    • 0026354053 scopus 로고
    • Ventricular enlargement and remodeling following acute myocardial infarction: Mechanisms and management
    • Braunwald E, Pfeffer MA. Ventricular enlargement and remodeling following acute myocardial infarction: mechanisms and management. Am J Cardiol. 1991;68(14):1D-6.
    • (1991) Am J Cardiol , vol.68 , Issue.14
    • Braunwald, E.1    Pfeffer, M.A.2
  • 3
    • 0025266820 scopus 로고
    • Ventricular remodeling after myocardial infarction: Experimental observations and clinical implications
    • Pfeffer MA, Braunwald E. Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications. Circulation. 1990;81(4):1161-72. (Pubitemid 20119612)
    • (1990) Circulation , vol.81 , Issue.4 , pp. 1161-1172
    • Pfeffer, M.A.1    Braunwald, E.2
  • 4
    • 0034720847 scopus 로고    scopus 로고
    • Left ventricular remodeling after myocardial infarction: Pathophysiology and therapy
    • Sutton MG, Sharpe N. Left ventricular remodeling after myocardial infarction: pathophysiology and therapy. Circulation. 2000;101(25):2981-8. (Pubitemid 30415891)
    • (2000) Circulation , vol.101 , Issue.25 , pp. 2981-2988
    • St., J.S.M.G.1    Sharpe, N.2
  • 5
    • 0034162004 scopus 로고    scopus 로고
    • Cardiac remodeling-concepts and clinical implications: A consensus paper from an International Forum on Cardiac Remodeling
    • DOI 10.1016/S0735-1097(99)00630-0, PII S0735109799006300
    • Cohn JN, Ferrari R, Sharpe N. Cardiac remodeling - concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling. J Am Coll Cardiol. 2000;35(3):569-82. (Pubitemid 30167013)
    • (2000) Journal of the American College of Cardiology , vol.35 , Issue.3 , pp. 569-582
    • Cohn, J.N.1    Ferrari, R.2    Sharpe, N.3
  • 9
    • 0013978932 scopus 로고
    • Osteogenesis in transplants of bone marrow cells
    • Research that led to the discovery of MSC and eventually their therapeutic properties
    • • Friedenstein AJ, Piatetzky-Shapiro II, Petrakova KV. Osteogenesis in transplants of bone marrow cells. J Embryol Exp Morphol. 1966;16(3):381-90. Research that led to the discovery of MSC and eventually their therapeutic properties.
    • (1966) J Embryol Exp Morphol , vol.16 , Issue.3 , pp. 381-390
    • Friedenstein, A.J.1    Piatetzky-Shapiro, I.I.2    Petrakova, K.V.3
  • 10
    • 84989485234 scopus 로고
    • The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells
    • Friedenstein AJ, Chailakhjan RK, Lalykina KS. The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells. Cell Tissue Kinet. 1970;3(4):393-403.
    • (1970) Cell Tissue Kinet , vol.3 , Issue.4 , pp. 393-403
    • Friedenstein, A.J.1    Chailakhjan, R.K.2    Lalykina, K.S.3
  • 11
    • 84990622726 scopus 로고
    • Bone marrow osteogenic stem cells: In vitro cultivation and transplantation in diffusion chambers
    • Friedenstein AJ, Chailakhyan RK, Gerasimov UV. Bone marrow osteogenic stem cells: in vitro cultivation and transplantation in diffusion chambers. Cell Tissue Kinet. 1987;20(3):263 -72.
    • (1987) Cell Tissue Kinet , vol.20 , Issue.3 , pp. 263-272
    • Friedenstein, A.J.1    Chailakhyan, R.K.2    Gerasimov, U.V.3
  • 12
    • 0024252149 scopus 로고
    • Stromal stem cells: Marrow-derived osteogenic precursors
    • Owen M, Friedenstein AJ. Stromal stem cells: marrow-derived osteogenic precursors. Ciba Found Symp. 1988;136:42-60.
    • (1988) Ciba Found Symp , vol.136 , pp. 42-60
    • Owen, M.1    Friedenstein, A.J.2
  • 13
    • 0026228558 scopus 로고
    • Mesenchymal stem cells
    • Caplan AI. Mesenchymal stem cells. J Orthop Res. 1991;9(5):641- 50.
    • (1991) J Orthop Res , vol.9 , Issue.5 , pp. 641-650
    • Caplan, A.I.1
  • 15
    • 33747713246 scopus 로고    scopus 로고
    • Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement
    • Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini FC, Krause DS, et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy. 2006;8(4):315-7.
    • (2006) Cytotherapy , vol.8 , Issue.4 , pp. 315-317
    • Dominici, M.1    Le Blanc, K.2    Mueller, I.3    Slaper-Cortenbach, I.4    Marini, F.C.5    Krause, D.S.6
  • 16
    • 24944503491 scopus 로고    scopus 로고
    • Mesenchymal stem cells: Cell-based reconstructive therapy in orthopedics
    • DOI 10.1089/ten.2005.11.1198
    • Caplan AI. Mesenchymal stem cells: cell-based reconstructive therapy in orthopedics. Tissue Eng. 2005;11(7-8):1198-211. (Pubitemid 41321423)
    • (2005) Tissue Engineering , vol.11 , Issue.7-8 , pp. 1198-1211
    • Caplan, A.I.1
  • 17
    • 58449135981 scopus 로고    scopus 로고
    • Why are MSCs therapeutic? New data: New insight
    • Caplan AI. Why are MSCs therapeutic? New data: new insight. J Pathol. 2009;217(2):318-24.
    • (2009) J Pathol , vol.217 , Issue.2 , pp. 318-324
    • Caplan, A.I.1
  • 18
    • 0036142213 scopus 로고    scopus 로고
    • Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart
    • DOI 10.1161/hc0102.101442
    • Toma C, Pittenger MF, Cahill KS, Byrne BJ, Kessler PD. Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart. Circulation. 2002;105(1):93-8. (Pubitemid 34049148)
    • (2002) Circulation , vol.105 , Issue.1 , pp. 93-98
    • Toma, C.1    Pittenger, M.F.2    Cahill, K.S.3    Byrne, B.J.4    Kessler, P.D.5
  • 19
  • 20
    • 77958012860 scopus 로고    scopus 로고
    • Bone marrow mesenchymal stem cells stimulate cardiac stem cell proliferation and differentiation
    • Hatzistergos KE, Quevedo H, Oskouei BN, Hu Q, Feigenbaum GS, Margitich IS, et al. Bone marrow mesenchymal stem cells stimulate cardiac stem cell proliferation and differentiation. Circ Res. 2010;107(7):913-22.
    • (2010) Circ Res , vol.107 , Issue.7 , pp. 913-922
    • Hatzistergos, K.E.1    Quevedo, H.2    Oskouei, B.N.3    Hu, Q.4    Feigenbaum, G.S.5    Margitich, I.S.6
  • 21
    • 84857838864 scopus 로고    scopus 로고
    • Harnessing the mesenchymal stem cell secretome for the treatment of cardiovascular disease
    • Ranganath SH, Levy O, Inamdar MS, Karp JM. Harnessing the mesenchymal stem cell secretome for the treatment of cardiovascular disease. Cell Stem Cell. 2012;10(3):244 -58.
    • (2012) Cell Stem Cell , vol.10 , Issue.3 , pp. 244-258
    • Ranganath, S.H.1    Levy, O.2    Inamdar, M.S.3    Karp, J.M.4
  • 22
    • 77957739928 scopus 로고    scopus 로고
    • Cytokine secretion profiling of human mesenchymal stem cells by antibody array
    • Park CW, Kim K, Bae S, Son HK, Myung P, Hong HJ, et al. Cytokine secretion profiling of human mesenchymal stem cells by antibody array. Int J Stem Cells. 2009;2(1):59-68.
    • (2009) Int J Stem Cells , vol.2 , Issue.1 , pp. 59-68
    • Park, C.W.1    Kim, K.2    Bae, S.3    Son, H.K.4    Myung, P.5    Hong, H.J.6
  • 24
    • 84890034484 scopus 로고    scopus 로고
    • The angiogenic properties of mesenchymal stem/stromal cells and their therapeutic potential
    • Watt SM, Gullo F, van der Garde M, Markeson D, Camicia R, Khoo CP, et al. The angiogenic properties of mesenchymal stem/stromal cells and their therapeutic potential. Br Med Bull. 2013;108:25-53.
    • (2013) Br Med Bull , vol.108 , pp. 25-53
    • Watt, S.M.1    Gullo, F.2    Van Der Garde, M.3    Markeson, D.4    Camicia, R.5    Khoo, C.P.6
  • 25
    • 84885294817 scopus 로고    scopus 로고
    • Amniotic mesenchymal stem cells with robust chemotactic properties are effective in the treatment of a myocardial infarction model
    • Kim SW, Zhang HZ, Kim CE, Kim JM, Kim MH. Amniotic mesenchymal stem cells with robust chemotactic properties are effective in the treatment of a myocardial infarction model. Int J Cardiol. 2013;168(2):1062- 9.
    • (2013) Int J Cardiol , vol.168 , Issue.2 , pp. 1062-1069
    • Kim, S.W.1    Zhang, H.Z.2    Kim, C.E.3    Kim, J.M.4    Kim, M.H.5
  • 26
    • 79953033149 scopus 로고    scopus 로고
    • The immunomodulatory properties of mesenchymal stem cells: Implications for surgical disease
    • Weil BR, Manukyan MC, Herrmann JL, Abarbanell AM, Poynter JA, Wang Y, et al. The immunomodulatory properties of mesenchymal stem cells: implications for surgical disease. J Surg Res. 2011;167(1):78-86.
    • (2011) J Surg Res , vol.167 , Issue.1 , pp. 78-86
    • Weil, B.R.1    Manukyan, M.C.2    Herrmann, J.L.3    Abarbanell, A.M.4    Poynter, J.A.5    Wang, Y.6
  • 28
    • 38349077498 scopus 로고    scopus 로고
    • Toll-like receptors on human mesenchymal stem cells drive their migration and immunomodulating responses
    • Tomchuck SL, Zwezdaryk KJ, Coffelt SB, Waterman RS, Danka ES, Scandurro AB. Toll-like receptors on human mesenchymal stem cells drive their migration and immunomodulating responses. Stem Cells. 2008;26(1):99-107.
    • (2008) Stem Cells , vol.26 , Issue.1 , pp. 99-107
    • Tomchuck, S.L.1    Zwezdaryk, K.J.2    Coffelt, S.B.3    Waterman, R.S.4    Danka, E.S.5    Scandurro, A.B.6
  • 29
    • 54149103668 scopus 로고    scopus 로고
    • Homing and engraftment of progenitor cells: A prerequisite for cell therapy
    • Chavakis E, Urbich C, Dimmeler S. Homing and engraftment of progenitor cells: a prerequisite for cell therapy. J Mol Cell Cardiol. 2008;45(4):514-22.
    • (2008) J Mol Cell Cardiol , vol.45 , Issue.4 , pp. 514-522
    • Chavakis, E.1    Urbich, C.2    Dimmeler, S.3
  • 30
    • 77952094325 scopus 로고    scopus 로고
    • Mesenchymal stem cells: A new strategy for immunosuppression and tissue repair
    • Shi Y, Hu G, Su J, Li W, Chen Q, Shou P, et al. Mesenchymal stem cells: a new strategy for immunosuppression and tissue repair. Cell Res. 2010;20(5):510-8.
    • (2010) Cell Res , vol.20 , Issue.5 , pp. 510-518
    • Shi, Y.1    Hu, G.2    Su, J.3    Li, W.4    Chen, Q.5    Shou, P.6
  • 31
  • 32
    • 84856630796 scopus 로고    scopus 로고
    • The immunomodulatory capacity of mesenchymal stem cells
    • Gebler A, Zabel O, Seliger B. The immunomodulatory capacity of mesenchymal stem cells. Trends Mol Med. 2012;18(2):128-34.
    • (2012) Trends Mol Med , vol.18 , Issue.2 , pp. 128-134
    • Gebler, A.1    Zabel, O.2    Seliger, B.3
  • 33
    • 33745231146 scopus 로고    scopus 로고
    • Immune modulation by mesenchymal stem cells
    • DOI 10.1016/j.yexcr.2006.03.019, PII S0014482706001224
    • Rasmusson I. Immune modulation by mesenchymal stem cells. Exp Cell Res. 2006;312(12):2169-79. (Pubitemid 43928946)
    • (2006) Experimental Cell Research , vol.312 , Issue.12 , pp. 2169-2179
    • Rasmusson, I.1
  • 35
    • 84855846623 scopus 로고    scopus 로고
    • Immunosuppressive treatments in acute myocardial infarction and stroke
    • Raffaghello L, Bianchi G, Pistoia V. Immunosuppressive treatments in acute myocardial infarction and stroke. Curr Pharm Biotechnol. 2012;13(1):59-67.
    • (2012) Curr Pharm Biotechnol , vol.13 , Issue.1 , pp. 59-67
    • Raffaghello, L.1    Bianchi, G.2    Pistoia, V.3
  • 36
    • 70549103270 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction
    • One of the first major clinical trials to prove the safety and efficacy of MSC therapy in cardiac repair
    • .• Hare JM, Traverse JH, Henry TD, Dib N, Strumpf RK, Schulman SP, et al. A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction. J Am Coll Cardiol. 2009;54(24):2277-86. One of the first major clinical trials to prove the safety and efficacy of MSC therapy in cardiac repair.
    • (2009) J Am Coll Cardiol , vol.54 , Issue.24 , pp. 2277-2286
    • Hare, J.M.1    Traverse, J.H.2    Henry, T.D.3    Dib, N.4    Strumpf, R.K.5    Schulman, S.P.6
  • 37
    • 84891705686 scopus 로고    scopus 로고
    • The advancing field of cell-based therapy: Insights and lessons from clinical trials
    • Telukuntla KS, Suncion VY, Schulman IH, Hare JM. The advancing field of cell-based therapy: insights and lessons from clinical trials. J Am Heart Assoc. 2013;2(5):e000338.
    • (2013) J Am Heart Assoc , vol.2 , Issue.5
    • Telukuntla, K.S.1    Suncion, V.Y.2    Schulman, I.H.3    Hare, J.M.4
  • 38
    • 84870887067 scopus 로고    scopus 로고
    • Comparison of allogeneic vs autologous bone marrow-derived mesenchymal stem cells delivered by transendocardial injection in patients with ischemic cardiomyopathy: The POSEIDON randomized trial
    • Hare JM, Fishman JE, Gerstenblith G, DiFede Velazquez DL, Zambrano JP, et al. Comparison of allogeneic vs autologous bone marrow-derived mesenchymal stem cells delivered by transendocardial injection in patients with ischemic cardiomyopathy: the POSEIDON randomized trial. JAMA. 2012;308(22):2369-79.
    • (2012) JAMA , vol.308 , Issue.22 , pp. 2369-2379
    • Hare, J.M.1    Fishman, J.E.2    Gerstenblith, G.3    DiFede Velazquez, D.L.4    Zambrano, J.P.5
  • 39
    • 84878722569 scopus 로고    scopus 로고
    • Cardiopoietic stem cell therapy in heart failure: The C-CURE (Cardiopoietic stem Cell therapy in heart failURE) multicenter randomized trial with lineage-specified biologics
    • Bartunek J, Behfar A, Dolatabadi D, Vanderheyden M, Ostojic M, Dens J, et al. Cardiopoietic stem cell therapy in heart failure: the C-CURE (Cardiopoietic stem Cell therapy in heart failURE) multicenter randomized trial with lineage-specified biologics. J Am Coll Cardiol. 2013;61(23):2329-38.
    • (2013) J Am Coll Cardiol , vol.61 , Issue.23 , pp. 2329-2338
    • Bartunek, J.1    Behfar, A.2    Dolatabadi, D.3    Vanderheyden, M.4    Ostojic, M.5    Dens, J.6
  • 40
    • 84856193410 scopus 로고    scopus 로고
    • First experience in humans using adipose tissue-derived regenerative cells in the treatment of patients with ST-segment elevation myocardial infarction
    • Houtgraaf JH, den Dekker WK, van Dalen BM, Springeling T, de Jong R, van Geuns RJ, et al. First experience in humans using adipose tissue-derived regenerative cells in the treatment of patients with ST-segment elevation myocardial infarction. J Am Coll Cardiol. 2012;59(5):539- 40.
    • (2012) J Am Coll Cardiol , vol.59 , Issue.5 , pp. 539-540
    • Houtgraaf, J.H.1    Den Dekker, W.K.2    Van Dalen, B.M.3    Springeling, T.4    De Jong, R.5    Van Geuns, R.J.6
  • 41
    • 84861316692 scopus 로고    scopus 로고
    • Adipose-derived mesenchymal stromal cells for chronic myocardial ischemia (MyStromalCell Trial): Study design
    • Qayyum AA, Haack-Sorensen M, Mathiasen AB, Jorgensen E, Ekblond A, Kastrup J. Adipose-derived mesenchymal stromal cells for chronic myocardial ischemia (MyStromalCell Trial): study design. Regen Med. 2012;7(3):421-8.
    • (2012) Regen Med , vol.7 , Issue.3 , pp. 421-428
    • Qayyum, A.A.1    Haack-Sorensen, M.2    Mathiasen, A.B.3    Jorgensen, E.4    Ekblond, A.5    Kastrup, J.6
  • 42
    • 84880573296 scopus 로고    scopus 로고
    • Intracoronary infusion of allogeneic mesenchymal precursor cells directly after experimental acute myocardial infarction reduces infarct size, abrogates adverse remodeling, and improves cardiac function
    • Houtgraaf JH, de Jong R, Kazemi K, de GrootD, van der Spoel TI, Arslan F, et al. Intracoronary infusion of allogeneic mesenchymal precursor cells directly after experimental acute myocardial infarction reduces infarct size, abrogates adverse remodeling, and improves cardiac function. Circ Res. 2013;113(2):153-66.
    • (2013) Circ Res , vol.113 , Issue.2 , pp. 153-166
    • Houtgraaf, J.H.1    De Jong, R.2    Kazemi, K.3    De Groot, D.4    Van Der Spoel, T.I.5    Arslan, F.6
  • 43
    • 84870453478 scopus 로고    scopus 로고
    • Human amniotic mesenchymal stem cell-derived induced pluripotent stem cells may generate a universal source of cardiac cells
    • Showed that iPSC derived from MSC could be used to generate immunoprivileged cardiac cells for transplantation
    • • Ge X, Wang IN, Toma I, Sebastiano V, Liu J, Butte MJ, et al. Human amniotic mesenchymal stem cell-derived induced pluripotent stem cells may generate a universal source of cardiac cells. Stem Cells Dev. 2012;21(15):2798-808. Showed that iPSC derived from MSC could be used to generate immunoprivileged cardiac cells for transplantation.
    • (2012) Stem Cells Dev , vol.21 , Issue.15 , pp. 2798-2808
    • Ge, X.1    Wang, I.N.2    Toma, I.3    Sebastiano, V.4    Liu, J.5    Butte, M.J.6
  • 44
    • 36248966518 scopus 로고    scopus 로고
    • Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
    • DOI 10.1016/j.cell.2007.11.019, PII S0092867407014717
    • Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007;131(5):861-72. (Pubitemid 350138099)
    • (2007) Cell , vol.131 , Issue.5 , pp. 861-872
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3    Narita, M.4    Ichisaka, T.5    Tomoda, K.6    Yamanaka, S.7
  • 45
    • 84883281972 scopus 로고    scopus 로고
    • Induced pluripotent stem cell intervention rescues wall motion disparity achieving biological cardiac resynchronization postinfarction
    • Epub ahead of print
    • Yamada S, Nelson T, Kane G, Martinez-Fernandez A, Crespo-Diaz RJ, Ikeda Y, et al. Induced pluripotent stem cell intervention rescues wall motion disparity achieving biological cardiac resynchronization postinfarction. J Physiol. 2013;Epub ahead of print.
    • (2013) J Physiol
    • Yamada, S.1    Nelson, T.2    Kane, G.3    Martinez-Fernandez, A.4    Crespo-Diaz, R.J.5    Ikeda, Y.6
  • 46
    • 84871293889 scopus 로고    scopus 로고
    • Increased potency of cardiac stem cells compared with bone marrow mesenchymal stem cells in cardiac repair
    • Oskouei BN, Lamirault G, Joseph C, Treuer AV, Landa S, Da Silva J, et al. Increased potency of cardiac stem cells compared with bone marrow mesenchymal stem cells in cardiac repair. Stem Cells Transl Med. 2012;1(2):116-24.
    • (2012) Stem Cells Transl Med , vol.1 , Issue.2 , pp. 116-124
    • Oskouei, B.N.1    Lamirault, G.2    Joseph, C.3    Treuer, A.V.4    Landa, S.5    Da Silva, J.6
  • 47
    • 84872281137 scopus 로고    scopus 로고
    • Enhanced effect of combining human cardiac stem cells and bone marrow mesenchymal stem cells to reduce infarct size and to restore cardiac function after myocardial infarction
    • Williams AR, Hatzistergos KE, Addicott B, McCall F, Carvalho D, Suncion V, et al. Enhanced effect of combining human cardiac stem cells and bone marrow mesenchymal stem cells to reduce infarct size and to restore cardiac function after myocardial infarction. Circulation. 2013;127(2):213-23.
    • (2013) Circulation , vol.127 , Issue.2 , pp. 213-223
    • Williams, A.R.1    Hatzistergos, K.E.2    Addicott, B.3    McCall, F.4    Carvalho, D.5    Suncion, V.6
  • 49
    • 67650505037 scopus 로고    scopus 로고
    • Long-term cultures of bone marrow-derived human mesenchymal stem cells frequently undergo spontaneous malignant transformation
    • Rosland GV, Svendsen A, Torsvik A, Sobala E, Mc-Cormack E, Immervoll H, et al. Long-term cultures of bone marrow-derived human mesenchymal stem cells frequently undergo spontaneous malignant transformation. Cancer Res. 2009;69(13):5331-9.
    • (2009) Cancer Res , vol.69 , Issue.13 , pp. 5331-5339
    • Rosland, G.V.1    Svendsen, A.2    Torsvik, A.3    Sobala, E.4    Mc-Cormack, E.5    Immervoll, H.6
  • 52
    • 84878611378 scopus 로고    scopus 로고
    • Risk of tumorigenicity in mesenchymal stromal cell-based therapies: Bridging scientific observations and regulatory viewpoints
    • Barkholt L, Flory E, Jekerle V, Lucas-Samuel S, Ahnert P, Bisset L, et al. Risk of tumorigenicity in mesenchymal stromal cell-based therapies: bridging scientific observations and regulatory viewpoints. Cytotherapy. 2013;15(7):753-9.
    • (2013) Cytotherapy , vol.15 , Issue.7 , pp. 753-759
    • Barkholt, L.1    Flory, E.2    Jekerle, V.3    Lucas-Samuel, S.4    Ahnert, P.5    Bisset, L.6
  • 53
    • 80052672888 scopus 로고    scopus 로고
    • Mesenchymal stem cells: Angels or demons?
    • Wong RS. Mesenchymal stem cells: angels or demons? J Biomed Biotechnol. 2011;2011:459510.
    • (2011) J Biomed Biotechnol , vol.2011 , pp. 459510
    • Wong, R.S.1
  • 54
    • 84865355509 scopus 로고    scopus 로고
    • Safety and efficacy of mesenchymal stromal cell therapy in autoimmune disorders
    • Bernardo ME, Fibbe WE. Safety and efficacy of mesenchymal stromal cell therapy in autoimmune disorders. Ann N Y Acad Sci. 2012;1266:107-17.
    • (2012) Ann N Y Acad Sci , vol.1266 , pp. 107-117
    • Bernardo, M.E.1    Fibbe, W.E.2
  • 55
    • 34548044258 scopus 로고    scopus 로고
    • Potential risks of bone marrow cell transplantation into infarcted hearts
    • Breitbach M, Bostani T, Roell W, Xia Y, Dewald O, Nygren JM, et al. Potential risks of bone marrow cell transplantation into infarcted hearts. Blood. 2007;110(4):1362- 9.
    • (2007) Blood , vol.110 , Issue.4 , pp. 1362-1369
    • Breitbach, M.1    Bostani, T.2    Roell, W.3    Xia, Y.4    Dewald, O.5    Nygren, J.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.