Risk of tumorigenicity in mesenchymal stromal cell-based therapies - Bridging scientific observations and regulatory viewpoints

Cytotherapy

Volumn 15, Issue 7, 2013, Pages 753-759

  Barkholt, Lisbeth ^a,f   Flory, Egbert ^a,g   Jekerle, Veronika ^a   Lucas Samuel, Sophie ^a,h   Ahnert, Peter ^b   Bisset, Louise ^a,k   Büscher, Dirk ⁱ   Fibbe, Willem ^j   Foussat, Arnaud ^c   Kwa, Marcel ^a,l   Lantz, Olivier ^d   MačIulaitis, Romaldas ^a,m   Palomäki, Tiina ^a,n   Schneider, Christian K ^a,o,p   Sensebé, Luc ^q   Tachdjian, Gérard ^e   Tarte, Karin ^r   Tosca, Lucie ^e   Salmikangas, Paula ^a,n  

^a EUROPEAN MEDICINES AGENCY   (United Kingdom)

^b UNIVERSITY OF LEIPZIG   (Germany)

^c Txcell   (France)

^d PSL RESEARCH UNIVERSITY   (France)

^e Centre National de la Recherche Scientifique   (France)

^f MEDICAL PRODUCTS AGENCY   (Sweden)

^g PAUL EHRLICH INSTITUT   (Germany)

^h Agence Nationale de Securité du Médicament et des Produits de Santé ANSM   (France)

ⁱ GRI CEL   (Spain)

^j LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^k MEDICINES AND HEALTHCARE PRODUCTS REGULATORY AGENCY   (United Kingdom)

^l MEDICINES EVALUATION BOARD   (Netherlands)

^m LITHUANIAN UNIVERSITY OF HEALTH SCIENCES   (Lithuania)

ⁿ Finnish Medicines Agency   (Finland)

^o Danish Health and Medicines Authority   (Denmark)

^p INSTITUTE OF INFECTION IMMUNOLOGY   (Germany)

^q Institut National de la Sant é et de la Recherche Medicale   (France)

^r INSERM U917   (France)

more..

Author keywords

cell; mesenchymal; stromal; tumorigenicity

Indexed keywords

IMMUNOSUPPRESSIVE AGENT;

CARCINOGENICITY; CELL AGING; CHROMOSOME ABERRATION; CYTOGENETICS; DNA DAMAGE; FLUORESCENCE IN SITU HYBRIDIZATION; FOLLOW UP; GRAFT VERSUS HOST REACTION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; KARYOTYPING; MESENCHYMAL STROMA CELL; NONHUMAN; PRIORITY JOURNAL; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM;

ADIPOSE TISSUE; BONE MARROW CELLS; CARCINOGENESIS; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL PROLIFERATION; HUMANS; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS;

EID: 84878611378     PISSN: 14653249     EISSN: 14772566     Source Type: Journal    
DOI: 10.1016/j.jcyt.2013.03.005     Document Type: Review

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