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Volumn 16, Issue 4, 2013, Pages 717-720

Muscarinic M1 receptor agonists: Can they improve cognitive performance?

Author keywords

[No Author keywords available]

Indexed keywords

GSK 1034702; MUSCARINIC M1 RECEPTOR AGONIST; UNCLASSIFIED DRUG; XANOMELINE; BENZIMIDAZOLE DERIVATIVE; MUSCARINIC M1 RECEPTOR;

EID: 84875694713     PISSN: 14611457     EISSN: 14695111     Source Type: Journal    
DOI: 10.1017/S1461145712001113     Document Type: Review
Times cited : (8)

References (41)
  • 1
  • 2
    • 0023943181 scopus 로고
    • Differential alteration of various cholinergic markers in cortical and subcortical regions of human brain in Alzheimer's disease
    • Araujo DM, Lapchak PA, Robitaille Y, Gauthier S, et al. (1988). Differential alteration of various cholinergic markers in cortical and subcortical regions of human brain in Alzheimer's disease. Journal of Neurochemistry 50, 1914-1923.
    • (1988) Journal of Neurochemistry , vol.50 , pp. 1914-1923
    • Araujo, D.M.1    Lapchak, P.A.2    Robitaille, Y.3    Gauthier, S.4
  • 3
    • 0030902127 scopus 로고    scopus 로고
    • Effects of xanomeline, a selective muscarinic receptor agonist, on cognitive function and behavioral symptoms in Alzheimer disease
    • Bodick NC, Offen WW, Levey AI, Cutler NR, et al. (1997). Effects of xanomeline, a selective muscarinic receptor agonist, on cognitive function and behavioral symptoms in Alzheimer disease. Archives of Neurology 54, 465-473.
    • (1997) Archives of Neurology , vol.54 , pp. 465-473
    • Bodick, N.C.1    Offen, W.W.2    Levey, A.I.3    Cutler, N.R.4
  • 4
    • 72049088792 scopus 로고    scopus 로고
    • AC-260584, an orally bioavailable M1 muscarinic receptor allosteric agonist, improves cognitive performance in an animal model
    • Bradley SR, Lameh J, Ohrmund L, Son T, et al. (2010). AC-260584, an orally bioavailable M1 muscarinic receptor allosteric agonist, improves cognitive performance in an animal model. Neuropharmacology 58, 365-373.
    • (2010) Neuropharmacology , vol.58 , pp. 365-373
    • Bradley, S.R.1    Lameh, J.2    Ohrmund, L.3    Son, T.4
  • 5
    • 57349113845 scopus 로고    scopus 로고
    • Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats
    • Brady AE, Jones CK, Bridges TM, Kennedy JP, et al. (2008). Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats. Journal of Pharmacology and Experimental Therapeutics 327, 941-953.
    • (2008) Journal of Pharmacology and Experimental Therapeutics , vol.327 , pp. 941-953
    • Brady, A.E.1    Jones, C.K.2    Bridges, T.M.3    Kennedy, J.P.4
  • 6
    • 77956510685 scopus 로고    scopus 로고
    • Novel N-substituted benzimidazolones as potent, selective, CNS-penetrant, and orally active M1 mAChR agonists
    • Budzik B, Garzya V, Shi D, Walker G, et al. (2010). Novel N-substituted benzimidazolones as potent, selective, CNS-penetrant, and orally active M1 mAChR agonists. ACS Medicinal Chemistry Letters 1, 244-248.
    • (2010) ACS Medicinal Chemistry Letters , vol.1 , pp. 244-248
    • Budzik, B.1    Garzya, V.2    Shi, D.3    Walker, G.4
  • 7
    • 0037375485 scopus 로고    scopus 로고
    • Use of M1-M5 muscarinic receptor knockout mice as novel tools to delineate the physiological roles of the muscarinic cholinergic system
    • Bymaster FP, McKinzie DL, Felder CC, Wess J (2003). Use of M1-M5 muscarinic receptor knockout mice as novel tools to delineate the physiological roles of the muscarinic cholinergic system. Neurochemistry Research 28, 437-442.
    • (2003) Neurochemistry Research , vol.28 , pp. 437-442
    • Bymaster, F.P.1    McKinzie, D.L.2    Felder, C.C.3    Wess, J.4
  • 8
    • 0030927142 scopus 로고    scopus 로고
    • Xanomeline: A selective muscarinic agonist for the treatment of Alzheimer's disease
    • Bymaster FP, Whitesitt CA, Shannon HE, DeLapp N, et al. (1997). Xanomeline: a selective muscarinic agonist for the treatment of Alzheimer's disease. Drug Development Research 40, 158-170.
    • (1997) Drug Development Research , vol.40 , pp. 158-170
    • Bymaster, F.P.1    Whitesitt, C.A.2    Shannon, H.E.3    Delapp, N.4
  • 10
    • 0017105216 scopus 로고
    • The inhibitory effect of gallamine on muscarinic receptors
    • Clark AL, Mitchelson F (1976). The inhibitory effect of gallamine on muscarinic receptors. British Journal of Pharmacology 58, 323-331.
    • (1976) British Journal of Pharmacology , vol.58 , pp. 323-331
    • Clark, A.L.1    Mitchelson, F.2
  • 11
    • 0020686674 scopus 로고
    • Alzheimer's disease: A disorder of cortical cholinergic innervation
    • Coyle JT, Price DL, Mahlon RD (1983). Alzheimer's disease: a disorder of cortical cholinergic innervation. Science 219, 1184-1190.
    • (1983) Science , vol.219 , pp. 1184-1190
    • Coyle, J.T.1    Price, D.L.2    Mahlon, R.D.3
  • 12
    • 0036932174 scopus 로고    scopus 로고
    • Decreased muscarinic(1) receptors in the dorsolateral prefrontal cortex of subjects with schizophrenia
    • Dean B, McLeod M, Keriakous D, McKenzie J, et al. (2002). Decreased muscarinic(1) receptors in the dorsolateral prefrontal cortex of subjects with schizophrenia. Molecular Psychiatry 7, 1083-1091.
    • (2002) Molecular Psychiatry , vol.7 , pp. 1083-1091
    • Dean, B.1    McLeod, M.2    Keriakous, D.3    McKenzie, J.4
  • 13
    • 84862864622 scopus 로고    scopus 로고
    • Novel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal models
    • Digby GJ, Noetzel MJ, Bubser M, Utley TJ, et al. (2012). Novel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal models. Journal of Neuroscience 32, 8532-8544.
    • (2012) Journal of Neuroscience , vol.32 , pp. 8532-8544
    • Digby, G.J.1    Noetzel, M.J.2    Bubser, M.3    Utley, T.J.4
  • 14
    • 0022786925 scopus 로고
    • Cholinergic mechanisms in depression
    • Dilsaver SC (1986). Cholinergic mechanisms in depression. Brain Research 396, 285-316.
    • (1986) Brain Research , vol.396 , pp. 285-316
    • Dilsaver, S.C.1
  • 15
    • 78649920380 scopus 로고    scopus 로고
    • M1 muscarinic receptors boost synaptic potentials and calcium influx in dendritic spines by inhibiting postsynaptic SK channels
    • Giessel AJ, Sabatini BL (2010). M1 muscarinic receptors boost synaptic potentials and calcium influx in dendritic spines by inhibiting postsynaptic SK channels. Neuron 68, 936-947.
    • (2010) Neuron , vol.68 , pp. 936-947
    • Giessel, A.J.1    Sabatini, B.L.2
  • 16
    • 0025917517 scopus 로고
    • Increased muscarinic receptor messenger RNA in Alzheimer's disease temporal cortex demonstrated by in situ hybridization histochemistry
    • Harrison PJ, Barton AJ, Najlerahim A, McDonald B, et al. (1991). Increased muscarinic receptor messenger RNA in Alzheimer's disease temporal cortex demonstrated by in situ hybridization histochemistry. Brain Research Molecular Brain Research 9, 15-21.
    • (1991) Brain Research Molecular Brain Research , vol.9 , pp. 15-21
    • Harrison, P.J.1    Barton, A.J.2    Najlerahim, A.3    McDonald, B.4
  • 17
    • 55249118679 scopus 로고    scopus 로고
    • Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats
    • Jones CK, Brady AE, Davis AA, Xiang Z, et al. (2008). Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats. Journal of Neuroscience 28, 10422-10433.
    • (2008) Journal of Neuroscience , vol.28 , pp. 10422-10433
    • Jones, C.K.1    Brady, A.E.2    Davis, A.A.3    Xiang, Z.4
  • 19
    • 76749144987 scopus 로고    scopus 로고
    • Molecular mechanisms of action and in vivo validation of an m(4) muscarinic acetylcholine receptor allosteric modulator with potential antipsychotic properties
    • Leach K, Loiacono RE, Felder CC, McKinzie DL, et al. (2010). Molecular mechanisms of action and in vivo validation of an m(4) muscarinic acetylcholine receptor allosteric modulator with potential antipsychotic properties. Neuropsychopharmacology 35, 855-869.
    • (2010) Neuropsychopharmacology , vol.35 , pp. 855-869
    • Leach, K.1    Loiacono, R.E.2    Felder, C.C.3    McKinzie, D.L.4
  • 20
  • 22
    • 62149135311 scopus 로고    scopus 로고
    • Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity
    • Marlo JE, Niswender CM, Days EL, Bridges TM, et al. (2009). Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity. Molecular Pharmacology 75, 577-588.
    • (2009) Molecular Pharmacology , vol.75 , pp. 577-588
    • Marlo, J.E.1    Niswender, C.M.2    Days, E.L.3    Bridges, T.M.4
  • 23
    • 84875697137 scopus 로고    scopus 로고
    • 1 receptor allosteric agonist GSK1034702 improves episodic memory in humans in the nicotine abstinence model of cognitive dysfunction
    • Published online: 29 August 2012. doi:10.1017/S1461145712000752
    • 1 receptor allosteric agonist GSK1034702 improves episodic memory in humans in the nicotine abstinence model of cognitive dysfunction. International Journal of Neuropsychopharmacology. Published online: 29 August 2012. doi:10.1017/S1461145712000752.
    • (2012) International Journal of Neuropsychopharmacology
    • Nathan, P.J.1    Watson, J.2    Lund, J.3    Davies, C.H.4
  • 25
    • 77952544279 scopus 로고    scopus 로고
    • Cortical M1 receptor concentration increases without a concomitant change in function in Alzheimer's disease
    • Overk CR, Felder CC, Tu Y, Schober DA, et al. (2010). Cortical M1 receptor concentration increases without a concomitant change in function in Alzheimer's disease. Journal of Chemical Neuroanatomy 40, 63-70.
    • (2010) Journal of Chemical Neuroanatomy , vol.40 , pp. 63-70
    • Overk, C.R.1    Felder, C.C.2    Tu, Y.3    Schober, D.A.4
  • 27
    • 79955479052 scopus 로고    scopus 로고
    • Discovery and optimization of a novel, selective and brain penetrant M1 positive allosteric modulator (PAM): The development of ML169, an MLPCN probe
    • Reid PR, Bridges TM, Sheffler DJ, Cho HP, et al. (2011). Discovery and optimization of a novel, selective and brain penetrant M1 positive allosteric modulator (PAM): the development of ML169, an MLPCN probe. Bioorganic and Medicinal Chemistry Letters 21, 2697-2701.
    • (2011) Bioorganic and Medicinal Chemistry Letters , vol.21 , pp. 2697-2701
    • Reid, P.R.1    Bridges, T.M.2    Sheffler, D.J.3    Cho, H.P.4
  • 28
    • 0020061023 scopus 로고
    • Muscarinic binding and choline acetyltransferase activity in Parkinsonian subjects with reference to dementia
    • Ruberg M, Ploska A, Javoy-Agid F, Agid Y (1982). Muscarinic binding and choline acetyltransferase activity in Parkinsonian subjects with reference to dementia. Brain Research 232, 129-139.
    • (1982) Brain Research , vol.232 , pp. 129-139
    • Ruberg, M.1    Ploska, A.2    Javoy-Agid, F.3    Agid, Y.4
  • 29
    • 70350446516 scopus 로고    scopus 로고
    • Decreased cortical muscarinic receptors define a subgroup of subjects with schizophrenia
    • Scarr E, Cowie TF, Kanellakis S, Sundram S, et al. (2009). Decreased cortical muscarinic receptors define a subgroup of subjects with schizophrenia. Molecular Psychiatry 14, 1017-1023.
    • (2009) Molecular Psychiatry , vol.14 , pp. 1017-1023
    • Scarr, E.1    Cowie, T.F.2    Kanellakis, S.3    Sundram, S.4
  • 31
    • 48949095543 scopus 로고    scopus 로고
    • Selective muscarinic receptor agonist xanomeline as a novel treatment approach for schizophrenia
    • Shekhar A, Potter WZ, Lightfoot J, Lienemann J, et al. (2008). Selective muscarinic receptor agonist xanomeline as a novel treatment approach for schizophrenia. American Journal of Psychiatry 165, 1033-1039.
    • (2008) American Journal of Psychiatry , vol.165 , pp. 1033-1039
    • Shekhar, A.1    Potter, W.Z.2    Lightfoot, J.3    Lienemann, J.4
  • 32
    • 0035892543 scopus 로고    scopus 로고
    • Distribution of m1 muscarinic acetylcholine receptors in the hippocampus of patients with Alzheimer's disease and dementia with Lewy bodies-an immunohistochemical study
    • Shiozaki K, Iseki E, Hino H, Kosaka K (2001). Distribution of m1 muscarinic acetylcholine receptors in the hippocampus of patients with Alzheimer's disease and dementia with Lewy bodies-an immunohistochemical study. Journal of the Neurological Sciences 193, 23-28.
    • (2001) Journal of the Neurological Sciences , vol.193 , pp. 23-28
    • Shiozaki, K.1    Iseki, E.2    Hino, H.3    Kosaka, K.4
  • 33
    • 70449640543 scopus 로고    scopus 로고
    • A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning
    • Shirey JK, Brady AE, Jones PJ, Davis AA, et al. (2009). A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning. Journal of Neuroscience 29, 14271-14286.
    • (2009) Journal of Neuroscience , vol.29 , pp. 14271-14286
    • Shirey, J.K.1    Brady, A.E.2    Jones, P.J.3    Davis, A.A.4
  • 34
    • 33751072945 scopus 로고    scopus 로고
    • Structural requirements of transmembrane domain 3 for activation by the M1 muscarinic receptor agonists AC-42, AC-260584, clozapine, and N-desmethylclozapine: Evidence for three distinct modes of receptor activation
    • Spalding TA, Ma JN, Ott TR, Friberg M, et al. (2006). Structural requirements of transmembrane domain 3 for activation by the M1 muscarinic receptor agonists AC-42, AC-260584, clozapine, and N-desmethylclozapine: evidence for three distinct modes of receptor activation. Molecular Pharmacology 70, 1974-1983.
    • (2006) Molecular Pharmacology , vol.70 , pp. 1974-1983
    • Spalding, T.A.1    Ma, J.N.2    Ott, T.R.3    Friberg, M.4
  • 35
    • 0029055030 scopus 로고
    • Allosteric modulation of muscarinic acetylcholine receptors
    • Tucek S, Proska J (1995). Allosteric modulation of muscarinic acetylcholine receptors. Trends in Pharmacological Sciences 16, 205-212.
    • (1995) Trends in Pharmacological Sciences , vol.16 , pp. 205-212
    • Tucek, S.1    Proska, J.2
  • 36
    • 84455173446 scopus 로고    scopus 로고
    • Probe dependence in the allosteric modulation of a G protein-coupled receptor: Implications for detection and validation of allosteric ligand effects
    • Valant C, Felder CC, Sexton PM, Christopoulos A (2012). Probe dependence in the allosteric modulation of a G protein-coupled receptor: implications for detection and validation of allosteric ligand effects. Molecular Pharmacology 81, 41-52.
    • (2012) Molecular Pharmacology , vol.81 , pp. 41-52
    • Valant, C.1    Felder, C.C.2    Sexton, P.M.3    Christopoulos, A.4
  • 38
    • 7844250486 scopus 로고    scopus 로고
    • Functional effects of the muscarinic receptor agonist, xanomeline, at 5-HT1 and 5-HT2 receptors
    • Watson J, Brough S, Coldwell MC, Gager T, et al. (1998). Functional effects of the muscarinic receptor agonist, xanomeline, at 5-HT1 and 5-HT2 receptors. British Journal of Pharmacology 125, 1413-1420.
    • (1998) British Journal of Pharmacology , vol.125 , pp. 1413-1420
    • Watson, J.1    Brough, S.2    Coldwell, M.C.3    Gager, T.4
  • 39
    • 1642415654 scopus 로고    scopus 로고
    • Investigation of m1/m4 muscarinic receptors in the anterior cingulate cortex in schizophrenia, bipolar disorder, and major depression disorder
    • Zavitsanou K, Katsifis A, Mattner F, Xu-Feng H (2004). Investigation of m1/m4 muscarinic receptors in the anterior cingulate cortex in schizophrenia, bipolar disorder, and major depression disorder. Neuropsychopharmacology 29, 619-625.
    • (2004) Neuropsychopharmacology , vol.29 , pp. 619-625
    • Zavitsanou, K.1    Katsifis, A.2    Mattner, F.3    Xu-Feng, H.4
  • 40
    • 13844255526 scopus 로고    scopus 로고
    • Disrupted tonotopy of the auditory cortex in mice lacking M1 muscarinic acetylcholine receptor
    • Zhang Y, Dyck RH, Hamilton SE, Nathanson NM, et al. (2005). Disrupted tonotopy of the auditory cortex in mice lacking M1 muscarinic acetylcholine receptor. Hearing Research 201, 145-155.
    • (2005) Hearing Research , vol.201 , pp. 145-155
    • Zhang, Y.1    Dyck, R.H.2    Hamilton, S.E.3    Nathanson, N.M.4
  • 41
    • 33747878910 scopus 로고    scopus 로고
    • Decreased input-specific plasticity of the auditory cortex in mice lacking M1 muscarinic acetylcholine receptors
    • Zhang Y, Hamilton SE, Nathanson NM, Yan J (2006). Decreased input-specific plasticity of the auditory cortex in mice lacking M1 muscarinic acetylcholine receptors. Cerebral Cortex 16, 1258-1265.
    • (2006) Cerebral Cortex , vol.16 , pp. 1258-1265
    • Zhang, Y.1    Hamilton, S.E.2    Nathanson, N.M.3    Yan, J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.