Measurement and interpretation of electrocardiographic QT intervals in murine hearts

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 306, Issue 11, 2014, Pages

  Zhang, Yanmin ^a,b   Wu, JingJing ^c   King, James H ^a   Huang, Christopher L H ^a   Fraser, James A ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b Heart Centre NW Women's and Children's Hosp (formerly Shaanxi Prov Maternity and Children Healthcare Hospital)   (China)

^c HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Action potential duration; ECG; Mouse heart; QT interval

Indexed keywords

BROMETHOL; KETAMINE; SODIUM CHANNEL NAV1.5;

ANESTHESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ELECTROCARDIOGRAPHY; HEART MUSCLE CELL; HEART MUSCLE POTENTIAL; HEART PERFUSION; HEART VENTRICLE; IN VITRO STUDY; IN VIVO STUDY; ISOLATED HEART; LONG QT SYNDROME; MEASUREMENT; MICROELECTRODE; MOUSE; NONHUMAN; PRIORITY JOURNAL; QRS COMPLEX; QT INTERVAL; T WAVE;

ACTION-POTENTIAL DURATION; ECG; MOUSE HEART; QT INTERVAL;

ACTION POTENTIALS; ANIMALS; ARRHYTHMIAS, CARDIAC; ELECTROCARDIOGRAPHY; HEART; HEART CONDUCTION SYSTEM; LONG QT SYNDROME; MALE; MICE;

EID: 84901718468     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00459.2013     Document Type: Article

References (18)

1. Adrian RH, Channell RC, Cohen I, Noble D. The Einthoven string galvanometer and the interpretation of the T wave of the electrocardiogram [proceedings]. J Physiol 263: 67P-70P, 1976.
2. Chiu HC, Kovacs A, Blanton RM, Han X, Courtois M, Weinheimer CJ, Yamada KA, Brunet S, Xu H, Nerbonne JM, Welch MJ, Fettig NM, Sharp TL, Sambandam N, Olson KM, Ory DS, Schaffer JE. Transgenic expression of fatty acid transport protein 1 in the heart causes lipotoxic cardiomyopathy. Circ Res 96: 225-233, 2005.
3. Danik S, Cabo C, Chiello C, Kang S, Wit AL, Coromilas J. Correlation of repolarization of ventricular monophasic action potential with ECG in the murine heart. Am J Physiol Heart Circ Physiol 283: H372-H381, 2002.
4. Demolombe S, Lande G, Charpentier F, van Roon MA, van den Hoff MJ, Toumaniantz G, Baro I, Guihard G, Le Berre N, Corbier A, de Bakker J, Opthof T, Wilde A, Moorman AF, Escande D. Transgenic mice overexpressing human KvLQT1 dominant-negative isoform. Part I: phenotypic characterisation. Cardiovasc Res 50: 314-327, 2001.
5. Guo W, Li H, London B, Nerbonne JM. Functional consequences of elimination of i(to, f) and i(to, s): early afterdepolarizations, atrioventricular block, and ventricular arrhythmias in mice lacking Kv1.4 and expressing a dominant-negative Kv4 alpha subunit. Circ Res 87: 73-79, 2000.
6. Head CE, Balasubramaniam R, Thomas G, Goddard CA, Lei M, Colledge WH, Grace AA, Huang CL. Paced electrogram fractionation analysis of arrhythmogenic tendency in DeltaKPQ Scn5a mice. J Cardiovasc Electrophysiol 16: 1329-1340, 2005.
7. Killeen MJ, Thomas G, Gurung IS, Goddard CA, Fraser JA, Mahaut-Smith MP, Colledge WH, Grace AA, Huang CL. Arrhythmogenic mechanisms in the isolated perfused hypokalaemic murine heart. Acta Physiol (Oxf) 189: 33-46, 2007.
8. Lande G, Demolombe S, Bammert A, Moorman A, Charpentier F, Escande D. Transgenic mice overexpressing human KvLQT1 dominantnegative isoform. Part II: pharmacological profile. Cardiovasc Res 50: 328-334, 2001.
9. Le Bouter S, Demolombe S, Chambellan A, Bellocq C, Aimond F, Toumaniantz G, Lande G, Siavoshian S, Baró I, Pond AL, Nerbonne JM, Léger JJ, Escande D, Charpentier F. Microarray analysis reveals complex remodeling of cardiac ion channel expression with altered thyroid status: relation to cellular and integrated electrophysiology. Circ Res 92: 234-242, 2003.
10. London B, Guo W, Pan Xh Lee JS, Shusterman V, Rocco CJ, Logothetis DA, Nerbonne JM, Hill JA. Targeted replacement of KV1.5 in the mouse leads to loss of the 4-aminopyridine-sensitive component of I(K, slow) and resistance to drug-induced qt prolongation. Circ Res 88: 940-946, 2001.
11. Mitchell GF, Jeron A, Koren G. Measurement of heart rate and Q-T interval in the conscious mouse. Am J Physiol Heart Circ Physiol 274: H747-H751, 1998.
12. Nerbonne JM. Studying cardiac arrhythmias in the mouse-a reasonable model for probing mechanisms? Trends Cardiovasc Med 14: 83-93, 2004.
13. Noble D, Cohen I. The interpretation of the T wave of the electrocardiogram. Cardiovasc Res 12: 13-27, 1978.
14. Saito T, Ciobotaru A, Bopassa JC, Toro L, Stefani E, Eghbali M. Estrogen contributes to gender differences in mouse ventricular repolarization. Circ Res 105: 343-352, 2009.
15. Surawicz B, Knilans T. Chou's Electrocardiography in Clinical Practice (6th ed.). Philadelphia: Saunders, Elsevier, 2008.
16. +) channel blockers in mice. Am J Physiol Cell Physiol 278: C73-C80, 2000.
17. Weber dos Santos R, Nygren A, Otaviano Campos F, Koch H, Giles WR. Experimental and theoretical ventricular electrograms and their relation to electrophysiological gradients in the adult rat heart. Am J Physiol Heart Circ Physiol 297: H1521-H1534, 2009.
18. Wu J, Zhang Y, Zhang X, Cheng L, Lammers WJ, Grace AA, Fraser JA, Zhang H, Huang CL, Lei M. Altered sinoatrial node function and intra-atrial conduction in murine gain-of-function Scn5a+/ΔKPQ hearts suggest an overlap syndrome. Am J Physiol Heart Circ Physiol 302: H1510-H1523, 2012.