PDE5 inhibitors enhance the lethality of standard of care chemotherapy in pediatric CNS tumor cells

Cancer Biology and Therapy

Volumn 15, Issue 6, 2014, Pages 758-767

  Roberts, Jane L ^a   Booth, Laurence ^a   Conley, Adam ^b   Cruickshanks, Nichola ^a   Malkin, Mark ^b   Kukreja, Rakesh C ^a   Grant, Steven ^b   Poklepovic, Andrew ^b   Dent, Paul ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Chemotherapy; Medulloblastoma; PDE5; Pediatric; Sildenafil

Indexed keywords

ATM PROTEIN; CASPASE 9; CISPLATIN; ETOPOSIDE; FAS ANTIGEN; FAS ASSOCIATED DEATH DOMAIN PROTEIN; FLICE INHIBITORY PROTEIN; NITRIC OXIDE SYNTHASE; PHOSPHODIESTERASE V; PROTEIN BCL XL; SILDENAFIL; TADALAFIL; VINCRISTINE; ANTINEOPLASTIC AGENT; PHOSPHODIESTERASE V INHIBITOR; PIPERAZINE DERIVATIVE; PURINE DERIVATIVE; SULFONE;

ARTICLE; AUTOPHAGY; CANCER CHEMOTHERAPY; CHILDHOOD CANCER; CONTROLLED STUDY; DNA DAMAGE; HEALTH CARE QUALITY; HUMAN; HUMAN CELL; LETHALITY; MEDULLOBLASTOMA; MEDULLOBLASTOMA CELL LINE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; CEREBELLAR NEOPLASMS; CHILD; DRUG EFFECTS; DRUG POTENTIATION; DRUG SCREENING; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CEREBELLAR NEOPLASMS; CHILD; CISPLATIN; DRUG SCREENING ASSAYS, ANTITUMOR; DRUG SYNERGISM; ETOPOSIDE; HUMANS; MEDULLOBLASTOMA; PHOSPHODIESTERASE 5 INHIBITORS; PIPERAZINES; PURINES; SULFONES; VINCRISTINE;

EID: 84901707619     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.28553     Document Type: Article

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