Genistein Sensitizes Bladder Cancer Cells to HCPT Treatment In Vitro and In Vivo via ATM/NF-κB/IKK Pathway-Induced Apoptosis

PLoS ONE

Volumn 8, Issue 1, 2013, Pages

  Wang, Yong ^a   Wang, He ^a   Zhang, Wei ^a   Shao, Chen ^b   Xu, Peng ^a   Shi, Chang Hong ^c   Shi, Jian Guo ^c   Li, Yu Mei ^a   Fu, Qiang ^a   Xue, Wei ^a   Lei, Yong Hua ^a   Gao, Jing Yu ^a   Wang, Juan Ying ^a   Gao, Xiao Ping ^a   Li, Jin Qing ^a   Yuan, Jian Lin ^b   Zhang, Yun Tao ^b  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^c FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

10 HYDROXYCAMPTOTHECIN; ATM PROTEIN; CASPASE 3; CASPASE 9; GAMMA HISTONE H2AX; GENISTEIN; HISTONE H2AX; I KAPPA B ALPHA; I KAPPA B KINASE; I KAPPA B KINASE 1; I KAPPA B KINASE 2; I KAPPA B KINASE GAMMA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NIBRIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BLADDER CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CELL VIABILITY; CHEMOSENSITIZATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DOUBLE STRANDED DNA BREAK; DOWN REGULATION; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENTIATION; ENZYME PHOSPHORYLATION; FEMALE; G2 PHASE CELL CYCLE CHECKPOINT; HISTONE PHOSPHORYLATION; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CAMPTOTHECIN; CELL CYCLE PROTEINS; CELL LINE, TUMOR; DNA FRAGMENTATION; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, NEOPLASM; DRUG SYNERGISM; G2 PHASE CELL CYCLE CHECKPOINTS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENISTEIN; HUMANS; I-KAPPA B KINASE; MICE; MICE, NUDE; NF-KAPPA B; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; TOPOISOMERASE I INHIBITORS; TUMOR SUPPRESSOR PROTEINS; URINARY BLADDER NEOPLASMS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

ATAXIA TELANGIECTASIA;

EID: 84872857718     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0050175     Document Type: Article

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