Evaluating the levels of interleukin-1 family cytokines in sporadic amyotrophic lateral sclerosis

Journal of Neuroinflammation

Volumn 11, Issue , 2014, Pages

  Italiani, Paola ^a   Carlesi, Cecilia ^b   Giungato, Paola ^a   Puxeddu, Ilaria ^b   Borroni, Barbara ^c   Bossù, Paola ^d   Migliorini, Paola ^b   Siciliano, Gabriele ^b   Boraschi, Diana ^a,e  

^a CNR   (Italy)

^b UNIVERSITY OF PISA   (Italy)

^c UNIVERSITY OF BRESCIA   (Italy)

^d IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^e INSTITUTE OF PROTEIN BIOCHEMISTRY   (Italy)

Author keywords

ALS; IL 1 family; IL 18; Inflammation

Indexed keywords

CYTOKINE; INFLAMMASOME; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1 RECEPTOR TYPE II; INTERLEUKIN 1 RECEPTOR TYPE IV; INTERLEUKIN 18; INTERLEUKIN 18 BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 33; INTERLEUKIN 36; INTERLEUKIN 37; UNCLASSIFIED DRUG;

ADULT; AGED; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; BLOOD SAMPLING; CEREBROSPINAL FLUID ANALYSIS; CONTROLLED STUDY; DISABILITY; DISEASE ASSOCIATION; DISEASE DURATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; PATHOPHYSIOLOGY; PROTEIN ANALYSIS; PROTEIN FAMILY; RATING SCALE; UPREGULATION; BLOOD; CEREBROSPINAL FLUID; MIDDLE AGED; NONPARAMETRIC TEST; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; AMYOTROPHIC LATERAL SCLEROSIS; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; MALE; MIDDLE AGED; STATISTICS, NONPARAMETRIC;

EID: 84901693760     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/1742-2094-11-94     Document Type: Article

References (51)

1. Hardiman O, van den Berg LH, Kiernan MC. Clinical diagnosis and management of amyotrophic lateral sclerosis. Nat Rev Neurol 2011, 7:639-649. 10.1038/nrneurol.2011.153, 21989247.
2. Troost D, van den Oord JJ, de Jong JM, Swaab DF. Lymphocytic infiltration in the spinal cord of patients with amyotrophic lateral sclerosis. Clin Neuropathol 1989, 8:289-294.
3. Zhang R, Gascon R, Miller RG, Gelinas DF, Mass J, Hadlock K, Jin X, Reis J, Narvaez A, McGrath MS. Evidence for systemic immune system alterations in sporadic amyotrophic lateral sclerosis (sALS). J Neuroimmunol 2005, 159:215-224. 10.1016/j.jneuroim.2004.10.009, 15652422.
4. Engelhardt JI, Appel SH. IgG reactivity in the spinal cord and motor cortex in amyotrophic lateral sclerosis. Arch Neurol 1990, 47:1210-1216. 10.1001/archneur.1990.00530110068019, 2122877.
5. Kawamata T, Akiyama H, Yamada T, McGeer PL. Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord tissue. Am J Pathol 1992, 140:691-707. 1886170, 1347673.
6. Hayashi S, Sakurai A, Amari M, Okamoto K. Pathological study of the diffuse myelin pallor in the anterolateral columns of the spinal cord in amyotrophic lateral sclerosis. J Neurol Sci 2001, 188:3-7. 10.1016/S0022-510X(01)00531-7, 11489277.
7. Baron P, Bussini S, Cardin V, Corbo M, Conti G, Galimberti D, Scarpini E, Bresolin N, Wharton SB, Shaw PJ, Silani V. Production of monocyte chemoattractant protein-1 in amyotrophic lateral sclerosis. Muscle Nerve 2005, 32:541-544. 10.1002/mus.20376, 15962273.
8. Sekizawa T, Openshaw H, Ohbo K, Sugamura K, Itoyama Y, Niland JC. Cerebrospinal fluid interleukin 6 in amyotrophic lateral sclerosis: immunological parameter and comparison with inflammatory and non-inflammatory central nervous system diseases. J Neurol Sci 1998, 154:194-199. 10.1016/S0022-510X(97)00228-1, 9562310.
9. Ono S, Hu J, Shimizu N, Imai T, Nakagawa H. Increased interleukin-6 of skin and serum in amyotrophic lateral sclerosis. J Neurol Sci 2001, 187:27-34. 10.1016/S0022-510X(01)00514-7, 11440741.
10. Poloni M, Facchetti D, Mai R, Micheli A, Agnoletti L, Francolini G, Mora G, Camana C, Mazzini L, Bachetti T. Circulating levels of tumour necrosis factor-alpha and its soluble receptors are increased in the blood of patients with amyotrophic lateral sclerosis. Neurosci Lett 2000, 287:211-214. 10.1016/S0304-3940(00)01177-0, 10863032.
11. Pasinelli P, Houseweart MK, Brown RH, Cleveland DW. Caspase-1 and -3 are sequentially activated in motor neuron death in Cu, Zn superoxide dismutase-mediated familial amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A 2000, 97:13901-13906. 10.1073/pnas.240305897, 17673, 11095709.
12. Li M, Ona VO, Guégan C, Chen M, Jackson-Lewis V, Andrews LJ, Olszewski AJ, Stieg PE, Lee JP, Przedborski S, Friedlander RM. Functional role of caspase-1 and caspase-3 in an ALS transgenic mouse model. Science 2000, 288:335-339. 10.1126/science.288.5464.335, 10764647.
13. Meissner F, Molawi K, Zychlinsky A. Mutant superoxide dismutase 1-induced IL-1β accelerates ALS pathogenesis. Proc Natl Acad Sci U S A 2010, 107:13046-13050. 10.1073/pnas.1002396107, 2919927, 20616033.
14. Garlanda C, Dinarello CA, Mantovani A. The interleukin-1 family: back to the future. Immunity 2013, 39:1003-1018. 10.1016/j.immuni.2013.11.010, 24332029.
15. Dinarello CA, Arend W, Sims J, Smith D, Blumberg H, O'Neill L, Goldbach-Mansky R, Pizarro T, Hoffman H, Bufler P, Nold M, Ghezzi P, Mantovani A, Garlanda C, Boraschi D, Rubartelli A, Netea M, van der Meer J, Joosten L, Mandrup-Poulsen T, Donath M, Lewis E, Pfeilschifter J, Martin M, Kracht M, Muehl H, Novick D, Lukic M, Conti B, Solinger A. IL-1 family nomenclature. Nat Immunol 2010, 11:973. 10.1038/ni1110-973, 20959797.
16. Boraschi D, Tagliabue A. The interleukin-1 receptor family. Semin Immunol 2013, 25:394-407. 10.1016/j.smim.2013.10.023, 24246227.
17. Franchi L, Eigenbrod T, Muñoz-Planillo R, Nuñez G. The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis. Nat Immunol 2009, 10:241-247. 2820724, 19221555.
18. Bulau AM, Nold MF, Li S, Nold-Petry CA, Fink M, Mansell A, Schwerd T, Hong J, Rubartelli A, Dinarello CA, Bufler P. Role of caspase-1 in nuclear translocation of IL-37, release of the cytokine, and IL-37 inhibition of innate immune responses. Proc Natl Acad Sci U S A 2014, 111:2650-2655. 10.1073/pnas.1324140111, 24481253.
19. Garlanda C, Riva F, Bonavita E, Gentile S, Mantovani A. Decoys and regulatory 'receptors' of the IL-1/Toll-Like receptor superfamily. Front Immunol 2013, 4:180. 3705552, 23847621.
20. Okamura H, Tsutsi H, Komatsu T, Yutsudo M, Hakura A, Tanimoto T, Torigoe K, Okura T, Nukada Y, Hattori K, Akita K, Namba M, Tanabe F, Konishi K, Fukuda S, Kurimoto M. Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature 1995, 378:88-91. 10.1038/378088a0, 7477296.
21. Nakanishi K, Yoshimoto T, Tsutsui H, Okamura H. Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu. Cytokine Growth Factor Rev 2001, 12:53-72. 10.1016/S1359-6101(00)00015-0, 11312119.
22. Zorrilla EP, Sanchez-Alavez M, Sugama S, Brennan M, Fernandez R, Bartfai T, Conti B. Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency. Proc Natl Acad Sci U S A 2007, 104:11097-11102. 10.1073/pnas.0611523104, 1904154, 17578927.
23. Netea MG, Joosten LA, Lewis E, Jensen DR, Voshol PJ, Kullberg BJ, Tack CJ, van Krieken H, Kim SH, Stalenhoef AF, van de Loo FA, Verschueren I, Pulawa L, Akira S, Eckel RH, Dinarello CA, van den Berg W, van der Meer JW. Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance. Nat Med 2006, 12:650-656. 10.1038/nm1415, 16732281.
24. Elinav E, Strowig T, Kau AL, Henao-Mejia J, Thaiss CA, Booth CJ, Peaper DR, Bertin J, Eisenbarth SC, Gordon JI, Flavell RA. NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell 2011, 145:745-757. 10.1016/j.cell.2011.04.022, 3140910, 21565393.
25. Boraschi D, Lucchesi D, Hainzl S, Leitner M, Maier E, Mangelberger D, Oostingh GJ, Pfaller T, Pixner C, Posselt G, Italiani P, Nold MF, Nold-Petry CA, Bufler P, Dinarello CA. IL-37: a new anti-inflammatory cytokine of the IL-1 family. Eur Cytokine Netw 2011, 22:127-147.
26. Arend WP, Palmer G, Gabay C. IL-1, IL-18, and IL-33 families of cytokines. Immunol Rev 2008, 223:20-38. 10.1111/j.1600-065X.2008.00624.x, 18613828.
27. Schmitz J, Owyang A, Oldham E, Song Y, Murphy E, McClanahan TK, Zurawski G, Moshrefi M, Qin J, Li X, Gorman DM, Bazan JF, Kastelein RA. IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity 2005, 23:479-490. 10.1016/j.immuni.2005.09.015, 16286016.
28. Cedarbaum JM, Stambler N, Malta E, Fuller C, Hilt D, Thurmond B, Nakanishi A. The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function. BDNF ALS Study Group (Phase III). J Neurol Sci 1999, 169:13-21. 10.1016/S0022-510X(99)00210-5, 10540002.
29. Novick D, Schwartsburd B, Pinkus R, Suissa D, Belzer I, Sthoeger Z, Keane WF, Chvatchko Y, Kim SH, Fantuzzi G, Dinarello CA, Rubinstein M. A novel IL-18BP ELISA shows elevated serum IL-18BP in sepsis and extensive decrease of free IL-18. Cytokine 2001, 14:334-342. 10.1006/cyto.2001.0914, 11497494.
30. Migliorini P, Anzilotti C, Pratesi F, Quattroni P, Bargagna M, Dinarello CA, Boraschi D. Serum and urinary levels of IL-18 and its inhibitor IL-18BP in systemic lupus erythematosus. Eur Cytokine Netw 2010, 21:264-271.
31. Kim SH, Eisenstein M, Reznikov L, Fantuzzi G, Novick D, Rubinstein M, Dinarello CA. Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18. Proc Natl Acad Sci U S A 2000, 97:1190-1195. 10.1073/pnas.97.3.1190, 15564, 10655506.
32. Bufler P, Azam T, Gamboni-Robertson F, Reznikov LL, Kumar S, Dinarello CA, Kim SH. A complex of the IL-1 homologue IL-1F7b and IL-18-binding protein reduces IL-18 activity. Proc Natl Acad Sci U S A 2002, 99:13723-13728. 10.1073/pnas.212519099, 129755, 12381835.
33. Boraschi D, Dinarello CA. IL-18 and autoimmunity. Eur Cytokine Netw 2006, 17:224-252.
34. Dinarello CA. Interleukin-18 and the pathogenesis of inflammatory diseases. Semin Nephrol 2007, 27:98-114. 10.1016/j.semnephrol.2006.09.013, 17336692.
35. Troseid M, Seljeflot I, Arnesen H. The role of interleukin-18 in the metabolic syndrome. Cardiovasc Diabetol 2010, 9:11. 10.1186/1475-2840-9-11, 2858122, 20331890.
36. Yoshimoto T, Tsutsui H, Tominaga K, Hoshino K, Okamura H, Akira S, Paul WE, Nakanishi K. IL-18, although antiallergic when administered with IL-12, stimulates IL-4 and histamine release by basophils. Proc Natl Acad Sci U S A 1999, 96:13962-13966. 10.1073/pnas.96.24.13962, 24173, 10570181.
37. Pizarro TT, Michie MH, Bentz M, Woraratanadharm J, Smith MF, Foley E, Moskaluk CA, Bickston SJ, Cominelli F. IL-18, a novel immunoregulatory cytokine, is upregulated in Crohn's disease: expression and localization in intestinal mucosal cells. J Immunol 1999, 162:6829-6835.
38. Kanai T, Kamada N, Hisamatsu T. Clinical strategies for the blockade of IL-18 in inflammatory bowel diseases. Curr Drug Targets 2013, 14:1392-1399. 10.2174/13894501113149990006, 23651166.
39. Martinon F, Burns K, Tschopp J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of pro-IL-1β. Mol Cell 2002, 10:417-426. 10.1016/S1097-2765(02)00599-3, 12191486.
40. Nguyen MD, Julien J-P, Rivest S. Induction of proinflammatory molecules in mice with amyotrophic lateral sclerosis: no requirement for proapoptotic interleukin-1β in neurodegeneration. Ann Neurol 2001, 50:630-639. 10.1002/ana.1256, 11706969.
41. Hensley K, Fedynyshyn J, Ferrel S, Floyd RA, Gordon B, Grammas P, Hamdheydari L, Mhatre M, Mou S, Pye QN, Stewart C, West M, West S, Williamson KS. Message and protein level elevations of tumor necrosis factor alpha (TNFα) and TNFα-modulating cytokines in spinal cords of the G93A-SOD1 mouse model for amyotrophic lateral sclerosis. Neurobiol Dis 2003, 14:74-80. 10.1016/S0969-9961(03)00087-1, 13678668.
42. Hensley K, Abdel-Moaty H, Hunter J, Mhatre M, Mou S, Nguyen K, Potapova T, Pye QN, Qi M, Rice H, Stewart C, Stroukoff K, West M. Primary glia expressing the G93A-SOD1 mutation present a neuroinflammatory phenotype and provide a cellular system for studies of glial inflammation. J Neuroinflammation 2006, 3:2. 10.1186/1742-2094-3-2, 1360663, 16436205.
43. Rosen DR, Siddique T, Patterson D, Figlewicz DA, Sapp P, Hentati A, Donaldson D, Goto J, O'Regan JP, Deng HX. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 1993, 362:59-62. 10.1038/362059a0, 8446170.
44. Schymick JC, Talbot K, Traynor BJ. Genetics of sporadic amyotrophic lateral sclerosis. Hum Mol Genet 2007, 16:R233-R242. 10.1093/hmg/ddm215, 17911166.
45. Dinarello CA, Bufler P. Interleukin-37. Semin Immunol 2013, 25:466-468. 10.1016/j.smim.2013.10.004, 24275599.
46. Imaeda H, Takahashi K, Fujimoto T, Kasumi E, Ban H, Bamba S, Sonoda H, Shimizu T, Fujiyama Y, Andoh A. Epithelial expression of interleukin-37b in inflammatory bowel disease. Clin Exp Immunol 2013, 172:410-416. 10.1111/cei.12061, 23600829.
47. Stamatovic SM, Shakui P, Keep RF, Moore BB, Kunkel SL, van Rooijen N, Andjelkovic AV. Monocyte chemoattractant protein-1 regulation of blood-brain barrier permeability. J Cereb Blood Flow Metab 2005, 25:593-606. 10.1038/sj.jcbfm.9600055, 15689955.
48. Gupta PK, Prabhakar S, Sharma S, Anand A. Vascular endothelial growth factor-A (VEGF-A) and chemokine ligand-2 (CCL2) in amyotrophic lateral sclerosis (ALS) patients. J Neuroinflammation 2011, 8:47. 10.1186/1742-2094-8-47, 3117705, 21569455.
49. Björkqvist M, Wild EJ, Thiele J, Silvestroni A, Andre R, Lahiri N, Raibon E, Lee RV, Benn CL, Soulet D, Magnusson A, Woodman B, Landles C, Pouladi MA, Hayden MR, Khalili-Shirazi A, Lowdell MW, Brundin P, Bates GP, Leavitt BR, Möller T, Tabrizi SJ. A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease. J Exp Med 2008, 205:1869-1877. 10.1084/jem.20080178, 2525598, 18625748.
50. Politis M, Pavese N, Tai YF, Kiferle L, Mason SL, Brooks DJ, Tabrizi SJ, Barker RA, Piccini P. Microglial activation in regions related to cognitive function predicts disease onset in Huntington's disease: a multimodal imaging study. Hum Brain Mapp 2011, 32:258-270. 10.1002/hbm.21008, 21229614.
51. Bettcher BM, Kramer JH. Inflammation and clinical presentation in neurodegenerative disease: a volatile relationship. Neurocase 2013, 19:182-200. 10.1080/13554794.2011.654227, 3733377, 22515699.