Exploring the mechanism how Marburg virus VP35 recognizes and binds dsRNA by molecular dynamics simulations and free energy calculations

Biopolymers

Volumn 101, Issue 8, 2014, Pages 849-860

  Xue, Qiao ^a   Zheng, Qing Chuan ^a   Zhang, Ji Long ^a   Cui, Ying Lu ^a   Zhang, Hong Xing ^a  

^a JILIN UNIVERSITY   (China)

Author keywords

dsRNA; MARV VP35; MM GBSA; molecular dynamics simulations

Indexed keywords

MOLECULAR DYNAMICS; VIRUSES;

DSRNA; FREE-ENERGY CALCULATIONS; INTERMOLECULAR ELECTROSTATIC INTERACTION; MARV VP35; MM-GBSA; MOLECULAR DYNAMICS SIMULATIONS; NONPOLAR INTERACTIONS; RECOGNITION MECHANISM;

BINDING ENERGY;

ANTIVIRUS AGENT; ARGININE; DOUBLE STRANDED RNA; MUTANT PROTEIN; PROTEIN BINDING; RIBONUCLEOTIDE; VIRUS PROTEIN;

ARTICLE; BINDING AFFINITY; CALCULATION; COMPLEX FORMATION; CONTROLLED STUDY; ENERGY; HYDROGEN BOND; MARBURG VIRUS; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; NONHUMAN; PROTEIN RNA BINDING; STATIC ELECTRICITY; VIRUS MUTANT; WILD TYPE; CHEMICAL PHENOMENA; CHEMISTRY; MARBURGVIRUS; METABOLISM; PROTEIN STABILITY; THERMODYNAMICS;

HYDROGEN BONDING; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MARBURGVIRUS; MOLECULAR DYNAMICS SIMULATION; MUTANT PROTEINS; PROTEIN BINDING; PROTEIN STABILITY; RIBONUCLEOTIDES; RNA, DOUBLE-STRANDED; STATIC ELECTRICITY; THERMODYNAMICS; VIRAL REGULATORY AND ACCESSORY PROTEINS;

EID: 84901651830     PISSN: 00063525     EISSN: 10970282     Source Type: Journal    
DOI: 10.1002/bip.22463     Document Type: Article

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