Ligaria cuneifolia flavonoid fractions modulate cell growth of normal lymphocytes and tumor cells as well as multidrug resistant cells

Immunobiology

Volumn 209, Issue 10, 2005, Pages 737-749

  Zolezzi, Paula Cerdá ^a   Fernández, Teresa ^a   Aulicino, Paula ^a   Cavaliere, Victoria ^a,b   Greczanik, Sofía ^a,b   Lopes, Eloisi Caldas ^a   Wagner, Marcelo ^a   Ricco, Rafael ^a   Gurni, Alberto ^a   Hajos, Silvia ^a,c   Àlvarez, Elida ^a,c  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b Cátedra de Farmacobotánica Facultad de Farmacia y Bioquímica Universidad de Buenos Aires ^*  (Argentina)

^c Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

Author keywords

Cytokines; Flavonoids; Ligaria cuneifolia; Lymphocytes; MDR; Tumor cells

Indexed keywords

ACETIC ACID ETHYL ESTER; AVICULARINE; CYTOKINE; FLAVONOID; FOENICULARIN; INTERLEUKIN 10; INTERLEUKIN 2; LIGARIA CUNEIFOLIA EXTRACT; MESSENGER RNA; METHANOL; PLANT EXTRACT; PROANTHOCYANIDIN DERIVATIVE; QUERCETIN; QUERCETIN 3 XYLOSIDE; QUERCITRIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANALYSIS OF VARIANCE; ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BIOLOGICAL ACTIVITY; CANCER INHIBITION; CELL CULTURE; CELL GROWTH; CELL LINE; CELL STIMULATION; CELL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIPLOIDY; DRUG IDENTIFICATION; DRUG ISOLATION; FEMALE; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GENE EXPRESSION REGULATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIGARIA CUNEIFOLIA; LORANTHACEAE; LYMPHOCYTE PROLIFERATION; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SPLEEN CELL; TUMOR CELL;

EID: 20944437998     PISSN: 01712985     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imbio.2005.03.001     Document Type: Article

References (58)

1. D. Abbiatti Las Lorantáceas argentinas Revista del Museo de La Plata (Nueva botánica) 1 1946 1-110
2. E. Alvarez C. Mongini C. Waldner T. Fernández D. Naor S. Hajos The interrelationship between spontaneous murine T cell leukemia LB and the immune system J. Exp. Clin. Cancer Res. 8 1989 181-192
3. S. Bhattacharya P. Sen M. Wallet B. Long A.S. Baldwin Jr. R. Tisch Immunoregulation of dendritic cells by IL-10 is mediated through suppression of the PI3K/Akt pathway and of I{kappa}B kinase activity Blood 104 2004 1000-1109
4. E.J. Calabrese L.A. Baldwin Applications of hormesis in toxicology, risk assessment and chemotherapeutics Trends Pharmacol. Sci. 23 2002 331-337
5. E. Caldas Lopes M. Scolnik E. Alvarez S. Hajos Modulator activity of PSC 833 and cyclosporin-A in vincristine and doxorubicin-selected multidrug resistant murine leukaemic cells Leuk. Res. 25 2001 85-93
6. E. Caldas Lopes M.G. García L. Vellón E. Alvarez S.E. Hajos Correlation between decreased apoptosis and multidrug resistance (MDR) in murine leukemic T cell lines Leuk. Lymphoma 42 2001 775-787
7. L. Cavallini A. Bindoli N. Siliprandi Comparative evaluation of antiperoxidative action of Silimaryn and other flavonoids Pharmacol. Res. Commun. 10 1978 133-136
8. C.-C. Chen M.-P. Chow W.-C. Huang Y.-C. Lin Y.-J. Chang Flavonoids inhibit tumor necrosis factor-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cells through activator protein-1 and nuclear factor-κB: Structure-activity relationships Mol. Pharmacol. 66 2004 683-693
9. F.L. Chung J. Schwartz C.R. Herzog Y.M. Yang Tea and cancer prevention: studies in animals and humans J. Nutr. 133 2003 3268-3274
10. K.C. De Souza E.E. Schapoval V.L. Bassani LC determination of flavonoids: Separation of quercetin, luteolin and 3-O-methylquercetin in Achyrocline satureioides preparations J. Pharm. Biomed. Anal. 28 2002 771-777
11. J.A. Domínguez Contribuciones a la materia médica 1928 Peuser Buenos Aires
12. T. Fernández M.L. Wagner B.G. Varela R.A. Ricco S.E. Hajos A.A. Gurni E. Alvarez Study of an Argentine mistletoe, the hemiparasite Ligaria cuneifolea (R. et P.) Tiegh (Loranthaceae) J. Ethnopharmacol. 62 1998 25-34
13. T. Fernández P. Cerdá Zolezzi P. Aulicino E. Caldas Lopes M. Wagner R. Ricco S. Hajos A. Gurni E. Alvarez Immunobiological features of the galactoside lectin l -Lc isolated from the Argentine mistletoe Ligaria cuneifolea J. Ethnopharmacol. 85 2003 81-92
14. S. Gabius S. Joshi K. Kayser H.J. Gabius The galactoside-specific lectin from mistletoe as biological response modifier Int. J. Oncol. 1 1992 705-708
15. H.J. Gabius S. Gabius S.S. Joshi B. Koch M. Schroeder W.M. Manzke M. Westerhausen From ill-defined extracts to the immunomodulatory lectin: will there be a reason for oncological application of mistletoe? Planta Med. 60 1994 2-7
16. M.J. Gravisaco C. Mongini E. Alvarez P. Ruybal A. Escalada M. Sánchez Lockhart S. Hajos C. Waldner IL-2, IL-10, IL-15 and TNF are key regulators of murine T cell lymphoma growth Int. J. Mol. Med. 12 2003 627-632
17. T. Hajto K. Hostanska J. Fischer R. Saller Immunomodulatory effects of Viscum album agglutinin-I on natural immunity Anticancer Drugs 8 1997 S43-S46
18. F. Hakimuddin G. Paliyath K. Meckling Selective cytotoxicity of a red grape wine flavonoid fraction against MCF-7 cells Breast Cancer Res. Treat. 85 2004 65-79
19. B.H. Havsteen The biochemistry and medical significance of the flavonoids Pharmacol. Ther. 96 2002 67-102
20. T. Hirano M. Gotoh K. Oka Natural flavonoids and lignans are potent cytostatic agents against human leukemic HL-60 cells Life Sci. 55 1994 1061-1069
21. T. Hirano K. Abe M. Gotoh K. Oka Citrus flavone tangeretin inhibits leukemia HL-60 cell growth partially through induction of apoptosis with less cytotoxicity on normal lymphocytes Br. J. Cancer 72 1995 1380-1388
22. K. Hostanska T. Hajto K. Weber J. Fischer H. Lentzen B. Sütterlin R. Saller A natural immunity-activating plant lectin, Viscum album agglutinin-I, induces apoptosis in human lymphocytes, monocytes, monocytic THP-1 cells and murine thymocytes Nat. Immun. 15 1996-97 295-311
23. C. Jiang R. Agarwal J. Lu Anti-angiogenic potential of a cancer chemopreventive flavonoid antioxidant, silymarin: Inhibition of key attributes of vascular endothelial cells and angiogenic cytokine secretion by cancer epithelial cells Biochem. Biophys. Res. Commun. 276 2000 371-378
24. M. Jurin N. Zarkovic M. Hrzenjak Z. Ilic Antitumorous and immunomodulatory effects of Viscum album L, preparation Isorel Oncology 50 1993 393-398
25. M. Kimata N. Inagaki H. Nagai Effects of luteolin and other flavonoids on IgE-mediated allergic reactions Planta Med. 66 2000 25-29
26. L.G. Korkina I.B. Afanas'ev Antioxidant and chelating properties of flavonoids Adv. Pharmacol. 38 1997 151-163
27. K. Kunishiro A. Tai I. Yamamoto Effects of rooibos tea extract on antigen-specific antibody production and cytokine generation in vitro and in vivo Biosci. Biotechnol. Biochem. 65 2001 2137-2145
28. E.U. Kurz S.E. Wilson K.B. Leader B.P. Sampey W.P. Allan J.C. Yalowich D.J. Kroll The histone deacetylase inhibitor sodium butyrate induces DNA topoisomerase II alpha expression and confers hypersensitivity to etoposide in human leukemic cell lines Mol. Cancer Ther. 1 2001 121-131
29. R.A. Larson The antioxidants of higher plants Phytochemistry 27 1988 969-978
30. D.A. Lawrence Transforming growth factor-beta: A general review Eur. Cytokine Netw. 7 1996 363-374
31. Y. Li S.R. Chinni A.M. Senderowicz F.H. Sarkar Induction of growth inhibition and apoptosis in prostate cancer cells by flavopiridol Int. J. Oncol. 17 2000 755-759
32. L.H. Long M.V. Clement B. Hallwell Artifacts in cell culture: Rapid generation of hydrogen peroxide on addition of (-)-epigallocatechin, (-)-epigallocatechin gallate, (+)-catechin and quercetin to commonly used cell culture media Biochem. Biophys. Res. Commun. 273 2000 50-53
33. T.J. Mabry K.R. Markham M.B. Thomas The Systematic Identification of the Flavonoids 1970 Springer Berlin pp. 1-175
34. G.G. Mackenzie F. Carrasquedo J.M. Delfino C.L. Keen C.G. Fraga P.I. Oteiza Epicatechin, catechin, and dimeric procyanidins inhibit PMA-induced NF-kappaB activation at multiple steps in Jurkat T cells FASEB J. 18 2004 167-169
35. S.K. Manna A. Mukhopadhyay N.T. Van B.B. Aggarwal Silymarin suppresses TNF-induced activation of NF-κB, c-Jun, N-terminal kinase and apoptosis J. Immunol. 163 1999 6800-6809
36. K.R. Markham Techniques of Flavonoid Identification 1982 Academic Press New York pp. 1-113
37. E. Middleton Jr. Effect of plant flavonoids on immune and inflammatory cell function Adv. Exp. Med. Biol. 439 1998 175-182
38. E. Middleton Jr. C. Kandaswami T.C. Theoharides The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease, and cancer Pharmacol. Rev. 52 2000 673-751
39. K. Morikawa M. Nonaka M. Narahara I. Torii K. Kawaguchi T. Yoshikawa Y. Kumazawa S. Morikawa Inhibitory effect of quercetin on carrageenan-induced inflammation in rats Life Sci. 74 2003 709-721
40. I. Nicoletti G. Migliorati M.C. Pagliacci F. Grignani C. Riccardi A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry J. Immunol. Methods 139 1991 271-279
41. J.M. Pezzuto Plant-derived anticancer agents Biochem. Pharmacol. 53 1997 121-133
42. E. Portalupi Il vischio nella terapia dei tumori: Valutazione critica dell'impiego dell'Iscador nella terapia antitumorale 1987 Arlesheim Istituto Hiscia Ed pp. 55-134
43. E.L. Ratera M.O. Ratera Plantas de la flora Argentina empleadas en Medicina Popular 1980 Buenos Aires Hemisferio Sur p. 82
44. W. Ren Z. Qiao H. Wang L. Zhu L. Zhang Flavonoids: Promising anticancer agents Med. Res. Rev. 23 2003 519-534
45. R.A. Ruggiero O.D. Bustuoabad R.D. Bonfil R.P. Meiss C.D. Pasqualini "Concomitant immunity" in murine tumours of non-detectable immunogenicity Br. J. Cancer 51 1985 37-48
46. F.H. Sarkar Y. Li The role of isoflavones in cancer chemoprevention Front. Biosci. 9 2004 2714-2724
47. G. Scambia F.O. Ranelletti P.B. Panici R. De Vincenzo G. Bonanno G. Ferrandina M. Piantelli S. Bussa C. Rumi M. Cianfriglia S. Mancuso Quercetin potentiates the effect of adriamycin in a multidrug-resistant MCF-7 human breast-cancer cell line: P-glycoprotein as a possible target Cancer Chemother. Pharmacol. 34 1994 459-464
48. S.O. Shaheen J.A. Sterne R.L. Thompson C.E. Songhurst B.M. Margetts P.G. Burney Dietary antioxidants and asthma in adults: Population-based case-control study Am. J. Respir. Crit. Care Med. 15 2001 1823-1828
49. A. Schwartz E. Middleton Jr. Comparison of the effects of quercetin with those of other flavonoids on the generation and effector function of cytotoxic T lymphocytes Immunopharmacology 7 1984 115-126
50. M.B. Sporn N. Suh Chemoprevention: An essential approach to controlling cancer Nat. Rev. Cancer 2 2002 537-543
51. M. Suganuma E. Sueoka N. Sueoka S. Okabe H. Fujiki Mechanisms of cancer prevention by tea polyphenols based on inhibition of TNF-alpha expression Biofactors 13 2000 67-72
52. C.A. Taira M.L. Wagner H.M. Adeados R. Pino A. Gurni Estudio farmacológico de un agente vasoactivo presente en Ligaria cuneifolia var. cuneifolia Acta Farmacéutica Bonaerense 13 1994 91-95
53. Wagner, M.L., 1993. Estudios fitoquímicos comparativos de los flavonoides de Loranthaceae de la flora Argentina. Relación con el muérdago Europeo. Ph.D. Thesis, University of Buenos Aires.
54. M.L. Wagner T. Fernández B. Varela E. Alvarez R. Ricco S. Hajos A. Gurni Anatomical, phytochemical and immunochemical studies on Ligaria cuneifolia (R. et P.) Tiegh. (Loranthaceae) Pharmaceut. Biol. 36 1998 131-139
55. C. Waldner C. Mongini E. Alvarez I. Roig S.E. Hajos Inhibitory activity of soluble IL-2R in sera, ascites and culture supernatants from murine leukaemic cells Scand. J. Immunol. 40 1994 308-316
56. P.G. Waterman S. Mole Analysis of Phenolic Plant Metabolites 1994 Backwell Scientific Publications Oxford p. 238
57. R.H. Wiltrout M.R. Boyd T.C. Back R.R. Salup J.A. Arthur R.L. Hornung Flavone-8-acetic acid augments systemic natural killer cell activity and synergizes with IL-2 for treatment of murine renal cancer J. Immunol. 14 1988 3261-3265
58. S. Zhang M.E. Morris Effect of the flavonoids: Biochanin A, morin, phloretin and silymarin on P-glycoprotein-mediated transport J. Pharmacol. Exp. Ther. 304 2003 1258-1267