메뉴 건너뛰기




Volumn 17, Issue , 2014, Pages 22-33

Phyllanthus urinaria induces mitochondrial dysfunction in human osteosarcoma 143B cells associated with modulation of mitochondrial fission/fusion proteins

Author keywords

Fission; Fusion; Mitochondrion; Phyllanthus urinaria

Indexed keywords

ACETYLCYSTEINE; ADENOSINE TRIPHOSPHATE; ANTINEOPLASTIC AGENT; CATALASE; GLUTATHIONE PEROXIDASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MANGANESE SUPEROXIDE DISMUTASE; MEMBRANE FUSION PROTEIN; MITOCHONDRIAL FISSION 1 PROTEIN; MITOCHONDRIAL PROTEIN; MITOFUSIN 1; PHYLLANTHUS URINARIA EXTRACT; PLANT EXTRACT; PROTEIN OPA1; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

EID: 84901621298     PISSN: 15677249     EISSN: 18728278     Source Type: Journal    
DOI: 10.1016/j.mito.2014.05.002     Document Type: Article
Times cited : (25)

References (46)
  • 2
    • 13944278132 scopus 로고    scopus 로고
    • Mitochondria, oxidants, and aging
    • Balaban R.S., Nemoto S., Finkel T. Mitochondria, oxidants, and aging. Cell 2005, 120:483-495.
    • (2005) Cell , vol.120 , pp. 483-495
    • Balaban, R.S.1    Nemoto, S.2    Finkel, T.3
  • 3
    • 0033796250 scopus 로고    scopus 로고
    • Mitochondrial free radical generation, oxidative stress, and aging
    • Cadenas E., Davies K.J. Mitochondrial free radical generation, oxidative stress, and aging. Free Radic. Biol. Med. 2000, 29:222-230.
    • (2000) Free Radic. Biol. Med. , vol.29 , pp. 222-230
    • Cadenas, E.1    Davies, K.J.2
  • 4
    • 0037455575 scopus 로고    scopus 로고
    • Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential are essential for embryonic development
    • Chen H., Detmer S.A., Ewald A.J., Griffin E.E., Fraser S.E., Chan D.C. Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential are essential for embryonic development. J. Cell Biol. 2003, 160:189-200.
    • (2003) J. Cell Biol. , vol.160 , pp. 189-200
    • Chen, H.1    Detmer, S.A.2    Ewald, A.J.3    Griffin, E.E.4    Fraser, S.E.5    Chan, D.C.6
  • 5
    • 0141815741 scopus 로고    scopus 로고
    • Production of reactive oxygen species by mitochondria: central role of complex III
    • Chen Q., Vazquez E.J., Moghaddas S., Hoppel C.L., Lesnefsky E.J. Production of reactive oxygen species by mitochondria: central role of complex III. J. Biol. Chem. 2003, 278:36027-36031.
    • (2003) J. Biol. Chem. , vol.278 , pp. 36027-36031
    • Chen, Q.1    Vazquez, E.J.2    Moghaddas, S.3    Hoppel, C.L.4    Lesnefsky, E.J.5
  • 6
    • 49249086654 scopus 로고    scopus 로고
    • Coordinated changes of mitochondrial biogenesis and antioxidant enzymes during osteogenic differentiation of human mesenchymal stem cells
    • Chen C.T., Shih Y.R., Kuo T.K., Lee O.K., Wei Y.H. Coordinated changes of mitochondrial biogenesis and antioxidant enzymes during osteogenic differentiation of human mesenchymal stem cells. Stem Cells 2008, 26:960-968.
    • (2008) Stem Cells , vol.26 , pp. 960-968
    • Chen, C.T.1    Shih, Y.R.2    Kuo, T.K.3    Lee, O.K.4    Wei, Y.H.5
  • 10
    • 39149103059 scopus 로고    scopus 로고
    • Anti-oxidant and inflammatory mediator's growth inhibitory effects of compounds isolated from Phyllanthus urinaria
    • Fang S.H., Rao Y.K., Tzeng Y.M. Anti-oxidant and inflammatory mediator's growth inhibitory effects of compounds isolated from Phyllanthus urinaria. J. Ethnopharmacol. 2008, 116:333-340.
    • (2008) J. Ethnopharmacol. , vol.116 , pp. 333-340
    • Fang, S.H.1    Rao, Y.K.2    Tzeng, Y.M.3
  • 11
    • 0042233907 scopus 로고    scopus 로고
    • Structural organization of the mitochondrial respiratory chain
    • Genova M.L., Bianchi C., Lenaz G. Structural organization of the mitochondrial respiratory chain. Ital. J. Biochem. 2003, 52:58-61.
    • (2003) Ital. J. Biochem. , vol.52 , pp. 58-61
    • Genova, M.L.1    Bianchi, C.2    Lenaz, G.3
  • 12
    • 0036648449 scopus 로고    scopus 로고
    • Novel substituted methylenedioxy lignan suppresses proliferation of cancer cells by inhibiting telomerase and activation of c-myc and caspases leading to apoptosis
    • Giridharan P., Somasundaram S.T., Perumal K., Vishwakarma R.A., Karthikeyan N.P., Velmurugan R., Balakrishnan A. Novel substituted methylenedioxy lignan suppresses proliferation of cancer cells by inhibiting telomerase and activation of c-myc and caspases leading to apoptosis. Br. J. Cancer 2002, 87:98-105.
    • (2002) Br. J. Cancer , vol.87 , pp. 98-105
    • Giridharan, P.1    Somasundaram, S.T.2    Perumal, K.3    Vishwakarma, R.A.4    Karthikeyan, N.P.5    Velmurugan, R.6    Balakrishnan, A.7
  • 13
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D., Weinberg R.A. The hallmarks of cancer. Cell 2000, 100:57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 15
    • 42049092501 scopus 로고    scopus 로고
    • Mitochondrial dynamics: to be in good shape to survive
    • Herzig S., Martinou J.C. Mitochondrial dynamics: to be in good shape to survive. Curr. Mol. Med. 2008, 8:131-137.
    • (2008) Curr. Mol. Med. , vol.8 , pp. 131-137
    • Herzig, S.1    Martinou, J.C.2
  • 16
    • 0037469915 scopus 로고    scopus 로고
    • Phyllanthus urinaria triggers the apoptosis and Bcl-2 down-regulation in Lewis lung carcinoma cells
    • Huang S.T., Yang R.C., Yang L.J., Lee P.N., Pang J.H. Phyllanthus urinaria triggers the apoptosis and Bcl-2 down-regulation in Lewis lung carcinoma cells. Life Sci. 2003, 72:1705-1716.
    • (2003) Life Sci. , vol.72 , pp. 1705-1716
    • Huang, S.T.1    Yang, R.C.2    Yang, L.J.3    Lee, P.N.4    Pang, J.H.5
  • 17
    • 33646086465 scopus 로고    scopus 로고
    • Anti-tumor and anti-angiogenic effects of Phyllanthus urinaria in mice bearing Lewis lung carcinoma
    • Huang S.T., Yang R.C., Lee P.N., Yang S.H., Liao S.K., Chen T.Y., Pang J.H. Anti-tumor and anti-angiogenic effects of Phyllanthus urinaria in mice bearing Lewis lung carcinoma. Int. Immunopharmacol. 2006, 6:870-879.
    • (2006) Int. Immunopharmacol. , vol.6 , pp. 870-879
    • Huang, S.T.1    Yang, R.C.2    Lee, P.N.3    Yang, S.H.4    Liao, S.K.5    Chen, T.Y.6    Pang, J.H.7
  • 18
    • 78249282258 scopus 로고    scopus 로고
    • Anti-cancer effect of Phyllanthus urinaria and its relevant mechanism
    • Huang S.T., Pang J.H., Yang R.C., Wu H.T. Anti-cancer effect of Phyllanthus urinaria and its relevant mechanism. Chang Gung Med. J. 2010, 33:477-487.
    • (2010) Chang Gung Med. J. , vol.33 , pp. 477-487
    • Huang, S.T.1    Pang, J.H.2    Yang, R.C.3    Wu, H.T.4
  • 19
    • 79952221664 scopus 로고    scopus 로고
    • Ellagic acid, the active compound of Phyllanthus urinaria, exerts in vivo anti-angiogenic effect and inhibits MMP-2 activity
    • Huang S.T., Wang C.Y., Yang R.C., Wu H.T., Yang S.H., Cheng Y.C., Pang J.H. Ellagic acid, the active compound of Phyllanthus urinaria, exerts in vivo anti-angiogenic effect and inhibits MMP-2 activity. Evid. Based Complement. Alternat. Med. 2011, 2011:215035. 10.1093/ecam/nep207.
    • (2011) Evid. Based Complement. Alternat. Med. , vol.2011 , pp. 215035
    • Huang, S.T.1    Wang, C.Y.2    Yang, R.C.3    Wu, H.T.4    Yang, S.H.5    Cheng, Y.C.6    Pang, J.H.7
  • 20
    • 79955757511 scopus 로고    scopus 로고
    • Zinc-chelation contributes to the anti-angiogenic effect of ellagic acid on inhibiting MMP-2 activity, cell migration and tube formation
    • Huang S.T., Yang R.C., Wu H.T., Wang C.N., Pang J.H. Zinc-chelation contributes to the anti-angiogenic effect of ellagic acid on inhibiting MMP-2 activity, cell migration and tube formation. PLoS One 2011, 6:e18986. 10.1371/journal. pone.0018986.
    • (2011) PLoS One , vol.6
    • Huang, S.T.1    Yang, R.C.2    Wu, H.T.3    Wang, C.N.4    Pang, J.H.5
  • 21
    • 13444287961 scopus 로고    scopus 로고
    • Mihara Mitofusin 1 and 2 play distinct roles in mitochondrial fusion reactions via GTPase activity
    • Ishihara N., Eura Y., Mihara Mitofusin 1 and 2 play distinct roles in mitochondrial fusion reactions via GTPase activity. J. Cell Sci. 2004, 117:6535-6546.
    • (2004) J. Cell Sci. , vol.117 , pp. 6535-6546
    • Ishihara, N.1    Eura, Y.2
  • 22
    • 0033026704 scopus 로고    scopus 로고
    • Effect of Emblica officinalis, Phyllanthus amarus and Picrorrhiza kurroa on N-nitrosodiethylamine induced hepatocarcinogenesis
    • Jeena K.J., Joy K.L., Kuttan R. Effect of Emblica officinalis, Phyllanthus amarus and Picrorrhiza kurroa on N-nitrosodiethylamine induced hepatocarcinogenesis. Cancer Lett. 1999, 8:11-16.
    • (1999) Cancer Lett. , vol.8 , pp. 11-16
    • Jeena, K.J.1    Joy, K.L.2    Kuttan, R.3
  • 25
    • 55349102294 scopus 로고    scopus 로고
    • Cardiolipin and electron transport chain abnormalities in mouse brain tumor mitochondria: lipidomic evidence supporting the Warburg theory of cancer
    • Kiebish M.A., Han X., Cheng H., Chuang J.H., Seyfried T.N. Cardiolipin and electron transport chain abnormalities in mouse brain tumor mitochondria: lipidomic evidence supporting the Warburg theory of cancer. J. Lipid Res. 2008, 49:2545-2556.
    • (2008) J. Lipid Res. , vol.49 , pp. 2545-2556
    • Kiebish, M.A.1    Han, X.2    Cheng, H.3    Chuang, J.H.4    Seyfried, T.N.5
  • 27
    • 47749135817 scopus 로고    scopus 로고
    • Inhibition of Helicobacter pylori-induced inflammation in human gastric epithelial AGS cells by Phyllanthus urinaria extracts
    • Lai C.H., Fang S.H., Rao Y.K., Geethangili M., Tang C.H., Lin Y.J., Hung C.H., Wang W.C., Tzeng Y.M. Inhibition of Helicobacter pylori-induced inflammation in human gastric epithelial AGS cells by Phyllanthus urinaria extracts. J. Ethnopharmacol. 2008, 118:522-526.
    • (2008) J. Ethnopharmacol. , vol.118 , pp. 522-526
    • Lai, C.H.1    Fang, S.H.2    Rao, Y.K.3    Geethangili, M.4    Tang, C.H.5    Lin, Y.J.6    Hung, C.H.7    Wang, W.C.8    Tzeng, Y.M.9
  • 28
    • 79959249586 scopus 로고    scopus 로고
    • Antimetastatic effects of Phyllanthus on human lung (A549) and breast (MCF-7) cancer cell lines
    • Lee S.H., Jaganath I.B., Wang S.M., Sekaran S.D. Antimetastatic effects of Phyllanthus on human lung (A549) and breast (MCF-7) cancer cell lines. PLoS One 2011, 6:e20994. 10.1371/journal.pone.0020994.
    • (2011) PLoS One , vol.6
    • Lee, S.H.1    Jaganath, I.B.2    Wang, S.M.3    Sekaran, S.D.4
  • 29
    • 0003484871 scopus 로고
    • Editorial Committee of the Flora of Taiwan, Taipei, Taiwan
    • Li H.L. Flora of Taiwan (II) 1993, 498. Editorial Committee of the Flora of Taiwan, Taipei, Taiwan. 2nd edition.
    • (1993) Flora of Taiwan (II) , pp. 498
    • Li, H.L.1
  • 30
    • 44749094194 scopus 로고    scopus 로고
    • Antioxidant, anti-semicarbazide-sensitive amine oxidase, and anti-hypertensive activities of geraniin isolated from Phyllanthus urinaria
    • Lin S.Y., Wang C.C., Lu Y.L., Wu W.C., Hou W.C. Antioxidant, anti-semicarbazide-sensitive amine oxidase, and anti-hypertensive activities of geraniin isolated from Phyllanthus urinaria. Food Chem. Toxicol. 2008, 46:2485-2492.
    • (2008) Food Chem. Toxicol. , vol.46 , pp. 2485-2492
    • Lin, S.Y.1    Wang, C.C.2    Lu, Y.L.3    Wu, W.C.4    Hou, W.C.5
  • 31
    • 79960230433 scopus 로고    scopus 로고
    • Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics
    • Martinou J.C., Youle R.J. Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics. Dev. Cell 2011, 21:92-101.
    • (2011) Dev. Cell , vol.21 , pp. 92-101
    • Martinou, J.C.1    Youle, R.J.2
  • 32
    • 33749991592 scopus 로고    scopus 로고
    • Mitochondrial inner-membrane fusion and crista maintenance requires the dynamin-related GTPase Mgm1
    • Meeusen S., DeVay R., Block J., Cassidy-Stone A., Wayson S., McCaffery J.M., Nunnari J. Mitochondrial inner-membrane fusion and crista maintenance requires the dynamin-related GTPase Mgm1. Cell 2006, 127:383-395.
    • (2006) Cell , vol.127 , pp. 383-395
    • Meeusen, S.1    DeVay, R.2    Block, J.3    Cassidy-Stone, A.4    Wayson, S.5    McCaffery, J.M.6    Nunnari, J.7
  • 34
    • 0022416744 scopus 로고
    • High-performance liquid chromatographic assay for the antitumor glycoside phyllanthoside and its stability in plasma of several species
    • Powis G., Moore D.J. High-performance liquid chromatographic assay for the antitumor glycoside phyllanthoside and its stability in plasma of several species. J. Chromatogr. 1985, 12:129-134.
    • (1985) J. Chromatogr. , vol.12 , pp. 129-134
    • Powis, G.1    Moore, D.J.2
  • 35
    • 80052023882 scopus 로고    scopus 로고
    • Inhibition of glucose-induced vascular endothelial growth factor expression by Salvia miltiorrhiza hydrophilic extract in human microvascular endothelial cells: evidence for mitochondrial oxidative stress
    • Qian S., Huo D., Wang S., Qian Q. Inhibition of glucose-induced vascular endothelial growth factor expression by Salvia miltiorrhiza hydrophilic extract in human microvascular endothelial cells: evidence for mitochondrial oxidative stress. J. Ethnopharmacol. 2011, 137:985-991.
    • (2011) J. Ethnopharmacol. , vol.137 , pp. 985-991
    • Qian, S.1    Huo, D.2    Wang, S.3    Qian, Q.4
  • 36
    • 0033797891 scopus 로고    scopus 로고
    • Phyllanthus amarus extract administration increases the life span of rats with hepatocellular carcinoma
    • Rajeshkumar N.V., Kuttan R. Phyllanthus amarus extract administration increases the life span of rats with hepatocellular carcinoma. J. Ethnopharmacol. 2000, 73:215-219.
    • (2000) J. Ethnopharmacol. , vol.73 , pp. 215-219
    • Rajeshkumar, N.V.1    Kuttan, R.2
  • 39
    • 45349094984 scopus 로고    scopus 로고
    • Mitochondrial dynamics and apoptosis
    • Suen D.F., Norris K.L., Youle R.J. Mitochondrial dynamics and apoptosis. Genes Dev. 2008, 22:1577-1590.
    • (2008) Genes Dev. , vol.22 , pp. 1577-1590
    • Suen, D.F.1    Norris, K.L.2    Youle, R.J.3
  • 40
    • 84870452019 scopus 로고    scopus 로고
    • Antimetastatic potentials of Phyllanthus urinaria L on A549 and Lewis lung carcinoma cells via repression of matrix-degrading proteases
    • Tseng H.H., Chen P.N., Kuo W.H., Wang J.W., Chu S.C., Hsieh Y.S. Antimetastatic potentials of Phyllanthus urinaria L on A549 and Lewis lung carcinoma cells via repression of matrix-degrading proteases. Integr. Cancer Ther. 2012, 11:267-278.
    • (2012) Integr. Cancer Ther. , vol.11 , pp. 267-278
    • Tseng, H.H.1    Chen, P.N.2    Kuo, W.H.3    Wang, J.W.4    Chu, S.C.5    Hsieh, Y.S.6
  • 41
    • 0024314080 scopus 로고
    • Pathophysiology of peroxisomal beta-oxidation
    • Vamecq J., Draye J.P. Pathophysiology of peroxisomal beta-oxidation. Essays Biochem. 1989, 24:115-225.
    • (1989) Essays Biochem. , vol.24 , pp. 115-225
    • Vamecq, J.1    Draye, J.P.2
  • 43
    • 84863279167 scopus 로고    scopus 로고
    • Phyllanthus urinaria induces apoptosis in human osteosarcoma 143B cells via activation of Fas/FasL- and mitochondria-mediated pathways
    • Wu H.Y., Lin T.K., Kuo H.M., Huang Y.L., Liou C.W., Wang P.W., Chuang J.H., Huang S.T. Phyllanthus urinaria induces apoptosis in human osteosarcoma 143B cells via activation of Fas/FasL- and mitochondria-mediated pathways. Evid. Based Complement. Alternat. Med. 2012, 2012:925824. 10.1155/2012/925824.
    • (2012) Evid. Based Complement. Alternat. Med. , vol.2012 , pp. 925824
    • Wu, H.Y.1    Lin, T.K.2    Kuo, H.M.3    Huang, Y.L.4    Liou, C.W.5    Wang, P.W.6    Chuang, J.H.7    Huang, S.T.8
  • 44
    • 34250825264 scopus 로고    scopus 로고
    • Mitochondrial reactive oxygen species-mediated signaling in endothelial cells
    • Zhang D.X., Gutterman D.D. Mitochondrial reactive oxygen species-mediated signaling in endothelial cells. Am. J. Physiol. Heart Circ. Physiol. 2007, 292:H2023-H2031.
    • (2007) Am. J. Physiol. Heart Circ. Physiol. , vol.292
    • Zhang, D.X.1    Gutterman, D.D.2
  • 45
    • 79952079462 scopus 로고    scopus 로고
    • The cytoprotective effect of N-acetyl-L-cysteine against ROS-induced cytotoxicity is independent of its ability to enhance glutathione synthesis
    • Zhang F., Lau S.S., Monks T.J. The cytoprotective effect of N-acetyl-L-cysteine against ROS-induced cytotoxicity is independent of its ability to enhance glutathione synthesis. Toxicol. Sci. 2011, 120:87-97.
    • (2011) Toxicol. Sci. , vol.120 , pp. 87-97
    • Zhang, F.1    Lau, S.S.2    Monks, T.J.3
  • 46
    • 84875213589 scopus 로고    scopus 로고
    • Regulation of mitochondrial dynamics: convergences and divergences between yeast and vertebrates
    • Zhao J., Lendahl U., Nistér M. Regulation of mitochondrial dynamics: convergences and divergences between yeast and vertebrates. Cell. Mol. Life Sci. 2013, 70:951-976.
    • (2013) Cell. Mol. Life Sci. , vol.70 , pp. 951-976
    • Zhao, J.1    Lendahl, U.2    Nistér, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.