Gαq, Gγ1 and Plc21C control drosophila body fat storage

Journal of Genetics and Genomics

Volumn 41, Issue 5, 2014, Pages 283-292

  Baumbach, Jens ^a   Xu, Yanjun ^a   Hehlert, Philip ^a   Kühnlein, Ronald P ^a  

^a MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

Author keywords

Adipokinetic hormone; Calcium; Fat storage; G q; G 1; Plc21C

Indexed keywords

ADIPOKINETIC HORMONE; CALCIUM; CALMODULIN; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN GAMMA SUBUNIT; PHOSPHOLIPASE C; DROSOPHILA PROTEIN; GGAMMA1 PROTEIN, DROSOPHILA; PHOSPHOLIPASE; PLC21C PROTEIN, DROSOPHILA;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY FAT; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; FAT BODY; FEMALE; FUNCTIONAL DISEASE; GENE; GENE ACTIVITY; GENE CONTROL; GENE EXPRESSION; GENE INTERACTION; GENE SILENCING; GENETIC TRANSCRIPTION; IN VIVO STUDY; LIPID METABOLISM; LIPID STORAGE; MALE; NONHUMAN; OBESITY; PROTEIN EXPRESSION; PROTEIN FUNCTION; SECOND MESSENGER; SIGNAL TRANSDUCTION; ADIPOSE TISSUE; ANIMAL; METABOLISM;

ANIMALIA; DROSOPHILA MELANOGASTER; HEXAPODA;

ADIPOSE TISSUE; ANIMALS; CALCIUM; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; GTP-BINDING PROTEIN GAMMA SUBUNITS; LIPID METABOLISM; PHOSPHOLIPASES; SIGNAL TRANSDUCTION;

EID: 84901619785     PISSN: 16738527     EISSN: 18735533     Source Type: Journal    
DOI: 10.1016/j.jgg.2014.03.005     Document Type: Article

References (54)

1. Anand A.N., Lorenz M.W. Age-dependent changes of fat body stores and the regulation of fat body lipid synthesis and mobilisation by adipokinetic hormone in the last larval instar of the cricket, Gryllus bimaculatus. J. Insect Physiol. 2008, 54:1404-1412.
2. Arrese E., Rojas-Rivas B., Wells M. The use of decapitated insects to study lipid mobilization in adult Manduca sexta: effects of adipokinetic hormone and trehalose on fat body lipase activity. Insect Biochem. Mol. Biol. 1996, 26:775-782.
3. Arrese E.L., Flowers M.T., Gazard J.L., Wells M.A. Calcium and cAMP are second messengers in the adipokinetic hormone-induced lipolysis of triacylglycerols in Manduca sexta fat body. J. Lipid Res. 1999, 40:556-564.
4. Arrese E.L., Rivera L., Hamada M., Mirza S., Hartson S.D., Weintraub S., Soulages J.L. Function and structure of lipid storage droplet protein 1 studied in lipoprotein complexes. Arch. Biochem. Biophys. 2008, 473:42-47.
5. Auerswald L., Gäde G. Endocrine control of TAG lipase in the fat body of the migratory locust, Locusta migratoria. Insect Biochem. Mol. Biol. 2006, 36:759-768.
6. Auerswald L., Siegert K., Gäde G. Activation of triacylglycerol lipase in the fat body of a beetle by adipokinetic hormone. Insect Biochem. Mol. Biol. 2005, 35:461-470.
7. Baumbach J., Hummel P., Bickmeyer I., Kowalczyk K.M., Frank M., Knorr K., Hildebrandt A., Riedel D., Jäckle H., Kühnlein R.P. A Drosophila invivo screen identifies store-operated calcium entry as a key regulator of adiposity. Cell Metab. 2014, 19:331-343.
8. Beenakkers A.M. The influence of Corpus Allatum and Corpus Cardiacum on lipid metabolism in Locusta migratoria. Gen. Comp. Endocrinol. 1969, 13:492.
9. Beller M., Bulankina A.V., Hsiao H.-H., Urlaub H., Jäckle H., Kühnlein R.P. PERILIPIN-dependent control of lipid droplet structure and fat storage in Drosophila. Cell Metab. 2010, 12:521-532.
10. Bharucha K.N., Tarr P., Zipursky S.L. A glucagon-like endocrine pathway in Drosophila modulates both lipid and carbohydrate homeostasis. J. Exp. Biol. 2008, 211:3103-3110.
11. Bligh E.G., Dyer W.J. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 1959, 37:911-917.
12. Brand A., Perrimon N. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 1993, 118:401-415.
13. Buszczak M., Lu X., Segraves W.A., Chang T.Y., Cooley L. Mutations in the midway gene disrupt a Drosophila acyl coenzyme A: diacylglycerol acyltransferase. Genetics 2002, 160:1511-1518.
14. 2+ entry. Nat. Cell Biol. 2009, 11:669-677.
15. Dietzl G., Chen D., Schnorrer F., Su K.-C., Barinova Y., Fellner M., Gasser B., Kinsey K., Oppel S., Scheiblauer S., Couto A., Marra V., Keleman K., Dickson B.J. A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila. Nature 2007, 448:151-156.
16. Fischer J., Lefèvre C., Morava E., Mussini J.-M., Laforêt P., Negre-Salvayre A., Lathrop M., Salvayre R. The gene encoding adipose triglyceride lipase (PNPLA2) is mutated in neutral lipid storage disease with myopathy. Nat. Genet. 2007, 39:28-30.
17. Gäde G., Auerswald L. Mode of action of neuropeptides from the adipokinetic hormone family. Gen. Comp. Endocrinol. 2003, 132:10-20.
18. Gokuldas M., Hunt P.A., Candy D.J. The inhibition of lipid synthesis invitro in the locust, Schistocerca gregaria, by factors from the corpora cardiaca. Physiol. Entomol. 1988, 13:43-48.
19. Grönke S., Beller M., Fellert S., Ramakrishnan H., Jäckle H., Kühnlein R.P. Control of fat storage by a Drosophila PAT domain protein. Curr. Biol. 2003, 13:603-606.
20. Grönke S., Bickmeyer I., Wunderlich R., Jäckle H., Kühnlein R.P. Curled encodes the Drosophila homolog of the vertebrate circadian deadenylase Nocturnin. Genetics 2009, 183:219-232.
21. Grönke S., Mildner A., Fellert S., Tennagels N., Petry S., Müller G., Jäckle H., Kühnlein R.P. Brummer lipase is an evolutionary conserved fat storage regulator in Drosophila. Cell Metab. 2005, 1:323-330.
22. Grönke S., Müller G., Hirsch J., Fellert S., Andreou A., Haase T., Jäckle H., Kühnlein R.P. Dual lipolytic control of body fat storage and mobilization in Drosophila. PLoS Biol. 2007, 5:e137.
23. Haemmerle G., Lass A., Zimmermann R., Gorkiewicz G., Meyer C., Rozman J., Heldmaier G., Maier R., Theussl C., Eder S., Kratky D., Wagner E.F., Klingenspor M., Hoefler G., Zechner R. Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase. Science 2006, 312:734-737.
24. Hildebrandt A., Bickmeyer I., Kühnlein R.P. Reliable Drosophila body fat quantification by a coupled colorimetric assay. PLoS ONE 2011, 6:e23796.
25. Huang H., He X., Deng X., Li G., Ying G., Sun Y., Shi L., Benovic J.L., Zhou N. Bombyx adipokinetic hormone receptor activates extracellular signal-regulated kinase 1 and 2 via G protein-dependent PKA and PKC but β-arrestin-independent pathways. Biochemistry 2010, 49:10862-10872.
26. Iijima K., Zhao L., Shenton C., Iijima-Ando K. Regulation of energy stores and feeding by neuronal and peripheral CREB activity in Drosophila. PLoS ONE 2009, 4:e8498.
27. Katewa S.D., Demontis F., Kolipinski M., Hubbard A., Gill M.S., Perrimon N., Melov S., Kapahi P. Intramyocellular fatty-acid metabolism plays a critical role in mediating responses to dietary restriction in Drosophila melanogaster. Cell Metab. 2012, 16:97-103.
28. Konuma T., Morooka N., Nagasawa H., Nagata S. Knockdown of the adipokinetic hormone receptor increases feeding frequency in the two-spotted cricket Gryllus bimaculatus. Endocrinology 2012, 153:3111-3122.
29. Kurat C., Natter K., Petschnigg J., Wolinski H., Scheuringer K., Scholz H., Zimmermann R., Leber R., Zechner R., Kohlwein S. Obese yeast: triglyceride lipolysis is functionally conserved from mammals to yeast. J. Biol. Chem. 2006, 281:491-500.
30. Lee G., Park J.H. Hemolymph sugar homeostasis and starvation-induced hyperactivity affected by genetic manipulations of the adipokinetic hormone-encoding gene in Drosophila melanogaster. Genetics 2004, 167:311-323.
31. Lindemans M., Janssen T., Beets I., Temmerman L., Meelkop E., Schoofs L. Gonadotropin-releasing hormone and adipokinetic hormone signaling systems share a common evolutionary origin. Front. Endocrinol. 2011, 2:16.
32. Lorenz M. Synthesis of lipids in the fat body of Gryllus bimaculatus: age- dependency and regulation by adipokinetic hormone. Arch. Insect Biochem. Physiol. 2001, 47:198-214.
33. Lorenz M.W., Gäde G. Hormonal regulation of energy metabolism in insects as a driving force for performance. Integr. Comp. Biol. 2009, 49:380-392.
34. Lorenz M.W., Zemek R., Kodrík D., Socha R. Lipid mobilization and locomotor stimulation in Gryllus bimaculatus by topically applied adipokinetic hormone. Physiol. Entomol. 2004, 29:146-151.
35. Lum P.Y., Chino H. Primary role of adipokinetic hormone in the formation of low density lipophorin in locusts. J. Lipid Res. 1990, 31:2039-2044.
36. Masuyama K., Zhang Y., Rao Y., Wang J.W. Mapping neural circuits with activity-dependent nuclear import of a transcription factor. J. Neurogenet. 2012, 26:89-102.
37. Mayer R.J., Candy D.J. Control of haemolymph lipid concentration during locust flight: an adipokinetic hormone from the corpora cardiaca. J. Insect Physiol. 1969, 15:611-620.
38. Mcguire S.E. Spatiotemporal rescue of memory dysfunction in Drosophila. Science 2003, 302:1765-1768.
39. Ogoyi D.O., Osir E.O., Olembo N.K. Fat body triacylglycerol lipase in solitary and gregarious phases of Schistocerca gregaria (Forskal) (Orthoptera: Acrididae). Comp. Biochem. Physiol. 1998, 119B:163-167.
40. Patel R.T., Soulages J.L., Hariharasundaram B., Arrese E.L. Activation of the lipid droplet controls the rate of lipolysis of triglycerides in the insect fat body. J. Biol. Chem. 2005, 280:22624-22631.
41. Pospisilik J.A., Schramek D., Schnidar H., Cronin S.J.F., Nehme N.T., Zhang X., Knauf C., Cani P.D., Aumayr K., Todoric J., Bayer M., Haschemi A., Puviindran V., Tar K., Orthofer M., Neely G.G., Dietzl G., Manoukian A., Funovics M., Prager G., Wagner O., Ferrandon D., Aberger F., Hui C.-C., Esterbauer H., Penninger J.M. Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate. Cell 2010, 140:148-160.
42. Roman G., Endo K., Zong L., Davis R.L. P[Switch], a system for spatial and temporal control of gene expression in Drosophila melanogaster. Proc. Natl. Acad. Sci. USA 2001, 98:12602-12607.
43. Slocinska M., Antos-Krzeminska N., Golebiowski M., Kuczer M., Stepnowski P., Rosinski G., Jarmuszkiewicz W. UCP4 expression changes in larval and pupal fat bodies of the beetle Zophobas atratus underadipokinetic hormone treatment. Comp. Biochem. Physiol. A 2013, 166:52-59.
44. Spandl J., White D.J., Peychl J., Thiele C. Live cell multicolor imaging of lipid droplets with a new dye, LD540. Traffic 2009, 10:1579-1584.
45. Spencer I.M., Candy D.J. Hormonal control of diacyl glycerol mobilization from fat body of the desert locust, Schistocerca gregaria. Insect Biochem. 1976, 6:289-296.
46. Stone J.V., Mordue W., Batley K.E., Morris H.R. Structure of locust adipokinetic hormone, a neurohormone that regulates lipid utilisation during flight. Nature 1976, 263:207-211.
47. Subramanian M., Metya S.K., Sadaf S., Kumar S., Schwudke D., Hasan G. Altered lipid homeostasis in Drosophila InsP3 receptor mutants leads to obesity and hyperphagia. Dis. Model. Mech. 2013, 6:734-744.
48. Tricoire H., Battisti V., Trannoy S., Lasbleiz C., Pret A.M., Monnier V. The steroid hormone receptor EcR finely modulates Drosophila lifespan during adulthood in a sex-specific manner. Mech. Ageing Dev. 2009, 130:547-552.
49. 2+ to potentiate cAMP-induced activation of glycogen phosphorylase. Cell Calcium 1995, 17:459-467.
50. Wang Z., Hayakawa Y., Downer R.G. Factors influencing cyclic AMP and diacylglycerol levels in fat body of Locusta migratoria. Insect Biochem. 1990, 20:325-330.
51. Wicher D., Agricola H., Sohler S., Gundel M., Heinemann S., Wollweber L., Stengl M., Derst C. Differential receptor activation by cockroach adipokinetic hormones produces differential effects on ion currents, neuronal activity, and locomotion. J. Neurophysiol. 2006, 95:2314-2325.
52. Yang H., He X., Yang J., Deng X., Liao Y., Zhang Z., Zhu C., Shi Y., Zhou N. Activation of cAMP-response element-binding protein is positively regulated by PKA and calcium-sensitive calcineurin and negatively by PKC in insect. Insect Biochem. Mol. Biol. 2013, 43:1028-1036.
53. Zhu C., Huang H., Hua R., Li G., Yang D., Luo J., Zhang C., Shi L., Benovic J.L., Zhou N. Molecular and functional characterization of adipokinetic hormone receptor and its peptide ligands in Bombyx mori. FEBS Lett. 2009, 583:1463-1468.
54. Ziegler R., Jasensky R.D., Morimoto H. Characterization of the adipokinetic hormone receptor form the fat body of Manduca sexta. Regul. Pept. 1995, 57:329-338.