Comparative "in vitro" evaluation of the antiresorptive activity residing in four Ayurvedic medicinal plants. Hemidesmus indicus emerges for its potential in the treatment of bone loss diseases

Journal of Ethnopharmacology

Volumn 154, Issue 2, 2014, Pages 462-470

  Di Pompo, Gemma ^a   Poli, Ferruccio ^b   Mandrone, Manuela ^b   Lorenzi, Beatrice ^b   Roncuzzi, Laura ^a   Baldini, Nicola ^a,c   Granchi, Donatella ^a  

^a RIZZOLI ORTHOPAEDIC INSTITUTE   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Asparagus racemosus; Bone resorption; Emblica officinalis; Hemidesmus indicus; Rubia cordifolia

Indexed keywords

AGENTS AFFECTING METABOLISM; ALENDRONIC ACID; ASPARAGUS RACEMOSUS EXTRACT; EMBLICA OFFICINALIS EXTRACT; FLAVONOID; HEMIDESMUS INDICUS EXTRACT; PLANT EXTRACT; POLYPHENOL DERIVATIVE; RUBIA CORDIFOLIA EXTRACT; SCAVENGER; UNCLASSIFIED DRUG; BONE DENSITY CONSERVATION AGENT;

ANIMAL CELL; ANTIOSTEOCLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; ASPARAGUS RACEMOSUS; AYURVEDA; BONE DISEASE; BONE LOSS DISEASE; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CYTOTOXICITY; EMBLICA OFFICINALIS; HEMIDESMUS INDICUS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCLAST; OSTEOCLAST ACTIVITY; OSTEOCLASTOGENESIS; OSTEOLYSIS; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; RUBIA CORDIFOLIA; STANDARDIZATION; ANIMAL; CELL LINE; CELL SURVIVAL; CHEMISTRY; CULTURE TECHNIQUE; DRUG EFFECTS; ETHNOPHARMACOLOGY; HEMIDESMUS; ISOLATION AND PURIFICATION; MACROPHAGE; MEDICINAL PLANT; PATHOLOGY; PREVENTION AND CONTROL; SPECIES DIFFERENCE; TOXICITY;

ASPARAGUS RACEMOSUS; HEMIDESMUS INDICUS; PHYLLANTHUS EMBLICA; RUBIA CORDIFOLIA;

ANIMALS; APOPTOSIS; BONE DENSITY CONSERVATION AGENTS; BONE RESORPTION; CELL CULTURE TECHNIQUES; CELL LINE; CELL SURVIVAL; ETHNOPHARMACOLOGY; HEMIDESMUS; HUMANS; MACROPHAGES; MEDICINE, AYURVEDIC; MICE; OSTEOCLASTS; PLANT EXTRACTS; PLANTS, MEDICINAL; SPECIES SPECIFICITY;

EID: 84901586915     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2014.04.033     Document Type: Article

References (49)

1. J.D. Adachi, R.G. Josse, and R.G. Russell If you don't take it - it can't work: the consequences of not being treated or nonadherence to osteoporosis therapy Therapeutics and Clinical Risk Management 7 2011 181 198
2. K. Arvidson, B.M. Abdallah, L.A. Applegate, N. Baldini, E. Cenni, E. Gomez-Barrena, D. Granchi, M. Kassem, Y.T. Konttinen, K. Mustafa, D.P. Pioletti, T. Sillat, and A. Finne-Wistrand Bone regeneration and stem cells Journal of Cellular and Molecular Medicine 15 2011 718 746
3. J. Banu, E. Varela, and G. Fernandes Alternative therapies for the prevention and treatment of osteoporosis Nutrition Reviews 70 2012 22 40
4. M. Bhatnagar, S.S. Sisodia, and R. Bhatnagar Antiulcer and antioxidant activity of Asparagus racemosus Willd and Withania somnifera Dunal in rats Annals of the New York Academy of Sciences 1056 2005 261 278
5. N. Bopana, and S. Saxena Asparagus racemosus - ethnopharmacological evaluation and conservation needs Journal of Ethnopharmacology 110 2007 1 15
6. E. Cenni, S. Avnet, D. Granchi, C. Fotia, M. Salerno, D. Micieli, M.G. Sarpietro, R. Pignatello, F. Castelli, and N. Baldini The effect of poly(d, l-lactide-co-glycolide)-alendronate conjugate nanoparticles on human osteoclast precursors Journal of Biomaterials Science. Polymer Edition 23 2011 1285 1300
7. H.R. Chitme, I.S. Muchandi, and S.C. Burli Effect of Asparagus racemosus willd root extract on ovariectomized rats The Open Natural Products Journal 2 2009 16 23
8. A. Chopra, and V. Doiphode Ayurvedic medicine and osteoarthritis Rheumatic Diseases Clinics of North America 26 2000 133 144
9. S. Cremers, and S. Papapoulos Pharmacology of bisphosphonates Bone 49 2011 42 49
10. G.C.H. Derksen, T.A. van Beek, A. de de Groota, and A. Capelle High-performance liquid chromatographic method for the analysis of anthraquinone glycosides and aglycones in madder root (Rubia tinctorum L.) Journal of Chromatography 816 1998 277 281
11. L. Ferruzzi, E. Turrini, S. Burattini, E. Falcieri, F. Poli, M. Mandrone, G. Sacchetti, M. Tacchini, A. Guerrini, R. Gotti, P. Hrelia, G. Cantelli-Forti, and C. Fimognari Hemidesmus indicus induces apoptosis as well as differentiation in a human promyelocytic leukemic cell line Journal of Ethnopharmacology 147 2013 84 91
12. C. Fimognari, M. Lenzi, L. Ferruzzi, E. Turrini, P. Scartezzini, F. Poli, R. Gotti, A. Guerrini, G. Carulli, V. Ottaviano, G. Cantelli-Forti, and P. Hrelia Mitochondrial pathway mediates the antileukemic effects of Hemidesmus indicus, a promising botanical drug PLoS ONE 6 2011 e21544
13. E. Fiorentini, D. Granchi, E. Leonardi, N. Baldini, and G. Ciapetti Effects of osteogenic differentiation inducers on in vitro expanded adult mesenchymal stromal cells The International Journal of Artificial Organs 34 2011 998 1011
14. O. Folin, and V. Ciocalteu On tyrosine and tryptophane determination in proteins Journal of Biological Chemistry 27 1927 627 650
15. C. Fotia, S. Avnet, D. Granchi, and N. Baldini The natural compound Alizarin as an osteotropic drug for the treatment of bone tumors Journal of Orthopaedic Research 30 2012 1486 1492
16. Government of India, Ministry of Health & Family Welfare, Department of Health The Ayurvedic Pharmacopoeia of India, 1989, 107.
17. D. Granchi, I. Amato, L. Battistelli, S. Avnet, S. Capaccioli, L. Papucci, M. Donnini, A. Pellicani, M.L. Brandi, A. Giunti, and N. Baldini in vitro blockade of receptor activator of nuclear factor-kappa B ligand prevents osteoclastogenesis induced by neuroblastoma cells International Journal of Cancer 111 2004 829 838
18. D. Granchi, A. Scarso, G. Bianchini, A. Chiminazzo, A. Minto, P. Sgarbossa, R.A. Michelin, G. Di Pompo, S. Avnet, and G. Strukul Low toxicity and unprecedented anti-osteoclast activity of a simple sulfur-containing gem-bisphosphonate: a comparative study European Journal of Medicinal Chemistry 65 2013 448 455
19. P.Y. Hayes, A.H. Jahidin, R. Lehmann, K. Penman, W. Kitching, and J.J. De Voss Steroidal saponins from the roots of Asparagus racemosus Phytochemistry 69 2008 796 804
20. N. Jaiswal, S.E. Haynesworth, A.I. Caplan, and S.P. Bruder Osteogenic differentiation of purified, culture-expanded human mesenchymal stem cells in vitro Journal of Cellular Biochemistry 64 1997 295 312
21. P. Kaur, B. Kumar, and S. Kaur in vitro evaluation of free radical scavenging activity of Rubia cordifolia L Journal of Chinese Clinical Medicine 3 2008 278 284
22. P. Kaur, M. Chandel, S. Kumar, N. Kumar, B. Singh, and S. Kaur Modulatory role of alizarin from Rubia cordifolia L. against genotoxicity of mutagens Food and Cosmetics Toxicology 48 2010 320 325
23. W.F. Lems, and M. den Heijer Established and forthcoming drugs for the treatment of osteoporosis Netherlands Journal of Medicine 71 2013 188 193
24. S.C. Manolagas From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis Endocrine Rewievs 31 2010 266 300
25. A. Mehta, N.K. Sethiya, C. Mehta, and G.B. Shah Anti-arthritis activity of roots of Hemidesmus indicus R.Br. (Anantmul) in rats Asian Pacific Journal of Tropical Medicine 5 2012 130 135
26. T. Miyazaki, M. Iwasawa, T. Nakashima, S. Mori, K. Shigemoto, H. Nakamura, H. Katagiri, H. Takayanagi, and S. Tanaka Intracellular and extracellular ATP coordinately regulate the inverse correlation between osteoclast survival and bone resorption The Journal of Biological Chemistry 287 2012 37808 37823
27. J.E. Mulder, N.S. Kolatkar, and M.S. LeBoff Drug insight: existing and emerging therapies for osteoporosis Nature Clinical Practice Endocrinology & Metabolism 2 2006 670 680
28. L. Penolazzi, I. Lampronti, M. Borgatti, M. Tareq, H. Khan, M. Zennato, R. Piva, and R. Gambari Induction of apoptosis of human primary osteoclasts treated with extracts from the medicinal plant Emblica officinalis BMC Complementary and Alternative Medicine 8 2008 59
29. R. Piva, L. Penolazzi, M. Borgatti, I. Lampronti, E. Lambertini, E. Torreggiani, and R. Gambari Apoptosis of human primary osteoclasts treated with molecules targeting nuclear factor-κB Annals of the New York Academy of Sciences 1171 2009 448 456
30. E.A. Poltanov, A.N. Shikov, H.J.D. Dorman, O.N. Pozharitskaya, V.G. Makarov, V.P. Tikhonov, and R. Hiltunen Chemical and antioxidant evaluation of indian gooseberry (Emblica officinalis Gaertn., syn. Phyllanthus emblica L.) supplements Phytotherapy Research 23 2009 1309 1315
31. B. Potduang, M. Meeploy, R. Giwanon, Y. Benmart, M. Kaewduang, and W. Supatanakul Biological activities of Asparagus racemosus African Journal Traditional Complementary and Alternative Medicines 5 2008 230 237
32. S.N. Prajapati, and K.A. Parmar Anti-viral and in-vitro free radical scavenging activity of leaves of Rubia cordifolia International Journal of Phytomedicine 3 2011 98 107
33. H.S. Puri Rasayana: Ayurvedic Herbs for Longevity and Rejuvenation 2003 Taylor and Francis London and New York
34. K. Purkh, S. Khalsa, and M. Tierra The Way of Ayurvedic Herbs: a Contemporary Introduction and Useful Manual for the World's Oldest Healing System 2008 Lotus Press Twin Lakes, Wisconsin, USA
35. S.E. Putnam, A.M. Scutt, K. Bicknell, C.M. Priestley, and E.M. Williamson Natural products as alternative treatments for metabolic bone disorders and for maintenance of bone health Phytotherapy Research 21 2007 99 112
36. V.R. Ramprasath, P. Shanthi, and P. Sachdanandam Curative effect of Semecarpus anacardium Linn. nut milk extract against adjuvant arthritis - with special reference to bone metabolism Chemico-Biological Interactions 160 2006 183 192
37. R.G. Russell Bisphosphonates: the first 40 years Bone 49 2011 2 19
38. T. Sandhya, K.M. Lathika, B.N. Pandey, and K.P. Mishra Potential of traditional ayurvedic formulation, Triphala, as a novel anticancer drug Cancer Letters 231 2006 206 214
39. S.S. Savrikar, and B. Ravishankar Bhaishajya Kalpanaa - the ayurvedic pharmaceutics - an overview African Journal of Traditional, Complementary, and Alternative Medicines 7 2010 174 184
40. A. Schindeler, and D.G. Little Bisphosphonate action: revelations and deceptions from in vitro studies Journal of Pharmaceutical Science 96 2007 1872 1878
41. A. Schrage, K. Hempel, M. Schulz, S.N. Kolle, B. van Ravenzwaay, and R. Landsiedel Refinement and reduction of acute oral toxicity testing: a critical review of the use of cytotoxicity data Alternatives to Laboratory Animals 39 2011 273 295
42. M. Shoemaker, B. Hamilton, S.H. Dairkee, I. Cohen, and M.J. Campbell in vitro anticancer activity of twelve Chinese medicinal herbs Phytotherapy Research 19 2005 649 651
43. M.I. Thabrew, R.R. Mitry, M.A. Morsy, and R.D. Hughes Cytotoxic effects of a decoction of Nigella sativa, Hemidesmus indicus and Smilax glabra on human hepatoma HepG2 cells Life Science 77 2005 1319 1330
44. The Russian Federation Ministry of Health and Medical Industry, 1989. Russian National Pharmacopoeia, Moscow, Russia.
45. K. Umezawa Inhibition of tumor growth by NF-kappa B inhibitors Cancer Science 97 2006 990 995
46. H.K. Väänänen, and T. Laitala-Leinonen Osteoclast lineage and function Archives of Biochemistry and Biophysics 473 2008 132 138
47. A. Venditti, M. Mandrone, A.M. Serrilli, A. Bianco, C. Iannello, F. Poli, and F. Antognoni Dihydroasparagusic acid: antioxidant and tyrosinase inhibitory activities and improved synthesis Journal of Agricultural and Food Chemistry 61 2013 6848 6855
48. C. Vincent, M. Kogawa, D.M. Findlay, and G.J. Atkins The generation of osteoclasts from RAW 264.7 precursors in defined, serum-free conditions Journal of Bone and Mineral Metabolism 27 2009 114 119
49. H. Zhao, and F. Patrick Ross Mechanisms of osteoclastic secretion Annals of the New York Academy of Sciences 1116 2007 238 244