Acute insulin resistance mediated by advanced glycation endproducts in severely burned rats

Critical Care Medicine

Volumn 42, Issue 6, 2014, Pages

  Zhang, Xing ^a   Xu, Jie ^a   Cai, Xiaoqing ^a   Ji, Lele ^a   Li, Jia ^a   Cao, Bing ^a   Li, Jun ^b   Hu, Dahai ^b   Li, Yan ^b   Wang, Haichang ^b   Xiong, Lize ^b   Xiao, Ruiping ^c   Gao, Feng ^a,b  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^c PEKING UNIVERSITY   (China)

Author keywords

Acute insulin resistance; advanced glycation endproducts; burn injury; carboxymethyllysine; insulin; soluble form of receptor for advanced glycation endproducts

Indexed keywords

6 N CARBOXYMETHYLLYSINE; ADVANCED GLYCATION END PRODUCT; ADVANCED GLYCATION END PRODUCT RECEPTOR; GLUCAGON; GLUCOSE; GLYCOGEN SYNTHASE KINASE 3BETA; HYDROCORTISONE; INSULIN; METHYLGLYOXAL; PROTEIN KINASE B; STRESS HORMONE;

ACUTE INSULIN RESISTANCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY SURFACE; BURN; COMPUTER ASSISTED EMISSION TOMOGRAPHY; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME PHOSPHORYLATION; GLUCAGON BLOOD LEVEL; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; GLUCOSE TRANSPORT; GLYCEMIC CONTROL; HEART MUSCLE; HYDROCORTISONE BLOOD LEVEL; HYPERGLYCEMIA; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; MORTALITY; NONHUMAN; PRIORITY JOURNAL; PROSPECTIVE STUDY; RAT; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; SURVIVAL RATE;

ANIMALS; BLOOD GLUCOSE; BURNS; CELL LINE; GLUCOSE TOLERANCE TEST; GLYCOGEN SYNTHASE KINASE 3; GLYCOSYLATION END PRODUCTS, ADVANCED; HYPERGLYCEMIA; INSULIN; INSULIN RESISTANCE; KAPLAN-MEIER ESTIMATE; LYSINE; PHOSPHORYLATION; POSITRON-EMISSION TOMOGRAPHY; PROSPECTIVE STUDIES; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84901502030     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0000000000000314     Document Type: Article

References (30)

1. Losser MR, Damoisel C, Payen D: Bench-to-bedside review: Glucose and stress conditions in the intensive care unit. Crit Care 2010; 14:231
2. van den Berghe G, Wouters P, Weekers F, et al: Intensive insulin therapy in critically ill patients. N Engl J Med 2001; 345:1359-1367
3. Su H, Sun X, Ma H, et al: Acute hyperglycemia exa cerbates myocardial ischemia/reperfusion injury and blunts cardioprotective effect of GIK. Am J Physiol Endocrinol Metab 2007; 293:E629-E635
4. Capes SE, Hunt D, Malmberg K, et al: Stress hypergl ycaemia and increased risk of death after myocardial infarction in patients with and without diabetes: A systematic overview. Lancet 2000; 355:773-778
5. Sung J, Bochicchio GV, Joshi M, et al: Admission hyperglycemia is predictive of outcome in critically ill trauma patients. J Trauma 2005; 59:80-83
6. Jeremitsky E, Omert LA, Dunham CM, et al: The impact of hyperglycemia on patients with severe brain injury. J Trauma 2005; 58:47-50
7. Thorell A,Nygren J,Ljungqvist O,Insulin resistance: A marker of surgical stress,Curr Opin Clin Nutr Metab Care,1999,2,69-78
8. Van den Berghe G, Schetz M, Vlasselaers D, et al: Clinical review: Intensive insulin therapy in critically ill patients: NICE-SUGAR or Leuven blood glucose target J Clin Endocrinol Metab 2009; 94:3163-3170
9. Patterson B, Fields AV, Shannon RP: New insights into myocardial glucose metabolism: Surviving under stress. Curr Opin Clin Nutr Metab Care 2009; 12:424-430
10. Brunkhorst FM, Engel C, Bloos F, et al; German Competence Network Sepsis (SepNet): Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med 2008; 358:125-139
11. Finfer S, Chittock DR, Su SY, et al: Intensive versus conventional glucose control in critically ill patients. N Engl J Med 2009; 360:1283-1297
12. Wiener RS, Wiener DC, Lars on RJ: Benefits and risks of tight glucose control in critically ill adults: A meta-analysis. JAMA 2008; 300:933-944
13. Li L, Messina JL: Acute insulin resistance following injury. Trends Endocrinol Metab 2009; 20:429-435
14. Jeschke MG, Kulp GA, Kraft R, et al: Intensive insulin therapy in severely burned pediatric patients: A prospective randomized trial. Am J Respir Crit Care Med 2010; 182:351-359
15. Schleicher ED, Wagner E, Nerlich AG: Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging. J Clin Invest 1997; 99:457-468
16. Horie K, Miyata T, Maeda K, et al: Immunohistochemical colocalization of glycoxidation products and lipid peroxidation products in diabetic renal glomerular lesions. Implication fo r glycoxidative stress in the pathogenesis of diabetic nephropathy. J Clin Invest 1997; 100:2995-3004
17. Goldin A, Beckman JA, Schmidt AM, et al: Advanced glycation end products: Sparking the development of diabetic vascular injury. Circulation 2006; 114:597-605
18. Cai W, Ramdas M, Zhu L, et al: Oral advanced glycation endproducts (AGEs) promote insulin resistance and diabetes by deple ting the antioxidant defenses AGE receptor-1 and sirtuin 1. Proc Natl Acad Sci USA 2012; 109:15888-15893
19. Rong LL, Yan SF, Wendt T, et al: RAGE modulates peripheral nerve regeneration via recruitment of both inflammatory and axonal outgrowth pathways. FASEB J 2004; 18:1818-1825
20. Cataldegirmen G, Zeng S, Feirt N, et al: RAGE limits regeneration after massive liver injury by coordin ated suppression of TNF-alpha and NF-kappaB. J Exp Med 2005; 201:473-484
21. Bucciarelli LG, Kaneko M, Ananthakrishnan R, et al: Receptor for advanced-glycation end products: Key modulator of myo cardial ischemic injury. Circulation 2006; 113:1226-1234
22. Ikezu T, Okamoto T, Yonezawa K, et al: Analysis of thermal injury-induced insulin resistance in rodents. Implication of postreceptor m echanisms. J Biol Chem 1997; 272:25289-25295
23. Gao F, Gao E, Yue TL, et al: Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemia-reperfusion: The roles of PI3-kinase , Akt, and endothelial nitric oxide synthase phosphorylation. Circulation 2002; 105:1497-1502
24. Riboulet-Chavey A, Pierron A, Durand I, et al: Methylglyoxal impairs the insulin signaling pathways independently of the formation of intracellular reactive oxygen species. Diabetes 2006; 55:1289-12 99
25. Jeschke MG, Gauglitz GG, Finnerty CC, et al: Survivors versus nonsurvivors postburn: Differences in inflammatory and hypermetabolic trajectories. Ann Surg 2013; 259:814-823
26. Puddu A, Viviani GL: Advanced glycation endproducts and diabetes. Beyond vascular complications. Endocr Metab Immune Disord Drug Targets 2011; 11:132-140
27. Unoki-Kubota H, Yama gishi S, Takeuchi M, et al: Pyridoxamine, an inhibitor of advanced glycation end product (AGE) formation ameliorates insulin resistance in obese, type 2 diabetic mice. Protein Pept Lett 2010; 17:1177-1181
28. Schiekofer S, Andrassy M, Chen J, et al: Acute hyperglycemia causes intracellular formation of CML and activation of ras, p42/44 MAPK, and nuclear factor kappaB in PBMCs. Diabetes 2003; 52:621-633
29. Ji L, Fu F, Zhang L, et al: Insulin attenuates myocardial ischemia/reperfusion injury via reducing oxidative/nitrative stress. Am J Physiol Endocrinol Metab 2010; 298:E871-880
30. Li J, Zhang H, Wu F, et al: Insulin inhibits tumor necrosis factor-alpha induction in myocardial ischemia/reperfusion: Role of Akt and endothelial nitric oxide synthase phosphorylation. Crit Care Med 2008; 36:1551-1558