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1
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33947239659
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Mechanisms of disease: The failing heart - an engine out of fuel
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Neubauer S. Mechanisms of disease: the failing heart - an engine out of fuel. N Engl J Med 2007; 356:1140-1151.
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(2007)
N Engl J Med
, vol.356
, pp. 1140-1151
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Neubauer, S.1
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2
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46749088305
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Insulin signaling in the heart
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An excellent summary of insulin-signaling mechanisms in myocardium
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Bertrand L, Horman S, Beauloye C, Vanoverschelde JL. Insulin signaling in the heart. Cardiovasc Res 2008; 79:238-248. An excellent summary of insulin-signaling mechanisms in myocardium.
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(2008)
Cardiovasc Res
, vol.79
, pp. 238-248
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Bertrand, L.1
Horman, S.2
Beauloye, C.3
Vanoverschelde, J.L.4
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3
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34548436875
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GLUT4 translocation: The last 200 nanometers
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Watson RT, Pessin JE. GLUT4 translocation: the last 200 nanometers. Cell Signal 2007; 19:2209-2217.
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(2007)
Cell Signal
, vol.19
, pp. 2209-2217
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Watson, R.T.1
Pessin, J.E.2
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4
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33947578085
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Rab10, a target of the AS160 Rab GAP, is required for insulin-stimulated translocation of GLUT4 to the adipocyte plasma membrane
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Sano H, Eguez L, Teruel MN, et al. Rab10, a target of the AS160 Rab GAP, is required for insulin-stimulated translocation of GLUT4 to the adipocyte plasma membrane. Cell Metab 2007; 5:293-303.
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(2007)
Cell Metab
, vol.5
, pp. 293-303
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Sano, H.1
Eguez, L.2
Teruel, M.N.3
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5
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33846178185
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Rabs 8A and 14 are targets of the insulin-regulated Rab-GAP AS160 regulating GLUT4 traffic in muscle cells
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Ishikura S, Bilan PJ, Klip A. Rabs 8A and 14 are targets of the insulin-regulated Rab-GAP AS160 regulating GLUT4 traffic in muscle cells. Biochem Biophys Res Commun 2007; 353:1074-1079.
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(2007)
Biochem Biophys Res Commun
, vol.353
, pp. 1074-1079
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Ishikura, S.1
Bilan, P.J.2
Klip, A.3
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7
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34548418134
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Glucose phosphorylation is required for insulin-dependent mTOR signalling in the heart
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Sharma S, Guthrie PH, Chan SS, et al. Glucose phosphorylation is required for insulin-dependent mTOR signalling in the heart. Cardiovasc Res 2007; 76:71-80.
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(2007)
Cardiovasc Res
, vol.76
, pp. 71-80
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Sharma, S.1
Guthrie, P.H.2
Chan, S.S.3
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8
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38049148308
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FoxO transcription factors activate Akt and attenuate insulin signaling in heart by inhibiting protein phosphatases
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Ni YG, Wang N, Cao DJ, et al. FoxO transcription factors activate Akt and attenuate insulin signaling in heart by inhibiting protein phosphatases. Proc Natl Acad Sci U S A 2007; 104:20517-20522.
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(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 20517-20522
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Ni, Y.G.1
Wang, N.2
Cao, D.J.3
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9
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33745204925
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AMPK alterations in cardiac physiology and pathology: Enemy or ally?
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Dyck JR, Lopaschuk GD. AMPK alterations in cardiac physiology and pathology: enemy or ally? J Physiol 2007; 574:95-112.
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(2007)
J Physiol
, vol.574
, pp. 95-112
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Dyck, J.R.1
Lopaschuk, G.D.2
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10
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41549134384
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Ischemia-induced activation of AMPK does not increase glucose uptake in glycogen-replete isolated working rat hearts
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This article describes an important observation in reconciling previously conflicting data on the role of AMPK in ischemia
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Omar MA, Fraser H, Clanachan AS. Ischemia-induced activation of AMPK does not increase glucose uptake in glycogen-replete isolated working rat hearts. Am J Physiol Heart Circ Physiol 2008; 294:H1266-H1273. This article describes an important observation in reconciling previously conflicting data on the role of AMPK in ischemia.
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(2008)
Am J Physiol Heart Circ Physiol
, vol.294
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Omar, M.A.1
Fraser, H.2
Clanachan, A.S.3
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11
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38749137749
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Miller EJ, Li J, Leng L, et al. Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart. Nature 2008; 451:578-582. Novel and important new insights into the relationship between myocardial substrate utilization and inflammation are described in this article.
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Miller EJ, Li J, Leng L, et al. Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart. Nature 2008; 451:578-582. Novel and important new insights into the relationship between myocardial substrate utilization and inflammation are described in this article.
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12
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57749083482
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Metabolic switch and hypertrophy of cardiomyocytes following treatment with angiotensin II are prevented by AMPactivated protein kinase
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An important demonstration of metabolic shifts that accompany cardiac hypertrophy
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Stuck BJ, Lenski M, Böhm M, et al. Metabolic switch and hypertrophy of cardiomyocytes following treatment with angiotensin II are prevented by AMPactivated protein kinase. J Biol Chem 2008; 283:32562-32569. An important demonstration of metabolic shifts that accompany cardiac hypertrophy.
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(2008)
J Biol Chem
, vol.283
, pp. 32562-32569
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Stuck, B.J.1
Lenski, M.2
Böhm, M.3
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13
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23744449508
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HO-1 induction by HIF-1: A new mechanism for delayed cardioprotection?
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Dawn B, Bolli R. HO-1 induction by HIF-1: a new mechanism for delayed cardioprotection? Am J Physiol Heart Circ Physiol 2005; 289:H522-H524.
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(2005)
Am J Physiol Heart Circ Physiol
, vol.289
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Dawn, B.1
Bolli, R.2
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14
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38849177423
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Ytrehus K. Hypoxia-inducible factor 1 alpha: a new piece in the preconditioning puzzle. Cardiovasc Res 2008; 77:443-444. A succinct review of new information linking HIF-1α and preconditioning.
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Ytrehus K. Hypoxia-inducible factor 1 alpha: a new piece in the preconditioning puzzle. Cardiovasc Res 2008; 77:443-444. A succinct review of new information linking HIF-1α and preconditioning.
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15
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38149059911
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Mitochondria and cellular oxygen sensing in the HIF pathway
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Taylor CT. Mitochondria and cellular oxygen sensing in the HIF pathway. Biochem J 2008; 409:19-26.
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(2008)
Biochem J
, vol.409
, pp. 19-26
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Taylor, C.T.1
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16
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37849054322
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Hibernating myocardium: Is the program to survive a pathway to failure?
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Kelly RF, Sluiter W, McFalls EO. Hibernating myocardium: is the program to survive a pathway to failure? Circ Res 2008; 102:3-5.
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(2008)
Circ Res
, vol.102
, pp. 3-5
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Kelly, R.F.1
Sluiter, W.2
McFalls, E.O.3
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17
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34547130863
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The role of mitochondria in protection of the heart by preconditioning
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Halestrap AP, Clarke SJ, Khaliulin I. The role of mitochondria in protection of the heart by preconditioning. Biochim Biophys Acta 2007; 1767:1007-1031.
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(2007)
Biochim Biophys Acta
, vol.1767
, pp. 1007-1031
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Halestrap, A.P.1
Clarke, S.J.2
Khaliulin, I.3
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18
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33947373973
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Preconditioning: The mitochondrial connection
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Murphy E, Steenbergen C. Preconditioning: the mitochondrial connection. Annu Rev Physiol 2007; 69:51-67.
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(2007)
Annu Rev Physiol
, vol.69
, pp. 51-67
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Murphy, E.1
Steenbergen, C.2
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19
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23744443462
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HIF-1 activation attenuates postischemic myocardial injury: Role for heme oxygenase-1 in modulating microvascular chemokine generation
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Ockaili R, Natarajan R, Salloum F, et al. HIF-1 activation attenuates postischemic myocardial injury: role for heme oxygenase-1 in modulating microvascular chemokine generation. Am J Physiol Heart Circ Physiol 2005; 289:H542-H548.
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(2005)
Am J Physiol Heart Circ Physiol
, vol.289
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Ockaili, R.1
Natarajan, R.2
Salloum, F.3
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20
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39149108824
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Prevention of HIF-1 activation andiNOSgene targeting by low-dose cadmium results in loss of myocardial hypoxic preconditioning in the rat
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The above article establishes a critical link between HIF-1α and a critical mediator of ischemic preconditioning
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Belaidi E,BeguinPC, Levy P, et al. Prevention of HIF-1 activation andiNOSgene targeting by low-dose cadmium results in loss of myocardial hypoxic preconditioning in the rat. Am J Physiol Heart Circ Physiol 2008; 294:H901-H908. The above article establishes a critical link between HIF-1α and a critical mediator of ischemic preconditioning.
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(2008)
Am J Physiol Heart Circ Physiol
, vol.294
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Belaidi, E.1
Beguin, P.C.2
Levy, P.3
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21
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35448982216
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Hypoxia, glucose metabolism and the Warburg's effect
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Bartrons R, Caro J. Hypoxia, glucose metabolism and the Warburg's effect. J Bioenerg Biomembr 2007; 39:223-229.
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(2007)
J Bioenerg Biomembr
, vol.39
, pp. 223-229
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Bartrons, R.1
Caro, J.2
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23
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38849182762
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Complete loss of ischaemic preconditioning-induced cardioprotection in mice with partial deficiency of HIF-1 alpha
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The above article provides conclusive evidence of the role of HIF-α in ischemic preconditioning in mice
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Cai Z, Zhong H, Bosch-Marce M, et al. Complete loss of ischaemic preconditioning-induced cardioprotection in mice with partial deficiency of HIF-1 alpha. Cardiovasc Res 2008; 77:463-470. The above article provides conclusive evidence of the role of HIF-α in ischemic preconditioning in mice.
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(2008)
Cardiovasc Res
, vol.77
, pp. 463-470
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Cai, Z.1
Zhong, H.2
Bosch-Marce, M.3
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24
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47649128513
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Hypoxia-inducible factor-1 is central to cardioprotection: A new paradigm for ischemic preconditioning
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This article shows that the inhibition of HIF-1a using siRNA prevents ischemic preconditioning
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Eckle T, Kö hler D, Lehmann R, et al. Hypoxia-inducible factor-1 is central to cardioprotection: a new paradigm for ischemic preconditioning. Circulation 2008; 118:166-175. This article shows that the inhibition of HIF-1a using siRNA prevents ischemic preconditioning.
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(2008)
Circulation
, vol.118
, pp. 166-175
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Eckle, T.1
Kö hler, D.2
Lehmann, R.3
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25
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43249089631
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Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor-dependent and -independent pathways
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An excellent mechanistic study of the effects of GLP-1 on ischemia-reperfusion injury
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Ban K, Noyan-Ashraf MH, Hoefer J, et al. Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor-dependent and -independent pathways. Circulation 2008; 117:2340-2350. An excellent mechanistic study of the effects of GLP-1 on ischemia-reperfusion injury.
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(2008)
Circulation
, vol.117
, pp. 2340-2350
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Ban, K.1
Noyan-Ashraf, M.H.2
Hoefer, J.3
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26
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34547930879
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Effect of glucagon-like peptide-1 (GLP-1) on glycemic control and left ventricular function in patients undergoing coronary artery bypass grafting
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Sokos GG, Bolukoglu H, German J, et al. Effect of glucagon-like peptide-1 (GLP-1) on glycemic control and left ventricular function in patients undergoing coronary artery bypass grafting. Am J Cardiol 2007; 100:824-829.
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(2007)
Am J Cardiol
, vol.100
, pp. 824-829
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Sokos, G.G.1
Bolukoglu, H.2
German, J.3
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27
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45149131667
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Effects of intensive glucose lowering in type 2 diabetes
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A critical randomized trial of the effects of tight glycemic control on cardiovascular outcomes. Action to Control Cardiovascular Risk in Diabetes (ACCORD) Study Group
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Action to Control Cardiovascular Risk in Diabetes (ACCORD) Study Group. Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med 2008; 358:2545-2559. A critical randomized trial of the effects of tight glycemic control on cardiovascular outcomes.
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(2008)
N Engl J Med
, vol.358
, pp. 2545-2559
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28
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45149133036
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ADVANCE Collaborative Group. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med 2008; 358:2560-2572. A critical study of the role of sulfonylureas-based intensive treatment in type 2 diabetes cardiovascular and renal outcomes in type 2 diabetes.
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ADVANCE Collaborative Group. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med 2008; 358:2560-2572. A critical study of the role of sulfonylureas-based intensive treatment in type 2 diabetes cardiovascular and renal outcomes in type 2 diabetes.
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29
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53749096863
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Holman RR, Paul SK, Bethel MA, et al. 10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med 2008; 359:1577-1589. Anunprecedented report of extensive follow-up of theUKPDSstudy demonstrating a time-dependent effect on reducing adverse cardiovascular events in type 2 diabetes
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Holman RR, Paul SK, Bethel MA, et al. 10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med 2008; 359:1577-1589. Anunprecedented report of extensive follow-up of theUKPDSstudy demonstrating a time-dependent effect on reducing adverse cardiovascular events in type 2 diabetes
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30
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53749094476
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UKPDS and the legacy effect
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Chalmers J, Cooper ME. UKPDS and the legacy effect. N Engl J Med 2008; 359:1618-1620.
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(2008)
N Engl J Med
, vol.359
, pp. 1618-1620
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Chalmers, J.1
Cooper, M.E.2
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