Survivors versus nonsurvivors postburn: Differences in inflammatory and hypermetabolic trajectories

Annals of Surgery

Volumn 259, Issue 4, 2014, Pages 814-823

  Jeschke, Marc G ^b,d   Gauglitz, Gerd G ^c   Finnerty, Celeste C ^a,b   Kraft, Robert ^a,b   Mlcak, Ronald P ^a,b   Herndon, David N ^a,b  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

^c UNIVERSITY OF MUNICH   (Germany)

^d SUNNYBROOK RESEARCH INSTITUTE   (Canada)

Author keywords

Burn size; critical care; hypermetabolism; inflammation; mortality; pediatric; survival

Indexed keywords

ALPHA 2 MACROGLOBULIN; APOLIPOPROTEIN A1; APOLIPOPROTEIN B; BILIRUBIN; C REACTIVE PROTEIN; COMPLEMENT COMPONENT C3; CREATININE; GAMMA INTERFERON; GLUCOSE; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HAPTOGLOBIN; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 7; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; NITROGEN; OROSOMUCOID; PLASMA PROTEIN; TUMOR NECROSIS FACTOR; UREA;

ACUTE PHASE RESPONSE; ARTICLE; BILIRUBIN BLOOD LEVEL; BODY SURFACE; BURN; BURN INFECTION; BURN PATIENT; CHILD; COHORT ANALYSIS; CONTROLLED STUDY; CREATININE BLOOD LEVEL; FEMALE; GLUCOSE BLOOD LEVEL; HORMONE BLOOD LEVEL; HUMAN; HYPERMETABOLISM; INFLAMMATION; INJURY SEVERITY; INSULIN BLOOD LEVEL; LUNG BURN; MAJOR CLINICAL STUDY; MALE; METABOLISM; MISCELLANEOUS NAMED GROUPS; MULTIPLE ORGAN FAILURE; NONSURVIVOR; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SCHOOL CHILD; SEPSIS; SKIN AUTOGRAFT; SURGICAL TECHNIQUE; SURVIVAL; SURVIVOR; UNITED STATES; UREA NITROGEN BLOOD LEVEL;

ACUTE-PHASE REACTION; ADOLESCENT; BIOLOGICAL MARKERS; BLOOD PROTEINS; BURNS; CALORIMETRY, INDIRECT; CHILD; CHILD, PRESCHOOL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRITICAL CARE; CYTOKINES; DECISION SUPPORT TECHNIQUES; ENERGY METABOLISM; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HORMONES; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; MULTIPLE ORGAN FAILURE; PROSPECTIVE STUDIES; SEPSIS; TRAUMA SEVERITY INDICES; TREATMENT OUTCOME;

EID: 84895922783     PISSN: 00034932     EISSN: 15281140     Source Type: Journal    
DOI: 10.1097/SLA.0b013e31828dfbf1     Document Type: Article

References (35)

1. Herndon DN, Tompkins RG. Support of the metabolic response to burn injury. Lancet. 2004;363:1895-1902.
2. Kraft R, Herndon DN, Al-Mousawi AM, et al. Burn size and survival probability in paediatric patients in modern burn care: A prospective observational cohort study. Lancet. 2012;379:1013-1021.
3. Williams FN, Herndon DN, Hawkins HK, et al. The leading causes of death after burn injury in a single pediatric burn center. Crit Care. 2009;13:R183.
4. Jeschke MG, Chinkes DL, Finnerty CC, et al. Pathophysiologic response to severe burn injury. Ann Surg. 2008;248:387-401.
5. Reiss E, Pearson E, Artz CP. The metabolic response to burns. J Clin Invest. 1956;35:62-77.
6. Gauglitz GG, Herndon DN, Kulp GA, et al. Abnormal insulin sensitivity persists up to three years in pediatric patients post-burn. J Clin Endocrinol Metab. 2009;94:1656-1664.
7. Jeschke MG, Gauglitz GG, Kulp GA, et al. Long-term persistence of the pathophysiologic response to severe burn injury. PLoS One. 2011;6:e21245.
8. Gore DC, Chinkes D, Heggers J, et al. Association of hyperglycemia with increased mortality after severe burn injury. J Trauma. 2001;51:540-544.
9. Jeschke MG, Kulp GA, Kraft R, et al. Intensive insulin therapy in severely burned pediatric patients: A prospective randomized trial. Am J Respir Crit Care Med. 2010;182:351-359.
10. Finnerty CC, Ju H, Spratt H, et al. Proteomics improves the prediction of burns mortality: Results from regression spline modeling. Clin Transl Sci. 2012;5:243-249.
11. Finnerty CC, Herndon DN, Jeschke MG. Inhalation injury in severely burned children does not augment the systemic inflammatory response. Crit Care. 2007;11:R22.
12. Gauglitz GG, Finnerty CC, Herndon DN, et al. Are serum cytokines early predictors for the outcome of burn patients with inhalation injuries who do not survive Crit Care. 2008;12:R81.
13. Greenhalgh DG, Saffle JR, Holmes JH, IV, et al. American Burn Association consensus conference to define sepsis and infection in burns. J Burn Care Res. 2007;28:776-790.
14. Finnerty CC, Herndon DN, Przkora R, et al. Cytokine expression profile over time in severely burned pediatric patients. Shock. 2006;26:13-19.
15. Mlcak RP, Jeschke MG, Barrow RE, et al. The influence of age and gender on resting energy expenditure in severely burned children. Ann Surg. 2006;244:121-130.
16. Jeschke MG, Mlcak RP, Finnerty CC, et al. Burn size determines the inflammatory and hypermetabolic response. Crit Care. 2007;11:R90.
17. Williams FN, Herndon DN, Suman OE, et al. Changes in cardiac physiology after severe burn injury. J Burn Care Res. 2011;32:269-274.
18. Kaplan E, Dinarello CA, Gelfand JA. Interleukin-1 and the response to injury. Immunol Res. 1989;8:118-129.
19. Goodman RB, Pugin J, Lee JS, et al. Cytokine-mediated inflammation in acute lung injury. Cytokine Growth Factor Rev. 2003;14:523-535.
20. Furukawa K, Kobayashi M, Herndon DN, et al. Appearance of monocyte chemoattractant protein 1 (MCP-1) early after thermal injury: Role in the subsequent development of burn-associated type 2 T-cell responses. Ann Surg. 2002;236:112-119.
21. Luster AD. Chemokines - chemotactic cytokines that mediate inflammation. N Engl J Med. 1998;338:436-445.
22. Sell H, Eckel J. Monocyte chemotactic protein-1 and its role in insulin resistance. Curr Opin Lipidol. 2007;18:258-262.
23. del Aguila LF, Claffey KP, Kirwan JP. TNF-alpha impairs insulin signaling and insulin stimulation of glucose uptake in C2C12 muscle cells. Am J Physiol. 1999;276:E849-855.
24. Fan J, Li YH, Wojnar MM, et al. Endotoxin-induced alterations in insulinstimulated phosphorylation of insulin receptor, IRS-1, and MAP kinase in skeletal muscle. Shock. 1996;6:164-170.
25. Kamolz LP, Andel H, Mittlbock M, et al. Serum cholesterol and triglycerides: Potential role in mortality prediction. Burns. 2003;29:810-815.
26. Gore DC, Chinkes DL, Hart DW, et al. Hyperglycemia exacerbates muscle protein catabolism in burn-injured patients. Crit Care Med. 2002;30:2438-2442.
27. Hemmila MR, Taddonio MA, Arbabi S, et al. Intensive insulin therapy is associated with reduced infectious complications in burn patients. Surgery. 2008;144:629-635; discussion 635-637.
28. Pham TN, Warren AJ, Phan HH, et al. Impact of tight glycemic control in severely burned children. J Trauma. 2005;59:1148-1154.
29. Jeschke MG, Klein D, Herndon DN. Insulin treatment improves the systemic inflammatory reaction to severe trauma. Ann Surg. 2004;239:553-560.
30. Jeschke MG, Kraft R, Emdad F, et al. Glucose control in severely thermally injured pediatric patients: What glucose range should be the target Ann Surg. 2010;252:521-527; discussion 527-528.
31. Finnerty CC, Herndon DN, Chinkes DL, et al. Serum cytokine differences in severely burned children with and without sepsis. Shock. 2007;27:4-9.
32. Gauglitz GG, Toliver-Kinsky TE, Williams FN, et al. Insulin increases resistance to burn wound infection-associated sepsis. Crit Care Med. 2010;38:202-208.
33. Hart DW, Wolf SE, Chinkes DL, et al. Determinants of skeletal muscle catabolism after severe burn. Ann Surg. 2000;232:455-465.
34. Hart DW, Wolf SE, Mlcak R, et al. Persistence of muscle catabolism after severe burn. Surgery. 2000;128:312-319.
35. Jeschke MG, Micak RP, Finnerty CC, et al. Changes in liver function and size after a severe thermal injury. Shock. 2007;28:172-177.