Leukocyte mitochondrial DNA copy number in blood is not associated with major depressive disorder in young adults

PLoS ONE

Volumn 9, Issue 5, 2014, Pages

  He, Ying ^a   Tang, Jinsong ^a   Li, Zongchang ^b   Li, Hong ^a   Liao, Yanhui ^a   Tang, Yanqing ^c   Tan, Liwen ^a   Chen, Jindong ^a   Xia, Kun ^d   Chen, Xiaogang ^a,d  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b WENZHOU MEDICAL UNIVERSITY   (China)

^c CHINA MEDICAL UNIVERSITY   (China)

^d CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

MITOCHONDRIAL DNA;

ADOLESCENT; ADULT; AGE; ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; DISEASE SEVERITY; EDUCATION; FEMALE; GENE DOSAGE; GENETIC ASSOCIATION; GLOBAL ASSESSMENT OF FUNCTIONING; HAMILTON SCALE; HUMAN; LEUKOCYTE; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; ONSET AGE; PATHOGENESIS; YOUNG ADULT; BLOOD; GENETICS; METABOLISM;

ADOLESCENT; ADULT; CASE-CONTROL STUDIES; DEPRESSIVE DISORDER, MAJOR; DNA, MITOCHONDRIAL; FEMALE; GENE DOSAGE; HUMANS; LEUKOCYTES; MALE; YOUNG ADULT;

EID: 84901501959     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0096869     Document Type: Article

References (40)

1. Kupfer DJ, Frank E, Phillips ML (2012) Major depressive disorder: new clinical, neurobiological, and treatment perspectives. Lancet 379: 1045-1055.
2. Murray CJ, Lopez AD (1996) Evidence-based health policy-lessons from the Global Burden of Disease Study. Science 274: 740-743. (Pubitemid 26398244)
3. Lohoff FW (2010) Overview of the genetics of major depressive disorder. Curr Psychiatry Rep 12: 539-546.
4. Gardner A, Boles RG (2005) Is a "Mitochondrial Psychiatry" in the Future? A Review. Current Psychiatry Reviews 1: 255-271.
5. Suomalainen A, Majander A, Haltia M, Somer H, Lonnqvist J, et al. (1992) Multiple deletions of mitochondrial DNA in several tissues of a patient with severe retarded depression and familial progressive external ophthalmoplegia. J Clin Invest 90: 61-66.
6. Shanske AL, Shanske S, Silvestri G, Tanji K, Wertheim D, et al. (1993) MELAS point mutation with unusual clinical presentation. Neuromuscul Disord 3: 191-193. (Pubitemid 23250402)
7. Koene S, Kozicz TL, Rodenburg RJ, Verhaak CM, de Vries MC, et al. (2009) Major depression in adolescent children consecutively diagnosed with mitochondrial disorder. J Affect Disord 114: 327-332.
8. Morava E, Gardeitchik T, Kozicz T, de Boer L, Koene S, et al. (2010) Depressive behaviour in children diagnosed with a mitochondrial disorder. Mitochondrion 10: 528-533.
9. Whatley SA, Curti D, Marchbanks RM (1996) Mitochondrial involvement in schizophrenia and other functional psychoses. Neurochem Res 21: 995-1004. (Pubitemid 26349764)
10. Ben-Shachar D, Karry R (2008) Neuroanatomical pattern of mitochondrial complex I pathology varies between schizophrenia, bipolar disorder and major depression. PLoS One 3: e3676.
11. Rezin GT, Cardoso MR, Goncalves CL, Scaini G, Fraga DB, et al. (2008) Inhibition of mitochondrial respiratory chain in brain of rats subjected to an experimental model of depression. Neurochem Int 53: 395-400.
12. Moore CM, Christensen JD, Lafer B, Fava M, Renshaw PF (1997) Lower levels of nucleoside triphosphate in the basal ganglia of depressed subjects: a phosphorous-31 magnetic resonance spectroscopy study. Am J Psychiatry 154: 116-118. (Pubitemid 27020205)
13. Volz HP, Rzanny R, Riehemann S, May S, Hegewald H, et al. (1998) 31P magnetic resonance spectroscopy in the frontal lobe of major depressed patients. Eur Arch Psychiatry Clin Neurosci 248: 289-295. (Pubitemid 29026984)
14. Buchsbaum MS, Wu J, DeLisi LE, Holcomb H, Kessler R, et al. (1986) Frontal cortex and basal ganglia metabolic rates assessed by positron emission tomography with [18F]2-deoxyglucose in affective illness. J Affect Disord 10: 137-152. (Pubitemid 16067656)
15. Gardner A, Johansson A, Wibom R, Nennesmo I, von Dobeln U, et al. (2003) Alterations of mitochondrial function and correlations with personality traits in selected major depressive disorder patients. J Affect Disord 76: 55-68. (Pubitemid 37013356)
16. Kato M, Nakamura M, Ichiba M, Tomiyasu A, Shimo H, et al. (2011) Mitochondrial DNA deletion mutations in patients with neuropsychiatric symptoms. Neurosci Res 69: 331-336.
17. Onishi H, Kawanishi C, Iwasawa T, Osaka H, Hanihara T, et al. (1997) Depressive disorder due to mitochondrial transfer RNALeu(UUR) mutation. Biol Psychiatry 41: 1137-1139. (Pubitemid 27240008)
18. Burnett BB, Gardner A, Boles RG (2005) Mitochondrial inheritance in depression, dysmotility and migraine? J Affect Disord 88: 109-116. (Pubitemid 41160422)
19. Molnar MJ, Perenyi J, Siska E, Nemeth G, Nagy Z (2009) The typical MERRF (A8344G) mutation of the mitochondrial DNA associated with depressive mood disorders. J Neurol 256: 264-265.
20. Bergemann ER, Boles RG (2010) Maternal inheritance in recurrent early-onset depression. Psychiatr Genet 20: 31-34.
21. Jeng JY, Yeh TS, Lee JW, Lin SH, Fong TH, et al. (2008) Maintenance of mitochondrial DNA copy number and expression are essential for preservation of mitochondrial function and cell growth. J Cell Biochem 103: 347-357.
22. Malik AN, Czajka A (2013) Is mitochondrial DNA content a potential biomarker of mitochondrial dysfunction? Mitochondrion 13: 481-492.
23. Kim MY, Lee JW, Kang HC, Kim E, Lee DC (2011) Leukocyte mitochondrial DNA (mtDNA) content is associated with depression in old women. Arch Gerontol Geriatr 53: e218-221.
24. de Sousa RT, Uno M, Zanetti MV, Shinjo SM, Busatto GF, et al. (2013) Leukocyte mitochondrial DNA copy number in bipolar disorder. Prog Neuropsychopharmacol Biol Psychiatry 48C: 32-35.
25. Association AP (2000) Diagnostic and statistical manual of mental disorders: DSM-IV-TR. American Psychiatric Pub.
26. Hamilton M (1960) A rating scale for depression. J Neurol Neurosurg Psychiatry 23: 56-62.
27. Winer J, Jung CK, Shackel I, Williams PM (1999) Development and validation of real-time quantitative reverse transcriptase-polymerase chain reaction for monitoring gene expression in cardiac myocytes in vitro. Anal Biochem 270: 41-49. (Pubitemid 29230718)
28. Schmittgen TD, Zakrajsek BA, Mills AG, Gorn V, Singer MJ, et al. (2000) Quantitative reverse transcription-polymerase chain reaction to study mRNA decay: comparison of endpoint and real-time methods. Anal Biochem 285: 194-204.
29. Bi R, Zhang AM, Zhang W, Kong QP, Wu BL, et al. (2010) The acquisition of an inheritable 50-bp deletion in the human mtDNA control region does not affect the mtDNA copy number in peripheral blood cells. Hum Mutat 31: 538-543.
30. Wang D, Su LY, Zhang AM, Li YY, Li XA, et al. (2012) Mitochondrial DNA copy number, but not haplogroup, confers a genetic susceptibility to leprosy in Han Chinese from Southwest China. PLoS One 7: e38848.
31. Wallace DC (2010) Mitochondrial DNA mutations in disease and aging. Environ Mol Mutagen 51: 440-450.
32. Curran JE, Johnson MP, Dyer TD, Goring HH, Kent JW, et al. (2007) Genetic determinants of mitochondrial content. Hum Mol Genet 16: 1504-1514. (Pubitemid 47055122)
33. Xing J, Chen M, Wood CG, Lin J, Spitz MR, et al. (2008) Mitochondrial DNA content: its genetic heritability and association with renal cell carcinoma. J Natl Cancer Inst 100: 1104-1112.
34. Blokhin A, Vyshkina T, Komoly S, Kalman B (2008) Variations in mitochondrial DNA copy numbers in MS brains. J Mol Neurosci 35: 283-287.
35. Choi YS, Kim S, Pak YK (2001) Mitochondrial transcription factor A (mtTFA) and diabetes. Diabetes Res Clin Pract 54 Suppl 2: S3-9. (Pubitemid 33081103)
36. Bai RK, Wong LJ (2005) Simultaneous detection and quantification of mitochondrial DNA deletion(s), depletion, and over-replication in patients with mitochondrial disease. J Mol Diagn 7: 613-622.
37. Yu M, Zhou Y, Shi Y, Ning L, Yang Y, et al. (2007) Reduced mitochondrial DNA copy number is correlated with tumor progression and prognosis in Chinese breast cancer patients. IUBMB Life 59: 450-457. (Pubitemid 47124001)
38. Laderman KA, Penny JR, Mazzucchelli F, Bresolin N, Scarlato G, et al. (1996) Aging-dependent functional alterations of mitochondrial DNA (mtDNA) from human fibroblasts transferred into mtDNA-less cells. J Biol Chem 271: 15891-15897. (Pubitemid 26236197)
39. Clay MLL, Deng JJ, Bai Y (2009) Number matters: control of mammalian mitochondrial DNA copy number. J Genet Genomics 36: 125-131.
40. Dimmock D, Tang LY, Schmitt ES, Wong LJ (2010) Quantitative evaluation of the mitochondrial DNA depletion syndrome. Clin Chem 56: 1119-1127.