Switch from canonical to noncanonical Wnt signaling mediates high glucose-induced adipogenesis

Stem Cells

Volumn 32, Issue 6, 2014, Pages 1649-1660

  Keats, Emily C ^a   Dominguez, James M ^b   Grant, Maria B ^b,d   Khan, Zia A ^a,c  

^a WESTERN UNIVERSITY   (Canada)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^c LAWSON HEALTH RESEARCH INSTITUTE   (Canada)

^d INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adipogenesis; Cell autogenous regulation; Diabetes; Noncanonical signaling; Protein kinase C; Wnt signaling

Indexed keywords

GLUCOSE; PROTEIN KINASE C; WNT PROTEIN; WNT11 PROTEIN; ANGIOPOIETIN 2; BETA CATENIN; CD133 ANTIGEN; GLYCOPROTEIN; LEUKOCYTE ANTIGEN; MOLECULAR LIBRARY; PEPTIDE; WNT11 PROTEIN, HUMAN;

ADIPOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; BONE MARROW CELL; CELL DIFFERENTIATION; CONTROLLED STUDY; DIABETES MELLITUS; HUMAN; HUMAN TISSUE; MESENCHYMAL STEM CELL; MOLECULAR BIOLOGY; MOUSE; MULTIPOTENT STEM CELL; NONHUMAN; OSTEOLYSIS; PHENOTYPE; PROTEIN EXPRESSION; RAT; STEM CELL NICHE; WNT SIGNALING PATHWAY; AGED; ANIMAL; BIOLOGICAL MODEL; BONE MARROW; CYTOLOGY; DRUG EFFECTS; EXPERIMENTAL DIABETES MELLITUS; MESENCHYMAL STROMA CELL; METABOLISM; MIDDLE AGED; MOLECULAR LIBRARY; PATHOLOGY; PHARMACOLOGY; SPRAGUE DAWLEY RAT;

ADIPOGENESIS; AGED; ANGIOPOIETIN-2; ANIMALS; ANTIGENS, CD; BETA CATENIN; BONE MARROW; CELL DIFFERENTIATION; DIABETES MELLITUS, EXPERIMENTAL; GLUCOSE; GLYCOPROTEINS; HUMANS; MESENCHYMAL STROMAL CELLS; MIDDLE AGED; MODELS, BIOLOGICAL; PEPTIDES; PROTEIN KINASE C; RATS, SPRAGUE-DAWLEY; SMALL MOLECULE LIBRARIES; WNT PROTEINS; WNT SIGNALING PATHWAY;

EID: 84901470184     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.1659     Document Type: Article

References (44)

1. Botolin S, Faugere MC, Malluche H, et al. Increased bone adiposity and peroxisomal proliferator-activated receptor-gamma2 expression in type I diabetic mice. Endocrinology 2005; 146: 3622-3631.
2. Botolin S, McCabe LR,. Bone loss and increased bone adiposity in spontaneous and pharmacologically induced diabetic mice. Endocrinology 2007; 148: 198-205.
3. Bouillon R,. Diabetic bone disease. Calcif Tissue Int 1991; 49: 155-160.
4. Hough S, Avioli LV, Bergfeld MA, et al. Correction of abnormal bone and mineral metabolism in chronic streptozotocin-induced diabetes mellitus in the rat by insulin therapy. Endocrinology 1981; 108: 2228-2234.
5. Glajchen N, Epstein S, Ismail F, et al. Bone mineral metabolism in experimental diabetes mellitus: Osteocalcin as a measure of bone remodeling. Endocrinology 1988; 123: 290-295.
6. Schwartz AV, Sellmeyer DE, Ensrud KE, et al. Older women with diabetes have an increased risk of fracture: A prospective study. J Clin Endocrinol Metab 2001; 86: 32-38.
7. de L, II, van der Klift, M, de Laet, CE, et al. Bone mineral density and fracture risk in type-2 diabetes mellitus: The Rotterdam Study. Osteoporos Int 2005; 16: 1713-1720.
8. Oikawa A, Siragusa M, Quaini F, et al. Diabetes mellitus induces bone marrow microangiopathy. Arterioscler Thromb Vasc Biol 2010; 30: 498-508.
9. Spinetti G, Cordella D, Fortunato O, et al. Global remodeling of the vascular stem cell niche in bone marrow of diabetic patients: Implication of the microRNA-155/FOXO3a signaling pathway. Circ Res 2013; 112: 510-522.
10. Keats E, Khan ZA,. Unique responses of stem cell-derived vascular endothelial and mesenchymal cells to high levels of glucose. PLoS One 2012; 7: e38752.
11. Kestler HA, Kuhl M,. From individual Wnt pathways towards a Wnt signalling network. Philos Trans R Soc Lond B Biol Sci 2008; 363: 1333-1347.
12. Ross SE, Hemati N, Longo KA, et al. Inhibition of adipogenesis by Wnt signaling. Science 2000; 289: 950-953.
13. Chocarro-Calvo A, Garcia-Martinez JM, Ardila-Gonzalez S, et al. Glucose-induced beta-catenin acetylation enhances Wnt signaling in cancer. Mol Cell 2013; 49: 474-486.
14. Anagnostou SH, Shepherd PR,. Glucose induces an autocrine activation of the Wnt/beta-catenin pathway in macrophage cell lines. Biochem J 2008; 416: 211-218.
15. Lin CL, Wang JY, Huang YT, et al. Wnt/beta-catenin signaling modulates survival of high glucose-stressed mesangial cells. J Am Soc Nephrol 2006; 17: 2812-2820.
16. Khan ZA, Melero-Martin JM, Wu X, et al. Endothelial progenitor cells from infantile hemangioma and umbilical cord blood display unique cellular responses to endostatin. Blood 2006; 108: 915-921.
17. Khan ZA, Boscolo E, Picard A, et al. Multipotential stem cells recapitulate human infantile hemangioma in immunodeficient mice. J Clin Invest 2008; 118: 2592-2599.
18. Keats EC, Khan ZA,. Vascular stem cells in diabetic complications: Evidence for a role in the pathogenesis and the therapeutic promise. Cardiovasc Diabetol 2012; 11: 37.
19. Tanaka S, Terada K, Nohno T,. Canonical Wnt signaling is involved in switching from cell proliferation to myogenic differentiation of mouse myoblast cells. J Mol Signal 2011; 6: 12.
20. Chen B, Dodge ME, Tang W, et al. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol 2009; 5: 100-107.
21. Schlessinger K, Hall A, Tolwinski N,. Wnt signaling pathways meet Rho GTPases. Genes Dev 2009; 23: 265-277.
22. Koh CG,. Rho GTPases and their regulators in neuronal functions and development. Neurosignals 2006; 15: 228-237.
23. Wojciak-Stothard B, Ridley AJ,. Rho GTPases and the regulation of endothelial permeability. Vascul Pharmacol 2002; 39: 187-199.
24. Webb PR, Doyle C, Anderson NG,. Protein kinase C-epsilon promotes adipogenic commitment and is essential for terminal differentiation of 3T3-F442A preadipocytes. Cell Mol Life Sci 2003; 60: 1504-1512.
25. Melero-Martin JM, Khan ZA, Picard A, et al. In vivo vasculogenic potential of human blood-derived endothelial progenitor cells. Blood 2007; 109: 4761-4768.
26. Melero-Martin JM, De Obaldia ME, Kang SY, et al. Engineering robust and functional vascular networks in vivo with human adult and cord blood-derived progenitor cells. Circ Res 2008; 103: 194-202.
27. Slade JM, Coe LM, Meyer RA, et al. Human bone marrow adiposity is linked with serum lipid levels not T1-diabetes. J Diabetes Complications 2012; 26: 1-9.
28. Motyl K, McCabe LR,. Streptozotocin, type I diabetes severity and bone. Biol Proced Online 2009; 11: 296-315.
29. Botolin S, McCabe LR,. Inhibition of PPARgamma prevents type I diabetic bone marrow adiposity but not bone loss. J Cell Physiol 2006; 209: 967-976.
30. Frenette PS, Pinho S, Lucas D, et al. Mesenchymal stem cell: Keystone of the hematopoietic stem cell niche and a stepping-stone for regenerative medicine. Annu Rev Immunol 2013; 31: 285-316.
31. Maisonpierre PC, Suri C, Jones PF, et al. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science 1997; 277: 55-60.
32. Gomei Y, Nakamura Y, Yoshihara H, et al. Functional differences between two Tie2 ligands, angiopoietin-1 and -2, in regulation of adult bone marrow hematopoietic stem cells. Exp Hematol 2010; 38: 82-89.
33. Yellowlees Douglas J, Bhatwadekar AD, Li Calzi S, et al. Bone marrow-CNS connections: Implications in the pathogenesis of diabetic retinopathy. Prog Retin Eye Res 2012; 31: 481-494.
34. Cristancho AG, Lazar MA,. Forming functional fat: A growing understanding of adipocyte differentiation. Nat Rev Mol Cell Biol 2011; 12: 722-734.
35. Kawai M, Mushiake S, Bessho K, et al. Wnt/Lrp/beta-catenin signaling suppresses adipogenesis by inhibiting mutual activation of PPARgamma and C/EBPalpha. Biochem Biophys Res Commun 2007; 363: 276-282.
36. Longo KA, Wright WS, Kang S, et al. Wnt10b inhibits development of white and brown adipose tissues. J Biol Chem 2004; 279: 35503-35509.
37. Kang S, Bennett CN, Gerin I, et al. Wnt signaling stimulates osteoblastogenesis of mesenchymal precursors by suppressing CCAAT/enhancer- binding protein alpha and peroxisome proliferator-activated receptor gamma. J Biol Chem 2007; 282: 14515-14524.
38. Kanazawa A, Tsukada S, Kamiyama M, et al. Wnt5b partially inhibits canonical Wnt/beta-catenin signaling pathway and promotes adipogenesis in 3T3-L1 preadipocytes. Biochem Biophys Res Commun 2005; 330: 505-510.
39. Takada I, Mihara M, Suzawa M, et al. A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation. Nat Cell Biol 2007; 9: 1273-1285.
40. Wakabayashi K, Okamura M, Tsutsumi S, et al. The peroxisome proliferator-activated receptor gamma/retinoid X receptor alpha heterodimer targets the histone modification enzyme PR-Set7/Setd8 gene and regulates adipogenesis through a positive feedback loop. Mol Cell Biol 2009; 29: 3544-3555.
41. Tu X, Joeng KS, Nakayama KI, et al. Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation. Dev Cell 2007; 12: 113-127.
42. Chang J, Sonoyama W, Wang Z, et al. Noncanonical Wnt-4 signaling enhances bone regeneration of mesenchymal stem cells in craniofacial defects through activation of p38 MAPK. J Biol Chem 2007; 282: 30938-30948.
43. Maeda K, Kobayashi Y, Udagawa N, et al. Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis. Nat Med 2012; 18: 405-412.
44. Arai F, Hirao A, Ohmura M, et al. Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell 2004; 118: 149-161.