Protective effect of resveratrol against acute lung injury induced by lipopolysaccharide via inhibiting the myd88-dependent Toll-like receptor 4 signaling pathway

Molecular Medicine Reports

Volumn 10, Issue 1, 2014, Pages 101-106

  Zhang, Zhuo ^a   Chen, Ni ^a   Liu, Jin Bo ^a   Wu, Jian Bo ^a   Zhang, Jing ^a   Zhang, Ying ^a   Jiang, Xian ^a  

^a SOUTHWEST MEDICAL UNIVERSITY   (China)

Author keywords

Acute lung injury; Lipopolysaccharide; Resveratrol; Toll like receptor 4

Indexed keywords

CYCLOOXYGENASE 2; EOSIN; HEMATOXYLIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MYELOID DIFFERENTIATION FACTOR 88; RESVERATROL; TOLL LIKE RECEPTOR 4; MYD88 PROTEIN, MOUSE; NONSTEROID ANTIINFLAMMATORY AGENT; STILBENE DERIVATIVE;

ACUTE LUNG INJURY; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL PERMEABILITY; BRONCHIAL PERFUSION; CONTROLLED STUDY; CYTOLYSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; ERYTHROCYTE; HISTOLOGY; LEUKOCYTE; LUNG; LUNG ALVEOLUS WALL; LUNG CONGESTION; LUNG EDEMA; LUNG LAVAGE; MOUSE; NEUTROPHIL; NONHUMAN; PERFUSION; PROTECTION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STAINING; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; CYTOLOGY; DISEASE MODEL; DRUG EFFECTS; METABOLISM; PATHOLOGY; TOXICITY;

ACUTE LUNG INJURY; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BRONCHOALVEOLAR LAVAGE FLUID; CYCLOOXYGENASE 2; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; INTERLEUKIN-6; LEUKOCYTES; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED BALB C; MYELOID DIFFERENTIATION FACTOR 88; NF-KAPPA B; SIGNAL TRANSDUCTION; STILBENES; TOLL-LIKE RECEPTOR 4;

EID: 84901468367     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2014.2226     Document Type: Article

References (35)

1. Li T, Zhang J, Feng J, Li Q, Wu L, Ye Q, Sun J, Lin Y, Zhang M, Huang R, Cheng J, Cao Y, Xiang G, Zhang J and Wu Q: Resveratrol reduces acute lung injury in a LPS-induced sepsis mouse model via activation of Sirt1. Mol Med Rep 7: 1889-1895, 2013.
2. Cabrera-Benitez NE, Pérez-Roth E, Casula M, Ramos-Nuez A, Ríos-Luci C, Rodríguez-Gallego C, Sologuren I, Jakubkiene V, Slutsky AS, Padrón JM and Villar J: Anti-inflammatory activity of a novel family of aryl ureas compounds in an endotoxin-induced airway epithelial cell injury model. PLoS One 7: e48468, 2012.
3. Rubenfeld G, Caldwell E, Peabody E, Weaver J, Martin DP, Neff M, Stern EJ and Hudson LD: Incidence and outcomes of acute lung injury. N Engl J Med 353: 1685-1693, 2005. (Pubitemid 41464707)
4. Zhang XQ, Lv CJ, Liu XY, Hao D, Qin J, Tian HH, Li Y and Wang XZ: Genome-wide analysis of DNA methylation in rat lungs with lipopolysaccharide- induced acute injury. Mol Med Rep 7: 1417-1424, 2013.
5. Devaney J, Contreras M and Laffey JG: Clinical review: gene-based therapies for ALI/ARDS: where are we now? Crit Care 15: 224, 2011.
6. Martínez O, Nin N and Esteban A: Prone position for the treatment of acute respiratory distress syndrome: a review of current literature. Arch Bronconeumol 45: 291-296, 2009 (In Spanish).
7. Nagaoka K, Takahara K, Tanaka K, Yoshida H, Steinman RM, Saitoh S, Akashi-Takamura S, Miyake K, Kang YS, Park CG and Inaba K: Association of SIGNR1 with TLR4-MD-2 enhances signal transduction by recognition of LPS in gram-negative bacteria. Int Immunol 17: 827-836, 2005. (Pubitemid 41417950)
8. Wang X, Bi Z, Wang Y and Wang Y: Increased MAPK and NF-κB expression of Langerhans cells is dependent on TLR2 and TLR4, and increased IRF-3 expression is partially dependent on TLR4 following UV exposure. Mol Med Rep 4: 541-546, 2011.
9. Andonegui G, Zhou H, Bullard D, Kelly MM, Mullaly SC, McDonald B, Long EM, Robbins SM and Kubes P: Mice that exclusively express TLR4 on endothelial cells can efficiently clear a lethal systemic Gram-negative bacterial infection. J Clin Invest 119: 1921-1930, 2009.
10. Diaz JV, Brower R, Calfee CS and Matthay MA: Therapeutic strategies for severe acute lung injury. Crit Care Med 38: 1644-1650, 2010.
11. Takeda K, Kaisho T and Akira S: Toll-like receptors. Annu Rev Immunol 21: 335-376, 2003. (Pubitemid 37174535)
12. Youn HS, Lee JY, Fitzgerald KA, Young HA, Akira S and Hwang DH: Specific inhibition of MyD88-independent signaling pathways of TLR3 and TLR4 by resveratrol: molecular targets are TBK1 and RIP1 in TRIF complex. J Immunol 175: 3339-3346, 2005. (Pubitemid 41170555)
13. Karpurapu M, Wang X, Deng J, Park H, Xiao L, Sadikot RT, Frey RS, Maus UA, Park GY, Scott EW and Christman JW: Functional PU.1 in macrophages has a pivotal role in NF-κB activation and neutrophilic lung inflammation during endotoxemia. Blood 118: 5255-5266, 2011.
14. Zheng M, Chen R, Zhong H, Lin Q, Wang X, Zhao Z and Xie L: Side-effects of resveratrol in HepG2 cells: reduced pten and increased bcl-xl mRNA expression. Mol Med Rep 6: 1367-1370, 2012.
15. Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, Wang M, Ramaswamy S, Fishbein KW, Spencer RG, Lakatta EG, Le Couteur D, Shaw RJ, Navas P, Puigserver P, Ingram DK, de Cabo R and Sinclair DA: Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444: 337-342, 2006. (Pubitemid 44764104)
16. Kim SY, Park KC, Kwon SB and Kim DS: Hypopigmentary effects of 4-n-butylresorcinol and resveratrol in combination. Pharmazie 67: 542-546, 2012.
17. Athar M, Back JH, Tang X, Kim KH, Kopelovich L, Bickers DR and Kim AL: Resveratrol: a review of preclinical studies for human cancer prevention. Toxicol Appl Pharmacol 224: 274-283, 2007. (Pubitemid 47575677)
18. Kim MY: Nitric oxide triggers apoptosis in A375 human melanoma cells treated with capsicin and resveratrol. Mol Med Rep 5: 585-591, 2012.
19. Li W, Dai S, An J, Li P and Chen X: Chronic but not acute treatment with caffeine attenuates traumatic brain injury in the mouse cortical impact model. Neuroscience 151: 1198-1207, 2008.
20. Li J, Zhao L, He X, Zeng YJ and Dai SS: Sinomenine protects against lipopolysaccharide-induced acute lung injury in mice via adenosine A(2A) receptor signaling. PLoS One 8: e59257, 2013.
21. Rogerio AP, Fontanari C, Borducchi E, Keller AC, Russo M, Soares EG, Albuquerque DA and Faccioli LH: Anti-inflammatory effects of Lafoensia pacari and ellagic acid in a murine model of asthma. Eur J Pharmacol 580: 262-270, 2008.
22. Frenzel J, Gessner C, Sandvoss T, Hammerschmidt S, Schellenberger W, Sack U, Eschrich K and Wirtz H: Outcome prediction in pneumonia induced ALI/ARDS by clinical features and peptide patterns of BALF determined by mass spectrometry. PLoS ONE 6: e25544, 2011.
23. Li J, Zhao L, He X, Zeng YJ and Dai SS: Sinomenine protects against lipopolysaccharide-induced acute lung injury in mice via adenosine A2A receptor signaling. PLoS ONE 8: e59257, 2013.
24. Wang Y, He H, Li D, Zhu W, Duan K, Le Y, Liao Y and Ou YW: The role of the TLR4 signaling pathway in cognitive deficits following surgery in aged rats. Mol Med Rep 7: 1137-1142, 2013.
25. Zhou J, Zhang X, Zhang H, Jia Y, Liu Y, Tang Y and Li X: Use of data mining to determine changes in the gene expression profiles of rat embryos following prenatal exposure to inflammatory stimulants. Mol Med Rep 8: 95-102, 2013.
26. Bai Y, Mao QQ, Qin J, Zheng XY, Wang YB, Yang K, Shen HF and Xie LP: Resveratrol induces apoptosis and cell cycle arrest of human T24 bladder cancer cells in vitro and inhibits tumor growth in vivo. Cancer Sci 101: 488-493, 2010.
27. Kim MH, Yoo DS, Lee SY, Byeon SE, Lee YG, Min T, Rho HS, Rhee MH, Lee J and Cho JY: The TRIF/TBK1/IRF-3 activation pathway is the primary inhibitory target of resveratrol, contributing to its broad-spectrum anti-inflammatory effects. Pharmazie 66: 293-300, 2011.
28. Hou HW, Li XG, Yan M, Hu ZQ and Song YE: Increased leukocyte Rho-kinase activity in a population with acute coronary syndrome. Mol Med Rep 8: 250-254, 2013.
29. Wheeler AP and Bernard GR: Acute lung injury and the acute respiratory distress syndrome: a clinical review. Lancet 369: 1553-1564, 2007. (Pubitemid 46670280)
30. Teng P, Li YH, Cheng WJ, Zhou L, Shen Y and Wang Y: Neuroprotective effects of Lycium barbarum polysaccharides in lipopolysaccharide-induced BV2 microglial cells. Mol Med Rep 7: 1977-1981, 2013.
31. Knapp S, Florquin S, Golenbock DT and van der Poll T: Pulmonary lipopolysaccharide (LPS)-binding protein inhibits the LPS-induced lung inflammation in vivo. J Immunol 176: 3189-3195, 2006.
32. Bachmaier K, Toya S, Gao X, Triantafillou T, Garrean S, Park GY, Frey RS, Vogel S, Minshall R, Christman JW, Tiryppathi C and Malik AB: E3 ubiquitin ligase Cblb regulates the acute inflammatory response underlying lung injury. Nat Med 13: 920-926, 2007. (Pubitemid 47222038)
33. Shen Y, Wang Q, Zhao Q and Zhao J: Leptin promotes the immune escape of lung cancer by inducing proinflammatory cytokines and resistance to apoptosis. Mol Med Rep 2: 295-299, 2009.
34. Medvedev AE, Lentschat A, Wahl LM, Golenbock DT and Vogel SN: Dysregulation of LPS-induced Toll-like receptor 4-MyD88 complex formation and IL-1 receptor-associated kinase 1 activation in endotoxin-tolerant cells. J Immunol 169: 5209-5216, 2002. (Pubitemid 35217192)
35. Ware LB and Matthay MA: The acute respiratory distress syndrome. N Engl J Med 342: 1334-1349, 2000. (Pubitemid 30408719)