Newly identified precipitating factors in mechanical ventilation-induced brain damage: Implications for treating ICU delirium

Expert Review of Neurotherapeutics

Volumn 14, Issue 6, 2014, Pages 583-588

  González López, Adrián ^a   Albaiceta, Guillermo M ^b   Talbot, Konrad ^c  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY OF OVIEDO   (Spain)

^c CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

apoptosis; cognition; critical care; dopamine; dopamine D2 receptor; dysbindin; haloperidol; hippocampus; mechanical ventilation; vagus nerve

Indexed keywords

DOPAMINE; DOPAMINE 2 RECEPTOR; HALOPERIDOL; PROTEIN KINASE B; SLOW ADAPTING RECEPTOR;

ARTIFICIAL VENTILATION; BRAIN DEATH; DELIRIUM; ENZYME INHIBITION; HUMAN; INTENSIVE CARE UNIT; OXIDATIVE STRESS; PROTEIN EXPRESSION; REVIEW; TIDAL VOLUME; TREATMENT DURATION; BRAIN INJURIES;

BRAIN INJURIES; DELIRIUM; HUMANS; RESPIRATION, ARTIFICIAL;

EID: 84901467633     PISSN: 14737175     EISSN: 17448360     Source Type: Journal    
DOI: 10.1586/14737175.2014.915743     Document Type: Review

References (61)

1. Esteban A, Ferguson ND, Meade MO, et al. Evolution of mechanical ventilation in response to clinical research. Am J Respir Crit Care Med 2008;177(2):170-7
2. Ely EW, Inouye SK, Bernard GR, et al. Delirium in mechanically ventilated patients, validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU). JAMA 2001;286(21):2703-10
3. Milbrandt EB, Deppen S, Harrison PL, et al. Costs associated with delirium in mechanically ventilated patients. Crit Care Med 2004;32(4):955-62
4. Pandharipande PP, Girard TD, Jackson JC, et al. Long-term cognitive impairment after critical illness. New Engl J Med 2013; 369(14):1306-16
5. Thomason JWW, Shintani A, Peterson JF, et al. Intensive care unit delirium is an independent predictor of longer hospital stay: a prospective analysis of 261 non-ventilated patients. Crit Care 2005;9:R375-81
6. Van Rompaey B, Schuurmans MJ, Shortridge-Baggett LM, et al. A comparison of the CAM-ICU and the NEECHAM Confusional Scale in intensive care delirium assessment: an observational study in non-intubated patients. Crit Care 2008; 12(1):R16
7. Cavallazzi R, Saad M, Marik PE. Delirium in the ICU: an overview. Ann Intensive Care 2012;2(1):49
8. Janz DR, Abel TW, Jackson JC, et al. Brain autopsy findings in intensive care unit patients previously suffering from delirium: a pilot study. J Crit Care 2010;25(3): 538.e7-12
9. Gunther ML, Morandi A, Krauskopf E, et al. The association between brain volumes, delirium duration, and cognitive outcomes in intensive care unit survivors: the VISIONS cohort magnetic resonance imaging study. Crit Care Med 2012;40(7): 2022-32
10. Morandi A, Rogers BP, Gunther ML, et al. The relationship between delirium duration, white matter integrity, and cognitive impairment in intensive care surviors as determined by diffusion tensor imaging: the VISIONS prospective cohort magnetic resonance imaging study. Crit Care Med 2012;40(7):2182-9
11. Girard TD, Jackson JC, Pandharipande PP, et al. Delirium as a predictor of long-term cognitive impairment in survivors of critical illness. Crit Care Med 2010;38(7):1513-20
12. Desai SV, Law TJ, Needham DM. Long-term complications of critical care. Crit Care Med 2011;39(2):371-9
13. Brummel NE, Jackson JC, Pandharipande PP, et al. Delirium in the ICU and subsequent long-term disability among survivors of mechanical ventilation. Crit Care Med 2014;42(2):369-77
14. Barr J, Fraser GL, Puntillo K, et al. Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit. Crit Care Med 2013;41(1):263-306
15. Reade MC, Finfer S. Sedation and delirium in the intensive care unit. N Engl J Med 2014;370(5):444-54
16. Brummel NE, Girard TD. Preventing delirium in the intensive care unit. Crit Care Clin 2013;29(1):51-65
17. Hipp DM, Ely EW. Pharmacological and nonpharmacological management of delirium in critically ill patients. Neurotherapeutics 2012;9(1):158-75
18. Balas MC, Vasilevskis EE, Olsen KM, et al. Effectiveness and safety of the awakening and breathing coordination, delirium monitoring/management, and early exercise/ mobility bundle. Crit Care Med 2014; 42(5):1024-36
19. Devlin JW, Fraser GL, Ely EW, et al. Pharmacolgical management of sedation and delirium in mechanically ventilated ICU patients: remaining evidence gaps and controversies. Semin Respir Crit Care Med 2013;34(2):201-15
20. Page VJ, Ely EW, Gates S, et al. Effect of intravenous haloperidol on the duration of delirium and coma in critically ill patients (Hope-ICU): a randomized, double-blind, placebo-controlled trial. Lancet Respir Med 2013;1(7):515-23
21. Khan BA, Zawahiri M, Campbell NL, Boustani MA. Biomarkers of delirium-a review. J Am Geriatr Soc 2011;59(Suppl 2): S256-61
22. Girard TD, Ware LB, Bernard GR, et al. Associations of markers of inflammation and coagulation with delirium during critical illness. Intensive Care Med 2012; 38(12):1965-73
23. Trzepacz PT. Is there a final common neural pathway in delirium? Focus on acetylcholine and dopamine. Semin Clin Neuropsychiatry 2000;5(2):132-48
24. Lee M. Neurotransmitters and microglial-mediated neuroinflammation. Curr Protein Pept Sci 2013;14(1):21-32
25. Gaskill PJ, Carvallo L, Eugenin EA, Berman JW. Characterization and function of the human macrophage dopaminergic system: implications for CNS disease and drug abuse. J Neuroinflammation 2012;9:203
26. Cunningham C, MacLullich AMJ. At the extreme end of the psychoneuroimmunological spectrum: delirium as a maladaptive sickness behavior response. Brain Behav Immun 2013;28:1-13
27. González-López A, López-Alonso I, Aguirre A, et al. Mechanical ventilation triggers hippocampal apoptosis by vagal and dopaminergic pathways. Am J Respir Crit Care Med 2013;188(6):693-702
28. Kesner RP, Hopkins RO. Mnemonic functions of the hippocampus: a comparison between animals and humans. Biol Psychol 2006;73(1):3-18
29. Keane RW, Srinivasan A, Foster LM, et al. Activation of CPP32 during apoptosis of neurons and astrocytes. J Neurosci Res 1997;48(2):168-80
30. Barth M, Schilling L, Schmiedek P. Time course of apoptotic cell death after experimental neurotrauma. Acta Neurochir Suppl 2000;76:121-4
31. Benchoua A, Guégan C, Couriaud C, et al. Specific caspase pathways are activated in the two stages of cerebral infarction. J Neurosci 2001;21(18):7127-34
32. Raghupathi R, Conti AC, Graham DI, et al. Mild traumatic brain injury induces apoptotic cell death in the cortex that is preceded by decreases in cellular Bcl-2 immunoreactivity. Neuroscience 2002; 110(4):605-16
33. Yu X, Sun L, Luo X, et al. Investigation of the neuronal death mode induced by glutamate treatment in serum-, antioxidant-free primary cultured cortical neurons. Brain Res Dev Brain Res 2003;145:263-8
34. Manning BD, Cantley LC. AKT/PKB signaling: navigating downstream. Cell 2007;129(7):1261-74
35. Beaulieu J-M, Del'Guidice T, Sotnikova TD, et al. Beyond cAMP: the regulation of Akt and GSK3 by dopamine receptors. Front Mol Neurosci 2011;4:38
36. Wang W, Li H-L, Wang D-X, et al. Haloperidol prophylaxis decreases delirium incidence in elderly patients after noncardiac surgery: a randomized controlled trial. Crit Care Med 2012;40(3):731-9
37. Kalia M, Mesulam MM. Brain stem projections of sensory and motor components of the vagus complex in the cat: I. The cervical vagus and nodose ganglion. J Comp Neurol 1980;193(2): 435-65
38. Davies RO, Kubin L, Pack AI. Pulmonary stretch receptor relay neurons of the cat: location and contralateral medullary projections. J Physiol 1987;383:571-85
39. Kubin L, Alheid GF, Zuperku EJ, McCrimmon DR. Central pathways of pulmonary and lower airway vagal afferents. J Appl Physiol 2006;101(2):618-27
40. Ezure K, Tanaka I. Pump neurons of the nucleus of the solitary tract project widely to the medulla. Neurosci Lett 1996;215(2): 123-6
41. Aicher SA, Kurucz OS, Reis DJ, Milner TA. Nucleus solitarius efferent terminals synapse on neurons in the caudal ventrolateral medulla that project to the rostral ventrolateral medulla. Brain Res 1995; 693(1-2):51-63
42. Hermes SM, Mitchell JL, Aicher SA. Most neurons in the nucleus tractus solitarii do not send collateral projections to multiple autonomic targets in the rat brain. Exp Neurol 2006;198(2):539-51
43. Moreira TS, Takakura AC, Colombari E, et al. Inhibitory input from slowly adapting lung stretch receptors to retrotrapezoid nucleus chemoreceptors. J Physiol 2007; 580(pt 1):285-300
44. Takakura AC, Moreira TS, West GH, et al. GABAergic pump cells of solitary tract nucleus innervate retrotrapezoid nucleus chemoreceptors. J Neurophysiol 2007;98(2): 374-81
45. Rosin DL, Chang DA, Guyenet PG. Afferent and efferent connections of the rat retrotrapezoid nucleus. J Comp Neurol 2006;499(1):64-89
46. Ezure K. Respiratory-related afferents to parabrachial pontine regions. Respir Physiol Neurobiol 2004;143(2-3):167-75
47. Herbert H, Moga MM, Saper CB. Connections of the parabrachial nucleus with the nucleus of the solitary tract and the medullary reticular formation in the rat. J Comp Neurol 1990;293(4):540-80
48. Bianchi R, Corsetti G, Rodella L, et al. Supraspinal connections and termination patterns of the parabrachial complex determined by the biocytin anterograde tract-tracing technique in the rat. J Anat 1998;193(pt. 3):417-30
49. Tokita K, Inoue T, Boughter JD. Jr. Afferent connections of the parabrachial nucleus in C57Bl/6J mice. Neuroscience 2009;161(2):475-88
50. Geisler S, Zahm DS. Afferents of the ventral tegmental area in the rat-anatomical substratum for integrative functions. J Comp Neurol 2005;490(3): 270-94
51. Luppi P-H, Aston-Jones G, Akoaka H, et al. Afferent projections to the rat locus coeruleus demonstrated by retrograde and anterograde tracing with cholera-toxin B subunit and Phaseolus Vulgaris leucoagglutinin. Neuroscience 1995;65(1): 119-60
52. Ennis M, Aston-Jones G. Activation of locus coeruleus from nucleus paragigantocellularis: a new excitatory amino acid pathway. J Neurosci 1988;8(10): 3644-57
53. Gasbarri A, Verney C, Innocenzi R, et al. Mesolimbic dopaminergic neurons innervating the hippocampal formation in the rat: a combined retrograde tracing and immunohistochemical study. Brain Res 1994;668(1-2):71-9
54. Lisman JE, Grace A. The hippocampal-VTA loop: controlling the entry of information into long-term memory. Neuron 2005;46(5):703-13
55. Manta S, El Mansari M, Debonnel G, Blier P. Electrophysiological and neurochemical effects of long-term vagus stimulation on the monoaminergic systems. Int J Neuropsychopharmacol 2013;16(2): 459-70
56. Hsu K-S. Characterization of dopamine receptors mediating inhibition of excitatory synaptic transmission in the rat hippocampal slice. J Neurophysiol 1996; 76(3):1887-95
57. Milner TA, Bacon CE. Ultrastructural localization of tyrosine hydroxylase-like immunoreactivity in the rat hippocampal formation. J Comp Neurol 1989;281(3): 479-95
58. Ji Y, Yang F, Papaleo F, et al. Role of dysbindin in dopamine receptor trafficking and cortical GABA function. Proc Natl Acad Sci USA 2009;106(46):19593-8
59. Talbot K, Ong WY, Blake DJ, et al. Dysbindin-1 and its protein family with special attention to the potential role of dysbindin-1 in neuronal functions and the pathophysiology of schizophrenia. In: Javitt DC, Kantrowitz J, editors. Handbook of neurochemistry and molecular neurobiology 3rd edition Schizophrenia volume, Springer, New York, USA; 2009. p. 107-241
60. Numakawa T, Yagasaki Y, Ishimoto T, et al. Evidence of novel neuronal functions of dysbindin, a susceptibility gene for schizophrenia. Hum Mol Genet 2004; 13(21):2699-708
61. Talbot K, Louneva N, Cohen JW, et al. Synaptic dysbindin-1 reductions in schizophrenia occur in an isoform-specific manner indicating their subsynaptic location. PLoS One 2011;6(3):e16886