Biomarkers for deliriuma - A review

Journal of the American Geriatrics Society

Volumn 59, Issue SUPPL. 2, 2011, Pages

  Khan, Babar A ^a,c,d   Zawahiri, Mohammed ^c,d   Campbell, Noll L ^c,d,e,f   Boustani, Malaz A ^b,c,f  

^a Div Pulmon and Critical Care Med   (United States)

^b Indiana University   (United States)

^c INDIANA UNIVERSITY   (United States)

^d REGENSTRIEF INSTITUTE   (United States)

^e WISHARD HEALTH SERVICES   (United States)

^f PURDUE UNIVERSITY   (United States)

Author keywords

biomarkers; delirium; serum

Indexed keywords

APOLIPOPROTEIN E; CYTOKINE; HYDROCORTISONE; NEURON SPECIFIC ENOLASE; PROTEIN S100B; SOMATOMEDIN C; BIOLOGICAL MARKER;

CLINICAL RESEARCH; DELIRIUM; DISEASE MARKER; DISEASE SEVERITY; HUMAN; INFLAMMATION; PATIENT MONITORING; PROGNOSIS; REVIEW; AGED; BLOOD;

AGED; BIOLOGICAL MARKERS; DELIRIUM; HUMANS;

EID: 81555220082     PISSN: 00028614     EISSN: 15325415     Source Type: Journal    
DOI: 10.1111/j.1532-5415.2011.03702.x     Document Type: Review

References (26)

1. Witlox J, Nurslings LS, de Jungle JF, et al. Delirium in elderly patients and the risk of postdischarge mortality, institutionalization, and dementia: A meta-analysis. JAMA 2010; 304: 443-451.
2. Boustani M, Baker MS, Campbell N, et al. Impact and recognition of cognitive impairment among hospitalized elders. J Hosp Med 2010; 5: 69-75.
3. Trzepacz PT,. Is there a final common neural pathway in delirium? Focus on acetylcholine and dopamine. Semin Clin Neuropsychiatry 2000; 5: 132-148.
4. De Rooij SE, van Munster BC, Korevaar JC, et al. Cytokines and acute phase response in delirium. J Psychosom Res 2007; 62: 521-525. (Pubitemid 46635470)
5. Adamis D, Lunn M, Martin FC, et al. Cytokines and IGF-I in delirious and non-delirious acutely ill older medical inpatients. Age Ageing 2009; 38: 326-332; discussion 251.
6. Eikelenboom P, Hoogendijk WJ, Jonker C, et al. Immunological mechanisms and the spectrum of psychiatric syndromes in Alzheimers disease. J Psychiatr Res 2002; 36: 269-280. (Pubitemid 34773401)
7. Leung JM, Sands LP, Wang Y, et al. Apolipoprotein E e4 allele increases the risk of early postoperative delirium in older patients undergoing noncardiac surgery. Anesthesiology 2007; 107: 406-411. (Pubitemid 47329538)
8. Van Munster BC, Korevaar JC, Zwinderman AH, et al. The association between delirium and the apolipoprotein E epsilon 4 allele: New study results and a meta-analysis. Am J Geriatr Psychiatry 2009; 17: 856-862.
9. Van Munster BC, Korevaar JC, de Rooij SE, et al. The association between delirium and the apolipoprotein E epsilon4 allele in the elderly. Psychiatr Genet 2007; 17: 261-266. (Pubitemid 47345747)
10. Tagarakis GI, Tsolaki-Tagaraki F, Tsolaki M, et al. The role of apolipoprotein E in cognitive decline and delirium after bypass heart operations. Am J Alzheimers Dis Other Demen 2007; 22: 223-228. (Pubitemid 47025522)
11. Adamis D, Treloar A, Martin FC, et al. ApoE and cytokines as biological markers for recovery of prevalent delirium in elderly medical inpatients. Int J Geriatr Psychiatry 2007; 22: 688-694. (Pubitemid 47180383)
12. Ely EW, Girard TD, Shintani AK, et al. Apolipoprotein E4 polymorphism as a genetic predisposition to delirium in critically ill patients. Crit Care Med 2007; 35: 112-117. (Pubitemid 46035685)
13. Van Munster BC, Bisschop PH, Zwinderman AH, et al. Cortisol, interleukins and S-100 β in delirium in the elderly. Brain Cogn 2010; 74: 18-23.
14. Van Munster BC, Korevaar JC, Zwinderman AH, et al. Time-course of cytokines during delirium in elderly patients with hip fractures. J Am Geriatr Soc 2008; 56: 1704-1709.
15. Macdonald A, Adamis D, Treloar A, et al. C-reactive protein levels predict the incidence of delirium and recovery from it. Age Ageing 2007; 36: 222-225. (Pubitemid 46455405)
16. Wilson K, Broadhurst C, Diver M, et al. Plasma insulin growth factor-1 and incident delirium in older people. Int J Geriatr Psychiatry 2005; 20: 154-159. (Pubitemid 40277894)
17. Tune L, Coyle JT,. Serum levels of Anticholinergic drugs in treatment of acute extrapyramidal side effects. Arch Gen Psychiatry 1980; 37: 293-297. (Pubitemid 10102554)
18. Thomas C, Hestermann U, Kopitz J, et al. Serum anticholinergic activity and cerebral cholinergic dysfunction: An EEG study in frail elderly with and without delirium. BMC Neurosci 2008; 9: 86.
19. Flacker JM, Cummings V, Mach JR, et al. The association of serum anticholinergic activity with delirium in elderly medical patients. Am J Geriatr Psychiatry 1998; 6: 31-41. (Pubitemid 28051719)
20. Plaschke K, Hill H, Engelhardt R, et al. EEG changes and serum anticholinergic activity measured in patients with delirium in the intensive care unit. Anaesthesia 2007; 62: 1217-1223. (Pubitemid 350060522)
21. Plaschke K, Fichtenkamm P, Schramm C, et al. Early postoperative delirium after open-heart cardiac surgery is associated with decreased bispectral EEG and increased cortisol and interleukin-6. Intensive Care Med 2010; 36: 2081-2089.
22. Lemstra AW, Kalisvaart KJ, Vreeswijk R, et al. Pre-operative inflammatory markers and the risk of postoperative delirium in elderly patients. Int J Geriatr Psychiatry 2008; 23: 943-948.
23. Van Munster BC, Korevaar JC, Korse CM, et al. Serum S-100 β in elderly patients with and without delirium. Int J Geriatr Psychiatry 2010; 25: 234-239.
24. Van Munster BC, Korse CM, de Rooij SE, et al. Markers of cerebral damage during delirium in elderly patients with hip fracture. BMC Neurol 2009 May 27; 9: 21.
25. Marcantonio ER, Rudolph JL, Culley D, et al. Serum biomarkers for delirium. J Gerontol A Biol Sci Med Sci 2006; 61A: 1281-1286. (Pubitemid 46147783)
26. Reichenberg A, Yirmiya R, Schuld A, et al. Cytokine-associated emotional and cognitive disturbances in humans. Arch Gen Psychiatry 2001; 58: 445-452. (Pubitemid 32411324)