The substrate capture mechanism of mycobacterium tuberculosis anthranilate phosphoribosyltransferase provides a mode for inhibition

Biochemistry

Volumn 52, Issue 10, 2013, Pages 1776-1787

  Castell, Alina ^a   Short, Francesca L ^a   Evans, Genevieve L ^a   Cookson, Tammie V M ^b   Bulloch, Esther M M ^a   Joseph, Dmitri D A ^b   Lee, Clare E ^a   Parker, Emily J ^b   Baker, Edward N ^a   Lott, J Shaun ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b UNIVERSITY OF CANTERBURY   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITUBERCULOSIS; CARBOXYL GROUPS; HOMODIMERIC ENZYME; MODE OF ACTION; MYCOBACTERIUM TUBERCULOSIS; NON-CATALYTIC; PHOSPHORIBOSYLTRANSFERASE; TRYPTOPHAN BIOSYNTHESIS;

AMINO ACIDS; ENZYME ACTIVITY; HYDROGEN BONDS; SCAFFOLDS; TUBES (COMPONENTS);

BINDING SITES;

ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE; CARBOXYL GROUP; GLYCOSYLTRANSFERASE INHIBITOR; MOLECULAR SCAFFOLD;

ARTICLE; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DESIGN; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBSTRATE; HYDROGEN BOND; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL;

ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE; ANTITUBERCULAR AGENTS; BINDING SITES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; KINETICS; MODELS, MOLECULAR; MYCOBACTERIUM TUBERCULOSIS; ORTHO-AMINOBENZOATES; PHOSPHORIBOSYL PYROPHOSPHATE; SUBSTRATE SPECIFICITY;

EID: 84874995489     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi301387m     Document Type: Article

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