The contribution of visceral fat to improved insulin signaling in Ames dwarf mice

Aging Cell

Volumn 13, Issue 3, 2014, Pages 497-506

  Menon, Vinal ^a   Zhi, Xu ^a,b   Hossain, Tanvir ^a   Bartke, Andrzej ^c   Spong, Adam ^c   Gesing, Adam ^a,d   Masternak, Michal M ^a,e  

^a UNIVERSITY OF CENTRAL FLORIDA COLLEGE OF MEDICINE   (United States)

^b PEKING UNIVERSITY THIRD HOSPITAL   (China)

^c SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d MEDICAL UNIVERSITY OF LODZ   (Poland)

^e INSTITUTE OF HUMAN GENETICS   (Poland)

Author keywords

Adiponectin; Adipose tissue; Ames dwarf; Insulin; Obesity

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; GLUCOSE; GLUCOSE TRANSPORTER 4; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B BETA; GLUCOSE BLOOD LEVEL; INTERLEUKIN 6;

AMES DWARF MICE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; EPIDIDYMIS FAT; GENE EXPRESSION; GENETICALLY ENGINEERED MOUSE STRAIN; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; GLUCOSE TOLERANCE TEST; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; INSULIN SIGNALING; INSULIN TOLERANCE TEST; INTRAABDOMINAL FAT; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; SUBCUTANEOUS FAT; AGING; ANIMAL; BLOOD; FEMALE; GENETICS; METABOLISM; OBESITY; PHOSPHORYLATION; PHYSIOLOGY; SURGERY;

ANIMALIA; MUS;

ADIPONECTIN; AGING; ANIMALS; BLOOD GLUCOSE; FEMALE; GENE EXPRESSION; GLUCOSE TOLERANCE TEST; INSULIN; INTERLEUKIN-6; INTRA-ABDOMINAL FAT; MALE; MICE; MUSCLE, SKELETAL; OBESITY; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 84901466488     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12201     Document Type: Article

References (34)

1. Auwerx J, Cock TA, Knouff C (2003) PPAR-gamma: a thrifty transcription factor. Nucl. Recept Signal 1, e006.
2. Bartke A (2005) Minireview: role of the growth hormone/insulin-like growth factor system in mammalian aging. Endocrinology 146, 3718-3723.
3. Bartke A, Brown-Borg H, Mattison J, Kinney B, Hauck S, Wright C (2001) Prolonged longevity of hypopituitary dwarf mice. Exp. Gerontol. 36, 21-28.
4. Bartke A, Chandrashekar V, Bailey B, Zaczek D, Turyn D (2002) Consequences of growth hormone (GH) overexpression and GH resistance. Neuropeptides 36, 201-208.
5. Bartke A, Bonkowski M, Masternak M (2008) How diet interacts with longevity genes. Hormones (Athens) 7, 17-23.
6. Barzilai N, She L, Liu BQ, Vuguin P, Cohen P, Wang J, Rossetti L (1999) Surgical removal of visceral fat reverses hepatic insulin resistance. Diabetes 48, 94-98.
7. Brown-Borg HM, Borg KE, Meliska CJ, Bartke A (1996) Dwarf mice and the ageing process. Nature, 384, 33.
8. Cnop M, Havel PJ, Utzschneider KM, Carr DB, Sinha MK, Boyko EJ, Retzlaff BM, Knopp RH, Brunzell JD, Kahn SE (2003) Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex. Diabetologia 46, 459-469.
9. Coelho M, Oliveira T, Fernandes R (2013) Biochemistry of adipose tissue: an endocrine organ. Arch. Med. Sci. 9, 191-200.
10. El-Wakkad A, Hassan N-M, Sibaii H, El-Zayat SR (2013) Proinflammatory, anti-inflammatory cytokines and adipokines in students with central obesity. Cytokine 61, 682-687.
11. Gabriely I, Ma XH, Yang XM, Atzmon G, Rajala MW, Berg AH, Scherer P, Rossetti L, Barzilai N (2002) Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: an adipokine-mediated process? Diabetes 51, 2951-2958.
12. Gesing A, Masternak M, Lewinski A, Karbownik-Lewinska M, Kopchick JJ, Bartke A (2013) Decreased levels of proapoptotic factors and increased key regulators of mitochondrial biogenesis constitute new potential beneficial features of long-lived growth hormone receptor gene-disrupted mice. J. Gerontol. A Biol. Sci. Med. Sci. 68, 639-651.
13. Guevara-Aguirre J, Balasubramanian P, Guevara-Aguirre M, Wei M, Madia F, Cheng CW, Hwang D, Martin-Montalvo A, Saavedra J, Ingles S, de Cabo R, Cohen P, Longo VD (2011) Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. Sci. Transl. Med. 3, 70ra13.
14. Halleux CM, Takahashi M, Delporte ML, Detry R, Funahashi T, Matsuzawa Y, Brichard SM (2001) Secretion of adiponectin and regulation of apM1 gene expression in human visceral adipose tissue. Biochem. Biophys. Res. Commun. 288, 1102-1107.
15. Hu E, Liang P, Spiegelman BM (1996) AdipoQ is a novel adipose-specific gene dysregulated in obesity. J. Biol. Chem. 271, 10697-10703.
16. Ikeno Y, Bronson RT, Hubbard GB, Lee S, Bartke A (2003) Delayed occurrence of fatal neoplastic diseases in ames dwarf mice: correlation to extended longevity. J. Gerontol. A Biol. Sci. Med. Sci. 58, 291-296.
17. Kern PA, Ranganathan S, Li C, Wood L, Ranganathan G (2001) Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance. Am. J. Physiol. Endocrinol. Metab. 280, E745-E751.
18. Kern PA, Di Gregorio GB, Lu T, Rassouli N, Ranganathan G (2003) Adiponectin expression from human adipose tissue: relation to obesity, insulin resistance, and tumor necrosis factor-alpha expression. Diabetes, 52, 1779-1785.
19. Kim YW, Kim JY, Lee SK (1999) Surgical removal of visceral fat decreases plasma free fatty acid and increases insulin sensitivity on liver and peripheral tissue in monosodium glutamate (MSG)-obese rats. J. Korean Med. Sci. 14, 539-545.
20. Kinney BA, Meliska CJ, Steger RW, Bartke A (2001) Evidence that Ames dwarf mice age differently from their normal siblings in behavioral and learning and memory parameters. Horm. Behav. 39, 277-284.
21. Kleiner S, Mepani RJ, Laznik D, Ye L, Jurczak MJ, Jornayvaz FR, Estall JL, Chatterjee Bhowmick D, Shulman GI, Spiegelman BM (2012) Development of insulin resistance in mice lacking PGC-1α in adipose tissues. Proc. Natl Acad. Sci. USA 109, 9635-9640.
22. Longo VD, Finch CE (2003) Evolutionary medicine: from dwarf model systems to healthy centenarians? Science 299, 1342-1346.
23. Lottati M, Kolka CM, Stefanovski D, Kirkman EL, Bergman RN (2009) Greater omentectomy improves insulin sensitivity in nonobese dogs. Obesity (Silver Spring) 17, 674-680.
24. Masternak MM, Bartke A (2007) PPARs in calorie restricted and genetically long-lived mice. PPAR Res. 2007, 28436.
25. Masternak MM, Al-Regaiey KA, Del Rosario Lim MM, Bonkowski MS, Panici JA, Przybylski GK, Bartke A (2005) Caloric restriction results in decreased expression of peroxisome proliferator-activated receptor superfamily in muscle of normal and long-lived growth hormone receptor/binding protein knockout mice. J. Gerontol. A Biol. Sci. Med. Sci. 60, 1238-1245.
26. Masternak MM, Panici JA, Bonkowski MS, Hughes LF, Bartke A (2009) Insulin sensitivity as a key mediator of growth hormone actions on longevity. J. Gerontol. A Biol. Sci. Med. Sci. 64, 516-521.
27. Masternak MM, Panici JA, Wang F, Wang Z, Spong A (2010) The effects of growth hormone (GH) treatment on GH and insulin/IGF-1 signaling in long-lived Ames dwarf mice. J. Gerontol. A Biol. Sci. Med. Sci. 65, 24-30.
28. Masternak MM, Bartke A, Wang F, Spong A, Gesing A, Fang Y, Salmon AB, Hughes LF, Liberati T, Boparai R, Kopchick JJ, Westbrook R (2012) Metabolic effects of intra-abdominal fat in GHRKO mice. Aging Cell 11, 73-81.
29. Motoshima H, Wu X, Sinha MK, Hardy VE, Rosato EL, Barbot DJ, Rosato FE, Goldstein BJ (2002) Differential regulation of adiponectin secretion from cultured human omental and subcutaneous adipocytes: effects of insulin and rosiglitazone. J. Clin. Endocrinol. Metab. 87, 5662-5667.
30. Norris AW, Chen L, Fisher SJ, Szanto I, Ristow M, Jozsi AC, Hirshman MF, Rosen ED, Goodyear LJ, Gonzalez FJ, Spiegelman BM, Kahn CR (2003) Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones. J. Clin. Invest. 112, 608-618.
31. Panici JA, Harper JM, Miller RA, Bartke A, Spong A, Masternak MM (2010) Early life growth hormone treatment shortens longevity and decreases cellular stress resistance in long-lived mutant mice. FASEB J. 24, 5073-5079.
32. Tran TT, Yamamoto Y, Gesta S, Kahn CR (2008) Beneficial effects of subcutaneous fat transplantation on metabolism. Cell Metab. 7, 410-420.
33. Wasada T, Aoki K, Sato A, Katsumori K, Muto K, Tomonaga O, Yokoyama H, Iwasaki N, Babazono T, Takahashi C, Iwamoto Y, Omori Y, Hizuka N (1997) Assessment of insulin resistance in acromegaly associated with diabetes mellitus before and after transsphenoidal adenomectomy. Endocr. J. 44, 617-620.
34. Zhou Y, Xu BC, Maheshwari HG, He L, Reed M, Lozykowski M, Okada S, Cataldo L, Coschigamo K, Wagner TE, Baumann G, Kopchick JJ (1997) A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse). Proc. Natl Acad. Sci. USA 94, 13215-13220.