A radical scavenger edaravone inhibits matrix metalloproteinase-9 upregulation and blood-brain barrier breakdown in a mouse model of prolonged cerebral hypoperfusion

Neuroscience Letters

Volumn 573, Issue , 2014, Pages 40-45

  Miyamoto, Nobukazu ^a   Pham, Loc Duyen D ^a   Maki, Takakuni ^a   Liang, Anna C ^a   Arai, Ken ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Blood brain barrier; Edaravone; Matrix metalloproteinase 9; Prolonged cerebral hypoperfusion; White matter injury

Indexed keywords

GELATINASE B; NEUROPROTECTIVE AGENT; NORPHENAZONE; MATRIX METALLOPROTEINASE INHIBITOR; PHENAZONE; PHENYLMETHYLPYRAZOLONE; SCAVENGER;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY OCCLUSION; ARTICLE; BLOOD BRAIN BARRIER; BRAIN PERFUSION; CEREBRAL HYPOPERFUSION; COMMON CAROTID ARTERY; DRUG EFFECT; ENZYME INHIBITION; HYPOXIA; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MALE; MOUSE; NEUROPROTECTION; NONHUMAN; OLIGODENDROCYTE PRECURSOR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; WESTERN BLOTTING; WHITE MATTER INJURY; ANALOGS AND DERIVATIVES; ANIMAL; BRAIN CIRCULATION; BRAIN CORTEX; C57BL MOUSE; CAROTID ARTERY OBSTRUCTION; CELL DEATH; CELL SURVIVAL; COMPLICATION; DRUG EFFECTS; HYPOXIA, BRAIN; METABOLISM; OLIGODENDROGLIA; PATHOLOGY; PATHOPHYSIOLOGY; UPREGULATION; VASCULARIZATION; WHITE MATTER;

ANIMALS; ANTIPYRINE; BLOOD-BRAIN BARRIER; CAROTID ARTERY, COMMON; CAROTID STENOSIS; CELL DEATH; CELL SURVIVAL; CEREBRAL CORTEX; CEREBROVASCULAR CIRCULATION; FREE RADICAL SCAVENGERS; HYPOXIA, BRAIN; MALE; MATRIX METALLOPROTEINASE 9; MATRIX METALLOPROTEINASE INHIBITORS; MICE, INBRED C57BL; OLIGODENDROGLIA; UP-REGULATION; WHITE MATTER;

EID: 84901463850     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2014.05.005     Document Type: Article

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