Anti-inflammatory effects of triptolide by inhibiting the NF-κB signalling pathway in LPS-induced acute lung injury in a murine model

Molecular Medicine Reports

Volumn 10, Issue 1, 2014, Pages 447-452

  Wang, Xian ^a,b   Zhang, Lei ^b   Duan, Wei ^b   Liu, Bin ^b   Gong, Ping ^b   Ding, Yusong ^b   Wu, Xiongwen ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b SHIHEZI UNIVERSITY   (China)

Author keywords

Acute lung injury; Inflammatory cytokines; Toll like receptor 4; Triptolide

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; MYELOPEROXIDASE; SYNAPTOTAGMIN I; TOLL LIKE RECEPTOR 4; TRIPTOLIDE; TUMOR NECROSIS FACTOR ALPHA; CHEMOKINE; DITERPENE; EPOXIDE; I KAPPA B; NF-KAPPAB INHIBITOR ALPHA; NONSTEROID ANTIINFLAMMATORY AGENT; PHENANTHRENE DERIVATIVE;

ACUTE LUNG INJURY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; ENHANCER REGION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HISTOPATHOLOGY; LEUKOCYTE; LUNG EDEMA; LUNG LAVAGE; LUNG WEIGHT; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; WESTERN BLOTTING; ANIMAL; BAGG ALBINO MOUSE; DISEASE MODEL; DRUG EFFECTS; METABOLISM; PATHOLOGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TOXICITY;

ACUTE LUNG INJURY; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BRONCHOALVEOLAR LAVAGE FLUID; CHEMOKINES; DISEASE MODELS, ANIMAL; DITERPENES; EPOXY COMPOUNDS; I-KAPPA B PROTEINS; INTERLEUKIN-1BETA; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED BALB C; NF-KAPPA B; PHENANTHRENES; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84901459099     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2014.2191     Document Type: Article

References (30)

1. Chang CH, Kao CH, Chio CC, Lin CH, Lin MT and Chang CP: Attenuating heatstroke-induced acute lung inflammation, edema, and injury in rats by exercise preconditioning. J Trauma Acute Care Surg 74: 1052-1059, 2013.
2. Sharma S, Smith A, Kumar S, et al: Mechanisms of nitric oxide synthase uncoupling in endotoxin-induced acute lung injury: role of asymmetric dimethylarginine. Vascul Pharmacol 52: 182-190, 2010.
3. Fu PK, Yang CY, Tsai TH and Hsieh CL: Moutan cortex radicis improves lipopolysaccharide-induced acute lung injury in rats through anti-inflammation. Phytomedicine 19: 1206-1215, 2012.
4. Pati S, Gerber MH, Menge TD, et al: Bone marrow derived mesenchymal stem cells inhibit inflammation and preserve vascular endothelial integrity in the lungs after hemorrhagic shock. PLoS One 6: e25171, 2011.
5. Goodman RB, Pugin J, Lee JS and Matthay MA: Cytokine-mediated inflammation in acute lung injury. Cytokine Growth Factor Rev 14: 523-535, 2003. (Pubitemid 37296025)
6. Wen HL, Liang ZS, Zhang R and Yang K: Anti-inflammatory effects of triptolide improve left ventricular function in a rat model of diabetic cardiomyopathy. Cardiovasc Diabetol 12: 50, 2013.
7. Seki H, Tasaka S, Fukunaga K, et al: Effect of Toll-like receptor 4 inhibitor on LPS-induced lung injury. Inflamm Res 59: 837-845, 2010.
8. Jeyaseelan S, Chu HW, Young SK, Freeman MW and Worthen GS: Distinct roles of pattern recognition receptors CD14 and Toll-like receptor 4 in acute lung injury. Infect Immun 73: 1754-1763, 2005. (Pubitemid 40470764)
9. Kennedy M, Phelps D and Ingenito E: Mechanisms of surfactant dysfunction in early acute lung injury. Exp Lung Res 23: 171-189, 1997. (Pubitemid 27250511)
10. Ben DF, Yu XY, Ji GY, et al: TLR4 mediates lung injury and inflammation in intestinal ischemia-reperfusion. J Surg Res 174: 326-333, 2012.
11. Huang D, Fang F and Xu F: Hyperoxia-induced up-regulation of Toll-like receptors expression in alveolar epithelial cells. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 23: 645-649, 2011 (In Chinese).
12. Zhong WT, Wu YC, Xie XX, et al: Phillyrin attenuates LPS-induced pulmonary inflammation via suppression of MAPK and NF-κB activation in acute lung injury mice. Fitoterapia 90: 132-139, 2013.
13. Matta R, Wang X, Ge H, Ray W, Nelin LD and Liu Y: Triptolide induces anti-inflammatory cellular responses. Am J Transl Res 1: 267-282, 2009.
14. Qiu D and Kao PN: Immunosuppressive and anti-inflammatory mechanisms of triptolide, the principal active diterpenoid from the Chinese medicinal herb Tripterygium wilfordii Hook. f. Drugs R D 4: 1-18, 2003.
15. Hoyle GW, Hoyle CI, Chen J, Chang W, Williams RW and Rando RJ: Identification of triptolide, a natural diterpenoid compound, as an inhibitor of lung inflammation. Am J Physiol Lung Cell Mol Physiol 298: L830-L836, 2010.
16. Lee HF, Lee TS and Kou YR: Anti-inflammatory and neuroprotective effects of triptolide on traumatic brain injury in rats. Respir Physiol Neurobiol 182: 1-8, 2012.
17. Klawitter M, Quero L, Klasen J, et al: Triptolide exhibits anti-inflammatory, anti-catabolic as well as anabolic effects and suppresses TLR expression and MAPK activity in IL-1β treated human intervertebral disc cells. Eur Spine J 21 (Suppl 6): S850-S859, 2012.
18. Mei Z, Li X, Wu Q, Hu S and Yang X: The research on the anti-inflammatory activity and hepatotoxicity of triptolide-loaded solid lipid nanoparticle. Pharmacol Res 51: 345-351, 2005. (Pubitemid 40430808)
19. Jeyaseelan S, Chu HW, Young SK and Worthen GS: Transcriptional profiling of lipopolysaccharide-induced acute lung injury. Infect Immun 72: 7247-7256, 2004. (Pubitemid 39552396)
20. Guo Z, Li Q, Han Y, Liang Y, Xu Z and Ren T: Prevention of LPS-induced acute lung injury in mice by progranulin. Mediators Inflamm 2012: 540794, 2012.
21. Fujino N, Kubo H, Suzuki T, et al: Administration of a specific inhibitor of neutrophil elastase attenuates pulmonary fibrosis after acute lung injury in mice. Exp Lung Res 38: 28-36, 2012.
22. Lewis CW, Taylor RG, Kubara PM, Marshall K, Meijer L and Golsteyn RM: A western blot assay to measure cyclin dependent kinase activity in cells or in vitro without the use of radioisotopes. FEBS Lett 587: 3089-3095, 2013.
23. Vallejo-Illarramendi A, Marciano DK and Reichardt LF: A novel method that improves sensitivity of protein detection in PAGE and Western blot. Electrophoresis 34: 1148-1150, 2013.
24. Lim YS, Chung MH, Park SH, et al: Acute and repeated inhalation lung injury by 3-methoxybutyl chloroformate in rats: CT-pathologic correlation. Eur J Radiol 62: 227-234, 2007. (Pubitemid 46613786)
25. Parsons PE, Eisner MD, Thompson BT, et al; NHLBI Acute Respiratory Distress Syndrome Clinical Trials Network: Lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injury. Crit Care Med 33: 1-6; discussion 230-232, 2005.
26. Trevejo JM, Marino MW, Philpott N, et al: TNF-alpha -dependent maturation of local dendritic cells is critical for activating the adaptive immune response to virus infection. Proc Natl Acad Sci USA 98: 12162-12167, 2001. (Pubitemid 32959844)
27. Ning J, Liu QF, Luo XD, Fan ZP and Zhang Y: Effect and mechanism of acute graft versus host disease on early diffuse murine lung injury following allogeneic stem cell transplantation. Sci China C Life Sci 52: 1016-1022, 2009.
28. + CTL response by dendritic cell vaccine. Cancer Res 65: 4947-4954, 2005.
29. Zhang N, Wang Z, Tang X, et al: Type 1 T-cell responses in chlamydial lung infections are associated with local MIP-1alpha response. Cell Mol Immunol 7: 355-360, 2010.
30. Peng XM, Xie JH, Shuai B, et al: Inhalation of aerosolized perfluorocarbon combined with tetramethylpyrazine ameliorates hemodynamics and pulmonary histopathology in a porcine model of acute lung injury. Nan Fang Yi Ke Da Xue Xue Bao 31: 1382-1386, 2011 (In Chinese).