Identification of triptolide, a natural diterpenoid compound, as an inhibitor of lung inflammation

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 298, Issue 6, 2010, Pages

  Hoyle, Gary W ^a   Hoyle, Christine I ^a   Chen, Jing ^a   Chang, Weiyuan ^a   Williams, Ronald W ^b   Rando, Roy J ^c  

^a UNIVERSITY OF LOUISVILLE   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY MEDICAL CENTER   (United States)

^c TULANE UNIVERSITY   (United States)

Author keywords

Acute lung injury; Chlorine gas; Nuclear factor B; Substance P; Tachykinin 1 receptor

Indexed keywords

ANTIINFLAMMATORY AGENT; CHLORINE; G PROTEIN COUPLED RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; SUBSTANCE P; TACHYKININ; TACHYKININ 1 RECEPTOR; TACHYKININ RECEPTOR; TRIPTERYGIUM WILFORDII EXTRACT; TRIPTOLIDE; UNCLASSIFIED DRUG;

ACUTE LUNG INJURY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; AUTOIMMUNE DISEASE; CHINESE MEDICINE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; INFLAMMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE; TRANSCRIPTION REGULATION; TRIPTERYGIUM;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE, TUMOR; CHLORINE; DITERPENES; EPOXY COMPOUNDS; HUMANS; INTERLEUKIN-8; LUNG; MICE; NF-KAPPA B; PHENANTHRENES; PNEUMONIA; SUBSTANCE P;

EID: 77952780937     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00014.2010     Document Type: Article

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