Evaluation of the In vitro Anti-hyperglycemic Effect of Cinnamomum cassia Derived Phenolic Phytochemicals, via Carbohydrate Hydrolyzing Enzyme Inhibition

Plant Foods for Human Nutrition

Volumn 69, Issue 2, 2014, Pages 155-160

  Kang, B H ^a   Racicot, K ^b   Pilkenton, S J ^a   Apostolidis, E ^a  

^a FRAMINGHAM STATE UNIVERSITY   (United States)

^b US Army Natick Soldier Research   (United States)

Author keywords

Alpha glucosidase inhibition; Cinnamomum cassia; Conjugated hydroxycinnamic acid; Maltase inhibition; Proanthocyanidins; Sucrase inhibition

Indexed keywords

CINNAMOMUM AROMATICUM; CINNAMOMUM VERUM; RATTUS;

ACETONE; ALPHA GLUCOSIDASE; ANTIDIABETIC AGENT; GLYCOSIDASE INHIBITOR; PHENOL DERIVATIVE; PLANT EXTRACT; PROANTHOCYANIDIN; SUCRASE;

ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; CINNAMOMUM CASSIA; DOSE RESPONSE; DRUG SCREENING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOLATION AND PURIFICATION; METABOLISM; PROCEDURES; RAT;

ACETONE; ALPHA-GLUCOSIDASES; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CINNAMOMUM AROMATICUM; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; GLYCOSIDE HYDROLASE INHIBITORS; HYPOGLYCEMIC AGENTS; PHENOLS; PLANT EXTRACTS; PROANTHOCYANIDINS; RATS; SUCRASE;

EID: 84901449660     PISSN: 09219668     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11130-014-0415-z     Document Type: Article

References (33)

1. Center for Disease Control. National diabetes fact sheet 2011. Available from http://www. cdc. gov/diabetes/pubs/estimates11. htm. Accessed Aug 2013.
2. The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (1997) Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 20: 1183-1197.
3. Krentz AJ, Bailey CJ (2005) Oral antidiabetic agents: current role in type 2 diabetes mellitus. Drugs 65: 385-411.
4. Yang J, Zhang D, Li J, Zhang X, Fan F, Guan Y (2009) Role of PPAR-gamma in renoprotection in type 2 diabetes: molecular mechanisms and therapeutic potential. Clin Sci 116: 17-26.
5. Apostolidis E, Karayannakidis PD, Kwon Y-I, Lee C, Seeram N (2011) Seasonal variation of phenolic antioxidant-mediated α-glucosidase inhibition of A. nodosum. Plant Foods Hum Nutr 4: 313-319.
6. Kwon Y-I, Vattem DA, Shetty K (2006) Clonal herbs of Lamiaceae species against diabetes and hypertension. Asia Pac J Clin Nutr 15: 107-118.
7. Kwon Y-I, Apostolidis E, Kim Y-C, Shetty K (2007) Health benefits of traditional corn, beans and pumpkin; in vitro studies for hyperglycemia and hypertension management. J Med Food 10: 266-275.
8. Kuroda M, Mimaki Y, Honda S, Tanaka Y, Yokota S, Mae T (2010) Phenolics from Glycyrrhiza glabra roots and their PPAR-gamma ligand-binding activity. Bioorg Med Chem 15: 962-970.
9. Khateeb J, Gantman A, Kreitenberg AJ, Aviram M, Fuhrman B (2010) Paraoxonase 1 (PON1) expression in hepatocytes is upregulated by pomegranate polyphenols: a role for PPAR-gamma pathway. Atherosclerosis 208: 119-125.
10. Rau O, Wurglics M, Paulke A, Zitzkowski J, Meindl N, Bock A, Dingermann T, Abdel-Tawab M, Schuber-Zsilavecz M (2006) Carnosic acid and carnosol, phenolic diterpene compounds of the labiate herbs rosemary and sage, are activators of the human peroxisome proliferator-activated receptor gamma. Planta Med 72: 881-887.
11. Mang B, Wolters M, Schmitt B, Kelb K, Lichtinghagen R, Stichtenoth DO, Hahn A (2006) Effects of a cinnamon extract on plasma glucose, HbA1c, and serum lipids in diabetes mellitus type 2. Eur J Clin Investig 36: 340-344.
12. Crawford P (2009) Effectiveness of cinnamon for lowering hemoglobin A1C in patients with type 2 diabetes: a randomized, controlled trial. J Am Board Fam Med 22: 507-512.
13. Akilen R, Tsiami A, Devendra D, Robinson N (2010) Glycated haemoglobin and blood pressure-lowering effect of cinnamon in multi-ethnic Type 2 diabetic patients in the UK: a randomized, placebo-controlled, double-blind clinical trial. Diabet Med 27: 1159-1167.
14. Lu T, Sheng H, Wu J, Cheng Y, Zhu J, Chen Y (2012) Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes. Nutr Res 32: 408-412.
15. Verspohl EJ, Bauer K, Nedderman E (2005) Antidiabetic effect of Cinnamomum cassia and Cinnamomum zeylanicum in vivo and in vitro. Phytother Res 19: 203-206.
16. Kannappan S, Jayraman T, Rajasekar P, Ravichandran MK, Anuradha CV (2006) Cinnamon bark extract improves glucose metabolism and lipid profile in the fructose-fed rat. Singap Med J 47: 858-863.
17. Jia Q, Liu X, Wu X, Wang R, Hu X, Li Y, Huang C (2009) Hypoglycemic activity of a polyphenolic oligomer-rich extract of Cinnamomum parthenoxylon bark in normal and streptozotocin-induced diabetic rats. Phytomedicine 16: 744-750.
18. Kim SH, Hyun SH, Choung SY (2006) Anti-diabetic effect of cinnamon extract on blood glucose in db/db mice. J Ethnopharmacol 104: 119-123.
19. Anderson RA, Broadhurst CL, Polansky MM, Schmidt WF, Khan A, Flanagan VP, Schoene NW, Graves DJ (2004) Isolation and characterization of polyphenol type-A polymers from cinnamon with insulin-like biological activity. J Agric Food Chem 52: 65-70.
20. Javrill-Taylor KJ, Anderson RA, Graves DJ (2001) A hydroxychalone derived from cinnamon features functions as a mimetic for insulin in 3T3-L1 adipocytes. J Am Coll Nutr 20: 327-336.
21. Cao H, Polansky MM, Anderson RA (2007) Cinnamon extract and polyphenols affect the expression of tristetraprolin, insulin receptor, and glucose transporter 4 in mouse 3T3-L1 adipocytes. Arch Biochem Biophys 459: 214-222.
22. Scalbert A, Morand C, Manach C, Remesy C (2002) Absorption and metabolism of polyphenols in the gut and impact on health. Biomed Pharmacother 56: 276-282.
23. Deprez S, Mila I, Huneau JF, Tome D, Scalbert A (2001) Transport of proanthocyanidin dimer, trimer and polymer across monolayers of human intestinal epithelial Caco-2 cells. Antioxid Redox Signal 3: 957-967.
24. Donovan JL, Manach C, Rios L, Monrad C, Scalbert A, Remesy C (2002) Procyanidins are not bioavailable in rats fed a single meal containing grape seed extract or procyanidin dimer B3. Br J Nutr 87: 299-306.
25. Holt RR, Lazarus SA, Sullards MC, Zhu QY, Schramm DD, Hammerstone GF, Fraga CG, Schmitz HH, Keen CL (2002) Procyanidin dimer B2 (epicatechin-(4b-8)-epicatechin) in human plasma after the consumption of a flavonol-rich cocoa. Am J Clin Nutr 76: 798-804.
26. Adisakwattana S, Lerdsuwankij O, Poputtachai U, Minipun A, Suparpprom C (2011) Inhibitory activity of cinnamon bark species and their combination effect with acarbose against intestinal α-glucosidase and pancreatic α-amylase. Plant Foods Hum Nutr 66: 143-148.
27. Shetty K, Curtis OF, Levin RE, Witkowsky R, Ang W (1995) Prevention of vitrification associated with in vitro shoot culture of oregano (Origanum vulgare) by Pseudomonas spp. J Plant Physiol 147: 447-451.
28. Wallace TC, Giusti MM (2010) Evaluation of parameters that affect the 4-dimethylaminocinnamaldehyde assay for flavanols and proanthocyanidins. J Food Sci 75: C619-C625.
29. Seeram NP, Adams LS, Hardy ML, Heber D (2004) Total cranberry extract versus its phytochemical constituents: antiproliferative and synergistic effects against human tumor cell lines. J Agric Food Chem 52: 2512-2517.
30. Kajdzanoska M, Petreska J, Stefova M (2011) Comparison of different extraction solvent mixtures for characterization of phenolic compounds in strawberries. J Agric Food Chem 59: 5272-5278.
31. Jo S-H, Ka E-H, Lee H-C, Apostolidis E, Jang H-D, Kwon Y-I (2011) Comparison of antioxidant potential and rat intestinal alpha-glucosidase inhibitory activities of quercetin, rutin and isoquercetin. Int J App Res Nat Prod 2: 52-60, http://ijarnp. org/index. php/ijarnp/article/view/41/41.
32. Demiray S, Pintado ME, Castro PML (2009) Evaluation of phenolic profiles and antioxidant activities of Turkish medicinal plants: Tilia argentea, Crataegi folium leaves and Polygonum bistorta roots. World Acad Sci Eng Technol 30: 307-312, http://www. docstoc. com/docs/19972037/Evaluation-of-phenolic-profiles-and-antioxidant-activities-of.
33. Lee J (2013) Proanthocyanidin A2 purification and quantification of American cranberry (Vaccinium macrocarpon Ait.) products. J Funct Foods 5: 144-153.